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ALLMedicine™ Bone Marrow Failure Center

Research & Reviews  2,317 results

Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype.
https://doi.org/10.1002/mgg3.1644
Molecular Genetics & Genomic Medicine; Amodeo ME, Inzaghi E et. al.

Mar 31st, 2021 - Dubowitz syndrome (DS) is a complex and rare condition characterized by postnatal growth retardation, microcephaly, short stature, mild developmental delay, facial dysmorphism, skin eruption and bone marrow failure. Though approximately 200 cases ...

Squamous cell carcinoma of the tongue in 5-year-old girl with dyskeratosis congenita.
https://doi.org/10.1016/j.ijom.2021.02.027
International Journal of Oral and Maxillofacial Surgery; Jh K, Cs K

Mar 19th, 2021 - Dyskeratosis congenita is a rare inherited bone marrow failure syndrome with three distinct clinical features: nail dystrophy, reticular skin pigmentation, and oral leukoplakia. The case of a 5-year-old female patient diagnosed with squamous cell ...

Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L...
https://doi.org/10.1038/s41375-021-01212-6 10.1182/blood-2016-03-643544 10.1038/s41467-017-01590-5 10.3324/haematol.2017.180778 10.1182/blood-2016-10-743302 10.1038/leu.2017.142 10.1182/blood-2017-09-806489 10.1038/ng.3569 10.1038/s41375-018-0074-4 10.1016/j.ccr.2013.08.011 10.1186/s13062-017-0185-2 10.1128/JVI.02262-14 10.1371/journal.ppat.1006884 10.1172/JCI91913 10.1186/1471-2164-8-92 10.1016/j.cell.2017.03.022 10.1093/nar/gky1131 10.1038/nature13619 10.1038/nature13035 10.1038/ncomms9548 10.1083/jcb.201009074 10.1128/MCB.00415-16 10.1586/ehm.11.2 10.1182/blood-2014-04-526301 10.1182/blood-2009-10-178129 10.1016/j.stem.2013.04.002 10.18632/oncotarget.8446 10.1038/leu.2013.33 10.1038/leu.2016.342 10.1053/j.seminhematol.2007.10.006 10.1038/nrc2047 10.3390/ijms16010966 10.1186/1756-8722-6-9 10.1002/hon.2175 10.1309/AJCP7W9VMJENZOVG 10.1182/blood-2011-01-330050 10.1016/j.exphem.2013.04.008 10.1016/j.stem.2018.01.011 10.1016/j.dnarep.2006.05.011 10.1182/blood-2017-01-764274 10.1182/blood-2017-09-765214 10.1016/j.stem.2010.05.016 10.1182/blood.V96.12.3932 10.1046/j.1365-2141.1998.01114.x 10.15252/embr.201847546 10.1038/s41375-018-0254-2
Leukemia Thomas ME, Abdelhamed S et. al.

Mar 18th, 2021 - Pediatric myelodysplastic syndromes (MDS) are a heterogeneous disease group associated with impaired hematopoiesis, bone marrow hypocellularity, and frequently have deletions involving chromosome 7 (monosomy 7). We and others recently identified h...

Continuous reference intervals for leukocyte telomere length in children: the method ma...
https://doi.org/10.1515/cclm-2021-0059
Clinical Chemistry and Laboratory Medicine; Lesmana A, Tian P et. al.

Mar 12th, 2021 - Children with very short telomeres commonly develop bone marrow failure and other severe diseases. Identifying the individuals with short telomeres can improve outcome of bone marrow transplantation, with accurate diagnosis requiring the use of ag...

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Guidelines  3 results

Acute Myeloid Leukemia - AML | ARUPConsult Lab Test Selection
https://arupconsult.com/content/acute-myeloid-leukemia

Jun 30th, 2019 - Acute myeloid leukemias (AMLs) are a heterogeneous group of disorders characterized by the clonal expansion of myeloid blasts (eg, undifferentiated myeloid precursors) in the peripheral blood, bone marrow, and/or other tissues, which results in im...

Late Effects Screening Guidelines after Hematopoietic Cell Transplantation for Inherite...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565711
Biology of Blood and Marrow Transplantation : Journal of ... Dietz AC, Savage SA et. al.

May 23rd, 2017 - Patients with inherited bone marrow failure syndromes (IBMFS), such as Fanconi anemia (FA), dyskeratosis congenita (DC), or Diamond Blackfan anemia (DBA), can have hematologic manifestations cured through hematopoietic cell transplantation (HCT). ...

Recommendations on hematopoietic stem cell transplantation for inherited bone marrow fa...
https://doi.org/10.1038/bmt.2015.117
Bone Marrow Transplantation; Peffault de Latour R, Peters C et. al.

Jun 8th, 2015 - Allogeneic hematopoietic stem cell transplantation (HSCT) offers the potential to cure patients with an inherited bone marrow failure syndrome (IBMFS). However, the procedure involves the risk of treatment-related mortality and may be associated w...

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Drugs  1 results see all →

Clinicaltrials.gov  2,343 results

Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype.
https://doi.org/10.1002/mgg3.1644
Molecular Genetics & Genomic Medicine; Amodeo ME, Inzaghi E et. al.

Mar 31st, 2021 - Dubowitz syndrome (DS) is a complex and rare condition characterized by postnatal growth retardation, microcephaly, short stature, mild developmental delay, facial dysmorphism, skin eruption and bone marrow failure. Though approximately 200 cases ...

