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About 78 results

ALLMedicine™ Plasma Cell Disorders Center

Research & Reviews  37 results

MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in ro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933343
Blood Cancer Journal; Mellors PW, Dasari S et. al.

Mar 5th, 2021 - Immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, offers several advantages over immunofixation for the detection and isotyping of serum monoclonal protein, includi...

Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and rel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873248
Blood Cancer Journal; Murray DL, Puig N et. al.

Feb 10th, 2021 - Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect and isotype M-proteins. In...

N-glycosylation of monoclonal light chains on routine MASS-FIX testing is a risk factor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529948
Leukemia Dispenzieri A, Larson DR et. al.

Jun 30th, 2020 - Our group previously demonstrated that M-protein light chain (LC) glycosylation can be detected on routine MASS-FIX testing. Glycosylation is increased in patients with immunoglobulin LC amyloidosis (AL) and rarely changes over the course of a pat...

Monoclonal Gammopathies After Renal Transplantation: A Single-center Study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450520
Clinical Lymphoma, Myeloma & Leukemia; Bhasin B, Szabo A et. al.

Apr 28th, 2020 - Plasma cell disorders (PCDs) are clonal plasma cell disorders that include conditions such as monoclonal gammopathy of undetermined significance (MGUS), monoclonal gammopathy of renal significance (MGRS), multiple myeloma (MM), smoldering MM (SMM)...

Direct Detection of Monoclonal Free Light Chains in Serum by Use of Immunoenrichment-Co...
https://doi.org/10.1373/clinchem.2018.299461
Clinical Chemistry; Sepiashvili L, Kohlhagen MC et. al.

Jun 6th, 2019 - Free light chain (FLC) quantification is the most analytically sensitive blood-based method commercially available to diagnose and monitor patients with plasma cell disorders (PCDs). However, instead of directly detecting monoclonal FLCs (mFLCs), ...

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Guidelines  1 results

International Myeloma Working Group guidelines for serum-free light chain analysis in m...
https://doi.org/10.1038/leu.2008.307
Leukemia Dispenzieri A, Kyle R et. al.

Nov 20th, 2008 - The serum immunoglobulin-free light chain (FLC) assay measures levels of free kappa and lambda immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma...

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Clinicaltrials.gov  39 results

MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in ro...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933343
Blood Cancer Journal; Mellors PW, Dasari S et. al.

Mar 5th, 2021 - Immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, offers several advantages over immunofixation for the detection and isotyping of serum monoclonal protein, includi...

Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and rel...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873248
Blood Cancer Journal; Murray DL, Puig N et. al.

Feb 10th, 2021 - Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect and isotype M-proteins. In...

N-glycosylation of monoclonal light chains on routine MASS-FIX testing is a risk factor...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529948
Leukemia Dispenzieri A, Larson DR et. al.

Jun 30th, 2020 - Our group previously demonstrated that M-protein light chain (LC) glycosylation can be detected on routine MASS-FIX testing. Glycosylation is increased in patients with immunoglobulin LC amyloidosis (AL) and rarely changes over the course of a pat...

Monoclonal Gammopathies After Renal Transplantation: A Single-center Study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450520
Clinical Lymphoma, Myeloma & Leukemia; Bhasin B, Szabo A et. al.

Apr 28th, 2020 - Plasma cell disorders (PCDs) are clonal plasma cell disorders that include conditions such as monoclonal gammopathy of undetermined significance (MGUS), monoclonal gammopathy of renal significance (MGRS), multiple myeloma (MM), smoldering MM (SMM)...

Direct Detection of Monoclonal Free Light Chains in Serum by Use of Immunoenrichment-Co...
https://doi.org/10.1373/clinchem.2018.299461
Clinical Chemistry; Sepiashvili L, Kohlhagen MC et. al.

Jun 6th, 2019 - Free light chain (FLC) quantification is the most analytically sensitive blood-based method commercially available to diagnose and monitor patients with plasma cell disorders (PCDs). However, instead of directly detecting monoclonal FLCs (mFLCs), ...

see more →

News  1 results

A Man With New Onset of Ascites and Edema
https://www.medscape.com/viewarticle/570889_5

Apr 8th, 2008 - Discussion The liver can be involved in many systemic diseases, including infectious, neoplastic, immunologic, metabolic, and vascular diseases.[4] Amyloidosis encompasses a group of systemic diseases caused by deposition of extracellular proteins...

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