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About 2,616 results

ALLMedicine™ Hyperbilirubinemia Center - Clinicaltrials.gov

A Randomized Trial of Phototherapy with Filtered Sunlight in African Neonates.
https://doi.org/10.1056/NEJMoa1501074
The New England Journal of Medicine; Slusher TM, Olusanya BO et. al.

Sep 16th, 2015 - Sequelae of severe neonatal hyperbilirubinemia constitute a substantial disease burden in areas where effective conventional phototherapy is unavailable. We previously found that the use of filtered sunlight for the purpose of phototherapy is a safe and efficacious method for reducing total bilirubin. However, its relative safety and efficacy as compared with conventional phototherapy are unkno...

Diagnosing Jaundice by Eye-Outpatient Assessment of Conjunctival Icterus in the Newborn.
https://doi.org/10.1016/j.jpeds.2016.01.032
The Journal of Pediatrics; Maisels MJ, Coffey MP et. al.

Feb 23rd, 2016 - In pediatric office practices, we compared transcutaneous bilirubin levels in 689 newborns, age 3-10 days, with and without conjunctival icterus. In this age range, and in the absence of other clinical or laboratory indications, the presence of conjunctival icterus does not imply the need to measure the transcutaneous bilirubin or serum bilirubin level, but the absence of conjunctival icterus h...

Risk of Autism Associated With Hyperbilirubinemia and Phototherapy.
https://doi.org/10.1542/peds.2016-1813
Pediatrics Wu YW, Kuzniewicz MW et. al.

Sep 27th, 2016 - Whether neonatal hyperbilirubinemia and/or phototherapy increase the risk of autism spectrum disorder (ASD) is unclear. We sought to quantify the risk of ASD associated with elevated total serum bilirubin (TSB) levels and with phototherapy. In a retrospective cohort study of 525 409 infants born at ≥35 weeks' gestation in 15 Kaiser Permanente Northern California (KPNC) hospitals, 1995-2011, we ...

Evaluation of Home Phototherapy for Neonatal Hyperbilirubinemia.
https://doi.org/10.1016/j.jpeds.2020.01.004
The Journal of Pediatrics; Chang PW, Waite WM

Feb 18th, 2020 - To characterize home phototherapy treatment for neonatal hyperbilirubinemia and assess the risk factors associated with the need for hospital admission during or after home phototherapy. This was a retrospective study of newborn infants born at ≥35 weeks of gestation who underwent comprehensive home phototherapy (that included daily in-home lactation support and blood draws) over an 18-month pe...

Predicting Nonhemolytic Neonatal Hyperbilirubinemia.
https://doi.org/10.1542/peds.2015-2001
Pediatrics Norman M, Åberg K et. al.

Nov 10th, 2015 - Before hospital discharge, newborn infants should be assessed for the risk of excessive hyperbilirubinemia. We determined maternal and obstetric risk factors for hyperbilirubinemia in infants born at term (gestational age ≥37 weeks) to form an individualized risk assessment tool for clinical use. This was a population-based study with data from the Swedish Medical Birth Register from 1999 to 20...

High rates of resolution of cholestasis in parenteral nutrition-associated liver diseas...
https://doi.org/10.1016/j.jpeds.2012.10.019
The Journal of Pediatrics; Premkumar MH, Carter BA et. al.

Nov 20th, 2012 - To determine factors leading to resolution of cholestasis in patients with parenteral nutrition-associated liver disease treated with fish oil-based lipid emulsion (FOLE). Prospective observational study of 57 infants <6 months of age with parenteral nutrition-associated liver disease who received parenteral FOLE as monotherapy. Median gestational age of subjects at birth was 28 weeks (range 22...

Effect of Ursodeoxycholic Acid on Indirect Hyperbilirubinemia in Neonates Treated With ...
https://doi.org/10.1097/MPG.0000000000000874
Journal of Pediatric Gastroenterology and Nutrition; Honar N, Ghashghaei Saadi E et. al.

