About 958 results

ALLMedicine™ Wilson Disease Center

Research & Reviews  355 results

Cardiac involvement in Wilson disease: review of the literature and description of thre...
Journal of Inherited Metabolic Disease; Chevalier K, Benyounes N et. al.

Jul 21st, 2021 - Wilson disease is a rare genetic condition that results from a build-up of copper in the body. It requires life-long treatment and is mainly characterized by hepatic and neurological features. Copper accumulation has been reported to be related to...

Therapeutic Use of Trace Elements in Dermatology.
Alternative Therapies in Health and Medicine; Gade A, Hwang JR et. al.

Jul 15th, 2021 - Trace elements (microminerals) play a role in many physiological functions, including hormone production and cellular growth. However, their importance in diagnosing and treating dermatologic disease has not been well examined. In this review, we ...

Exogenous copper exposure causing clinical wilson disease in a patient with copper defi...
BMC Gastroenterology; Lizaola-Mayo BC, Dickson RC et. al.

Jul 9th, 2021 - Human Swayback is a disease characterized by acquired copper deficiency which primarily manifests as myeloneuropathy. Common causes include malabsorptive disorders, gastric surgery, total parenteral nutrition and excessive zinc intake. In contrast...

The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnet...
https://doi.org/10.1186/s12968-021-00760-1 10.33176/AACB-18-00014 10.1136/gut.32.12.1541 10.1016/S1474-4422(14)70190-5 10.1038/s41572-018-0018-3 10.1172/JCI45401 10.1172/JCI85226 10.1002/hep.22261 10.1016/j.neulet.2011.04.058 10.1016/S0140-6736(07)60196-2 10.5114/aoms.2017.69728 10.1378/chest.91.4.579 10.3389/fphys.2017.00778 10.1186/s13023-019-1007-7 10.1016/j.amjcard.2017.08.025 10.1186/s12968-017-0389-8 10.1161/CIRCIMAGING.112.978627 10.1186/1532-429X-10-42 10.1186/s12968-017-0419-6 10.1002/hep.23910 10.1034/j.1600-0676.2003.00824.x 10.1002/mds.21761 10.1093/ehjci/jeu183 10.1007/s00392-018-1371-7 10.1002/jmri.21119 10.1186/s12968-015-0199-9 10.1186/s12968-015-0127-z 10.1186/1532-429X-15-35 10.1161/CIRCULATIONAHA.109.930636 10.1016/j.jcmg.2009.11.015 10.1186/s12968-014-0069-x 10.1037/0033-2909.112.1.155 10.1093/eurheartj/ehv510 10.1016/j.amjcard.2014.07.051 10.1186/s12968-017-0376-0 10.1016/j.jacc.2012.04.043 10.1016/j.jacc.2010.06.044 10.1016/j.jcmg.2015.02.005 10.1093/eurheartj/eht133 10.1161/CIRCULATIONAHA.107.754424 10.1021/tx025518q 10.1007/BF00496571 10.1186/1532-429X-14-42 10.1016/j.jcmg.2018.05.028 10.1186/s12968-018-0477-4 10.1016/j.jacc.2018.08.2197 10.1002/jez.1402630105 10.1042/CS20130036 10.1186/s12968-020-00622-2 10.1002/hep.30280 10.1016/j.cgh.2013.03.012 10.1016/j.eplepsyres.2018.01.016 10.1161/CIRCRESAHA.117.311170 10.1016/j.seizure.2019.07.002 10.1002/mds.21693 10.1002/ehf2.12395 10.1038/s41598-018-32226-3 10.1038/s41598-019-48685-1
Journal of Cardiovascular Magnetic Resonance : Official J... Salatzki J, Mohr I et. al.

Jun 24th, 2021 - Systemic effects of altered serum copper processing in Wilson Disease (WD) might induce myocardial copper deposition and consequently myocardial dysfunction and structural remodeling. This study sought to investigate the prevalence, manifestation ...

Investigation of Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Ch...
Fetal and Pediatric Pathology; Durankuş F, Albayrak Y et. al.

May 4th, 2021 - The aim of the present study was to assess thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) levels in children with Wilson Disease (WD) and to compare them to healthy controls. Methods: Based on the inclusion and ex...

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Clinicaltrials.gov  8 results

A Multi-Center Trial to Study Acute Liver Failure in Adults

Mar 8th, 2020 - Although ALF is truly an orphan disease affecting only about 2,000 persons per year, its severity, its frequency among young adults, and its high resource utilization justifies the attention paid to it. In addition, ALF has captured the interest a...

Natural History of Wilson Disease

May 23rd, 2019 - There are three aims outlined as part of this research study. Aim 1 is to study the natural history of a carefully characterized cohort of patients with WD followed longitudinally at Centers of Excellence for WD in the United States and in the Uni...

A Controlled Study of Potential Therapeutic Effect of Oral Zinc in Manifesting Carriers of Wilson Disease

Sep 5th, 2018 - The research group is composed of patients over the age of 18 referred for unexplained elevation of liver enzymes and carry a single mutation in the ATP7B gene. After a washout period of 3 months these patients will be re-checked for liver enzymes...

Study to Assess Long-Term Outcomes of Trientine in Wilson Disease Patients Withdrawn From Therapy With d-Penicillamine

Aug 22nd, 2017 - A retrospective study to review Wilson disease patients who have previously been prescribed d- Penicillamine but were changed to trientine as treatment for their disease, and to follow them prospectively for a further 12 months.

Efficacy and Safety, Long-term Study of Zinc Acetate to Treat Wilson's Disease in Japan.

May 13th, 2014 - Wilson disease is an autosomal recessive disorder with copper metabolism. In Japan, the standard treatment is the use of copper chelating agents, such as D-penicillamine and trientine. In this study, we investigate efficacy on zinc acetate in Japa...

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News  15 results

Wilson Disease: Osmosis Study Video

Jun 18th, 2020 - Wilson disease is an autosomal recessive genetic disorder in which copper accumulates in tissues; this manifests as neurological or psychiatric symptoms and liver disease. It is the result of inadequate copper excretion into bile and blood, result...

High-calorie diet may worsen Wilson disease

Mar 7th, 2019 - Copper testing showed that Wilson disease rats fed the high-calorie diet had high serum levels of non–ceruloplasmin-bound copper, which is a sign of overt liver damage; based on histologic findings, the copper likely came from destroyed hepatocyte.

Wilson Disease: Osmosis Study Video

Feb 27th, 2019 - What is Wilson disease? Individuals typically take in more copper than the body needs every day, and any excess is excreted. In patients with Wilson disease, a genetic defect affecting the ATP7B transport protein causes copper to accumulate in the...

Gottron Papules Mimicking Dermatomyositis: An Unusual Manifestation of Systemic Lupus Erythematosus
Ji Won Ahn, MD, Sherry Yang, MD et. al.

Jul 26th, 2018 - To the Editor: An 11-year-old girl presented to the dermatology clinic with an asymptomatic rash on the bilateral forearms, dorsal hands, and ears of 1 month’s duration. Recent history was notable for persistent low-grade fevers, dizziness, headac.

Biotech M&A rolls on as Alexion snaps up Wilson for $855 million

Apr 11th, 2018 - (Reuters) - Alexion Pharmaceuticals (ALXN.O) has agreed to buy Sweden’s Wilson Therapeutics WTX.ST for 7.1 billion Swedish crowns ($855 million), boosting its line-up of rare disease drugs as a wave of deal-making in the biotechnology sector conti...

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Patient Education  5 results see all →