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About 353 results

ALLMedicine™ Protein C Deficiency Center

Research & Reviews  124 results

Novel prenatal diagnosis of protein C deficiency and primary prophylaxis with protein C...
https://doi.org/10.1016/j.thromres.2021.10.011
Thrombosis Research; Prosser A, Amos L et. al.

Nov 17th, 2021 - Novel prenatal diagnosis of protein C deficiency and primary prophylaxis with protein C concentrate.|2021|Prosser A,Amos L,Sharma M,|

Surgical technique and the long-term outcomes of pediatric living donor domino liver tr...
https://doi.org/10.1111/petr.14174
Pediatric Transplantation; Shimizu S, Sakamoto S et. al.

Oct 24th, 2021 - The native liver of patients with maple syrup urine disease (MSUD) (1st recipients) can be used as a graft for non-MSUD patients with end-stage liver disease (2nd recipients). This study aimed to demonstrate the optimal operational procedures and ...

Successful perioperative management using prothrombin complex concentrates in patients ...
https://doi.org/10.1002/pbc.29380
Pediatric Blood & Cancer; Inoue K, Arakawa Y et. al.

Oct 20th, 2021 - Perioperative management of severe congenital protein C deficiency remains unestablished. This deficiency is often treated with anticoagulants, such as warfarin. Although anticoagulants need to be perioperatively discontinued, there are few method...

Severe protein C deficiency in a newborn caused by a homozygous pathogenic variant in t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520241
BMC Pediatrics; Song U, Ryu YH et. al.

Oct 17th, 2021 - Severe protein C deficiency is a rare and inherited cause of thrombophilia in neonates. Protein C acts as an anticoagulant, and its deficiency results in vascular thrombosis. Herein, we report a case of protein C deficiency with a homozygous patho...

Thrombus formation and ischemic necrosis of the uterus and adnexa due to purpura fulmin...
https://doi.org/10.1111/jog.15027
The Journal of Obstetrics and Gynaecology Research; Maebayashi A, Hayashi N et. al.

Sep 16th, 2021 - Purpura fulminans (PF) is a syndrome characterized by the sudden onset of progressive skin hemorrhage, necrosis of the extremities, and thrombotic occlusion. Although the cause is believed to be protein C deficiency, many aspects of this syndrome ...

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Drugs  1 results see all →

Clinicaltrials.gov  2 results

Efficacy and Safety Study of Protein C Concentrate in Subjects With Severe Congenital Protein C Deficiency
https://clinicaltrials.gov/ct2/show/NCT00157118

May 5th, 2021 - The purpose of this study is to show that Protein C Concentrate is a safe and effective treatment for subjects with congenital protein C deficiency. Depending on the type of treatment required, patients are assigned to one of 3 study parts: Part 1...

Validation of a Novel Dabigatran Based Peri-Operative Bridging Anticoagulation Protocol for Patients on Chronic Warfarin Therapy
https://clinicaltrials.gov/ct2/show/NCT01810237

Jan 31st, 2017 - Subject Selection: The study population will include low risk patients on long-term warfarin therapy for venous thromboembolic disease (VTE) followed by the hematology anticoagulation clinic. Low risk will be defined as status greater than 12 mont...

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News  14 results

A 60-year-old white woman presented with a 3-month history of a painful, nonhealing ulceration on her left lateral lower leg
https://www.mdedge.com/dermatology/article/194337/medical-dermatology/60-year-old-white-woman-presented-3-month-history?channel=39212
Donna Bilu Martin, MD

Feb 12th, 2019 - Livedoid vasculopathy, also known as atrophie blanche and PURPLE (painful purpuric ulcers with reticular pattern of the lower extremities) is a rare, chronic vascular condition. It is a vasculopathy rather than a vasculitis as the former is caused.

March 2019
https://www.mdedge.com/dermatology/article/194337/medical-dermatology/march-2019
Donna Bilu Martin, MD

Feb 12th, 2019 - Livedoid vasculopathy, also known as atrophie blanche and PURPLE (painful purpuric ulcers with reticular pattern of the lower extremities) is a rare, chronic vascular condition. It is a vasculopathy rather than a vasculitis as the former is caused.

VTE Prophylaxis Warranted in Pregnant Women With Rare Thrombophilias
https://www.medscape.com/viewarticle/888208

Nov 9th, 2017 - NEW YORK (Reuters Health) - Women with some rare forms of thrombophilia can benefit from ante- or postpartum thrombosis prophylaxis, but those with more common types generally do not need preventive treatment, according to a new meta-analysis. Pre...

Peering into My Own Genome
https://www.medpagetoday.com/genetics/genetictesting/53088

Aug 16th, 2015 - I have looked into my genome and seen ... nothing much to worry about. I carry 15 rare genetic variants that have been associated with some form of disease, but I am heterozygous for all of them -- I have one intact copy of the same gene. So I car...

An 'Ignominious End' for a Landmark Sepsis Trial
https://www.medscape.com/viewarticle/771954

Oct 8th, 2012 - Drotrecogin Alfa (Activated) in Adults With Septic Shock Ranieri VM, Thompson BT, Barie PS, et al N Engl J Med. 2012;366:2055-2064 Summary The saga of recombinant human activated protein C (rhAPC), also known as drotrecogin alfa, activated (DrotAA...

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