Squamous cell carcinoma of the tongue in 5-year-old girl with dyskeratosis congenita.
https://doi.org/10.1016/j.ijom.2021.02.027
International Journal of Oral and Maxillofacial Surgery; Jh K, Cs K

Mar 19th, 2021 - Dyskeratosis congenita is a rare inherited bone marrow failure syndrome with three distinct clinical features: nail dystrophy, reticular skin pigmentation, and oral leukoplakia. The case of a 5-year-old female patient diagnosed with squamous cell ...

Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L...
https://doi.org/10.1038/s41375-021-01212-6 10.1182/blood-2016-03-643544 10.1038/s41467-017-01590-5 10.3324/haematol.2017.180778 10.1182/blood-2016-10-743302 10.1038/leu.2017.142 10.1182/blood-2017-09-806489 10.1038/ng.3569 10.1038/s41375-018-0074-4 10.1016/j.ccr.2013.08.011 10.1186/s13062-017-0185-2 10.1128/JVI.02262-14 10.1371/journal.ppat.1006884 10.1172/JCI91913 10.1186/1471-2164-8-92 10.1016/j.cell.2017.03.022 10.1093/nar/gky1131 10.1038/nature13619 10.1038/nature13035 10.1038/ncomms9548 10.1083/jcb.201009074 10.1128/MCB.00415-16 10.1586/ehm.11.2 10.1182/blood-2014-04-526301 10.1182/blood-2009-10-178129 10.1016/j.stem.2013.04.002 10.18632/oncotarget.8446 10.1038/leu.2013.33 10.1038/leu.2016.342 10.1053/j.seminhematol.2007.10.006 10.1038/nrc2047 10.3390/ijms16010966 10.1186/1756-8722-6-9 10.1002/hon.2175 10.1309/AJCP7W9VMJENZOVG 10.1182/blood-2011-01-330050 10.1016/j.exphem.2013.04.008 10.1016/j.stem.2018.01.011 10.1016/j.dnarep.2006.05.011 10.1182/blood-2017-01-764274 10.1182/blood-2017-09-765214 10.1016/j.stem.2010.05.016 10.1182/blood.V96.12.3932 10.1046/j.1365-2141.1998.01114.x 10.15252/embr.201847546 10.1038/s41375-018-0254-2
Leukemia Thomas ME, Abdelhamed S et. al.

Mar 18th, 2021 - Pediatric myelodysplastic syndromes (MDS) are a heterogeneous disease group associated with impaired hematopoiesis, bone marrow hypocellularity, and frequently have deletions involving chromosome 7 (monosomy 7). We and others recently identified h...

Continuous reference intervals for leukocyte telomere length in children: the method ma...
https://doi.org/10.1515/cclm-2021-0059
Clinical Chemistry and Laboratory Medicine; Lesmana A, Tian P et. al.

Mar 12th, 2021 - Children with very short telomeres commonly develop bone marrow failure and other severe diseases. Identifying the individuals with short telomeres can improve outcome of bone marrow transplantation, with accurate diagnosis requiring the use of ag...

see more →

News  27 results

The evolving landscape of complement inhibition therapy
https://www.mdedge.com/fedprac/article/215831/anemia/evolving-landscape-complement-inhibition-therapy?channel=41022
I. Romina Sosa, MD, PhD

Jan 21st, 2020 - The introduction of eculizumab, a monoclonal antibody targeting C5 of the complement cascade, revolutionized the treatment of paroxysmal nocturnal hemoglobinuria (PNH), a rare hematologic disorder characterized by complement-mediated intravascular.

Acute Myeloid Leukemia - AML | ARUPConsult Lab Test Selection
https://arupconsult.com/content/acute-myeloid-leukemia

Jun 30th, 2019 - Acute myeloid leukemias (AMLs) are a heterogeneous group of disorders characterized by the clonal expansion of myeloid blasts (eg, undifferentiated myeloid precursors) in the peripheral blood, bone marrow, and/or other tissues, which results in im...

HSCT approach provides ‘excellent’ survival in FA
https://www.mdedge.com/hematology-oncology/article/185101/anemia/hsct-approach-provides-excellent-survival-fa
Jen Smith

Mar 2nd, 2018 - Parinda A. Mehta, MD SALT LAKE CITY—A “risk-adjusted” approach leads to “excellent” survival in patients with Fanconi anemia (FA) undergoing alternative donor hematopoietic stem cell transplant (HSCT), according to a speaker at the 2018 BMT Tandem.

PBSCs used to treat BMF despite drawbacks
https://www.mdedge.com/hematology-oncology/article/188548/transplantation/pbscs-used-treat-bmf-despite-drawbacks
HT Staff

Jan 13th, 2016 - PBSC collection Photo from the Canterbury District Health Board Although studies have suggested that peripheral blood stem cells (PBSCs) are not the ideal graft source for patients with bone marrow failure (BMF), new research suggests transplant c.

iPSCs reveal new insight into Fanconi anemia
https://www.mdedge.com/hematology-oncology/article/188080/anemia/ipscs-reveal-new-insight-fanconi-anemia
HT Staff

Mar 13th, 2015 - Colony of iPSCs Image by James Thompson Induced pluripotent stem cells (iPSCs) may help elucidate the pathogenesis of bone marrow failure (BMF) in Fanconi anemia (FA), researchers say. They generated iPSCs from FA patients and found evidence sugge.

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Patient Education  1 results see all →