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About 37,027 results

ALLMedicine™ Acute Lymphoblastic Leukemia Center

Research & Reviews  17,253 results

Outcomes and prognostic factors in adolescents and young adults with ALL treated with a...
https://doi.org/10.1182/bloodadvances.2020003526
Blood Advances; Rajendra A, Jain H et. al.

Feb 26th, 2021 - The use of pediatrics-inspired protocols in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) results in superior survival compared with the adult protocols. Pediatrics-inspired protocols carry an increased risk of toxicity and t...

Adequate asparaginase is important to prevent central nervous system and testicular rel...
https://doi.org/10.1002/ijc.33529
International Journal of Cancer; Liu C, Huang B et. al.

Feb 26th, 2021 - Asparaginase (Asp) is one of the most important drugs for treating acute lymphoblastic leukemia (ALL). However, off-protocol Asp administration (OPAA) or hypersensitivity may disturb its pharmacokinetic profile. In this retrospective study, we sou...

Deleterious Point Mutations in T-cell Acute Lymphoblastic Leukemia: Mechanistic Insight...
https://doi.org/10.1002/ijc.33527
International Journal of Cancer; Roy U, Raghavan SC

Feb 26th, 2021 - T-cell acute lymphoblastic leukemia (T-ALL) is characterized by the leukemogenic transformation of immature T-cells, which accumulate an array of genetic and epigenetic lesions, leading to a sustained proliferation of abnormal T cells. Genetic alt...

CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapse...
https://doi.org/10.1158/1078-0432.CCR-20-3863
Clinical Cancer Research : an Official Journal of the Ame... Hu Y, Zhou Y et. al.

Feb 25th, 2021 - Autologous chimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for relapsed/refractory acute lymphoblastic leukemia (r/r ALL). However, certain characteristics of autologous CAR-T cells can delay treatment availability. Rela...

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Guidelines  47 results

Adult Acute Lymphoblastic Leukemia Treatment (PDQ®)–Health Professional Version
https://www.cancer.gov/types/leukemia/hp/adult-all-treatment-pdq?cid=eb_govdel
National Cancer Institute

Jan 14th, 2021 - ALL (also called acute lymphocytic leukemia) is an aggressive type of leukemia characterized by the presence of too many lymphoblasts or lymphocytes in the bone marrow and peripheral blood. It can spread to the lymph nodes, spleen, liver, central ...

Children with Down syndrome, ALL at higher risk for poor outcomes
https://www.healio.com/hematology-oncology/leukemia/news/online/{4b3c1cc4-4e4a-462e-b738-7ee6b1d20fd3}/children-with-down-syndrome-all-at-higher-risk-for-poor-outcomes

May 30th, 2020 - Children with Down syndrome and acute lymphoblastic leukemia continue to experience poorer outcomes than children with ALL who do not have Down syndrome, according to study results presented during the ASCO20 Virtual Scientific Program.

Strict Cytogenetics, MRD Criteria Identifies Pediatric B-ALL Subgroup With Favorable Prognosis
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200195/full/

May 28th, 2020 - Application of a set of stringent clinical and cytogenetic features as well as minimal residual disease (MRD) criteria can identify a subset of low-risk (LR) pediatric patients with standard-risk B-cell acute lymphoblastic leukemia (B-ALL) who can...

Tisagenlecleucel Outcomes in Trial of Pediatric, Young Adult R/R ALL Are Consistent With Those Previously Reported
https://dailynews.ascopubs.org/do/10.1200/ADN.20.200130/full/

May 12th, 2020 - In pediatric and young adult patients with relapsed/refractory acute lymphoblastic leukemia (ALL) who received prior blinatumomab exposure or inotuzumab ozogamicin as bridging therapy, treatment with tisagenlecleucel is associated with consistent ...

Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelin...
https://doi.org/10.6004/jnccn.2020.0001
Journal of the National Comprehensive Cancer Network : JN... Brown P, Inaba H et. al.

Jan 7th, 2020 - Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Advancements in technology that enhance our understanding of the biology of the disease, risk-adapted therapy, and enhanced supportive care have contributed to improved su...

