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About 1,087 results

ALLMedicine™ Beta Thalassemia Center

Research & Reviews  521 results

Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studi...
https://doi.org/10.1016/j.bcmd.2021.102561
Blood Cells, Molecules & Diseases; Pace BS, Perrine S et. al.

Mar 21st, 2021 - Increased expression of developmentally silenced fetal globin (HBG) reduces the clinical severity of β-hemoglobinopathies. Benserazide has a relatively benign safety profile having been approved for 50 years in Europe and Canada for Parkinson's di...

The value of the red cell distribution width index versus other parameters in the diffe...
https://doi.org/10.1080/17474086.2021.1905514
Expert Review of Hematology; Al-Numan AH, Al-Obeidi RA

Mar 19th, 2021 - Iron deficiency anemia (IDA) in children may be confounded with the beta-thalassemia trait (BTT). This study aimed to reevaluate the role of the red blood cell distribution width index (RDWI) in distinguishing BTT from IDA. This cross-sectional st...

The potential hepatoprotective effect of metformin in hepatitis C virus-infected adoles...
https://doi.org/10.1111/ijcp.14104
International Journal of Clinical Practice; Abdel Monem MS, Farid SF et. al.

Feb 22nd, 2021 - Iron overload-induced oxidative stress and transfusion-acquired hepatitis C virus (HCV) infection are the main reasons of liver damage in beta thalassemia major (β-TM). Based on metformin's hepatic benefits in nondiabetic populations, the study ai...

Comparison of efficacy and safety of thalidomide vs hydroxyurea in patients with Hb E-β...
https://doi.org/10.1016/j.bcmd.2021.102544
Blood Cells, Molecules & Diseases; Jain M, Chakrabarti P et. al.

Feb 20th, 2021 - Hemoglobin (Hb)-F inducers are known to improve Hb level and transfusion dependence in thalassemia. This pilot study was conducted to assess the efficacy and safety of Hb-F inducer thalidomide compared to hydroxyurea (HU) in Hb E-β thalassemia pat...

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Guidelines  1 results

Cardiovascular Function and Treatment in Beta-Thalassemia Major
https://www.ahajournals.org/doi/abs/10.1161/CIR.0b013e31829b2be6?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
Pennell, D.,et al.

Jun 30th, 2013 - This aim of this statement is to report an expert consensus on the diagnosis and treatment of cardiac dysfunction in ?-thalassemia major (TM). This consensus statement does not cover other hemoglobinopathies, including thalassemia intermedia and s.

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Drugs  1 results see all →

Clinicaltrials.gov  543 results

Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studi...
https://doi.org/10.1016/j.bcmd.2021.102561
Blood Cells, Molecules & Diseases; Pace BS, Perrine S et. al.

Mar 21st, 2021 - Increased expression of developmentally silenced fetal globin (HBG) reduces the clinical severity of β-hemoglobinopathies. Benserazide has a relatively benign safety profile having been approved for 50 years in Europe and Canada for Parkinson's di...

The value of the red cell distribution width index versus other parameters in the diffe...
https://doi.org/10.1080/17474086.2021.1905514
Expert Review of Hematology; Al-Numan AH, Al-Obeidi RA

Mar 19th, 2021 - Iron deficiency anemia (IDA) in children may be confounded with the beta-thalassemia trait (BTT). This study aimed to reevaluate the role of the red blood cell distribution width index (RDWI) in distinguishing BTT from IDA. This cross-sectional st...

FDA Places Clinical Hold on Sickle Cell Gene Therapy
https://www.medscape.com/viewarticle/946434

Feb 23rd, 2021 - Updated February 25, 2021 // Editor’s note: The original text has been corrected to accurately reflect the status of the patients with AML and MDS. The FDA placed a clinical hold yesterday on two gene therapy trials for sickle cell disease (SCD) a...

The potential hepatoprotective effect of metformin in hepatitis C virus-infected adoles...
https://doi.org/10.1111/ijcp.14104
International Journal of Clinical Practice; Abdel Monem MS, Farid SF et. al.

Feb 22nd, 2021 - Iron overload-induced oxidative stress and transfusion-acquired hepatitis C virus (HCV) infection are the main reasons of liver damage in beta thalassemia major (β-TM). Based on metformin's hepatic benefits in nondiabetic populations, the study ai...

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News  19 results

FDA Places Clinical Hold on Sickle Cell Gene Therapy
https://www.medscape.com/viewarticle/946434

Feb 23rd, 2021 - Updated February 25, 2021 // Editor’s note: The original text has been corrected to accurately reflect the status of the patients with AML and MDS. The FDA placed a clinical hold yesterday on two gene therapy trials for sickle cell disease (SCD) a...

FDA approves anemia treatment for transfusion-dependent beta thalassemia patients
https://www.mdedge.com/familymedicine/article/211922/anemia/fda-approves-anemia-treatment-transfusion-dependent-beta?channel=39313
MDedge Hematology and Oncology; Mary Ellen Schneider

Nov 8th, 2019 - The Food and Drug Administration has approved the first treatment for anemia in adults with transfusion-dependent beta thalassemia. Olivier Le Moal/Getty Images Luspatercept-aamt (Reblozyl) is an erythroid maturation agent that reduced the transfu.

EU Panel Backs First Gene Therapy for Beta Thalassemia
https://www.medscape.com/viewarticle/911116

Mar 28th, 2019 - The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended approval of the first gene therapy for transfusion-dependent β-thalassemia (TDT), a rare inherited blood condition that causes chronic...

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Patient Education  2 results see all →