May 28th, 2015 - Hyperbilirubinemia is a common neonatal problem. The present study aimed to investigate the effect of ursodeoxycholic acid in reducing indirect hyperbilirubinemia of infants under phototherapy. This double-blind randomized clinical trial was conducted on neonates with jaundice, who had received phototherapy in the hospitals affiliated with the Shiraz University of Medical Sciences in 2013. A to...

Evaluating eosin-5-maleimide binding as a diagnostic test for hereditary spherocytosis ...
https://doi.org/10.1038/jp.2014.202
Journal of Perinatology : Official Journal of the Califor... Christensen RD, Agarwal AM et. al.

Oct 30th, 2014 - Neonates with undiagnosed hereditary spherocytosis (HS) are at risk for developing hazardous hyperbilirubinemia and anemia. Making an early diagnosis of HS in a neonate can prompt anticipatory guidance to prevent these adverse outcomes. A recent comparison study showed that a relatively new diagnostic test for HS, eosin-5-maleimide (EMA)-flow cytometry, performs better than other available test...

Impact of universal bilirubin screening on severe hyperbilirubinemia and phototherapy use.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858633
Pediatrics Kuzniewicz MW, Escobar GJ et. al.

Sep 29th, 2009 - The goal was to assess the impact of universal bilirubin screening on severe hyperbilirubinemia and phototherapy use. In this retrospective cohort study of 358086 infants of > or =35 weeks and > or =2000 g born between January 1, 1995, and June 30, 2007, we obtained demographic data, bilirubin levels, and codes for inpatient phototherapy from existing databases. We compared the incidence of hig...

Direct antiglobulin titer strength and hyperbilirubinemia.
https://doi.org/10.1542/peds.2014-1290
Pediatrics Kaplan M, Hammerman C et. al.

Oct 21st, 2014 - We recently demonstrated that direct antiglobulin titer (DAT) positive, blood group A or B newborns born to group O mothers had a high incidence of hyperbilirubinemia, attributable to increased hemolysis. We reanalyzed our data asking whether increasing DAT strength plays a modulating role in the pathophysiology of the hemolysis and hyperbilirubinemia. Data from previously published DAT-positiv...

Follow-up of neonates with total serum bilirubin levels ≥ 25 mg/dL: a Danish population...
https://doi.org/10.1542/peds.2011-2760
Pediatrics Vandborg PK, Hansen BM et. al.

Jun 26th, 2012 - To study if severe hyperbilirubinemia in infants with no or minor neurologic symptoms in the neonatal period affects children's development at the age of 1 to 5 years. Controlled descriptive follow-up study of a national cohort of Danish children. The exposed group consisted of all live-born infants in Denmark from 2004 to 2007 with a gestational age ≥ 35 weeks and severe hyperbilirubinemia in ...

Management of jaundice and prevention of severe neonatal hyperbilirubinemia in infants ...
https://doi.org/10.1159/000113463
Neonatology Bhutani VK, Maisels MJ et. al.

Jan 21st, 2008 - Kernicterus is still occurring but should be largely preventable if health care personnel follow the recommendations listed in this guideline. These recommendations emphasize the importance of universal, systematic assessment of the risk of severe hyperbilirubinemia, lactation support, close follow-up, and prompt intervention when necessary. A systems-based approach to prevent severe neonatal h...

The clinical syndrome of bilirubin-induced neurologic dysfunction.
https://doi.org/10.1053/j.semperi.2011.02.003
Seminars in Perinatology; Johnson L, Bhutani VK

Jun 6th, 2011 - We believe that the syndrome of bilirubin-induced neurologic dysfunction [BIND] represents a spectrum of neurologic manifestations among vulnerable infants who have experienced an exposure to bilirubin of lesser degree than generally described in previous publications. Clinical neuro-motor manifestations extend to a range of subtle processing disorders with objective disturbances of visual-moto...

