×
About 3,724 results

ALLMedicine™ Factor VII Center

Research & Reviews  1,823 results

Management of surgery, menorrhagia and child-birth for patients with unclassified bleed...
https://doi.org/10.1097/MBC.0000000000001045
Blood Coagulation & Fibrinolysis : an International Journ... Desborough MJR, Obaji S et. al.

May 11th, 2021 - Unclassified bleeding disorders account for 2.6% of all new bleeding disorder registrations in the UK. The management of the bleeding phenotype associated with these disorders is poorly described. Systematic review and meta-analysis to determine t...

Preventing Surgical and Postpartum Hemorrhage in an Active Duty Patient With an Undiagn...
https://doi.org/10.1093/milmed/usab169
Military Medicine; Kopelman ZA, Villazana-Kretzer D et. al.

Apr 22nd, 2021 - Factor VII (FVII) deficiency is a hereditary bleeding disorder that significantly increases the risk of hemorrhage during the intrapartum and postpartum periods as well as during surgery. Management often requires careful pre- and post-operative p...

Aortic valve and coronary artery bypass surgery in a patient with factor VII deficiency.
https://doi.org/10.4103/aca.ACA_181_20
Annals of Cardiac Anaesthesia; Henze L, Junghanss C et. al.

Apr 22nd, 2021 - Congenital factor VII (FVII) deficiency is a rare bleeding disorder (RBD) with phenotypes ranging from asymptomatic state to life threatening bleeding episodes. There is no established recommendation for the perioperative management of patients sc...

Efficacy, Safety, and Strategies for Recombinant-Activated Factor VII in Cardiac Surgic...
https://doi.org/10.1053/j.jvca.2021.03.021
Journal of Cardiothoracic and Vascular Anesthesia; Kidd B, Sutherland L et. al.

Apr 20th, 2021 - As perioperative bleeding continues to be a major source of morbidity and mortality in cardiac surgery, the search continues for an ideal hemostatic agent for use in this patient population. Transfusion of blood products has been associated both w...

Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intrac...
https://doi.org/10.1055/a-1450-8568
Thrombosis and Haemostasis; Andersen E, Chollet ME et. al.

Mar 20th, 2021 - Clinical parameters have been extensively studied in factor (F) VII deficiency, but the knowledge of molecular mechanisms of this disease is scarce. We report on three probands with intracranial bleeds at an early age, one of which had concomitant...

see more →

Guidelines  2 results

Damage control resuscitation in patients with severe traumatic hemorrhage: A practice m...
https://doi.org/10.1097/TA.0000000000001333
The Journal of Trauma and Acute Care Surgery; Cannon JW, Khan MA et. al.

Feb 22nd, 2017 - The resuscitation of severely injured bleeding patients has evolved into a multi-modal strategy termed damage control resuscitation (DCR). This guideline evaluates several aspects of DCR including the role of massive transfusion (MT) protocols, th...

How we use recombinant activated Factor VII in patients with haemophilia A or B complic...
https://doi.org/10.1111/j.1445-5994.2012.02942.x
Internal Medicine Journal; Brown SA, Barnes C et. al.

Nov 19th, 2012 - The management of bleeds in patients with haemophilia A or B complicated by inhibitors is complex. Recombinant activated Factor VII (rFVIIa; NovoSeven RT) is an established therapy in these patients. To develop a consensus-based guide on the pract...

see more →

Drugs  7 results see all →

Clinicaltrials.gov  1,855 results

Management of surgery, menorrhagia and child-birth for patients with unclassified bleed...
https://doi.org/10.1097/MBC.0000000000001045
Blood Coagulation & Fibrinolysis : an International Journ... Desborough MJR, Obaji S et. al.

May 11th, 2021 - Unclassified bleeding disorders account for 2.6% of all new bleeding disorder registrations in the UK. The management of the bleeding phenotype associated with these disorders is poorly described. Systematic review and meta-analysis to determine t...

Preventing Surgical and Postpartum Hemorrhage in an Active Duty Patient With an Undiagn...
https://doi.org/10.1093/milmed/usab169
Military Medicine; Kopelman ZA, Villazana-Kretzer D et. al.

