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About 2,128 results

ALLMedicine™ Von Willebrand Disease Center

Research & Reviews  764 results

Potentially inappropriate medications and anticholinergic and sedative burden in older ...
https://doi.org/10.1111/jcpt.13607
Journal of Clinical Pharmacy and Therapeutics; Novais T, Prudent C et. al.

Jan 14th, 2022 - In older patients, multiple chronic conditions lead to the intake of multiple medications and a higher risk of adverse drug events. The exposure to inappropriate medications in older patients with bleeding disorders is poorly explored. The aim of ...

Prospective Comparison of Incidence of Heavy Menstrual Bleeding in Women Treated With Direct Oral Anticoagulants
https://clinicaltrials.gov/ct2/show/NCT04477837

Jan 14th, 2022 - Patients will be treated as standard of care, no randomization schedule, no blinded investigational product (IP). The decision which DOAC will be given is made before the subject will enter the trial. The DOAC has to be taken at least for seven da...

Novel cysteine substitution p.(Cys1084Tyr) causes variable expressivity of qualitative ...
https://doi.org/10.1182/bloodadvances.2021005928
Blood Advances; Rawley O, Swystun LL et. al.

Jan 13th, 2022 - Von Willebrand factor (VWF) is an extremely cysteine-rich multimeric protein that is essential for maintaining normal hemostasis. The cysteine residues of VWF monomers form intra- and inter-molecular disulfide bonds that regulate its structural co...

Efficacy of emicizumab in von Willebrand disease (VWD) patients with and without alloan...
https://doi.org/10.1111/hae.14491
Haemophilia : the Official Journal of the World Federatio... Shanmukhaiah C, Jijina F et. al.

Jan 12th, 2022 - von Willebrand disease (VWD) is the common bleeding disorder with a clinically relevant bleeding prevalence of 1:10,000. von Willebrand disease patients lack both von Willebrand factor (VWF) and factor VIII (FVIII), which are critical for normal h...

A novel mouse model of type 2N VWD was developed by CRISPR/Cas9 gene editing and recapi...
https://doi.org/10.1182/bloodadvances.2021006353
Blood Advances; Shi Q, Fahs SA et. al.

Jan 12th, 2022 - Type 2N von Willebrand disease is caused by mutations in the factor VIII (FVIII) binding site of von Willibrand factor (VWF), resulting in dysfunctional VWF with defective binding capacity for FVIII. Here we developed a novel type 2N mouse model u...

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Guidelines  4 results

No. 163-Gynaecological and Obstetric Management of Women With Inherited Bleeding Disord...
https://doi.org/10.1016/j.jogc.2017.11.036
Journal of Obstetrics and Gynaecology Canada : JOGC = Jou... Demers C, Derzko C et. al.

Feb 16th, 2018 - The prevalence of bleeding disorders, notably von Willebrand disease (vWD), among adult women with objectively documented menorrhagia is consistently reported to be 10% to 20% and is even higher in adolescents presenting with menorrhagia. Diagnost...

Evidence-based recommendations on the treatment of von Willebrand disease in Italy.
https://doi.org/10.2450/2008.0052-08
Blood Transfusion = Trasfusione Del Sangue; Mannucci PM, Franchini M et. al.

Jun 9th, 2009 - von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissu...

Clinical and laboratory diagnosis of von Willebrand disease: a synopsis of the 2008 NHL...
https://doi.org/10.1002/ajh.21405
American Journal of Hematology; Nichols WL, Rick ME et. al.

May 6th, 2009 - Von Willebrand factor (VWF) mediates blood platelet adhesion and accumulation at sites of blood vessel injury, and also carries coagulation factor VIII (FVIII) that is important for generating procoagulant activity. Von Willebrand disease (VWD), t...

von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the N...
https://doi.org/10.1111/j.1365-2516.2007.01643.x
Haemophilia : the Official Journal of the World Federatio... Nichols WL, Hultin MB et. al.

Mar 5th, 2008 - von Willebrand disease (VWD) is a commonly encountered inherited bleeding disorder affecting both males and females, causing mucous membrane and skin bleeding symptoms, and bleeding with surgical or other haemostatic challenges. VWD may be disprop...

