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About 2,030 results

ALLMedicine™ Hemochromatosis Center

Research & Reviews  697 results

Evaluation of Patients With Liver Disease
https://clinicaltrials.gov/ct2/show/NCT00001971

Nov 18th, 2021 - This is a general clinical research protocol to allow for evaluation, investigation and long-term follow up of patients who have an acute or chronic liver disease. The protocol is designed to study the natural history and pathogenesis of various l...

In silico and in vivo protective effect of Morus nigra leaves on oxidative damage induc...
https://doi.org/10.1080/01480545.2021.1991946
Drug and Chemical Toxicology; Figueredo KC, Guex CG et. al.

Oct 20th, 2021 - Morus nigra L. is a plant popularly known as 'amoreira preta', very used in folk medicine. Iron overload (hemochromatosis) is a clinical condition that causes damage to various tissues due to oxidative stress. Therapy to control iron overload is s...

Treatment of Hemochromatosis
https://clinicaltrials.gov/ct2/show/NCT00007150

Oct 19th, 2021 - Hereditary hemochromatosis (HH) occurs in 1 in every 200-250 individuals of northern European descent, and is the most common inherited disease in this population. Although the molecular pathophysiology remains incompletely understood, a homozygou...

Serum Biomarkers of Iron Status and Risk of Hepatocellular Carcinoma Development in Pat...
https://doi.org/10.1158/1055-9965.EPI-21-0754
Cancer Epidemiology, Biomarkers & Prevention : a Publicat... Yu YC, Luu HN et. al.

Oct 16th, 2021 - Nonalcoholic fatty liver disease (NAFLD) has become a major contributor to the rising incidence of hepatocellular carcinoma (HCC) in the United States and other developed countries. Iron, an essential metal primarily stored in hepatocytes, may pla...

Hepcidin induces intestinal calcium uptake while suppressing iron uptake in Caco-2 cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513844
PloS One; Phoaubon S, Lertsuwan K et. al.

Oct 14th, 2021 - Abnormal calcium absorption and iron overload from iron hyperabsorption can contribute to osteoporosis as found in several diseases, including hemochromatosis and thalassemia. Previous studies in thalassemic mice showed the positive effects of the...

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Guidelines  5 results

ACG Clinical Guideline: Hereditary Hemochromatosis.
https://doi.org/10.14309/ajg.0000000000000315
The American Journal of Gastroenterology; Kowdley KV, Brown KE et. al.

Jul 25th, 2019 - Hereditary hemochromatosis (HH) is one of the most common genetic disorders among persons of northern European descent. There have been recent advances in the diagnosis, management, and treatment of HH. The availability of molecular diagnostic tes...

ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.
https://doi.org/10.1038/ajg.2016.517
The American Journal of Gastroenterology; Kwo PY, Cohen SM et. al.

Dec 21st, 2016 - Clinicians are required to assess abnormal liver chemistries on a daily basis. The most common liver chemistries ordered are serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase and bilirubin. These tests sh...

EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochr...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929861
European Journal of Human Genetics : EJHG; Porto G, Brissot P et. al.

Jul 15th, 2015 - Molecular genetic testing for hereditary hemochromatosis (HH) is recognized as a reference test to confirm the diagnosis of suspected HH or to predict its risk. The vast majority (typically >90%) of patients with clinically characterized HH are ho...

Diagnosis and management of hemochromatosis: 2011 practice guideline by the American As...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149125
Hepatology (Baltimore, Md.); Bacon BR, Adams PC et. al.

Apr 1st, 2011 - Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases.|2011|Bacon BR,Adams PC,Kowdley KV,Powell LW,Tavill AS,|blood,diagnosis,physiopathology,therapy,metabolism,pathology,m...

EASL clinical practice guidelines for HFE hemochromatosis.
https://doi.org/10.1016/j.jhep.2010.03.001
Journal of Hepatology;

May 18th, 2010 - Iron overload in humans is associated with a variety of genetic and acquired conditions. Of these, HFE hemochromatosis (HFE-HC) is by far the most frequent and most well-defined inherited cause when considering epidemiological aspects and risks fo...

