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About 394 results

ALLMedicine™ Macrocytosis Center

Research & Reviews  195 results

Reticulocyte Hemoglobin Equivalent in Patients with Idiopathic Warm Autoimmune Hemolyti...
https://www.ncbi.nlm.nih.gov/pubmed/33941561
Annals of Clinical and Laboratory Science; Higuchi T, Hoshi T et. al.

May 4th, 2021 - Patients with warm autoimmune hemolytic anemia (WAIHA) present with anemia that is highly heterogeneous, and often have macrocytic anemia with inappropriately elevated mean corpuscular volume (MCV). The goal of this retrospectivecase study is to e...

MYH9-Related Disease - GeneReviews® - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/n/gene/myh9/

Feb 17th, 2021 - MYH9-related disease (MYH9-RD) is characterized in all affected individuals by hematologic features present from birth consisting of platelet macrocytosis (i.e., >40% of platelets larger than 3.9 μm in diameter), thrombocytopenia (platelet count ...

Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in ac...
https://doi.org/10.1038/s41375-020-01075-3
Leukemia Sportoletti P, Sorcini D et. al.

Nov 7th, 2020 - Recurrent loss-of-function mutations of BCL6 co-repressor (BCOR) gene are found in about 4% of AML patients with normal karyotype and are associated with DNMT3a mutations and poor prognosis. Therefore, new anti-leukemia treatments and mouse models...

ETV6-related thrombocytopenia and platelet dysfunction.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666051
Platelets Di Paola J, Fisher MH

May 14th, 2020 - We and others recently described families with germline heterozygote mutations in ETV6 leading to autosomal dominant highly penetrant thrombocytopenia, red cell macrocytosis and predisposition to leukemia.The bone marrow of affected individuals sh...

Bone Marrow Failure Workup
https://emedicine.medscape.com/article/199003-workup

Dec 10th, 2019 - Approach Considerations Laboratory features of bone marrow failure include a single cytopenia, as in pure red cell aplasia, and amegakaryocytic thrombocytopenic purpura or pancytopenia, as in aplastic anemia. Peripheral blood findings Anemia is co...

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Clinicaltrials.gov  195 results

Reticulocyte Hemoglobin Equivalent in Patients with Idiopathic Warm Autoimmune Hemolyti...
https://www.ncbi.nlm.nih.gov/pubmed/33941561
Annals of Clinical and Laboratory Science; Higuchi T, Hoshi T et. al.

May 4th, 2021 - Patients with warm autoimmune hemolytic anemia (WAIHA) present with anemia that is highly heterogeneous, and often have macrocytic anemia with inappropriately elevated mean corpuscular volume (MCV). The goal of this retrospectivecase study is to e...

MYH9-Related Disease - GeneReviews® - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/n/gene/myh9/

Feb 17th, 2021 - MYH9-related disease (MYH9-RD) is characterized in all affected individuals by hematologic features present from birth consisting of platelet macrocytosis (i.e., >40% of platelets larger than 3.9 μm in diameter), thrombocytopenia (platelet count ...

Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in ac...
https://doi.org/10.1038/s41375-020-01075-3
Leukemia Sportoletti P, Sorcini D et. al.

Nov 7th, 2020 - Recurrent loss-of-function mutations of BCL6 co-repressor (BCOR) gene are found in about 4% of AML patients with normal karyotype and are associated with DNMT3a mutations and poor prognosis. Therefore, new anti-leukemia treatments and mouse models...

ETV6-related thrombocytopenia and platelet dysfunction.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666051
Platelets Di Paola J, Fisher MH

May 14th, 2020 - We and others recently described families with germline heterozygote mutations in ETV6 leading to autosomal dominant highly penetrant thrombocytopenia, red cell macrocytosis and predisposition to leukemia.The bone marrow of affected individuals sh...

Bone Marrow Failure Workup
https://emedicine.medscape.com/article/199003-workup

Dec 10th, 2019 - Approach Considerations Laboratory features of bone marrow failure include a single cytopenia, as in pure red cell aplasia, and amegakaryocytic thrombocytopenic purpura or pancytopenia, as in aplastic anemia. Peripheral blood findings Anemia is co...

see more →

News  4 results

What is causing my patients’ macrocytosis?
https://www.mdedge.com/familymedicine/article/167350/hematology/what-causing-my-patients-macrocytosis/page/0/1
Internal Medicine News;

Jun 5th, 2018 - For this patient, the correct answer would be an abnormal GGT, because chronic moderate to heavy alcohol use can raise GGT levels, as well as MCVs. Dr.

Germline mutations linked to ALL
https://www.mdedge.com/hematology-oncology/article/188040/anemia/germline-mutations-linked-all
HT Staff

Mar 26th, 2015 - Researchers in the lab Photo by Rhoda Baer New research suggests that heritable mutations in the gene ETV6 can predispose people to acute lymphoblastic leukemia (ALL). Somatic mutations in ETV6 have previously been implicated in the development of.

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