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About 7,753 results

ALLMedicine™ Hemophilia Center

Research & Reviews  2,392 results

Correction of a Factor VIII genomic inversion with designer-recombinases.
https://doi.org/10.1038/s41467-022-28080-7
Nature Communications; Lansing F, Mukhametzyanova L et. al.

Jan 22nd, 2022 - Despite advances in nuclease-based genome editing technologies, correcting human disease-causing genomic inversions remains a challenge. Here, we describe the potential use of a recombinase-based system to correct the 140 kb inversion of the F8 ge...

Multidisciplinary Team Care of Patients with Hemophilic Arthropathy: A Qualitative Asse...
https://doi.org/10.1177/10760296211070002
Clinical and Applied Thrombosis/hemostasis : Official Jou... St-Louis J, Chowdary P et. al.

Jan 22nd, 2022 - We used a structured interview to explore approaches to comprehensive hemophilia and arthropathy care among 24 healthcare professionals (HCPs) from multidisciplinary teams (MDTs) in Canada and the UK. Represented MDTs typically comprise a hematolo...

Prophylaxis Regimen for Hemophilia A Patients
https://clinicaltrials.gov/ct2/show/NCT05036278

Jan 21st, 2022 - Researchers are looking for a better way to treat people who have hemophilia A. Hemophilia A is a genetic bleeding disorder that is caused by the lack of a protein in the blood called "clotting factor 8" (FVIII). FVIII is naturally found in the bl...

Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors
https://clinicaltrials.gov/ct2/show/NCT05145127

Jan 20th, 2022 - Study B7841007 is an open-label extension study to assess the long-term safety, tolerability, and efficacy of prophylaxis treatment with marstacimab in participants who did not require "Early Termination" from the Phase 3 Study B7841005. Approxima...

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Guidelines  6 results

WFH Guidelines for the Management of Hemophilia, 3rd edition.
https://doi.org/10.1111/hae.14046
Haemophilia : the Official Journal of the World Federatio... Srivastava A, Santagostino E et. al.

Aug 4th, 2020 - WFH Guidelines for the Management of Hemophilia, 3rd edition.|2020|Srivastava A,Santagostino E,Dougall A,Kitchen S,Sutherland M,|therapy,

Minimal dataset for post-registration surveillance of new drugs in hemophilia: communic...
https://doi.org/10.1111/jth.13762
Journal of Thrombosis and Haemostasis : JTH; Peyvandi F, Makris M et. al.

Aug 3rd, 2017 - Minimal dataset for post-registration surveillance of new drugs in hemophilia: communication from the SSC of the ISTH.|2017|Peyvandi F,Makris M,Collins P,Lillicrap D,Pipe SW,|adverse effects,therapeutic use,standards,blood,diagnosis,drug therapy,s...

Proposal for standardized preanalytical and analytical conditions for measuring thrombi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680042
Journal of Thrombosis and Haemostasis : JTH; Dargaud Y, Wolberg AS et. al.

Jun 29th, 2017 - Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH.|2017|Dargaud Y,Wolberg AS,Gray E,Negrier C,Hemker HC,|standards,blood,drug effects,standards...

Guidelines for the management of hemophilia.
https://doi.org/10.1111/j.1365-2516.2012.02909.x
Haemophilia : the Official Journal of the World Federatio... Srivastava A, Brewer AK et. al.

Jul 11th, 2012 - Hemophilia is a rare disorder that is complex to diagnose and to manage. These evidence-based guidelines offer practical recommendations on the diagnosis and general management of hemophilia, as well as the management of complications including mu...

Preventing venous thromboembolic disease in patients undergoing elective hip and knee a...
https://doi.org/10.5435/00124635-201112000-00007
The Journal of the American Academy of Orthopaedic Surgeons; Mont MA, Jacobs JJ et. al.

Dec 3rd, 2011 - This guideline supersedes a prior one from 2007 on a similar topic. The work group evaluated the available literature concerning various aspects of patient screening, risk factor assessment, and prophylactic treatment against venous thromboembolic...

