ALLMedicine™ Hemochromatosis Center
Research & Reviews 673 results
Advances in Anatomic Pathology; Khan S, Saxena R
Jul 31st, 2021 - Fibrosis is not a unidirectional, linear process, but a dynamic one resulting from an interplay of fibrogenesis and fibrolysis depending on the extent and severity of a biologic insult, or lack thereof. Regression of fibrosis has been documented b...
The American Journal of Clinical Nutrition; Julián-Serrano S, Yuan F et. al.
Jul 15th, 2021 - Epidemiological studies have suggested positive associations for iron and red meat intake with risk of pancreatic ductal adenocarcinoma (PDAC). Inherited pathogenic variants in genes involved in the hepcidin-regulating iron metabolism pathway are ...
Trends in Pharmacological Sciences; Roemhild K, von Maltzahn F et. al.
Jun 7th, 2021 - Iron is essential in many physiological processes, including DNA metabolism, oxygen transport, and cellular energy generation. Deregulated iron metabolism, which results in iron overload or iron deficiency, is observed in many different diseases. ...
Hepatology (Baltimore, Md.); Viveiros A, Schaefer B et. al.
May 29th, 2021 - High serum ferritin is frequent among patients with chronic liver disease and commonly associated with hepatic iron overload. Genetic causes of high liver iron include homozygosity for the p.Cys282Tyr variant in homeostatic iron regulator (HFE) an...
https://doi.org/10.1007/s10620-021-07048-5 10.3322/caac.21492 10.1038/s41575-019-0186-y 10.1002/hep.20027 10.1158/1055-9965.EPI-07-2806 10.3748/wjg.v13.i5.781 10.3390/medicina55090526 10.1146/annurev-pathol-052016-100322 10.1186/1471-230X-14-117 10.1016/j.dld.2012.08.018 10.1007/s10620-006-3209-9 10.1111/apt.15464 10.3748/wjg.v21.i4.1189 10.1111/j.1440-1746.2007.04908.x 10.1159/000170881 10.1111/liv.14087 10.1007/s10620-012-2260-y 10.1002/hep.29913 10.1001/jamanetworkopen.2019.6412 10.1371/journal.pone.0204412 10.20892/j.issn.2095-3941.2016.0058 10.1177/1756283X17710247 10.1159/000477173 10.1038/nrc1934 10.1177/1758835919861914 10.1016/S0168-8278(05)80609-9 10.4254/wjh.v7.i22.2384 10.1007/s12072-013-9494-4 10.4254/wjh.v11.i1.1 10.1097/COC.0000000000000388 10.1186/s12957-015-0713-4 10.1002/hep.29003 10.1111/jgh.12999 10.1371/journal.pone.0095485 10.1371/journal.pone.0174333 10.1002/1097-0142(20010301)91:5<957::AID-CNCR1085>3.0.CO;2-J 10.1620/tjem.227.73 10.1111/liv.13877 10.1002/hep.22734
Digestive Diseases and Sciences; Pinyopornpanish K, Al-Yaman W et. al.
May 25th, 2021 - The data on hepatocellular carcinoma (HCC) patients without liver cirrhosis is scarce. To study the epidemiology, underlying etiology and fibrosis distribution in noncirrhotic HCC and compare the survival outcomes to cirrhotic HCC. We conducted a ...
Guidelines 5 results
The American Journal of Gastroenterology; Kowdley KV, Brown KE et. al.
Jul 25th, 2019 - Hereditary hemochromatosis (HH) is one of the most common genetic disorders among persons of northern European descent. There have been recent advances in the diagnosis, management, and treatment of HH. The availability of molecular diagnostic tes...
The American Journal of Gastroenterology; Kwo PY, Cohen SM et. al.
Dec 21st, 2016 - Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin. These tests sh...
European Journal of Human Genetics : EJHG; Porto G, Brissot P et. al.
Jul 15th, 2015 - Molecular genetic testing for hereditary hemochromatosis (HH) is recognized as a reference test to confirm the diagnosis of suspected HH or to predict its risk. The vast majority (typically >90%) of patients with clinically characterized HH are ho...
Hepatology (Baltimore, Md.); Bacon BR, Adams PC et. al.
Apr 1st, 2011 - Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases.|2011|Bacon BR,Adams PC,Kowdley KV,Powell LW,Tavill AS,|blood,diagnosis,physiopathology,therapy,metabolism,pathology,m...
Journal of Hepatology;
May 18th, 2010 - Iron overload in humans is associated with a variety of genetic and acquired conditions. Of these, HFE hemochromatosis (HFE-HC) is by far the most frequent and most well-defined inherited cause when considering epidemiological aspects and risks fo...
Drugs 19 results see all →
Clinicaltrials.gov 26 results
Apr 22nd, 2020 - The purpose of this study is to evaluate the efficacy and safety of deferasirox film coated tablet (FCT) versus phlebotomy for the management of iron overload in adults with HH at risk of iron-related morbidity. This evaluation will provide inform...
Apr 20th, 2020 - Hereditary hemochromatosis (HH) occurs in 1 in every 200-250 individuals of northern European descent, and is the most common inherited disease in this population. Although the molecular pathophysiology remains incompletely understood, a homozygou...
Mar 4th, 2020 - This study is a Phase 2 multicenter, randomized, placebo controlled, single-blind study. The primary objective of the study is to compare the effect of weekly dosing of LJPC-401 (synthetic human hepcidin) versus placebo on transferrin saturation (...
Feb 28th, 2020 - This is a general clinical research protocol to allow for evaluation, investigation and long-term follow up of patients who have an acute or chronic liver disease. The protocol is designed to study the natural history and pathogenesis of various l...
Feb 21st, 2020 - Hereditary hemochromatosis (HH) is the most common hereditary metabolic abnormality among Caucasians. Homozygosity for the Cys282Tyr mutation, which is the most common known mutation with a predisposition to iron overload, occurs with an estimated...
News 58 results
Feb 5th, 2021 - Men with iron overload due to hereditary hemochromatosis are at increased risk of developing dementia, an analysis of UK Biobank data indicates. Results of a large analysis showed that among men who had two mutations that cause hemochromatosis (HF...
Mar 16th, 2020 - This transcript has been edited for clarity. Hello. I'm Dr David Johnson, professor of medicine and chief of gastroenterology at Eastern Virginia Medical School in Norfolk, Virginia. Welcome back to another GI Common Concerns. This past week, I sa...
MDedge Family Medicine;
Nov 7th, 2019 - Pseudoporphyria has a similar presentation to PCT but with no abnormalities in porphyrin metabolism. Risk factors include UV radiation exposure; use of medications such as nonsteroidal anti-inflammatory drugs, diuretics, and retinoids; chronic ren.
Brett M. Coldiron, MD
Oct 19th, 2019 - Like many of you, my wife and I took the DNA plunge for fun and spit in the cup. She is genetically perfect, but I, however, am a carrier for alpha-1 anti-trypsin deficiency, hemochromatosis, and like 1 in 19 Irish people, cystic fibrosis.
Apr 30th, 2019 - Q1. Correct Answer: A Rationale: This is an example of Yersinia infection.