Apr 22nd, 2021 - Factor VII (FVII) deficiency is a hereditary bleeding disorder that significantly increases the risk of hemorrhage during the intrapartum and postpartum periods as well as during surgery. Management often requires careful pre- and post-operative p...

Aortic valve and coronary artery bypass surgery in a patient with factor VII deficiency.
https://doi.org/10.4103/aca.ACA_181_20
Annals of Cardiac Anaesthesia; Henze L, Junghanss C et. al.

Apr 22nd, 2021 - Congenital factor VII (FVII) deficiency is a rare bleeding disorder (RBD) with phenotypes ranging from asymptomatic state to life threatening bleeding episodes. There is no established recommendation for the perioperative management of patients sc...

Efficacy, Safety, and Strategies for Recombinant-Activated Factor VII in Cardiac Surgic...
https://doi.org/10.1053/j.jvca.2021.03.021
Journal of Cardiothoracic and Vascular Anesthesia; Kidd B, Sutherland L et. al.

Apr 20th, 2021 - As perioperative bleeding continues to be a major source of morbidity and mortality in cardiac surgery, the search continues for an ideal hemostatic agent for use in this patient population. Transfusion of blood products has been associated both w...

Molecular Characterization of Two Homozygous Factor VII Variants Associated with Intrac...
https://doi.org/10.1055/a-1450-8568
Thrombosis and Haemostasis; Andersen E, Chollet ME et. al.

Mar 20th, 2021 - Clinical parameters have been extensively studied in factor (F) VII deficiency, but the knowledge of molecular mechanisms of this disease is scarce. We report on three probands with intracranial bleeds at an early age, one of which had concomitant...

see more →

News  37 results

FDA approves recombinant treatment for hemophilia A or B with inhibitors
https://www.mdedge.com/hematology-oncology/article/220097/bleeding-disorders/fda-approves-recombinant-treatment-hemophilia?channel=191
Christopher Palmer

Apr 2nd, 2020 - The Food and Drug Administration has approved a new rabbit-derived recombinant analog of human coagulation factor VII (Sevenfact) for the treatment of hemophilia A or B, according to a release from the agency. The treatment’s approval is for use i.

Clotting Protein May Not Improve Hemorrhagic Stroke Outcomes
https://www.mdedge.com/neurology/article/134452/stroke/clotting-protein-may-not-improve-hemorrhagic-stroke-outcomes

Mar 28th, 2017 - HOUSTON—Acute hemostatic treatment with a clotting protein does not improve short- or long-term outcomes in patients with intracerebral hemorrhage (ICH), according to research presented at the International Stroke Conference 2017. David Gladstone,.

No Benefit of Hemostatic Therapy in Patients With 'Spot Sign' ICH
https://www.medscape.com/viewarticle/877707

Mar 23rd, 2017 - HOUSTON, Texas — A new trial shows no benefit of hemostatic therapy with recombinant factor VII in patients with intracerebral hemorrhage (ICH) but supports the utility of a neuroimaging strategy for patient selection. Researchers selected patient...

rFVII didn’t improve hemorrhagic stroke outcomes in twin trials
https://www.mdedge.com/neurology/article/132301/stroke/rfvii-didnt-improve-hemorrhagic-stroke-outcomes-twin-trials
Michele G. Sullivan

Feb 27th, 2017 - HOUSTON – Acute hemostatic treatment with a clotting protein didn’t improve either short- or long-term outcomes in patients with intracerebral hemorrhage (ICH), according to findings from twin studies. When given to patients who displayed a high-r.

Gene therapy could treat FVII deficiency
https://www.mdedge.com/hematology-oncology/article/188523/thrombosis/gene-therapy-could-treat-fvii-deficiency
HT Staff

Jan 22nd, 2016 - Beagle Photo by Julien Valroff Gene therapy can safely and effectively treat factor VII (FVII) deficiency in dogs, according to research published in Blood. Three of the 4 dogs treated expressed levels of FVII that would be therapeutic in humans,.

see more →