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Drugs  18 results see all →

Clinicaltrials.gov  22 results

Prospective Comparison of Incidence of Heavy Menstrual Bleeding in Women Treated With Direct Oral Anticoagulants
https://clinicaltrials.gov/ct2/show/NCT04477837

Jan 14th, 2022 - Patients will be treated as standard of care, no randomization schedule, no blinded investigational product (IP). The decision which DOAC will be given is made before the subject will enter the trial. The DOAC has to be taken at least for seven da...

Registry of Patients With Von WilLEbrand Disease Treated With Voncento®
https://clinicaltrials.gov/ct2/show/NCT04657887

Jan 11th, 2022 - Inherited von Willebrand disease (VWD) is considered the most common bleeding disorder. Its prevalence is approximately 1% in the general population but symptomatic patients are rarer (0.01%). It is caused by a partial or total quantitative defici...

ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
https://clinicaltrials.gov/ct2/show/NCT04398628

Dec 8th, 2021 - This is a longitudinal, natural history observational cohort study being conducted at approximately 150 ATHN-affiliated sites. Participants will be followed for a minimum of 15 years. Harmonized data elements will be collected at time of enrollmen...

Real-life Data of Constitutional Von Willebrand Disease in Western France
https://clinicaltrials.gov/ct2/show/NCT04887324

Oct 15th, 2021 - The objective of this observational study HOPSCOTcH-WILL II is to provide an accurate and detailed account of current Von Willebrand Disease (VWD) therapeutic management by collecting real-life data on hemorrhagic treated events in the 5 Western F...

Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial
https://clinicaltrials.gov/ct2/show/NCT04344860

Aug 4th, 2021 - The purpose of this 8-week single center, randomized, open-label phase III trial to compare recombinant von Willebrand factor (rVWF, Vonvendi®)) plus tranexamic acid (TA, Cyclokapron®) vs. rVWF alone to prevent postpartum hemorrhage (PPH) in women...

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News  38 results

Hemophilia, von Willebrand disease do not increase postop complications for ACL reconstruction
https://www.mdedge.com/hematology-oncology/article/232223/bleeding-disorders/hemophilia-von-willebrand-disease-do-not
Mark S. Lesney, PhD

Nov 20th, 2020 - Patients with hemophilia A or von Willebrand disease undergoing anterior cruciate ligament (ACL) reconstruction had rates of postoperative complications and ACL reinjuries that were not significantly different from those control patients. However,.

Labor outcomes unchanged by alternate anesthesia in bleeding disorder patients
https://www.mdedge.com/obgyn/article/204480/bleeding-disorders/labor-outcomes-unchanged-alternate-anesthesia-bleeding?channel=27970
Caleb Rans

Jul 11th, 2019 - Among pregnant women with inherited bleeding disorders, having a contraindication to regional anesthesia appears not to impact labor outcomes, according to a retrospective analysis. oceandigital/Thinkstock “The purpose of this study was to determi.

Labor outcomes unchanged by alternate anesthesia in bleeding disorder patients
https://www.mdedge.com/hematology-oncology/article/204480/bleeding-disorders/labor-outcomes-unchanged-alternate-anesthesia
Caleb Rans

Jul 11th, 2019 - Among pregnant women with inherited bleeding disorders, having a contraindication to regional anesthesia appears not to impact labor outcomes, according to a retrospective analysis. oceandigital/Thinkstock “The purpose of this study was to determi.

Fast Five Quiz: Bleeding Disorders
https://reference.medscape.com/viewarticle/915458

Jul 11th, 2019 - Bleeding disorders are conditions in which an individual's blood does not properly clot. Although hemophilia is perhaps the most well-known bleeding disorder, it is somewhat rare. Although it is typically less severe than other similar conditions,...

Fast Five Quiz: Bleeding Disorders
https://reference.medscape.com/viewarticle/915458_1

Jul 11th, 2019 - Bleeding disorders are conditions in which an individual's blood does not properly clot. Although hemophilia is perhaps the most well-known bleeding disorder, it is somewhat rare. Although it is typically less severe than other similar conditions,...

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Patient Education  5 results see all →