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Drugs  191 results see all →

Clinicaltrials.gov  18,347 results

Outcomes and prognostic factors in adolescents and young adults with ALL treated with a...
https://doi.org/10.1182/bloodadvances.2020003526
Blood Advances; Rajendra A, Jain H et. al.

Feb 26th, 2021 - The use of pediatrics-inspired protocols in adolescent and young adult (AYA) acute lymphoblastic leukemia (ALL) results in superior survival compared with the adult protocols. Pediatrics-inspired protocols carry an increased risk of toxicity and t...

Adequate asparaginase is important to prevent central nervous system and testicular rel...
https://doi.org/10.1002/ijc.33529
International Journal of Cancer; Liu C, Huang B et. al.

Feb 26th, 2021 - Asparaginase (Asp) is one of the most important drugs for treating acute lymphoblastic leukemia (ALL). However, off-protocol Asp administration (OPAA) or hypersensitivity may disturb its pharmacokinetic profile. In this retrospective study, we sou...

Deleterious Point Mutations in T-cell Acute Lymphoblastic Leukemia: Mechanistic Insight...
https://doi.org/10.1002/ijc.33527
International Journal of Cancer; Roy U, Raghavan SC

Feb 26th, 2021 - T-cell acute lymphoblastic leukemia (T-ALL) is characterized by the leukemogenic transformation of immature T-cells, which accumulate an array of genetic and epigenetic lesions, leading to a sustained proliferation of abnormal T cells. Genetic alt...

CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapse...
https://doi.org/10.1158/1078-0432.CCR-20-3863
Clinical Cancer Research : an Official Journal of the Ame... Hu Y, Zhou Y et. al.

Feb 25th, 2021 - Autologous chimeric antigen receptor T (CAR-T) cell therapy is an effective treatment for relapsed/refractory acute lymphoblastic leukemia (r/r ALL). However, certain characteristics of autologous CAR-T cells can delay treatment availability. Rela...

see more →

News  1,185 results

TBI Beats Chemoconditioning for ALL Transplants in Children
https://www.medscape.com/viewarticle/945225

Feb 2nd, 2021 - For now at least, total body irradiation (TBI) plus etoposide remains the conditioning regimen of choice for children undergoing allogeneic hematopoietic stem cell transplant for acute lymphoblastic leukemia (ALL), according to an open-label phase...

Adult Acute Lymphoblastic Leukemia Treatment (PDQ®)–Health Professional Version
https://www.cancer.gov/types/leukemia/hp/adult-all-treatment-pdq?cid=eb_govdel
National Cancer Institute

Jan 14th, 2021 - ALL (also called acute lymphocytic leukemia) is an aggressive type of leukemia characterized by the presence of too many lymphoblasts or lymphocytes in the bone marrow and peripheral blood. It can spread to the lymph nodes, spleen, liver, central ...

'Impressive' Outcomes Sans Chemo in Poor-Prognosis ALL
https://www.staging.medscape.com/viewarticle/939520

Oct 20th, 2020 - The days of using chemotherapy to treat Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) may be numbered. In a phase 2 trial, up-front chemo-free induction/consolidation with the tyrosine kinase inhibitor dasatinib (Sprycel)...

New Guideline Helps Patients and Parents Navigate Pediatric Acute Lymphoblastic Leukemia
https://www.staging.medscape.com/viewarticle/938748

Oct 7th, 2020 - NEW YORK (Reuters Health) - A new guideline from the National Comprehensive Cancer Network (NCCN) provides information about pediatric acute lymphoblastic leukemia (ALL) to patients and their families in an easy-to-learn format. The guideline, bas...

New Guideline Helps Patients and Parents Navigate Pediatric Acute Lymphoblastic Leukemia
https://www.medscape.com/viewarticle/938748

Oct 7th, 2020 - NEW YORK (Reuters Health) - A new guideline from the National Comprehensive Cancer Network (NCCN) provides information about pediatric acute lymphoblastic leukemia (ALL) to patients and their families in an easy-to-learn format. The guideline, bas...

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Patient Education  4 results see all →