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About 784 results

ALLMedicine™ Platelet Disorders Center

Research & Reviews  383 results

Genomic Analysis for the Detection of Bleeding and Thrombotic Disorders.
https://doi.org/10.1055/s-0041-1722865
Seminars in Thrombosis and Hemostasis; Gomez K

Feb 26th, 2021 - The development of high-throughput sequencing technologies has ushered in a new era of genomic testing in clinical medicine. This has greatly enhanced our diagnostic repertoire for hemostatic diseases particularly for milder or rarer bleeding diso...

Improving interpretation of genetic testing for hereditary hemorrhagic, thrombotic, and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727548
Hematology. American Society of Hematology. Education Pro... Lambert MP

Dec 4th, 2020 - The last 10 years have seen an explosion in the amount of data available through next-generation sequencing. These data are advancing quickly, and this pace makes it difficult for most practitioners to easily keep up with all of the new informatio...

Update on Clinical Ex Vivo Hematopoietic Stem Cell Gene Therapy for Inherited Monogenic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854296
Molecular Therapy : the Journal of the American Society O... Tucci F, Scaramuzza S et. al.

Nov 22nd, 2020 - Gene transfer into autologous hematopoietic stem progenitor cells (HSPCs) has the potential to cure monogenic inherited disorders caused by an altered development and/or function of the blood system, such as immune deficiencies and red blood cell ...

Inherited platelet diseases with normal platelet count: phenotypes, genotypes and diagn...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849565
Haematologica Nurden P, Stritt S et. al.

Nov 5th, 2020 - Inherited platelet disorders resulting from platelet function defects and a normal platelet count cause a moderate or severe bleeding diathesis. Since the description of Glanzmann thrombasthenia resulting from defects of ITGA2B and ITGB3, new inhe...

The molecular basis of immune-based platelet disorders.
https://doi.org/10.1042/CS20191101
Clinical Science (London, England : 1979); Hicks SM, Lee CSM et. al.

Nov 3rd, 2020 - Platelets have a predominant role in haemostasis, the maintenance of blood volume and emerging roles as innate immune cells, in wound healing and in inflammatory responses. Platelets express receptors that are important for platelet adhesion, aggr...

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Guidelines  1 results

Management of bleeding and of invasive procedures in patients with platelet disorders a...
https://doi.org/10.1016/j.thromres.2009.06.009
Thrombosis Research; Tosetto A, Balduini CL et. al.

Jul 27th, 2009 - The optimal management of bleeding or its prophylaxis in patients with disorders of platelet count or function is controversial. The bleeding diathesis of these patients is usually mild to moderate: therefore, transfusion of platelet concentrates ...

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Clinicaltrials.gov  391 results

Genomic Analysis for the Detection of Bleeding and Thrombotic Disorders.
https://doi.org/10.1055/s-0041-1722865
Seminars in Thrombosis and Hemostasis; Gomez K

Feb 26th, 2021 - The development of high-throughput sequencing technologies has ushered in a new era of genomic testing in clinical medicine. This has greatly enhanced our diagnostic repertoire for hemostatic diseases particularly for milder or rarer bleeding diso...

Improving interpretation of genetic testing for hereditary hemorrhagic, thrombotic, and...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727548
Hematology. American Society of Hematology. Education Pro... Lambert MP

Dec 4th, 2020 - The last 10 years have seen an explosion in the amount of data available through next-generation sequencing. These data are advancing quickly, and this pace makes it difficult for most practitioners to easily keep up with all of the new informatio...

Update on Clinical Ex Vivo Hematopoietic Stem Cell Gene Therapy for Inherited Monogenic...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854296
Molecular Therapy : the Journal of the American Society O... Tucci F, Scaramuzza S et. al.

Nov 22nd, 2020 - Gene transfer into autologous hematopoietic stem progenitor cells (HSPCs) has the potential to cure monogenic inherited disorders caused by an altered development and/or function of the blood system, such as immune deficiencies and red blood cell ...

Inherited platelet diseases with normal platelet count: phenotypes, genotypes and diagn...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849565
Haematologica Nurden P, Stritt S et. al.

Nov 5th, 2020 - Inherited platelet disorders resulting from platelet function defects and a normal platelet count cause a moderate or severe bleeding diathesis. Since the description of Glanzmann thrombasthenia resulting from defects of ITGA2B and ITGB3, new inhe...

The molecular basis of immune-based platelet disorders.
https://doi.org/10.1042/CS20191101
Clinical Science (London, England : 1979); Hicks SM, Lee CSM et. al.

Nov 3rd, 2020 - Platelets have a predominant role in haemostasis, the maintenance of blood volume and emerging roles as innate immune cells, in wound healing and in inflammatory responses. Platelets express receptors that are important for platelet adhesion, aggr...

see more →

News  7 results

Better, cheaper test developed to identify BPDs
https://www.mdedge.com/hematology-oncology/article/187282/thrombosis/better-cheaper-test-developed-identify-bpds
HT Staff

Jun 14th, 2016 - Platelets in a blood smear Investigators from more than 50 institutions across the globe have developed a high-throughput sequencing platform—the ThromboGenomics platform—targeting 63 genes relevant for inherited bleeding, thrombotic, and platelet.

Method could improve diagnosis of platelet disorders
https://www.mdedge.com/hematology-oncology/article/188476/thrombosis/method-could-improve-diagnosis-platelet-disorders
HT Staff

Feb 10th, 2016 - SIM image of platelets Courtesy of Dan Cutler A proof-of-concept study suggests structured illumination microscopy (SIM) enables accurate diagnosis of Hermansky-Pudlak syndrome (HPS), an autosomal recessive disorder characterized by platelet dysfu.

Surgical bleeding risk ‘remarkable’ with platelet disorders
https://www.mdedge.com/surgery/article/100829/bleeding-disorders/surgical-bleeding-risk-remarkable-platelet-disorders
Patrice Wendling

Jun 26th, 2015 - VIENNA – Inherited platelet function disorders are associated with a significant bleeding risk during surgery, a retrospective, multicenter study shows. “The frequency of excessive bleeding assessed by one of three criteria at surgery is pretty re.

A Case of Chronic Thrombocytopenia in a 17-Year-Old Female
https://www.staging.medscape.com/viewarticle/920128

Abstract and Introduction Abstract Storage pool deficiency (SPD) is a group of rare platelet disorders that result from deficiencies in α-granules, δ-granules, or both. One type of α-SPD is gray platelet syndrome (GPS), caused by mutations in the ...

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Patient Education  2 results see all →