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About 4,810 results

ALLMedicine™ Immune Thrombocytopenia Center

Research & Reviews  1,554 results

Contribution of interleukin 27 serum level to pathogenesis and prognosis in children wi...
https://doi.org/10.1097/MD.0000000000029504
Medicine Hassan T, Abdel Rahman D et. al.

Jun 28th, 2022 - Concepts surrounding the mechanisms of thrombocytopenia in ITP have shifted from the traditional view of autoantibody mediated platelet destruction to more complex mechanisms in which impaired platelet production, T-cell-mediated effects, and dist...

Frequency and utility of bone marrow examination in relapsed/ refractory immune thrombo...
https://doi.org/10.1111/jth.15802
Journal of Thrombosis and Haemostasis : JTH; Taparia K, Wall E et. al.

Jun 26th, 2022 - The diagnosis of immune thrombocytopenia (ITP) is one of exclusion. While guidelines recommend against routine bone marrow examination (BME) at time of ITP diagnosis, the role of BME in relapsed/refractory ITP is unclear. To examine the frequency ...

Regulatory T cells are replenished in the splenic microenvironment of patients with imm...
https://doi.org/10.1111/bjh.18332
British Journal of Haematology; Kapur R

Jun 25th, 2022 - Therapeutic management of patients with immune thrombocytopenia (ITP) remains challenging; however, thrombopoietin receptor agonists (TPO-RAs) have revolutionised the treatment landscape of ITP. It is increasingly hypothesised that TPO-RAs may hav...

Anchoring IgG-degrading enzymes to the surface of platelets selectively neutralizes ant...
https://doi.org/10.1182/bloodadvances.2022007195
Blood Advances; Lynch DR, Stringham EN et. al.

Jun 24th, 2022 - Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by IgG-mediated platelet destruction. Current therapies primarily focus on reducing antiplatelet antibodies using immunosuppression or increasing platelet production with...

Myelodysplastic Syndrome (MDS) Clinical Presentation
https://emedicine.medscape.com/article/207347-clinical

Jun 23rd, 2022 - History The development of myelodysplastic syndrome (MDS) may be preceded by a few years by an unexplained macrocytic anemia with no evidence of megaloblastic anemia and a mild thrombocytopenia or neutropenia. Clinical symptoms that should prompt ...

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Guidelines  4 results

American Society of Hematology 2019 guidelines for immune thrombocytopenia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963252
Blood Advances; Neunert C, Terrell DR et. al.

Dec 4th, 2019 - Despite an increase in the number of therapies available to treat patients with immune thrombocytopenia (ITP), there are minimal data from randomized trials to assist physicians with the management of patients. These evidence-based guidelines of t...

The prevention of glucocorticoid-induced osteoporosis in patients with immune thrombocy...
https://doi.org/10.1111/bjh.15735
British Journal of Haematology; Hill QA, Grainger JD et. al.

Jan 5th, 2019 - The prevention of glucocorticoid-induced osteoporosis in patients with immune thrombocytopenia receiving steroids: a British Society for Haematology Good Practice Paper.|2019|Hill QA,Grainger JD,Thachil J,Provan D,Evans G,|adverse effects,therapeu...

The American Society of Hematology 2011 evidence-based practice guideline for immune th...
https://doi.org/10.1182/blood-2010-08-302984
Blood Neunert C, Lim W et. al.

Feb 18th, 2011 - Immune thrombocytopenia (ITP) is commonly encountered in clinical practice. In 1996 the American Society of Hematology published a landmark guidance paper designed to assist clinicians in the management of this disorder. Since 1996 there have been...

International consensus report on the investigation and management of primary immune th...
https://doi.org/10.1182/blood-2009-06-225565
Blood Provan D, Stasi R et. al.

Oct 23rd, 2009 - Previously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysio...

