About 1,445 results

ALLMedicine™ Neutrophilia Center

Research & Reviews  531 results

Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency.
Circulation Dou H, Kotini A et. al.

Dec 1st, 2021 - LNK/SH2B3 inhibits JAK/STAT signaling by hematopoietic cytokine receptors. GWAS have shown association of a common SNP in LNK (R262W, T allele) with neutrophilia, thrombocytosis and coronary artery disease (CAD). We have shown that LNK(TT) reduces...

A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic A...
American Journal of Respiratory Cell and Molecular Biology; Wrennall JA, Ahmad S et. al.

Nov 23rd, 2021 - Orai1 is a plasma membrane Ca2+ channel that mediates store operated Ca2+ entry (SOCE) and regulates inflammation. Short palate lung and nasal epithelial clone 1 (SPLUNC1) is an asthma gene modifier which inhibits Orai1/SOCE via its C-terminal α6 ...

International Journal of Infectious Diseases : IJID : Off... Fernández LS, Iturriaga LAR et. al.

Nov 21st, 2021 - Analyse differences in clinical presentation and outcome between bacteraemic pneumococcal community-acquired pneumonia (B-PCAP), and SARS-CoV-2 pneumonia. Observational multicenter study conducted on patients hospitalized for B-PCAP between 2000-2...

Variability in azithromycin practices among lung transplant providers in the Internatio...
The Journal of Heart and Lung Transplantation : the Offic... Kapnadak SG, Morrell ED et. al.

Nov 18th, 2021 - Chronic lung allograft dysfunction (CLAD) is the most important long-term complication after lung transplant (LTx), and clinical experience suggests significant variability in its management. We sought to capture azithromycin practices among LTx p...

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Drugs  2 results see all →

Clinicaltrials.gov  8 results

Non-Eosinophilic Neutrophilic Asthma

Oct 8th, 2021 - Neutrophilic asthma (NA) is the asthma phenotype less known, causes a severe disease and does not have a specific treatment. Research on the neutrophilia mechanisms, new neutrophil (NEU) types and bronchial microbiome, can provide an opportunity t...

CC-11050 in Human Immunodeficiency Virus-1-Infected Adults With Suppressed Plasma Viremia on Antiretroviral Therapy (APHRODITE)

Nov 6th, 2018 - CC-11050 is a novel anti-inflammatory compound with potential to treat a variety of chronic inflammatory conditions and cytokine storms associated with infectious diseases. CC-11050 is a selective phosphodiesterase-4 inhibitor (PDE4) that is activ...

Biomarkers in Saliva and Stool

Mar 12th, 2018 - Many soluble factors found in blood can be detected in saliva and stool. Often levels of these factors are found to correlate between body fluids, though the exact relationship between systemic (blood) and local (saliva and stool) immunity is not ...

Two-Part Study to Evaluate the Dose Response of SCH 527123 on Sputum Neutrophilia Following Ozone Challenge in Healthy Subjects and Chronic Obstructive Pulmonary Disease (COPD) Patients (P05567 AM7)

Mar 26th, 2015 - Trial to evaluate the dose response of SCH 527123 in reducing inflammation from an ozone-induced sputum neutrophilia in both healthy subjects and subjects with COPD.

Lung Mucus Hypersecretion and NQO1

Sep 29th, 2014 - Recent epidemiologic studies have re-ignited an old controversy and opinions are forming as to whether mucus hypersecretion is crucial in the etiology of airway disease. For patients with asthma, chronic obstructive pulmonary disease (COPD), and c...

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News  37 results

Interpreting the CBC: What's Truly Important?

Sep 28th, 2021 - This transcript has been edited for clarity. Matthew F. Watto, MD: I'm Dr Matthew Watto. This is The Curbsiders. I'm here with my good friend, Dr Paul Nelson Williams. Can you tell us what we're going to do on this short video? Paul N. Williams, M...

Prognostic and Predictive Factors in Renal Cell Carcinoma

Apr 2nd, 2021 - Transcript:Daniel Heng, MD, MPH, FRCPC: Hello, and thank you for joining this OncLive TV Peer Exchange. Today we are going to be talking about metastatic kidney cancer. With the availability of several approved targeted therapies for both first an...

Gomella Discusses Radium-223 Impact in mCRPC

Dec 20th, 2020 - Leonard G. Gomella, MD Radium-223 dichloride (Xofigo) was originally developed as a palliative agent, similar to the earlier radiopharmaceuticals strontium-89 (Metastron) and samarium-153 (Quadramet), explains Leonard Gomella, MD. It was looked ...

Frontline Therapeutic Planning for Metastatic Renal Cell Carcinoma

Nov 18th, 2020 - Renal cell carcinoma (RCC) is the most common type of kidney cancer. In 2019, 73,820 patients received a diagnosis of kidney cancer according to data from the American Cancer Society. Of those patients, roughly 30% to 35% present with de novo meta...

Red, Swollen, Tender Ear
Diego Abbenante, MD, Valeria Evangelista, MD et. al.

Oct 26th, 2020 - The Diagnosis: Relapsing Polychondritis Due to suspicion of relapsing polychondritis (RP), we also performed an audiometric evaluation, which demonstrated bilateral sensorineural hearing loss. Echocardiography highlighted mild to moderate mitralic.

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