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About 2,579 results

ALLMedicine™ Hemophilia B Center

Research & Reviews  1,057 results

Health care resource utilization and cost burden of hemophilia B in the United States.
https://doi.org/10.1182/bloodadvances.2020003424
Blood Advances; Buckner TW, Bocharova I et. al.

Apr 8th, 2021 - Hemophilia B is a rare congenital blood disorder characterized by factor IX deficiency. Clinical profiles of hemophilia B range from mild to severe forms of the disease. The objective of this study was to characterize the economic burden associate...

Genetic analysis of carrier status in female members of Japanese hemophilia families.
https://doi.org/10.1111/jth.15301
Journal of Thrombosis and Haemostasis : JTH; Shinozawa K, Amano K et. al.

Mar 24th, 2021 - Genetic characteristics and genetic carrier diagnosis in Japanese hemophilia female carriers have not been evaluated. To provide genetic information on Japanese hemophilia female carriers and demonstrate the advantages of genetic testing in carrie...

Clinical, humanistic, and economic burden of severe hemophilia B in the United States: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981988
Orphanet Journal of Rare Diseases; Burke T, Asghar S et. al.

Mar 21st, 2021 - Hemophilia B is a rare congenital bleeding disorder that has a significant negative impact on patients' functionality and health-related quality of life. The standard of care for severe hemophilia B in the United States is prophylactic factor IX r...

Gene Therapy For Hemophilia B Using CB 2679d-GT: A Novel Factor IX Variant With Higher ...
https://doi.org/10.1182/blood.2020006005
Blood Nair N, De Wolf D et. al.

Mar 18th, 2021 - Sustained expression of therapeutic factor IX (FIX) levels has been achieved after adeno-associated viral (AAV) vector-based gene therapy in patients with hemophilia B. Nevertheless, patients are still at risk of vector dose-limiting toxicity, par...

Hemostatic Management in an Infant With Neuroblastoma and Severe Hemophilia B With Exte...
https://doi.org/10.1097/MPH.0000000000002109
Journal of Pediatric Hematology/oncology; Cuntz F, Deubzer HE et. al.

Mar 4th, 2021 - In the rare co-occurrence of childhood cancer and severe hemophilia, hemostatic management is of paramount therapeutic importance. We present the case of an 11-month-old boy with severe congenital hemophilia B, who was diagnosed with metastatic hi...

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Guidelines  41 results

Natural history study of factor IX deficiency with focus on treatment and complications (B‐Natural)
https://onlinelibrary.wiley.com/doi/10.1111/hae.14139
Haemophilia Shapiro AD

Dec 4th, 2020 - Haemophilia B (HB) is less well studied than haemophilia A (HA); despite similarities between the two inherited bleeding disorders, important differences remain that require further research.

The role of total ankle replacement in patients with hemophilia and end‐stage ankle arthropathy: A review
https://onlinelibrary.wiley.com/doi/10.1111/hae.14196
Haemophilia Sackstein P

Nov 7th, 2020 - Hemophilia is the most common X‐linked bleeding disorder, affecting over 1 million individuals throughout the world. Patients are subclassified into mild, moderate and severe disease based on per cent factor activity level.

Current practices in hemophilic patients undergoing orthopedic surgery - a systematic review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588779/
Experimental and Therapeutic Medicine; Badulescu OV

Oct 13th, 2020 - Hemophilia is an inherited disease that requires a different approach in order to evaluate, monitor and treat patients. Despite the great advances in therapeutic agents that have emerged, reports on the impact of monitoring outcomes on treatment d...

WFH Guidelines for the Management of Hemophilia, 3rd edition
https://onlinelibrary.wiley.com/doi/10.1111/hae.14046
Haemophilia

Aug 2nd, 2020 - This new edition of the World Federation of Hemophilia (WFH) guidelines for the management of hemophilia comes at an exciting time in the evolution of the diagnosis and treatment of this condition. Since the publication of the second edition in 20...

Guidelines for the management of acute joint bleeds and chronic synovitis in haemophilia: A United Kingdom Haemophilia Centre Doctors’ Organisation (UKHCDO) guideline
http://www.ukhcdo.org/wp-content/uploads/2017/03/Guidelines-for-the-management-of-acute-joint-bleeds-and-chronic-synovitis-in-haemophilia.pdf
Haemophilia

Jan 23rd, 2017 - Prior to the availability of clotting factor concentrates, the natural history of arthropathy in severe haemophilia was well described, with recurrent bleeds into joints leading to progressive joint damage and ultimate destruction with associa...