Does Ibuprofen increase neonatal hyperbilirubinemia?
https://doi.org/10.1542/peds.2008-2433
Pediatrics Zecca E, Romagnoli C et. al.

Jul 21st, 2009 - The aim of this study was to investigate whether ibuprofen exposure was associated with increased hyperbilirubinemia in preterm infants. Since 2000, ibuprofen has been administered to all infants at <30 weeks of gestation who are admitted to our unit, to prevent patent ductus arteriosus. We retrospectively compared data for 418 infants subjected to ibuprofen prophylaxis (2000-2007) and 288 infa...

Green teeth are a late complication of prolonged conjugated hyperbilirubinemia in extre...
https://www.ncbi.nlm.nih.gov/pubmed/23014082
Pediatric Dentistry; Battineni S, Clarke P

Sep 27th, 2012 - Eruption of green, discolored teeth affecting the primary dentition has been described in association with congenital viral infection, sepsis, hemolytic jaundice, and cholestasis. The purpose of this paper was to present the cases of 3 extremely low birth weight preterm infants who were noted to have green teeth at the corrected ages of 10 to 12 months. All had a history of prolonged conjugated...

Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873706
Pediatric Research; Bhutani VK, Zipursky A et. al.

Dec 24th, 2013 - Rhesus (Rh) disease and extreme hyperbilirubinemia (EHB) result in neonatal mortality and long-term neurodevelopmental impairment, yet there are no estimates of their burden. Systematic reviews and meta-analyses were undertaken of national prevalence, mortality, and kernicterus due to Rh disease and EHB. We applied a compartmental model to estimate neonatal survivors and impairment cases for 20...

Reduction of severe hyperbilirubinemia after institution of predischarge bilirubin scre...
https://doi.org/10.1542/peds.2009-1412
Pediatrics Mah MP, Clark SL et. al.

Apr 6th, 2010 - The objective of this study was to demonstrate efficacy of universal predischarge neonatal bilirubin screening in reducing potentially dangerous hyperbilirubinemia in a large, diverse national population. This was a 5-year prospective study directed at neonates who were aged < or =28 days and evaluated at facilities of the Hospital Corporation of America with a serum bilirubin level of > or =20...

Risk factors for severe hyperbilirubinemia among infants with borderline bilirubin leve...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142930
The Journal of Pediatrics; Kuzniewicz MW, Escobar GJ et. al.

Jun 6th, 2008 - To estimate the effect of phototherapy and other predictors on the risk of total serum bilirubin (TSB) >or= 25 mg/dL in infants with a TSB of 17 to 22.9 mg/dL at age >or= 48 hours. From a cohort of 285295 infants >or= 34 weeks gestation and >or= 2000 g born between 1995 and 2004 in northern California Kaiser hospitals, we identified 17986 with a TSB of 17 to 22.9 mg/dL at age >or= 48 hours. All...

Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of b...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4123958
The Journal of Pediatrics; Maruo Y, Morioka Y et. al.

Mar 21st, 2014 - To evaluate the role of bilirubin UDP-glucuronosyltransferase family 1, polypeptide A1 (UGT1A1) gene variations on prolonged unconjugated hyperbilirubinemia associated with breast milk feeding (breast milk jaundice [BMJ]). UGT1A1 gene allelic variation was analyzed in 170 Japanese infants with BMJ with polymerase chain reaction-direct sequencing, and their genotypes compared with serum bilirubi...

Systematic review of screening for bilirubin encephalopathy in neonates.
https://doi.org/10.1542/peds.2008-3545
Pediatrics Trikalinos TA, Chung M et. al.

Sep 29th, 2009 - Severe neonatal hyperbilirubinemia is associated with chronic bilirubin encephalopathy (kernicterus). To systematically review the effectiveness of specific screening modalities to prevent neonatal bilirubin encephalopathy. We identified studies through Medline searches, perusing reference lists and by consulting with US Preventive Services Task Force lead experts. We included English-language ...