About 33,768 results

ALLMedicine™ Leukemia Center

Research & Reviews  12,687 results

Acute myeloid leukemia due to germline CEBPA mutation in a Syrian family.
Molecular Genetics & Genomic Medicine; Wafa A, Ali B et. al.

Jan 16th, 2022 - Familial cases of adult acute myeloid leukemia (AML) with germline-mutated CCAAT/enhancer-binding protein-α (CEBPA) gene are a rare entity classified in World Health Organization (WHO) classification 2016. Most families reported in the literature ...

Optimizing use of L-asparaginase-based treatment of adults with acute lymphoblastic leu...
Blood Reviews; Douer D, Gökbuget N et. al.

Jan 16th, 2022 - Acute lymphoblastic leukemia (ALL) is a malignancy of lymphoid progenitor cells occurring at an annual incidence rate of approximately 1.1 to 2.1 per 100,000 person-years globally. Approximately 40% of annual ALL cases occur in adults, yet estimat...

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Guidelines  15 results

NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021.
Journal of the National Comprehensive Cancer Network : JN... Pollyea DA, Bixby D et. al.

Jan 7th, 2021 - The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regard...

Chronic Myeloid Leukemia, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Journal of the National Comprehensive Cancer Network : JN... Deininger MW, Shah NP et. al.

Oct 7th, 2020 - Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome (Ph) which results from a reciprocal translocation between chromosomes 9 and 22 [t(9;22] that gives rise to a BCR-ABL1 fusion gene. CML occurs in 3 different phas...

Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myel...
Biology of Blood and Marrow Transplantation : Journal of ... Dholaria B, Savani BN et. al.

Sep 24th, 2020 - The role of hematopoietic cell transplantation (HCT) in the management of newly diagnosed adult acute myeloid leukemia (AML) is reviewed and critically evaluated in this evidence-based review. An AML expert panel, consisting of both transplant and...

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Version 4.2020, NCCN Clinical ...
Journal of the National Comprehensive Cancer Network : JN... Wierda WG, Byrd JC et. al.

Feb 6th, 2020 - Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are characterized by a progressive accumulation of leukemic cells in the peripheral blood, bone marrow, and lymphoid tissues. Treatment of CLL/SLL has evolved significantly in...

Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelin...
Journal of the National Comprehensive Cancer Network : JN... Brown P, Inaba H et. al.

Jan 8th, 2020 - Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy. Advancements in technology that enhance our understanding of the biology of the disease, risk-adapted therapy, and enhanced supportive care have contributed to improved su...

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Drugs  192 results see all →

News  608 results

Improved Survival in ALL Patients Who Relapse After Transplant

Jan 13th, 2022 - A transplant offers a chance of a cure from leukemia, but when the transplant is not successful, such patients are left with few other options and a poor prognosis. But the management of such patients has been improving, and over the past 20 years...

COVID-19 Vaccine Responses Vary Among Hematological Malignancies

Jan 8th, 2022 - Key Takeaways The primary outcome was the rate of seropositivity after 2 doses of a COVID-19 vaccine with rates of seropositivity after 1 dose, rates of positive neutralizing antibody (nAb), cellular responses and adverse events as secondary outco...

AGILE: 'Exciting' Survival Results for IDH1-mutated AML

Dec 13th, 2021 - ATLANTA — Patients with acute myeloid leukemia (AML) bearing mutations in isocitrate dehydrogenase 1 (IDH1) who could not withstand the rigors of intensive therapy had improved event-free and overall survival when they were treated with the combin...

'Shocking' Lack of Lifesaving Leukemia Drug at US Hospitals

Dec 6th, 2021 - A drug crucial for the emergency management of acute promyelocytic leukemia (APL) simply isn't stocked by many US hospitals, according to a recent report in the Journal of the National Comprehensive Cancer Network. The drug — all-trans retinoic ac...

FDA Approves Rituximab for Multiple Pediatric Cancers

Dec 3rd, 2021 - The US Food and Drug Administration yesterday approved rituximab (Rituxan) in combination with chemotherapy for pediatric patients (age 6 months to <18 years) with previously untreated, advanced stage, CD20-positive diffuse large B-cell lymphoma (...

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Patient Education  5 results see all →