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About 1,710 results

ALLMedicine™ Wilson Disease Center

Research & Reviews  831 results

Structural and functional brain changes in hepatic and neurological Wilson disease.
https://doi.org/10.1007/s11682-020-00420-5
Brain Imaging and Behavior; Tinaz S, Arora J et. al.

Nov 27th, 2020 - Wilson disease (WD) can manifest with hepatic or neuropsychiatric symptoms. Our understanding of the in vivo brain changes in WD, particularly in the hepatic phenotype, is limited. Thirty subjects with WD and 30 age- and gender-matched controls pa...

Observation on the changes of clinical symptoms, blood and brain copper deposition in W...
https://doi.org/10.1016/j.jocn.2020.09.017
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia; Zhou XX, Pu XY et. al.

Nov 23rd, 2020 - To compare the clinical symptoms, brain copper deposition changes of Meso-2,3-dimercaptosuccinic acid (DMSA) and penicillamine therapy in patients with Wilson disease (WD) within 2 years. 68 drug-naive patients with WD were enrolled. 10 WD patient...

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Cont...
https://doi.org/10.1523/JNEUROSCI.1284-20.2020
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience; Hartwig C, Méndez GM et. al.

Nov 19th, 2020 - Rare genetic diseases preponderantly affect the nervous system causing neurodegeneration to neurodevelopmental disorders. This is the case for both Menkes and Wilson disease, arising from mutations in ATP7A and ATP7B, respectively. The ATP7A and A...

Wilson disease, ABCC2 c.3972C > T polymorphism and primary liver cancers: suggestions f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673086
BMC Medical Genetics; Brandi G, Rizzo A et. al.

Nov 19th, 2020 - Polymorphisms in genes modulating xenobiotics metabolism, in particular the ABCC2 c.3972C > T single nucleotide polymorphism (SNP) at exon 28, have been suggested to increase primary liver cancer (PLC) risk. Conversely, the occurrence of PLCs in W...

Effect of homeostatic iron regulator protein gene mutation on Wilson's disease clinical...
https://doi.org/10.1080/00207454.2020.1849190
The International Journal of Neuroscience; Gromadzka G, Wierzbicka DW et. al.

Nov 11th, 2020 - Wilson's disease (WD) is a hereditary disorder of copper metabolism. The metabolic pathways of copper and iron are interrelated. Our goal was to determine the frequency of the two most common mutations in the coding region of the human iron homeos...

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Guidelines  2 results

Guidelines Insights: Hepatobiliary Cancers, Version 2.2019
https://jnccn.org/view/journals/jnccn/17/4/article-p302.xml
Benson,A.,et al

Mar 31st, 2019 - Incidence and mortality rates for cancer overall are declining, but both incidence and mortality rates for hepatocellular carcinoma (HCC) are increasing.1,2 Risk factors for development of HCC include infection with hepatitis B virus (HBV) and/or ...

Diagnosis and treatment of Wilson disease: an update.
https://doi.org/10.1002/hep.22261
Hepatology (Baltimore, Md.); Roberts EA, Schilsky ML et. al.

May 28th, 2008 - Diagnosis and treatment of Wilson disease: an update.|2008|Roberts EA,Schilsky ML, ,|genetics,genetics,metabolism,diagnosis,genetics,therapy,metabolism,genetics,

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Clinicaltrials.gov  853 results

Structural and functional brain changes in hepatic and neurological Wilson disease.
https://doi.org/10.1007/s11682-020-00420-5
Brain Imaging and Behavior; Tinaz S, Arora J et. al.

Nov 27th, 2020 - Wilson disease (WD) can manifest with hepatic or neuropsychiatric symptoms. Our understanding of the in vivo brain changes in WD, particularly in the hepatic phenotype, is limited. Thirty subjects with WD and 30 age- and gender-matched controls pa...

Observation on the changes of clinical symptoms, blood and brain copper deposition in W...
https://doi.org/10.1016/j.jocn.2020.09.017
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia; Zhou XX, Pu XY et. al.

Nov 23rd, 2020 - To compare the clinical symptoms, brain copper deposition changes of Meso-2,3-dimercaptosuccinic acid (DMSA) and penicillamine therapy in patients with Wilson disease (WD) within 2 years. 68 drug-naive patients with WD were enrolled. 10 WD patient...

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Cont...
https://doi.org/10.1523/JNEUROSCI.1284-20.2020
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience; Hartwig C, Méndez GM et. al.

Nov 19th, 2020 - Rare genetic diseases preponderantly affect the nervous system causing neurodegeneration to neurodevelopmental disorders. This is the case for both Menkes and Wilson disease, arising from mutations in ATP7A and ATP7B, respectively. The ATP7A and A...

Wilson disease, ABCC2 c.3972C > T polymorphism and primary liver cancers: suggestions f...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673086
BMC Medical Genetics; Brandi G, Rizzo A et. al.

Nov 19th, 2020 - Polymorphisms in genes modulating xenobiotics metabolism, in particular the ABCC2 c.3972C > T single nucleotide polymorphism (SNP) at exon 28, have been suggested to increase primary liver cancer (PLC) risk. Conversely, the occurrence of PLCs in W...

Effect of homeostatic iron regulator protein gene mutation on Wilson's disease clinical...
https://doi.org/10.1080/00207454.2020.1849190
The International Journal of Neuroscience; Gromadzka G, Wierzbicka DW et. al.

Nov 11th, 2020 - Wilson's disease (WD) is a hereditary disorder of copper metabolism. The metabolic pathways of copper and iron are interrelated. Our goal was to determine the frequency of the two most common mutations in the coding region of the human iron homeos...

see more →

News  19 results

Wilson Disease: Osmosis Study Video
https://www.medscape.com/viewarticle/932327

Jun 18th, 2020 - Wilson disease is an autosomal recessive genetic disorder in which copper accumulates in tissues; this manifests as neurological or psychiatric symptoms and liver disease. It is the result of inadequate copper excretion into bile and blood, result...

Guidelines Insights: Hepatobiliary Cancers, Version 2.2019
https://jnccn.org/view/journals/jnccn/17/4/article-p302.xml
Benson,A.,et al

Mar 31st, 2019 - Incidence and mortality rates for cancer overall are declining, but both incidence and mortality rates for hepatocellular carcinoma (HCC) are increasing.1,2 Risk factors for development of HCC include infection with hepatitis B virus (HBV) and/or ...

High-calorie diet may worsen Wilson disease
https://www.mdedge.com/gihepnews/article/195884/liver-disease/high-calorie-diet-may-worsen-wilson-disease/page/0/1?channel=69

Mar 7th, 2019 - Copper testing showed that Wilson disease rats fed the high-calorie diet had high serum levels of non–ceruloplasmin-bound copper, which is a sign of overt liver damage; based on histologic findings, the copper likely came from destroyed hepatocyte.

Wilson Disease: Osmosis Study Video
https://www.medscape.com/viewarticle/908986

Feb 27th, 2019 - What is Wilson disease? Individuals typically take in more copper than the body needs every day, and any excess is excreted. In patients with Wilson disease, a genetic defect affecting the ATP7B transport protein causes copper to accumulate in the...

When Missing a 'Zebra' Can Land You in Court
https://www.medscape.com/viewarticle/892452_3

Feb 19th, 2018 - Being Careful in Early Diagnosis Not listening to the patient was a crucial element that led a Missouri jury to award $29 million last year to a young Springfield woman with Wilson disease that went misdiagnosed for 9 months.[4] The college senior...

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Patient Education  5 results see all →