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About 438 results

ALLMedicine™ Antithrombin Deficiency Center

Research & Reviews  158 results

Gene editing addresses antithrombin deficiency.
https://doi.org/10.1038/d41573-023-00008-w
Nature Reviews. Drug Discovery; Crunkhorn S

Jan 12th, 2023 - Gene editing addresses antithrombin deficiency.|2023|Crunkhorn S,|

Identification and functional analysis of three novel genetic variants resulting in pre...
https://doi.org/10.1007/s12185-022-03509-3
International Journal of Hematology; Imai Y, Nagaya S et. al.

Dec 17th, 2022 - Hereditary antithrombin (AT) deficiency is an autosomal dominant inherited thrombophilia. In three pedigrees of hereditary type I AT deficiency, we identified novel variants c.126delC (p.Lys43Serfs*7), c.165C > G (p.Tyr55*), and c.546delA (p.Lys18...

Peripartum management of deep venous thrombosis in the context of antithrombin deficien...
https://doi.org/10.1097/MBC.0000000000001183
Blood Coagulation & Fibrinolysis : an International Journ... Stevens-Haas CL, Livergood MC et. al.

Nov 29th, 2022 - Literature regarding the management of thrombus refractory to first-line treatment in the setting of pregnancy is limited, and management is made even more complicated in the context of thrombophilia. This case reviews the management of a patient ...

Safety and Efficacy of Argatroban Applicated in Anticoagulation of V-V ECMO
https://clinicaltrials.gov/ct2/show/NCT04925167

Nov 9th, 2022 - Unfractionated heparin is most common in the anticoagulation management of V-V ECMO. However, many side effects of unfractionated heparin, such as HIT, antithrombin deficiency, etc seriously affects the prognosis of patients. Argatroban is kind of...

Inherited antithrombin deficiency caused by a mutation in the SERPINC1 gene: A case rep...
https://doi.org/10.1097/MD.0000000000031240
Medicine Hou X, Zhang K et. al.

Nov 8th, 2022 - Inherited antithrombin deficiency (ATD) is a major cause of thrombotic deficiency. Genetic testing is of great value in the diagnosis of hereditary thrombophilia. Herein, we report a case of inherited ATD admitted to our hospital. We include the r...

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Drugs  1 results see all →

Clinicaltrials.gov  8 results

Safety and Efficacy of Argatroban Applicated in Anticoagulation of V-V ECMO
https://clinicaltrials.gov/ct2/show/NCT04925167

Nov 9th, 2022 - Unfractionated heparin is most common in the anticoagulation management of V-V ECMO. However, many side effects of unfractionated heparin, such as HIT, antithrombin deficiency, etc seriously affects the prognosis of patients. Argatroban is kind of...

Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery
https://clinicaltrials.gov/ct2/show/NCT04918173

Sep 19th, 2022 - Assess the incidence of the composite of thrombotic events (TEs) and thromboembolic events (TEEs) in patients with congenital antithrombin deficiency under cover of Atenativ for surgical procedures or parturition.

Safety, Pharmacokinetics and Efficacy of an ATIII Concentrate
https://clinicaltrials.gov/ct2/show/NCT00319228

May 11th, 2022 - This study will be a prospective, unblinded, non-randomized, open-label, multi-center Phase II/III study with 2 segments, i.e. a PK evaluation (Segment I), and an assessment of prophylaxis in surgical interventions and pregnancy/delivery, (Segment...

Evaluation of Antithrombin Deficiency in Patients of Intensive Care Unit Placed on Extracorporeal Membrane Oxygenation
https://clinicaltrials.gov/ct2/show/NCT04133844

Jun 4th, 2021 - Our hypothesis is that ECMO initiation is responsible for a severe decrease of antithrombin level in a high proportion of patients who develop heparin resistance.

"Incidence and Consequences of Disorders of Glycosylation in Patients With Conotruncal and Septal Heart Defects"
https://clinicaltrials.gov/ct2/show/NCT02503267

Mar 27th, 2017 - Congenital disorders of glycosylation (CDG) are a family of inherited disorders caused by defects in the synthesis of glycans, glycoproteins or other glycoconjugates. Congenital disorders of glycosylation (CDG) are a family of inherited disorders ...

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News  6 results

COVID-Heart Reporting Rules; HVAD Batteries Recalled; Leaky Cement Stabs Heart
https://www.medpagetoday.com/cardiology/prevention/99483

Jun 28th, 2022 - The American College of Cardiology and American Heart Association released unified data standards for reporting of cardiovascular conditions related to COVID-19. (Circulation: Cardiovascular Quality and Outcomes) Environmental predictors of cardio...

VTE Prophylaxis Warranted in Pregnant Women With Rare Thrombophilias
https://www.medscape.com/viewarticle/888208

Nov 9th, 2017 - NEW YORK (Reuters Health) - Women with some rare forms of thrombophilia can benefit from ante- or postpartum thrombosis prophylaxis, but those with more common types generally do not need preventive treatment, according to a new meta-analysis. Pre...

Pregnancy-Linked VTE Risk Varies by Type of Thrombophilia
https://www.medpagetoday.com/obgyn/pregnancy/68853

Oct 27th, 2017 - Absolute risk of pregnancy-associated venous thromboembolism (VTE) varied depending on the type of thrombophilia among women with a family history of VTE, a systematic review and meta-analysis found. While all thrombophilias increased the risk of ...

Purpuric lesion on the elbow
https://www.mdedge.com/ccjm/article/95725/dermatology/purpuric-lesion-elbow?channel=194
Naveen K. Voore, MD, Asima Rahman, MD, MRCGP, MRCOG et. al.

Apr 1st, 2012 - A 75-year-old man was admitted to the hospital with new-onset atrial fibrillation. He underwent rate control, and a heparin infusion was started.

New FDA Orphan Drugs: CDX-110, ATryn, ISIS 333611
https://www.medscape.com/viewarticle/567860

Dec 21st, 2007 - December 21, 2007 -- The US Food and Drug Administration (FDA) has granted orphan drug designation to CDX-110 for the treatment of glioblastoma multiforme, ATryn for the treatment of hereditary antithrombin deficiency, and ISIS 333611 for the trea...

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Patient Education  2 results see all →