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About 4,153 results

ALLMedicine™ Hemochromatosis Center

Research & Reviews  1,957 results

A perspective on RNA interference-based therapeutics for metabolic liver diseases.
https://doi.org/10.1080/13543784.2021.1879792
Expert Opinion on Investigational Drugs; Alkhouri N, Gawrieh S

Jan 20th, 2021 - Introduction: Therapeutic oligonucleotides have emerged as a promising new class of drug that could silence undruggable targets; they can potentially treat metabolic liver diseases such as nonalcoholic fatty liver disease (NAFLD), hereditary hemoc...

HFE Genotype and Endurance Performance in Competitive Male Athletes.
https://doi.org/10.1249/MSS.0000000000002595
Medicine and Science in Sports and Exercise; Thakkar D, Sicova M et. al.

Jan 12th, 2021 - Hereditary hemochromatosis can cause individuals to absorb too much iron from their diet. Higher tissue iron content, below the threshold of toxicity, may enhance oxygen carrying capacity and offer a competitive advantage. Single nucleotide polymo...

Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.
https://doi.org/10.3233/JAD-201080
Journal of Alzheimer's Disease : JAD; Atkins JL, Pilling LC et. al.

Jan 11th, 2021 - Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. To estimated p.C282Y associations with brain MRI features plus incident de...

Activation of TRPC Channel Currents in Iron Overloaded Cardiac Myocytes.
https://doi.org/10.1161/CIRCEP.120.009291
Circulation. Arrhythmia and Electrophysiology; Siri-Angkul N, Song Z et. al.

Jan 8th, 2021 - Background - Arrhythmias and heart failure are common cardiac complications leading to substantial morbidity and mortality in patients with hemochromatosis, yet mechanistic insights remain incomplete. We investigated the effects of iron (Fe) on el...

A predictive model for estimating the number of erythrocytapheresis or phlebotomy treat...
https://doi.org/10.1002/jca.21867
Journal of Clinical Apheresis REFERENCES; Rombout-Sestrienkova E, Winkens B et. al.

Dec 28th, 2020 - Standard treatment for naïve hereditary hemochromatosis patients consists of phlebotomy or a personalized erythrocytapheresis. Erythrocytapheresis is more efficient, but infrequently used because of perceived costs and specialized equipment being ...

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Guidelines  17 results

ACG Clinical Guideline: Hereditary Hemochromatosis
https://journals.lww.com/ajg/Fulltext/2019/08000/ACG_Clinical_Guideline__Hereditary_Hemochromatosis.11.aspx
Kowdley,K.,et al

Aug 1st, 2019 - Hereditary hemochromatosis (HH) is one of the most common genetic disorders among persons of northern European descent. There have been recent advances in the diagnosis, management, and treatment of HH. The availability of molecular diagnostic tes...

ACG Clinical Guideline: Hereditary Hemochromatosis.
https://doi.org/10.14309/ajg.0000000000000315
The American Journal of Gastroenterology; Kowdley KV, Brown KE et. al.

Jul 24th, 2019 - Hereditary hemochromatosis (HH) is one of the most common genetic disorders among persons of northern European descent. There have been recent advances in the diagnosis, management, and treatment of HH. The availability of molecular diagnostic tes...

Direct-to-consumer genetic testing
https://www.ama-assn.org/delivering-care/precision-medicine/direct-consumer-genetic-testing

Apr 2nd, 2019 - Types of DTC genetic tests A broad range of genetic test types are offered DTC, including: Carrier testing for diseases such as cystic fibrosis and hemochromatosis Pharmacogenomic testing Testing for predisposition to complex diseases such as her...

Guidelines Insights: Hepatobiliary Cancers, Version 2.2019
https://jnccn.org/view/journals/jnccn/17/4/article-p302.xml
Benson,A.,et al

Mar 31st, 2019 - Incidence and mortality rates for cancer overall are declining, but both incidence and mortality rates for hepatocellular carcinoma (HCC) are increasing.1,2 Risk factors for development of HCC include infection with hepatitis B virus (HBV) and/or ...

Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous ...
https://link.springer.com/article/10.1007%2Fs12072-018-9855-0
Adams, P.,et al.

Mar 30th, 2018 - Although guidelines are available for hereditary hemochromatosis, a high percentage of the recommendations within them are not shared between the different guidelines. Our main aim is to provide an objective, simple, brief, and practical set of re.

