ALLMedicine™ Alpha2-plasmin Inhibitor Deficiency Center

Feb 24th, 2022 - Medication Summary Traditionally, fresh frozen plasma (FFP) has been the source of clotting factors used to treat coagulation factor deficiencies for which no concentrates are available. Alpha2–plasmin inhibitor (alpha2-PI) falls into this categor...

Feb 24th, 2022 - Medical Care The extent of medical care depends on the severity of the bleeding. Minor bleeding can be handled with oral antifibrinolytic drugs, but more extensive bleeding may require temporary plasma supplementation. Bleeding into critical sites...

Feb 24th, 2022 - Laboratory Studies Appropriate testing methodology (ie, functional vs antigenic, biologic vs chromogenic substrate assays) is an important consideration in the workup of patients with alpha2–plasmin inhibitor (alpha 2-PI) deficiency. Testing blood...

Feb 24th, 2022 - Practice Essentials Alpha2–plasmin inhibitor (alpha2-PI), also known as alpha2-antiplasmin, is a protein that is primarily synthesized by the liver and is present in plasma and platelets. It is the most important physiologic inhibitor of plasmin, ...

Feb 24th, 2022 - Practice Essentials Alpha2–plasmin inhibitor (alpha2-PI), also known as alpha2-antiplasmin, is a protein that is primarily synthesized by the liver and is present in plasma and platelets. It is the most important physiologic inhibitor of plasmin, ...