About 3,380 results

ALLMedicine™ Aplastic Anemia Center

Research & Reviews  1,031 results

Linalool reverses benzene-induced cytotoxicity, oxidative stress and lysosomal/mitochon...
Drug and Chemical Toxicology; Salimi A, Khodaparast F et. al.

Jul 27th, 2021 - Benzene exposure results in bone marrow suppression, leading to a decrease in the number of circulating white blood cells, an increased risk of chronic lymphocytic leukemia, acute myeloid leukemia and aplastic anemia. Since the mechanism of induct...

First-line haploidentical stem cell transplantation in children and adolescents with se...
Pediatric Transplantation; Gonzalez-Villarreal G, Pequeño-Luevano M et. al.

Jul 14th, 2021 - The only curative treatment for severe aplastic anemia in children is an allogeneic stem cell transplant; however, few patients have a matched related or unrelated donor. Haploidentical stem cell transplantation (haplo-SCT) using bone marrow (BM) ...

see more →

Guidelines  1 results

Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellula...
Haematologica Bennett JM, Orazi A

Jan 16th, 2009 - Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three wo...

see more →

Drugs  141 results see all →

Clinicaltrials.gov  110 results

Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

May 7th, 2020 - The purpose of this protocol is to collect blood (ages 8 and older), bone marrow (ages 18 and older), skin tissue samples (ages 18 and older), and/or buccal mucosa samples (ages 8 and older) from healthy volunteers. Samples will be used for clinic...

Improving Immunosuppressive Treatment for Patients With Severe Aplastic Anemia

Apr 30th, 2020 - Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder characterized by pancytopenia and a hypocellular bone marrow. Allogeneic bone marrow transplantation and immunosuppressive treatment with anti-thymocyte globulin (ATG)...

Collection of Biological Samples From Patients With Hepatitis-Associated Aplastic Anemia

Apr 29th, 2020 - Our laboratory has a long-standing interest in viruses that affect the bone marrow, especially those causing bone marrow failure. One specific syndrome, hepatitis-associated aplastic anemia, suggests that the same agent is responsible for the seve...

Eltrombopag for People With Fanconi Anemia

Apr 27th, 2020 - Fanconi anemia (FA) is a rare genetic disease that often presents as a bone marrow failure (BMF) syndrome but also can affect any other organ. Etiologically, loss of function mutations in more than 21 different gene members of the FA core complex ...

Combination Therapy of Severe Aplastic Anemia

Apr 24th, 2020 - Severe acquired aplastic anemia (SAA) has a poor prognosis if untreated. Bone marrow transplantation is available to only a minority of patients due to lack of a matched sibling donor, advanced age of the patient, or cost. Clinical studies at NIH ...

see more →

News  56 results

Chimerism and the use of fludarabine associated with secondary graft failure in aplastic anemia
Mark S. Lesney

Mar 6th, 2020 - Inferior overall survival was observed in patients with aplastic anemia who had mixed or complete recipient-type chimerism or complete donor chimerism after hematopoietic stem cell transplantation (HSCT), according to the results of a registry dat.

Aplastic Anemia: Diagnosis and Treatment

Oct 7th, 2019 - Treatment of Acquired Aplastic Anemia Supportive Care While the workup and treatment plan are being established, attention should be directed at supportive care for prevention of complications. The most common complications leading to death in pat.

Combination Immunotherapy Leading to Severe Hepatotoxicity and Fatal Aplastic Anemia: Case Report and Review of the Literature
Dominick A, Fields-Meehan JE et. al.

Sep 5th, 2019 - Background: Dual immune checkpoint blockade (DICB) is utilized for a variety of malignancies. These therapies have a unique and often unpredictable side effect profile compared to conventional chemotherapy.

Aplastic Anemia: Current Treatment

Jan 23rd, 2019 - Immunosuppressive Therapy For patients without an HLA-matched sibling donor or those who are older than 50 years of age, immunosuppressive therapy is the first-line therapy. ATG and cyclosporine A are the treatments of choice.

Aplastic Anemia: Evaluation and Diagnosis

Jan 18th, 2019 - In addition to peripheral blood findings, bone marrow biopsy is essential for the diagnosis, and should demonstrate a markedly hypocellular marrow (cellularity < 25%), occasionally with an increase in T lymphocytes. 7,39 Because marrow cellularity.

see more →

Patient Education  13 results see all →