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About 485 results

ALLMedicine™ Protein C Deficiency Center

Research & Reviews  165 results

N-Glycosylation Deficiency Reduces the Activation of Protein C and Disrupts the Endothe...
https://doi.org/10.1055/s-0042-1744378
Thrombosis and Haemostasis; Pascreau T, Saller F et. al.

Jun 20th, 2022 - Phosphomannomutase 2 (PMM2) deficiency is the most prevalent congenital disorder of glycosylation. It is associated with coagulopathy, including protein C deficiency. Since all components of the anticoagulant and cytoprotective protein C system ar...

Pediatric Retinal Detachment in Homozygous Protein C Deficiency: Genetic and Phenotypic...
https://doi.org/10.3928/23258160-20220414-01
Ophthalmic Surgery, Lasers & Imaging Retina; Alotaibi MD, Albakri AS et. al.

May 17th, 2022 - Homozygous protein C deficiency is a rare hypercoagulability disorder. This study describes the ocular manifestations and the genetic background in a family with two affected children. This is a retrospective review of ophthalmic examinations, inv...

Diagnosis and management of severe congenital protein C deficiency (SCPCD): Communicati...
https://doi.org/10.1111/jth.15732
Journal of Thrombosis and Haemostasis : JTH; Minford A, Brandão LR et. al.

May 16th, 2022 - Severe congenital protein C deficiency (SCPCD) is rare and there is currently substantial variation in the management of this condition. A joint project by three Scientific and Standardization Committees of the ISTH: Plasma Coagulation Inhibitors,...

A Study of TAK-662 for Japanese Patients With Congenital Protein C Deficiency
https://clinicaltrials.gov/ct2/show/NCT04984889

Apr 11th, 2022 - A Phase 1/2 Single-Dose Study of TAK-662 in Japanese Patients with Congenital Protein C Deficiency

Dermatologic Manifestations of Hematologic Disease
https://emedicine.medscape.com/article/1096183-overview

Mar 29th, 2022 - Coagulation Disorders Antiphospholipid syndrome Antiphospholipid syndrome (APS) is an acquired, multisystemic disorder characterized by recurrent thromboses in the arterial system, venous system, or both. Antiphospholipid syndrome is classified in...

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Drugs  1 results see all →

Clinicaltrials.gov  10 results

A Study of TAK-662 for Japanese Patients With Congenital Protein C Deficiency
https://clinicaltrials.gov/ct2/show/NCT04984889

Apr 11th, 2022 - A Phase 1/2 Single-Dose Study of TAK-662 in Japanese Patients with Congenital Protein C Deficiency

Efficacy and Safety Study of Protein C Concentrate in Subjects With Severe Congenital Protein C Deficiency
https://clinicaltrials.gov/ct2/show/NCT00157118

May 5th, 2021 - The purpose of this study is to show that Protein C Concentrate is a safe and effective treatment for subjects with congenital protein C deficiency. Depending on the type of treatment required, patients are assigned to one of 3 study parts: Part 1...

Thromboprophylaxis in Pregnant Women in Hospital: A Prospective Clinical Trial
https://clinicaltrials.gov/ct2/show/NCT02600260

Apr 28th, 2021 - Thromboembolic events are among the leading causes of maternal morbidity and mortality in pregnancy / postpartum period. They are the leading cause of maternal death in developed countries. Risk factors for venous thromboembolism (VTE) during preg...

Retrospective Study to Capture Dosing and Treatment Outcome Data in Participants With Severe Congenital Protein C Deficiency Who Were Treated With Protein C Concentrate Under an Emergency Use IND
https://clinicaltrials.gov/ct2/show/NCT00161720

Apr 8th, 2021 - This is a data collection study with the purpose of capturing dosing and treatment outcome data in participants with severe congenital protein C deficiency who were treated with protein C concentrate under an Emergency Use Investigational New Drug...

Sepsis-Associated Purpura Fulminans International Registry - Europe
https://clinicaltrials.gov/ct2/show/NCT02238795

Feb 21st, 2021 - Purpura fulminans is the clinical manifestation of disseminated thrombosis in dermal and systemic microcirculation. This rare disease is frequently associated with multiple organ failure and represents a life-threatening condition with mortality e...

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News  18 results

Retiform Purpura on the Buttocks in 6 Critically Ill COVID-19 Patients
https://www.mdedge.com/dermatology/article/248888/infectious-diseases/retiform-purpura-buttocks-6-critically-ill-covid-19
Bukhtawar Waqas, BA, Fernanda Salgado, MD et. al.

Nov 18th, 2021 - To the Editor: There is emerging evidence of skin findings in patients with COVID-19, including perniolike changes of the toes as well as urticarial and vesicular eruptions. 1 Magro et al2 reported 3 cases of livedoid and purpuric skin eruptions in.

A 60-year-old white woman presented with a 3-month history of a painful, nonhealing ulceration on her left lateral lower leg
https://www.mdedge.com/dermatology/article/194337/medical-dermatology/60-year-old-white-woman-presented-3-month-history?channel=39212
Donna Bilu Martin, MD

Feb 12th, 2019 - Livedoid vasculopathy, also known as atrophie blanche and PURPLE (painful purpuric ulcers with reticular pattern of the lower extremities) is a rare, chronic vascular condition. It is a vasculopathy rather than a vasculitis as the former is caused.

March 2019
https://www.mdedge.com/dermatology/article/194337/medical-dermatology/march-2019
Donna Bilu Martin, MD

Feb 12th, 2019 - Livedoid vasculopathy, also known as atrophie blanche and PURPLE (painful purpuric ulcers with reticular pattern of the lower extremities) is a rare, chronic vascular condition. It is a vasculopathy rather than a vasculitis as the former is caused.

A 60-year-old white woman presented with a 3-month history of a painful, nonhealing ulceration on her left lateral lower leg
https://www.mdedge.com/dermatology/article/194337/medical-dermatology/60-year-old-white-woman-presented-3-month-history
Donna Bilu Martin, MD

Feb 12th, 2019 - Livedoid vasculopathy, also known as atrophie blanche and PURPLE (painful purpuric ulcers with reticular pattern of the lower extremities) is a rare, chronic vascular condition. It is a vasculopathy rather than a vasculitis as the former is caused.

Terra Firma-Forme Dermatosis Mimicking Livedo Racemosa
https://www.mdedge.com/dermatology/article/174708/pigmentation-disorders/terra-firma-forme-dermatosis-mimicking-livedo
Christina H. Walker, MD, Ashley Sturgeon, MD et. al.

Sep 13th, 2018 - To the Editor: A 17-year-old adolescent boy presented with dark spots on the legs and back of 2 months’ duration. He was not taking any medications and the spots could not be washed away by scrubbing with soap and water.

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