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Drugs  18 results see all →

Clinicaltrials.gov  195 results

A Study of TAK-079 in Adults With Persistent/Chronic Primary Immune Thrombocytopenia
https://clinicaltrials.gov/ct2/show/NCT04278924

Jun 23rd, 2022 - The drug being tested in this study is called TAK-079. TAK-079 is being tested to treat people who have primary immune thrombocytopenia (ITP). This study will evaluate the safety and biologic activity of TAK-079 or matching placebo in combination ...

Long-term Study of Romiplostim in Thrombocytopenic Pediatric Patients With Immune Thrombocytopenia (ITP)
https://clinicaltrials.gov/ct2/show/NCT02279173

Jun 23rd, 2022 - This is a phase 3b single arm, open label, multicenter study describing the percentage of time pediatric participants with ITP have a platelet response while receiving romiplostim, defined as a platelet count ≥ 50 x 10^9/L in the absence of ITP re...

A Study to Investigate the Long-term Safety, Tolerability, and Efficacy of Rozanolixizumab in Study Participants With Persistent or Chronic Primary Immune Thrombocytopenia (ITP)
https://clinicaltrials.gov/ct2/show/NCT04596995

Jun 21st, 2022 - The purpose of this study is to assess the long-term safety, tolerability and clinical efficacy of treatment with rozanolixizumab.

Basket Study to Assess Efficacy, Safety and PK of Iptacopan (LNP023) in Autoimmune Benign Hematological Disorders
https://clinicaltrials.gov/ct2/show/NCT05086744

Jun 21st, 2022 - The main purpose of this study is to evaluate the efficacy and safety of iptacopan in participants with autoimmune benign hematological disorders such as primary immune thrombocytopenia and primary cold agglutinin disease.

Intravenous Immunoglobulin (IVIG, Bioven) Efficacy and Safety in Chronic Primary Immune Thrombocytopenia (ITP) in Adults
https://clinicaltrials.gov/ct2/show/NCT05422365

Jun 16th, 2022 - The investigational drug, IVIG, is used for immunomodulatory therapy in the treatment of autoimmune diseases. The study will involve patients with chronic immune thrombocytopenia. This autoimmune disease is diagnosed in the presence of isolated th...

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News  148 results

Fast Five Quiz: Thrombocytopenia
https://www.medscape.com/viewarticle/973998

May 20th, 2022 - Thrombocytopenia is an abnormally low platelet count with various causes. Low levels of platelets present risks such as bleeding and thrombosis. The National Organization for Rare Diseases (NORD) estimates that more than 200,000 people have primar...

Fast Five Quiz: Thrombocytopenia
https://reference.medscape.com/viewarticle/973998

May 20th, 2022 - Thrombocytopenia is an abnormally low platelet count with various causes. Low levels of platelets present risks such as bleeding and thrombosis. The National Organization for Rare Diseases (NORD) estimates that more than 200,000 people have primar...

ITP Armamentarium Expands With the Hope of Limiting Long-Term Steroid Exposure
https://www.onclive.com/view/itp-armamentarium-expands-with-the-hope-of-limiting-long-term-steroid-exposure

Apr 18th, 2022 - Although patients with primary and secondary immune thrombocytopenia (ITP) can derive good responses from corticosteroids, long-term exposure to steroids is associated with unique adverse effects (AEs), said Kanwarpal S. Kahlon, MD, who added that...

BTK Inhibitor Shows Potential in Immune Thrombocytopenia
https://www.medpagetoday.com/hematologyoncology/hematology/98188

Apr 13th, 2022 - An investigational oral Bruton's tyrosine kinase (BTK) inhibitor was tolerable and yielded rapid and durable responses in pretreated patients with immune thrombocytopenia (ITP), according to results of an open-label phase I/II trial. In the 60-pat...

Role of Splenectomy in Immune Thrombocytopenia Treatment
https://www.onclive.com/view/role-of-splenectomy-in-immune-thrombocytopenia-treatment

Feb 2nd, 2022 - James Bussel, MD: For this patient, who might be a young woman, Caroline outlined specifically why dexamethasone and rituximab may be good. We’ve been talking about the risks of vaccination, and I thought you’d bring up flu vaccines. The other thi...

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Patient Education  5 results see all →