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Drugs  31 results see all →

Clinicaltrials.gov  1,177 results

Health care resource utilization and cost burden of hemophilia B in the United States.
https://doi.org/10.1182/bloodadvances.2020003424
Blood Advances; Buckner TW, Bocharova I et. al.

Apr 8th, 2021 - Hemophilia B is a rare congenital blood disorder characterized by factor IX deficiency. Clinical profiles of hemophilia B range from mild to severe forms of the disease. The objective of this study was to characterize the economic burden associate...

Genetic analysis of carrier status in female members of Japanese hemophilia families.
https://doi.org/10.1111/jth.15301
Journal of Thrombosis and Haemostasis : JTH; Shinozawa K, Amano K et. al.

Mar 24th, 2021 - Genetic characteristics and genetic carrier diagnosis in Japanese hemophilia female carriers have not been evaluated. To provide genetic information on Japanese hemophilia female carriers and demonstrate the advantages of genetic testing in carrie...

Clinical, humanistic, and economic burden of severe hemophilia B in the United States: ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981988
Orphanet Journal of Rare Diseases; Burke T, Asghar S et. al.

Mar 21st, 2021 - Hemophilia B is a rare congenital bleeding disorder that has a significant negative impact on patients' functionality and health-related quality of life. The standard of care for severe hemophilia B in the United States is prophylactic factor IX r...

Gene Therapy For Hemophilia B Using CB 2679d-GT: A Novel Factor IX Variant With Higher ...
https://doi.org/10.1182/blood.2020006005
Blood Nair N, De Wolf D et. al.

Mar 18th, 2021 - Sustained expression of therapeutic factor IX (FIX) levels has been achieved after adeno-associated viral (AAV) vector-based gene therapy in patients with hemophilia B. Nevertheless, patients are still at risk of vector dose-limiting toxicity, par...

Benefix - coagulation factor ix (recombinant) kit-Wyeth BioPharma Division of Wyeth Pharmaceuticals LLC
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=85faa5bc-cee5-4ef1-8d80-bdbcb7eba1e4

Mar 17th, 2021 - BeneFIX®, Coagulation Factor IX (Recombinant), is a human blood coagulation factor indicated in adults and children with hemophilia B (congenital factor IX deficiency or Christmas disease) for: on-demand treatment and control of bleeding episodes ...

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News  273 results

Gene Therapy a Potential 'Game Changer' for Hemophilia B
https://www.medscape.com/viewarticle/942762

Dec 17th, 2020 - NEW YORK (Reuters Health) - An investigational gene therapy for hemophilia B substantially increased production of the blood-clotting protein factor IX and reduced the number of bleeding episodes and need for prophylactic therapy in a phase-3 tria...

Natural history study of factor IX deficiency with focus on treatment and complications (B‐Natural)
https://onlinelibrary.wiley.com/doi/10.1111/hae.14139
Haemophilia Shapiro AD

Dec 4th, 2020 - Haemophilia B (HB) is less well studied than haemophilia A (HA); despite similarities between the two inherited bleeding disorders, important differences remain that require further research.

The role of total ankle replacement in patients with hemophilia and end‐stage ankle arthropathy: A review
https://onlinelibrary.wiley.com/doi/10.1111/hae.14196
Haemophilia Sackstein P

Nov 7th, 2020 - Hemophilia is the most common X‐linked bleeding disorder, affecting over 1 million individuals throughout the world. Patients are subclassified into mild, moderate and severe disease based on per cent factor activity level.

Fast Five Quiz: Presentation and Diagnosis of Hemophilia A
https://reference.medscape.com/viewarticle/939102_2

Oct 21st, 2020 - Hemophilia A is an inherited deficiency of FVIII and an X-linked recessive disorder. Hemophilia B, another recessive disorder, is characterized by a deficiency in factor IX. Hemophilia C is an autosomal recessive disorder in which patients are def...

Current practices in hemophilic patients undergoing orthopedic surgery - a systematic review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588779/
Experimental and Therapeutic Medicine; Badulescu OV

Oct 13th, 2020 - Hemophilia is an inherited disease that requires a different approach in order to evaluate, monitor and treat patients. Despite the great advances in therapeutic agents that have emerged, reports on the impact of monitoring outcomes on treatment d...

see more →