About 440 results

ALLMedicine™ Platelet Disorders Center

Research & Reviews  163 results

Platelet Disorders

Nov 19th, 2021 - The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. The platelets arise from the fragmentation of the cytoplasm of megakaryocytes in the bone marrow and circulate in blood as disc-s...

Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction...
Journal of Thrombosis and Haemostasis : JTH; Stapley RJ, Poulter NS et. al.

Nov 11th, 2021 - A significant challenge is faced for the genetic diagnosis of inherited platelet disorders in which candidate genetic variants can be found in more than 100 bleeding, thrombotic, and platelet disorder genes, especially within families in which the...

Consensus recommendations on flow cytometry for the assessment of inherited and acquire...
Journal of Thrombosis and Haemostasis : JTH; Frelinger AL, Rivera J et. al.

Sep 29th, 2021 - Flow cytometry is increasingly used in the study of platelets in inherited and acquired disorders of platelet number and function. However, wide variation exists in specific reagents, methods, and equipment used, making interpretation and comparis...

Prevalence, burden and treatment effects of vaginal bleeding in women with (suspected) ...
British Journal of Haematology; Punt MC, Ruigrok ND et. al.

Sep 19th, 2021 - Congenital platelet disorders (CPDs) are rare bleeding disorders that are associated with mucocutaneous bleeds. However, data on vaginal bleeding in women with CPDs are scarce. A set of generic and bleeding-specific questionnaires were used to eva...

Heritable platelet disorders: an enigma even guidelines can't unravel.
British Journal of Haematology; Bussel JB, Peerschke E

Sep 9th, 2021 - Heritable platelet disorders: an enigma even guidelines can't unravel.|2021|Bussel JB,Peerschke E,|

see more →

Clinicaltrials.gov  4 results

Use of Proteomics for the Diagnosis of a Platelet-related Bleeding Disorder

Aug 25th, 2021 - The goal of this study is to identify the platelet defect responsible for the bleeding in families from our inherited platelet disorders Israeli-Palestinian registry. The investigators plan to characterize platelet proteome expression after removi...

Characterization of Laboratory Response to DDAVP in Adult Hemophilia A Carriers

Jul 16th, 2018 - DDAVP (Desmopressin) is commonly used in the treatment of persons with bleeding disorders such as hemophilia, von Willebrand disease, or qualitative platelet disorders to help them clot better. The investigator wants to assess the increase in the ...

Study of Megakaryocytes From Patients With Abnormal Platelet Vesicles

Jul 2nd, 2017 - Congenital bleeding disorders characterized by abnormal platelet granules include Gray Platelet syndrome (GPS; defective alpha-granules), Hermansky-Pudlak syndrome (HPS; defective delta-granules), and combined alpha delta-storage pool deficiency (...

Thrombin Generation and Platelet Activation in CRS/HIPEC

Jan 27th, 2017 - The purpose of this study was to quantitatively assess the impact of CRS and HIPEC, on various components of hemostasis. Routine laboratory assays such as activated clotting time, activated partial thromboplastin time, prothrombin time, or platele...

see more →

News  9 results

Recognizing Predisposition Syndromes Can Impact Pediatric MDS and AML Treatment

Dec 4th, 2020 - Marcin Wlodarski, MD Early identification of inherited predisposition to forms of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in pediatric patients can assist in treatment decisions and selection for familial stem cell transpl...

Eye Hemorrhage Signals Myeloid Leukemia
Jan Dyer

Feb 23rd, 2018 - A 40-year-old man suddenly began to lose vision in his left eye. The retinal exam was normal for the right eye.

Teach your adolescent patients about normal menses, so they know when it’s abnormal
Pediatric News;

Nov 6th, 2017 - Von Willebrand syndrome Von Willebrand syndrome is a deficiency or dysfunction of von Willebrand factor (vWF), a protein with binding sites for platelets, collagen, and factor VIII that “serves as a bridge between platelets and injury sites in ves.

Better, cheaper test developed to identify BPDs
HT Staff

Jun 14th, 2016 - Platelets in a blood smear Investigators from more than 50 institutions across the globe have developed a high-throughput sequencing platform—the ThromboGenomics platform—targeting 63 genes relevant for inherited bleeding, thrombotic, and platelet.

see more →