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Drugs  4 results see all →

Clinicaltrials.gov  2,051 results

A perspective on RNA interference-based therapeutics for metabolic liver diseases.
https://doi.org/10.1080/13543784.2021.1879792
Expert Opinion on Investigational Drugs; Alkhouri N, Gawrieh S

Jan 20th, 2021 - Introduction: Therapeutic oligonucleotides have emerged as a promising new class of drug that could silence undruggable targets; they can potentially treat metabolic liver diseases such as nonalcoholic fatty liver disease (NAFLD), hereditary hemoc...

HFE Genotype and Endurance Performance in Competitive Male Athletes.
https://doi.org/10.1249/MSS.0000000000002595
Medicine and Science in Sports and Exercise; Thakkar D, Sicova M et. al.

Jan 12th, 2021 - Hereditary hemochromatosis can cause individuals to absorb too much iron from their diet. Higher tissue iron content, below the threshold of toxicity, may enhance oxygen carrying capacity and offer a competitive advantage. Single nucleotide polymo...

Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort.
https://doi.org/10.3233/JAD-201080
Journal of Alzheimer's Disease : JAD; Atkins JL, Pilling LC et. al.

Jan 11th, 2021 - Brain iron deposition occurs in dementia. In European ancestry populations, the HFE p.C282Y variant can cause iron overload and hemochromatosis, mostly in homozygous males. To estimated p.C282Y associations with brain MRI features plus incident de...

Activation of TRPC Channel Currents in Iron Overloaded Cardiac Myocytes.
https://doi.org/10.1161/CIRCEP.120.009291
Circulation. Arrhythmia and Electrophysiology; Siri-Angkul N, Song Z et. al.

Jan 8th, 2021 - Background - Arrhythmias and heart failure are common cardiac complications leading to substantial morbidity and mortality in patients with hemochromatosis, yet mechanistic insights remain incomplete. We investigated the effects of iron (Fe) on el...

Hemochromatosis - Diagnosis and treatment - Mayo Clinic
https://www.mayoclinic.org/diseases-conditions/hemochromatosis/diagnosis-treatment/drc-20351448

Dec 29th, 2020 - Diagnosis Hereditary hemochromatosis can be difficult to diagnose. Early symptoms such as stiff joints and fatigue may be due to conditions other than hemochromatosis. Many people with the disease don't have any signs or symptoms other than elevat...

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News  105 results

New Guidelines to Help You Manage Hereditary Hemochromatosis
https://www.medscape.com/viewarticle/926286

Mar 15th, 2020 - This transcript has been edited for clarity. Hello. I'm Dr David Johnson, professor of medicine and chief of gastroenterology at Eastern Virginia Medical School in Norfolk, Virginia. Welcome back to another GI Common Concerns. This past week, I sa...

Sixty-five roses
https://www.mdedge.com/node/210356/path_term/51947
Brett M. Coldiron, MD

Oct 19th, 2019 - Like many of you, my wife and I took the DNA plunge for fun and spit in the cup. She is genetically perfect, but I, however, am a carrier for alpha-1 anti-trypsin deficiency, hemochromatosis, and like 1 in 19 Irish people, cystic fibrosis.

ACG Clinical Guideline: Hereditary Hemochromatosis
https://journals.lww.com/ajg/Fulltext/2019/08000/ACG_Clinical_Guideline__Hereditary_Hemochromatosis.11.aspx
Kowdley,K.,et al

Aug 1st, 2019 - Hereditary hemochromatosis (HH) is one of the most common genetic disorders among persons of northern European descent. There have been recent advances in the diagnosis, management, and treatment of HH. The availability of molecular diagnostic tes...

May 2019 - Question 1
https://www.mdedge.com/gihepnews/article/199937/mixed-topics/may-2019-question-1?channel=27442

Apr 30th, 2019 - Q1. Correct Answer: A Rationale: This is an example of Yersinia infection.

Direct-to-consumer genetic testing
https://www.ama-assn.org/delivering-care/precision-medicine/direct-consumer-genetic-testing

Apr 2nd, 2019 - Types of DTC genetic tests A broad range of genetic test types are offered DTC, including: Carrier testing for diseases such as cystic fibrosis and hemochromatosis Pharmacogenomic testing Testing for predisposition to complex diseases such as her...

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Patient Education  19 results see all →