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About 2,550 results

ALLMedicine™ Familial Adenomatous Polyposis Center

Research & Reviews  875 results

A Study of JNJ-64251330 in Participants With Familial Adenomatous Polyposis
https://clinicaltrials.gov/ct2/show/NCT05014360

Jun 21st, 2022 - Familial adenomatous polyposis (FAP) is the most common polyposis syndrome. It is an autosomal dominant inherited disorder characterized by the early onset of hundreds to thousands of adenomatous polyps throughout the colon. JNJ-64251330 (lorpucit...

Evolving strategies for management of desmoid tumor.
https://doi.org/10.1002/cncr.34332
Cancer Riedel RF, Agulnik M

Jun 8th, 2022 - Desmoid tumors (DTs) are rare soft tissue mesenchymal neoplasms that may be associated with impairments, disfigurement, morbidity, and (rarely) mortality. DT disease course can be unpredictable. Most DTs are sporadic, harboring somatic mutations i...

Testing Obeticholic Acid for Familial Adenomatous Polyposis
https://clinicaltrials.gov/ct2/show/NCT05223036

Jun 8th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the effect of treatment with OCA versus treatment with placebo on duodenal polyp burden (sum of polyp diameters) in participants with familial adenomatous polyposis (FAP). SECONDARY OBJECTIVES: I. To assess the sa...

Testing Obeticholic Acid for Familial Adenomatous Polyposis
https://clinicaltrials.gov/ct2/show/NCT05112822

Jun 8th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the effect of treatment with OCA versus treatment with placebo on duodenal polyp burden (sum of polyp diameters) in participants with familial adenomatous polyposis (FAP). SECONDARY OBJECTIVES: I. To assess the sa...

Endoscopic management of duodenal and ampullary adenomas
https://www.mdedge.com/gihepnews/article/255250/gi-oncology/endoscopic-management-duodenal-and-ampullary-adenomas
Grace E. Kim, MD, Uzma D. Siddiqui, MD

Jun 7th, 2022 - Duodenal polyps are a relatively rare entity with a reported incidence of 0. 3%-4.

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Guidelines  3 results

ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal c...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695986
The American Journal of Gastroenterology; Syngal S, Brand RE et. al.

Feb 4th, 2015 - This guideline presents recommendations for the management of patients with hereditary gastrointestinal cancer syndromes. The initial assessment is the collection of a family history of cancers and premalignant gastrointestinal conditions and shou...

Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321096
Journal of Clinical Oncology : Official Journal of the Am... Stoffel EM, Mangu PB et. al.

Dec 3rd, 2014 - To provide recommendations on prevention, screening, genetics, treatment, and management for people at risk for hereditary colorectal cancer (CRC) syndromes. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for e...

Guide to endoscopy of the ileo-anal pouch following restorative proctocolectomy with il...
https://doi.org/10.1002/ibd.20874
Inflammatory Bowel Diseases; McLaughlin SD, Clark SK et. al.

Jan 31st, 2009 - Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the surgical procedure of choice for patients with ulcerative colitis (UC). It is also performed in selected patients with familial adenomatous polyposis (FAP). A significant p...

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Clinicaltrials.gov  79 results

A Study of JNJ-64251330 in Participants With Familial Adenomatous Polyposis
https://clinicaltrials.gov/ct2/show/NCT05014360

Jun 21st, 2022 - Familial adenomatous polyposis (FAP) is the most common polyposis syndrome. It is an autosomal dominant inherited disorder characterized by the early onset of hundreds to thousands of adenomatous polyps throughout the colon. JNJ-64251330 (lorpucit...

Testing Obeticholic Acid for Familial Adenomatous Polyposis
https://clinicaltrials.gov/ct2/show/NCT05112822

Jun 8th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the effect of treatment with OCA versus treatment with placebo on duodenal polyp burden (sum of polyp diameters) in participants with familial adenomatous polyposis (FAP). SECONDARY OBJECTIVES: I. To assess the sa...

Testing Obeticholic Acid for Familial Adenomatous Polyposis
https://clinicaltrials.gov/ct2/show/NCT05223036

Jun 8th, 2022 - PRIMARY OBJECTIVE: I. To evaluate the effect of treatment with OCA versus treatment with placebo on duodenal polyp burden (sum of polyp diameters) in participants with familial adenomatous polyposis (FAP). SECONDARY OBJECTIVES: I. To assess the sa...

Erlotinib Hydrochloride in Reducing Duodenal Polyp Burden in Patients With Familial Adenomatous Polyposis at Risk of Developing Colon Cancer
https://clinicaltrials.gov/ct2/show/NCT02961374

Jun 6th, 2022 - PRIMARY OBJECTIVES: I. To assess the mean percent change in duodenal polyp burden (sum of diameters from all polyps) from baseline to 6 months post-intervention for familial adenomatous polyposis (FAP) subjects receiving weekly erlotinib hydrochlo...

The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis
https://clinicaltrials.gov/ct2/show/NCT05402891

Jun 2nd, 2022 - For this study, monitoring was requested from Clinical Monitoring Center (CMC). After approval by the METC, a monitoring intake visit will be scheduled to set up a monitoring plan. In this study, no randomisation will take place, every participant...

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News  56 results

Endoscopic management of duodenal and ampullary adenomas
https://www.mdedge.com/gihepnews/article/255250/gi-oncology/endoscopic-management-duodenal-and-ampullary-adenomas
Grace E. Kim, MD, Uzma D. Siddiqui, MD

Jun 7th, 2022 - Duodenal polyps are a relatively rare entity with a reported incidence of 0. 3%-4.

Polyp Mutations May Hold Key to CRC Prevention
https://www.onclive.com/view/polyp-mutations-may-hold-key-to-crc-prevention

Oct 6th, 2021 - Eduardo Vilar-Sanchez, MD, PhD Precancerous colon polyps exhibit many of the same driver mutations that fuel the development of colorectal cancer (CRC), according to results of a study published in Cancer Prevention Research. Identifying and bet...

Genetic testing for colon cancer: Who, when, and how
https://www.mdedge.com/gihepnews/article/246889/gi-oncology/genetic-testing-colon-cancer-who-when-and-how

Sep 30th, 2021 - Gastroenterologists should be skilled in recognition of patients with inherited risk of colorectal neoplasia. During the session on colonic diseases, the case presentations provided tools to help clinicians identify and evaluate high-risk individu.

Observation May Be Preferrable to Surgery in Certain Cases of Desmoid Tumor Fibromatosis
https://www.onclive.com/view/observation-may-be-preferrable-to-surgery-in-certain-cases-of-desmoid-tumor-fibromatosis

Apr 29th, 2021 - The local recurrence rate after surgical excision was similar to the rate of progression with active surveillance in patients with extra-abdominal desmoid tumor fibromatosis (DTF), suggesting that observation may be sufficient in some cases of DTF...

Chemoprevention With Low-Dose Aspirin Promising in Familial Adenomatous Polyposis
https://www.medscape.com/viewarticle/948958

Apr 9th, 2021 - NEW YORK (Reuters Health) - Low-dose aspirin can suppress the recurrence of colorectal polyps larger than 5.0 mm in patients with familial adenomatous polyposis (FAP), according to results of the J-FAPP Study IV. "Because colorectal polyps larger ...

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Patient Education  7 results see all →