About 2,700 results

ALLMedicine™ Lymphoproliferative Disorders Center

Research & Reviews  1,006 results

Genomic Landscape of TCR Alpha-Beta and TCR Gamma-Delta T-Large Granular Lymphocyte Leu...
Blood Cheon H, Xing JC et. al.

Jan 12th, 2022 - Large granular lymphocyte (LGL) leukemia comprises a group of rare lymphoproliferative disorders whose molecular landscape is incompletely defined. We leveraged paired whole exome and transcriptome sequencing in the largest LGL leukemia cohort to ...

Primary cutaneous CD8+ cytotoxic T-cell lymphoma of the face with intraoral involvement...
Journal of Cutaneous Pathology; Travassos DC, Silveira HA et. al.

Jan 11th, 2022 - The primary cutaneous (PC) CD8+ T-cell lymphoproliferative disorders (LPDs) comprise clinically and histologically heterogeneous entities including mycosis fungoides, lymphomatoid papulosis, hydroa-vacciniforme-like LPD, subcutaneous panniculitis-...

Top Ten Tips Palliative Care Clinicians Should Know About Caring for Patients with Cuta...
Journal of Palliative Medicine; Salant JA, Khan N et. al.

Jan 4th, 2022 - Cutaneous T cell lymphoma and its subtypes, mycosis fungoides (MF) and Sézary syndrome (SS), comprise a spectrum of chronic lymphoproliferative disorders in which neoplastic T cells accumulate within the skin and visceral organs. This process is f...

CB-LPD, MGUS, T-LGLL, and PRCA: A rare case report of 4 concomitant hematological disor...
Medicine Xu Q, Yu J et. al.

Dec 30th, 2021 - Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic clonal plasma cell or lymphoplasmacytic proliferative disorder. Recently, some case reports have described the association of pure red cell aplasia (PRCA) with ...

CD5-Negative, CD10-Negative Low-Grade B-Cell Lymphoproliferative Disorders of the Spleen.
Current Oncology (Toronto, Ont.); Schmieg JJ, Muir JM et. al.

Dec 24th, 2021 - CD5-negative, CD10-negative low-grade B-cell lymphoproliferative disorders (CD5-CD10-LPD) of the spleen comprise a fascinating group of indolent, neoplastic, mature B-cell proliferations that are essential to accurately identify but can be difficu...

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Guidelines  3 results

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
Arthritis & Rheumatology (Hoboken, N.J.); Fraenkel L, Bathon JM et. al.

Jun 9th, 2021 - To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grad...

Non-Hodgkin's lymphomas, version 4.2014.
Journal of the National Comprehensive Cancer Network : JN... Zelenetz AD, Gordon LI et. al.

Sep 6th, 2014 - Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Mantle cell lymphoma (MCL) accounts for approximately 6% of all newly diagnosed NHL case...

Non-Hodgkin's lymphomas, version 2.2014.
Journal of the National Comprehensive Cancer Network : JN... Zelenetz AD, Gordon LI et. al.

Jun 14th, 2014 - Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Follicular lymphoma (FL) is the most common subtype of indolent NHL, accounting for app...

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Clinicaltrials.gov  24 results

SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)

Nov 12th, 2021 - The Study Drug: Brentuximab vedotin is an antibody that is designed to find a certain protein (called CD30) on cancer cells and bind to it. It is designed to then enter the cell and release a molecule that may kill the cancer cells. Study Drug Adm...

Family Study of Lymphoproliferative Disorders

Sep 1st, 2021 - Blood and lymph node cancers can begin in either the lymphatic tissues (as in the case of lymphoma) or in the bone marrow (as with leukemia and myeloma), and they all are involved with the uncontrolled growth of white blood cells. There are many s...

Expression of Ku70/XRCC6 in Waldenström's Macroglobulinemia

Aug 6th, 2021 - Waldenström's macroglobulinemia is a rare disease whose pathophysiology remains at present poorly understood, although a recurrent mutation (L265P MYD88) has recently been described. Unlike other lymphoproliferative disorders, there is a defect in...

Risk-stratified Sequential Treatment of Post-transplant Lymphoproliferative Disease (PTLD) With Rituximab SC and Immunochemotherapy

Jul 21st, 2020 - Post-transplant lymphoproliferative disorders (PTLD) differ clinically from lymphoma in the general (immunocompetent) population due to their higher incidence and their frequent association with Epstein-Barr virus. Previous clinical trials have sh...

Therapeutic Effects of Epstein-Barr Virus Immune T-Lymphocytes Derived From a Normal HLA-Compatible Or Partially-Matched Third-Party Donor in the Treatment of EBV Lymphoproliferative Disorders and ...

Jul 10th, 2020 - This is a Phase II trial to evaluate the efficacy and safety of human leukocyte antigen (HLA) partially-matched third-party allogeneic Epstein-Barr virus cytotoxic T lymphocytes (EBV-CTLs) for the treatment of EBV-induced lymphomas and EBV-associa...

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News  45 results

Approaches to Initiating Therapy for a Patient With CLL and Worsening Symptoms

Dec 7th, 2021 - Anthony Mato, MD, MSCE: Let’s talk about a case of a typical patient, a 67-year-old woman who presents with lymphocytosis. It was noted on routine examination with their PCP [primary care physician]. Her past medical history is notable for GERD [g...

Drug to Delay T1D Gets Tepid Endorsement by FDA Advisors

May 28th, 2021 - Teplizumab got a reticent thumbs-up from FDA advisors for an indication in delaying progression of at-risk patients to clinical type 1 diabetes (T1D). The agency's Endocrinologic and Metabolic Drugs Advisory Committee on Thursday voted 10-7 that s...

Nodule on the Neck
Malan Kern, MD, Kelsey Parks, BS et. al.

May 11th, 2021 - The Diagnosis: Primary Cutaneous Anaplastic Large Cell Lymphoma Microscopic analysis showed a dense proliferation of mononuclear cells filling and expanding the dermis with focal epidermotropism (Figure 1). Immunohistochemistry demonstrated strong.

Current and Emerging Strategies for Managing Relapsed/Refractory Hodgkin Lymphoma

Dec 5th, 2020 - Leo I. Gordon, MD Transplant remains the cornerstone of treatment for relapsed/refractory Hodgkin lymphoma, but some new approaches are on the horizon and may also prove to be valid options, explained Leo I. Gordon, MD, Northwestern University, ...

Lower Dose ATLG Safer, More Effective in Children With Hematologic Malignancies

Nov 13th, 2020 - A 15 mg/kg dose of rabbit anti-T-lymphocyte globulin (ATLG) was associated with similar graft-vs-host-disease (GVHD), less nonrelapse mortality, and less disease recurrence compared with a 30 mg/kg dose for children with hematological malignancies...

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Patient Education  2 results see all →