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About 6,019 results

ALLMedicine™ Aplastic Anemia Center

Research & Reviews  2,831 results

Relationship between plasma rabbit anti-thymocyte globulin concentration and immunosupp...
https://doi.org/10.1111/ejh.13644
European Journal of Haematology; Narita A, Muramatsu H et. al.

May 5th, 2021 - Patients with acquired aplastic anemia (AA) without HLA-matched sibling donors or aged >40 years receive immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG). We investigated the relationship between plasma rabbit ATG (r-ATG) concent...

Optimizing outcomes for haploidentical hematopoietic stem cell transplantation in sever...
https://doi.org/10.1080/17474086.2021.1923475
Expert Review of Hematology; Xu ZL, Huang XJ

May 4th, 2021 - : Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has resulted in increased levels of disease-free survival in severe aplastic anemia (SAA). Haploidentical transplantation (haplo-SCT) was previously not recommended due to unacceptab...

BCOR gene alterations in hematological diseases.
https://doi.org/10.1182/blood.2021010958
Blood Falini B, Sportoletti P et. al.

May 4th, 2021 - The BCL6 co-repressor (BCOR) is a transcription factor involved in the control of embryogenesis, mesenchymal stem cells function, hematopoiesis and lymphoid development. Recurrent somatic clonal mutations of the BCOR gene and its homologue BCORL1 ...

Predicting response of severe aplastic anemia to immunosuppression combined with eltrom...
https://doi.org/10.3324/haematol.2021.278413
Haematologica Zaimoku Y, Patel BA et. al.

Apr 29th, 2021 - Pretreatment blood counts, particularly the absolute reticulocyte count (ARC) ≥25×109/L, correlate with response to immunosuppressive therapy (IST) in severe aplastic anemia (SAA). In recent trials, eltrombopag (EPAG) combined with standard IST yi...

Eltrombopag in children with severe aplastic anemia.
https://doi.org/10.1002/pbc.29066
Pediatric Blood & Cancer; Lesmana H, Jacobs T et. al.

Apr 15th, 2021 - Immunosuppressive therapy with horse antithymocyte globulin and cyclosporine currently remains the standard therapy for children with severe aplastic anemia (SAA) who lack human leukocyte antigen (HLA)-identical sibling. The thrombopoietin recepto...

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Guidelines  2 results

Diagnosis and management of acquired aplastic anemia in childhood. Guidelines from the ...
https://doi.org/10.1016/j.bcmd.2015.03.007
Blood Cells, Molecules & Diseases; Barone A, Lucarelli A et. al.

May 15th, 2015 - Acquired aplastic anemia (AA) is a rare heterogeneous disease characterized by pancytopenia and hypoplastic bone marrow. The incidence is 2-3/million inhabitants/year, in Europe, but higher in East Asia. Survival in severe aplastic anemia (SAA) ha...

Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellula...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635414
Haematologica Bennett JM, Orazi A

Jan 15th, 2009 - Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three wo...

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Drugs  95 results see all →

Clinicaltrials.gov  2,983 results

Relationship between plasma rabbit anti-thymocyte globulin concentration and immunosupp...
https://doi.org/10.1111/ejh.13644
European Journal of Haematology; Narita A, Muramatsu H et. al.

May 5th, 2021 - Patients with acquired aplastic anemia (AA) without HLA-matched sibling donors or aged >40 years receive immunosuppressive therapy (IST) with anti-thymocyte globulin (ATG). We investigated the relationship between plasma rabbit ATG (r-ATG) concent...

Optimizing outcomes for haploidentical hematopoietic stem cell transplantation in sever...
https://doi.org/10.1080/17474086.2021.1923475
Expert Review of Hematology; Xu ZL, Huang XJ

May 4th, 2021 - : Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has resulted in increased levels of disease-free survival in severe aplastic anemia (SAA). Haploidentical transplantation (haplo-SCT) was previously not recommended due to unacceptab...

BCOR gene alterations in hematological diseases.
https://doi.org/10.1182/blood.2021010958
Blood Falini B, Sportoletti P et. al.

May 4th, 2021 - The BCL6 co-repressor (BCOR) is a transcription factor involved in the control of embryogenesis, mesenchymal stem cells function, hematopoiesis and lymphoid development. Recurrent somatic clonal mutations of the BCOR gene and its homologue BCORL1 ...

Predicting response of severe aplastic anemia to immunosuppression combined with eltrom...
https://doi.org/10.3324/haematol.2021.278413
Haematologica Zaimoku Y, Patel BA et. al.

Apr 29th, 2021 - Pretreatment blood counts, particularly the absolute reticulocyte count (ARC) ≥25×109/L, correlate with response to immunosuppressive therapy (IST) in severe aplastic anemia (SAA). In recent trials, eltrombopag (EPAG) combined with standard IST yi...

Eltrombopag in children with severe aplastic anemia.
https://doi.org/10.1002/pbc.29066
Pediatric Blood & Cancer; Lesmana H, Jacobs T et. al.

Apr 15th, 2021 - Immunosuppressive therapy with horse antithymocyte globulin and cyclosporine currently remains the standard therapy for children with severe aplastic anemia (SAA) who lack human leukocyte antigen (HLA)-identical sibling. The thrombopoietin recepto...

see more →

News  89 results

Chimerism and the use of fludarabine associated with secondary graft failure in aplastic anemia
https://www.mdedge.com/hematology-oncology/article/218544/anemia/chimerism-and-use-fludarabine-associated-secondary-graft?channel=39313
Mark S. Lesney

Mar 6th, 2020 - Inferior overall survival was observed in patients with aplastic anemia who had mixed or complete recipient-type chimerism or complete donor chimerism after hematopoietic stem cell transplantation (HSCT), according to the results of a registry dat.

Aplastic Anemia: Diagnosis and Treatment
https://www.mdedge.com/jcomjournal/article/208651/hematology/aplastic-anemia-diagnosis-and-treatment/page/0/4?channel=325

Oct 7th, 2019 - Treatment of Acquired Aplastic Anemia Supportive Care While the workup and treatment plan are being established, attention should be directed at supportive care for prevention of complications. The most common complications leading to death in pat.

Combination Immunotherapy Leading to Severe Hepatotoxicity and Fatal Aplastic Anemia: Case Report and Review of the Literature
https://www.mdedge.com/fedprac/avaho/article/207600/mixed-topics/combination-immunotherapy-leading-severe-hepatotoxicity?channel=53
Dominick A, Fields-Meehan JE et. al.

Sep 5th, 2019 - Background: Dual immune checkpoint blockade (DICB) is utilized for a variety of malignancies. These therapies have a unique and often unpredictable side effect profile compared to conventional chemotherapy.

Aplastic Anemia: Current Treatment
https://www.mdedge.com/hematology-oncology/article/192810/anemia/aplastic-anemia-current-treatment/page/0/2

Jan 23rd, 2019 - Immunosuppressive Therapy For patients without an HLA-matched sibling donor or those who are older than 50 years of age, immunosuppressive therapy is the first-line therapy. ATG and cyclosporine A are the treatments of choice.

Aplastic Anemia: Evaluation and Diagnosis
https://www.mdedge.com/hematology-oncology/article/192807/anemia/aplastic-anemia-evaluation-and-diagnosis/page/0/2

Jan 18th, 2019 - In addition to peripheral blood findings, bone marrow biopsy is essential for the diagnosis, and should demonstrate a markedly hypocellular marrow (cellularity < 25%), occasionally with an increase in T lymphocytes. 7,39 Because marrow cellularity.

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Patient Education  19 results see all →