About 1,990 results

ALLMedicine™ Hemochromatosis Center

Research & Reviews  673 results

Regression of Hepatic Fibrosis and Evolution of Cirrhosis: A Concise Review.
Advances in Anatomic Pathology; Khan S, Saxena R

Jul 31st, 2021 - Fibrosis is not a unidirectional, linear process, but a dynamic one resulting from an interplay of fibrogenesis and fibrolysis depending on the extent and severity of a biologic insult, or lack thereof. Regression of fibrosis has been documented b...

Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathw...
The American Journal of Clinical Nutrition; Julián-Serrano S, Yuan F et. al.

Jul 15th, 2021 - Epidemiological studies have suggested positive associations for iron and red meat intake with risk of pancreatic ductal adenocarcinoma (PDAC). Inherited pathogenic variants in genes involved in the hepcidin-regulating iron metabolism pathway are ...

Iron metabolism: pathophysiology and pharmacology.
Trends in Pharmacological Sciences; Roemhild K, von Maltzahn F et. al.

Jun 7th, 2021 - Iron is essential in many physiological processes, including DNA metabolism, oxygen transport, and cellular energy generation. Deregulated iron metabolism, which results in iron overload or iron deficiency, is observed in many different diseases. ...

MRI-Based Iron Phenotyping and Patient Selection for Next-Generation Sequencing of Non-...
Hepatology (Baltimore, Md.); Viveiros A, Schaefer B et. al.

May 29th, 2021 - High serum ferritin is frequent among patients with chronic liver disease and commonly associated with hepatic iron overload. Genetic causes of high liver iron include homozygosity for the p.Cys282Tyr variant in homeostatic iron regulator (HFE) an...

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Guidelines  5 results

ACG Clinical Guideline: Hereditary Hemochromatosis.
The American Journal of Gastroenterology; Kowdley KV, Brown KE et. al.

Jul 25th, 2019 - Hereditary hemochromatosis (HH) is one of the most common genetic disorders among persons of northern European descent. There have been recent advances in the diagnosis, management, and treatment of HH. The availability of molecular diagnostic tes...

ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
The American Journal of Gastroenterology; Kwo PY, Cohen SM et. al.

Dec 21st, 2016 - Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin. These tests sh...

EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochr...
European Journal of Human Genetics : EJHG; Porto G, Brissot P et. al.

Jul 15th, 2015 - Molecular genetic testing for hereditary hemochromatosis (HH) is recognized as a reference test to confirm the diagnosis of suspected HH or to predict its risk. The vast majority (typically >90%) of patients with clinically characterized HH are ho...

Diagnosis and management of hemochromatosis: 2011 practice guideline by the American As...
Hepatology (Baltimore, Md.); Bacon BR, Adams PC et. al.

Apr 1st, 2011 - Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases.|2011|Bacon BR,Adams PC,Kowdley KV,Powell LW,Tavill AS,|blood,diagnosis,physiopathology,therapy,metabolism,pathology,m...

EASL clinical practice guidelines for HFE hemochromatosis.
Journal of Hepatology;

May 18th, 2010 - Iron overload in humans is associated with a variety of genetic and acquired conditions. Of these, HFE hemochromatosis (HFE-HC) is by far the most frequent and most well-defined inherited cause when considering epidemiological aspects and risks fo...

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Drugs  19 results see all →

Clinicaltrials.gov  26 results

A Two-year Study to Evaluate the Efficacy and Safety of Deferasirox Film-coated Tablet Versus Phlebotomy in Patients With Hereditary Hemochromatosis.

Apr 22nd, 2020 - The purpose of this study is to evaluate the efficacy and safety of deferasirox film coated tablet (FCT) versus phlebotomy for the management of iron overload in adults with HH at risk of iron-related morbidity. This evaluation will provide inform...

Treatment of Hemochromatosis

Apr 20th, 2020 - Hereditary hemochromatosis (HH) occurs in 1 in every 200-250 individuals of northern European descent, and is the most common inherited disease in this population. Although the molecular pathophysiology remains incompletely understood, a homozygou...

A Study of LJPC-401 for the Treatment of Iron Overload in Adult Patients With Hereditary Hemochromatosis

Mar 4th, 2020 - This study is a Phase 2 multicenter, randomized, placebo controlled, single-blind study. The primary objective of the study is to compare the effect of weekly dosing of LJPC-401 (synthetic human hepcidin) versus placebo on transferrin saturation (...

Evaluation of Patients With Liver Disease

Feb 28th, 2020 - This is a general clinical research protocol to allow for evaluation, investigation and long-term follow up of patients who have an acute or chronic liver disease. The protocol is designed to study the natural history and pathogenesis of various l...

Cardiac Function in Patients With Hereditary Hemochromatosis

Feb 21st, 2020 - Hereditary hemochromatosis (HH) is the most common hereditary metabolic abnormality among Caucasians. Homozygosity for the Cys282Tyr mutation, which is the most common known mutation with a predisposition to iron overload, occurs with an estimated...

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News  58 results

Common Genetic Disorder Tied to Increased Dementia Risk in Men

Feb 5th, 2021 - Men with iron overload due to hereditary hemochromatosis are at increased risk of developing dementia, an analysis of UK Biobank data indicates. Results of a large analysis showed that among men who had two mutations that cause hemochromatosis (HF...

New Guidelines to Help You Manage Hereditary Hemochromatosis

Mar 16th, 2020 - This transcript has been edited for clarity. Hello. I'm Dr David Johnson, professor of medicine and chief of gastroenterology at Eastern Virginia Medical School in Norfolk, Virginia. Welcome back to another GI Common Concerns. This past week, I sa...

Chronic blistering rash on hands
MDedge Family Medicine;

Nov 7th, 2019 - Pseudoporphyria has a similar presentation to PCT but with no abnormalities in porphyrin metabolism. Risk factors include UV radiation exposure; use of medications such as nonsteroidal anti-inflammatory drugs, diuretics, and retinoids; chronic ren.

Sixty-five roses
Brett M. Coldiron, MD

Oct 19th, 2019 - Like many of you, my wife and I took the DNA plunge for fun and spit in the cup. She is genetically perfect, but I, however, am a carrier for alpha-1 anti-trypsin deficiency, hemochromatosis, and like 1 in 19 Irish people, cystic fibrosis.

May 2019 - Question 1

Apr 30th, 2019 - Q1. Correct Answer: A Rationale: This is an example of Yersinia infection.

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Patient Education  15 results see all →