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Drugs  15 results see all →

Clinicaltrials.gov  20 results

Evaluation of Patients With Liver Disease
https://clinicaltrials.gov/ct2/show/NCT00001971

Nov 18th, 2021 - This is a general clinical research protocol to allow for evaluation, investigation and long-term follow up of patients who have an acute or chronic liver disease. The protocol is designed to study the natural history and pathogenesis of various l...

Treatment of Hemochromatosis
https://clinicaltrials.gov/ct2/show/NCT00007150

Oct 19th, 2021 - Hereditary hemochromatosis (HH) occurs in 1 in every 200-250 individuals of northern European descent, and is the most common inherited disease in this population. Although the molecular pathophysiology remains incompletely understood, a homozygou...

PTG-300 in Subjects With Hereditary Hemochromatosis
https://clinicaltrials.gov/ct2/show/NCT04202965

Sep 16th, 2021 - This study is a multicenter, open-label study. The objective of the study is to assess the effect of PTG-300 on transferrin saturation (TSAT) and serum iron in adult hereditary hemochromatosis patients.

Inhibiting Dietary Iron Absorption in Subjects With Hereditary Hemochromatosis by a Natural Polyphenol Supplement
https://clinicaltrials.gov/ct2/show/NCT03990181

May 26th, 2021 - Polyphenolic compounds are very strong Inhibitors of non-heme iron absorption, as they form insoluble complexes with ferrous iron. Patients with hereditary hemochromatosis (HH) have an increased intestinal non-heme iron absorption due to a genetic...

Hepatocellular Carcinoma in HIV-infected Individuals in Asian Population
https://clinicaltrials.gov/ct2/show/NCT03702998

Jan 27th, 2021 - The incidence of hepatocellular carcinoma (HCC) is increasing over time among the HIV-infected population, and is an increasingly important cause of morbidity and mortality in HIV-infected individuals. Despite effective treatment for HBV and HCV i...

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News  66 results

Dr. Fitzgerald on Minimizing Use of Chemotherapy in Breast Cancer
https://www.onclive.com/view/dr-fitzgerald-on-minimizing-use-of-chemotherapy-in-breast-cancer

Oct 6th, 2021 - Dennis Fitzgerald, MD, a specialist in breast cancer, lung cancer, non-Hodgkin lymphoma and hemochromatosis, Hackensack Meridian Health Riverview Medical Center, discusses the pivotal TAILORx trial, which found that for intermediate-risk women wit...

Pediatric NAFLD almost always stems from excess body weight, not other etiologies
https://www.mdedge.com/pediatrics/article/238291/obesity/pediatric-nafld-almost-always-stems-excess-body-weight-not-other
Will Pass

Apr 7th, 2021 - Nonalcoholic fatty liver disease (NAFLD) in children is almost always caused by excess body weight, not other etiologies, based on a retrospective analysis of 900 patients. Just 2% of children with overweight or obesity and suspected NAFLD had oth.

Iron Chelation Therapy Efficacy and Safety in MDS
https://www.onclive.com/view/iron-chelation-therapy-efficacy-and-safety-in-mds

Apr 2nd, 2021 - Transcript:James M. Foran, MD, FRCPC: What is the role of the patient in deciding on iron chelation therapy? There are two oral chelating agents—a third one that’s approved in a different setting, deferiprone—and then there’s Desferal, or de...

Diagnosis of HCC: Presentation of Disease
https://www.onclive.com/view/diagnosis-of-hcc-presentation-of-disease

Apr 2nd, 2021 - Transcript: Ghassan K. Abou-Alfa, MD: Hello, and welcome to this OncLive® Peer Exchange® panel discussion titled Global Perspective on Treatment of Hepatocellular Carcinoma. The treatment of advanced hepatocellular carcinoma is complicated by ...

Common Genetic Disorder Tied to Increased Dementia Risk in Men
https://www.medscape.com/viewarticle/945393

Feb 5th, 2021 - Men with iron overload due to hereditary hemochromatosis are at increased risk of developing dementia, an analysis of UK Biobank data indicates. Results of a large analysis showed that among men who had two mutations that cause hemochromatosis (HF...

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Patient Education  9 results see all →