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Drugs  108 results see all →

Clinicaltrials.gov  182 results

Prophylaxis Regimen for Hemophilia A Patients
https://clinicaltrials.gov/ct2/show/NCT05036278

Jan 21st, 2022 - Researchers are looking for a better way to treat people who have hemophilia A. Hemophilia A is a genetic bleeding disorder that is caused by the lack of a protein in the blood called "clotting factor 8" (FVIII). FVIII is naturally found in the bl...

Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors
https://clinicaltrials.gov/ct2/show/NCT05145127

Jan 20th, 2022 - Study B7841007 is an open-label extension study to assess the long-term safety, tolerability, and efficacy of prophylaxis treatment with marstacimab in participants who did not require "Early Termination" from the Phase 3 Study B7841005. Approxima...

Needs Assessment of Knowledge, Beliefs, and Attitudes of Patients With Hemophilia B About Gene Therapy
https://clinicaltrials.gov/ct2/show/NCT05044845

Jan 19th, 2022 - This prospective cohort study will use qualitative methods, specifically semi structured interviews to evaluate knowledge, beliefs, and attitude about gene therapy in patients 12 years and older with a diagnosis of moderate and severe hemophilia B...

National Longitudinal Cohort of Hematological Diseases
https://clinicaltrials.gov/ct2/show/NCT04645199

Jan 14th, 2022 - Background Hematological diseases are disorders of the blood and hematopoietic organs. The current hematological cohorts are mostly based on single-center or multi-center cases, or cohorts with limited sample size in China. There is a lack of comp...

Pre-clinical Models for Mesenchymal Stem Cell Therapy in Hemophilic Arthropathy
https://clinicaltrials.gov/ct2/show/NCT05187936

Jan 12th, 2022 - Hemophilia is a constitutional coagulation disorder responsible for a hemorrhagic phenotype in patients from an early age. Hemarthrosis is one of the most frequent complications in hemophiliacs and leads to the development of severe and early arth...

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News  405 results

Dr Eric Winer's Unusual Journey Home
https://www.medscape.com/viewarticle/961409

Oct 22nd, 2021 - High-profile breast cancer specialist Eric Winer, MD, is moving from the Dana-Farber Cancer Institute in Boston to take up a new position as director of the Yale Cancer Center and physician-in-chief of Smilow Cancer Hospital at Yale New Haven, in ...

Overcoming Imposter Syndrome as a New Fellow
https://www.onclive.com/view/overcoming-imposter-syndrome-as-a-new-fellow

Oct 7th, 2021 - Welcome to fellowship! You have mastered the art of internal medicine, served as the senior resident for a medicine team, and perhaps even served as a chief medical resident. Now you are a fellowship frosh, and are suddenly being called in the mid...

Intracranial hemorrhaging a high risk for patients with hemophilia, especially neonates
https://www.mdedge.com/hematology-oncology/article/246726/bleeding-disorders/intracranial-hemorrhaging-high-risk-patients
Mark S. Lesney, PhD

Sep 28th, 2021 - The observed rates of intracranial hemorrhaging (ICH) in patients with hemophilia were higher compared to the general populations among all age groups examined, according to a meta-analysis of studies reported online ahead of print in Blood. As pr.

Bispecifics Prove to Have Intriguing Role in Lung Cancer
https://www.onclive.com/view/bispecifics-prove-to-have-intriguing-role-in-lung-cancer

Jul 30th, 2021 - Bispecific antibodies have become an interesting new class of agents in the lung cancer pipeline, most recently with the developments of amivantamab-vmjw (Rybrevant), zenocutuzumab (MCLA-128), and tarlatamab (AMG-757), according to Giorgio V. Scag...

First year of life sees initial bleeding episodes in children with von Willebrand disease
https://www.mdedge.com/hematology-oncology/article/241277/bleeding-disorders/first-year-life-sees-initial-bleeding-episodes
Mark S. Lesney, PhD

Jun 9th, 2021 - To remedy a lack of data on infants and toddlers with von Willebrand disease (VWD), researchers examined data on patients collected from the U. S.

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Patient Education  8 results see all →