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About 3,358 results

ALLMedicine™ Aplastic Anemia Center

Research & Reviews  1,054 results

Interferon Gamma and perforin positive T cells in acquired aplastic anemia: implication...
https://doi.org/10.1093/cei/uxab006
Clinical and Experimental Immunology; Sharma V, Kumar P et. al.

Jan 13th, 2022 - Acquired aplastic anemia (aAA) is an autoimmune disease, characterized by infiltration of T lymphocytes in the bone marrow with destruction of hematopoietic stem cells by the effector cells. Interferon gamma (IFN-γ) and perforin are important medi...

Combination of Eltrombopag With Immunosuppressive Therapy in East-Asian Patients With Severe Aplastic Anemia
https://clinicaltrials.gov/ct2/show/NCT04328727

Jan 11th, 2022 - This study is designed to evaluate the efficacy and safety of eltrombopag when added to r-ATG and CsA in treatment naive East-Asian adult and pediatric patients with SAA.

A New Standard Immunosuppression Regimen in Severe Aplastic Anemia.
https://doi.org/10.1056/NEJMe2118143
The New England Journal of Medicine; Scheinberg P

Jan 6th, 2022 - A New Standard Immunosuppression Regimen in Severe Aplastic Anemia.|2022|Scheinberg P,|

Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia.
https://doi.org/10.1056/NEJMoa2109965
The New England Journal of Medicine; Peffault de Latour R, Kulasekararaj A et. al.

Jan 6th, 2022 - A single-group, phase 1-2 study indicated that eltrombopag improved the efficacy of standard immunosuppressive therapy that entailed horse antithymocyte globulin (ATG) plus cyclosporine in patients with severe aplastic anemia. In this prospective,...

LincRNA-p21 promotes p21-mediated cell cycle arrest in benzene-induced hematotoxicity b...
https://doi.org/10.1016/j.envpol.2021.118706
Environmental Pollution (Barking, Essex : 1987); Wang B, Xu S et. al.

Jan 1st, 2022 - Benzene is widely employed in manufacturing and causes hematotoxic effects and leukemia in humans. A long intergenic noncoding RNA (lincRNA)-microRNA (miRNA)-mRNA coexpression and competing endogenous RNA (ceRNA) regulatory network was constructed...

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Guidelines  1 results

Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellula...
https://doi.org/10.3324/haematol.13755
Haematologica Bennett JM, Orazi A

Jan 16th, 2009 - Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three wo...

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Drugs  139 results see all →

Clinicaltrials.gov  66 results

Combination of Eltrombopag With Immunosuppressive Therapy in East-Asian Patients With Severe Aplastic Anemia
https://clinicaltrials.gov/ct2/show/NCT04328727

Jan 11th, 2022 - This study is designed to evaluate the efficacy and safety of eltrombopag when added to r-ATG and CsA in treatment naive East-Asian adult and pediatric patients with SAA.

Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite ...
https://clinicaltrials.gov/ct2/show/NCT03173937

Dec 27th, 2021 - Severe aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are life-threatening bone marrow disorders. For SAA patients, long term survival can be achieved with immunosuppressive treatment. However, of those patients treated with immunosuppre...

Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers
https://clinicaltrials.gov/ct2/show/NCT00442195

Dec 17th, 2021 - The purpose of this protocol is to collect blood (ages 8 and older), bone marrow (ages 18 and older), skin tissue samples (ages 18 and older), and/or buccal mucosa samples (ages 8 and older) from healthy volunteers. Samples will be used for clinic...

Eltrombopag Combined With Cyclosporine as First Line Therapy in Patients With Severe Acquired Aplastic Anemia
https://clinicaltrials.gov/ct2/show/NCT02998645

Dec 7th, 2021 - This interventional Phase II, single-arm, multicenter, open-label study will investigate the efficacy and safety of a combination regimen of 6 months eltrombopag and cyclosporine treatment in adult patients with severe aplastic anemia (SAA) as fir...

The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic Anemia
https://clinicaltrials.gov/ct2/show/NCT02745717

Oct 12th, 2021 - Eligible patients should be under 60 years old with confirmed SAA, without HLA matched siblings and previous ATG treatment history. Patients will be excluded if they present any fatal disease, including respiratory failure, heart failure, liver or...

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News  74 results

Complete Response Rate Doubles When Aplastic Anemia Patients Receive Eltrombopag
https://www.medscape.com/viewarticle/966117

Jan 6th, 2022 - (Reuters Health) - Adding the Novartis drug eltrombopag to standard immunosuppressive therapy with horse antithymocyte globulin (ATG) more than doubles the three-month complete response rate for people receiving first-time treatment for severe apl...

Finally, a 'New Standard' for Severe Aplastic Anemia
https://www.medpagetoday.com/hematologyoncology/anemia/96519

Jan 5th, 2022 - For first-line treatment of severe aplastic anemia, adding eltrombopag (Promacta) to standard immunosuppressive therapy improved the rate, speed, and depth of hematologic response in the phase III RACE trial. The oral thrombopoietin-receptor agoni...

Report Says Drugmakers Impose Unjustified US Price Increases; Spending on AbbVie Drug Rises $1.4 Billion
https://www.medscape.com/viewarticle/963028

Nov 17th, 2021 - WASHINGTON (Reuters) - Drugmakers hiked U.S. prices on seven of the 10 costliest prescription drugs in 2020 without justification, increasing drug spending by $1.67 billion, a U.S. group that reviews the value of medicines said on Tuesday. AbbVie ...

Infectious disease pop quiz: Clinical challenges for the ObGyn
https://www.mdedge.com/obgyn/article/248281/mixed-topics/infectious-disease-pop-quiz-clinical-challenges-obgyn
Emily Susan Edwards, MD, MS, Patrick Duff, MD

Nov 4th, 2021 - In this question-and-answer article (the first in a series), our objective is to reinforce for the clinician several practical points of management for common infectious diseases. The principal references for the answers to the questions are 2 tex.

Preventive and Early Intervention Strategies Among Next Steps in cGVHD Management
https://www.onclive.com/view/preventive-and-early-intervention-strategies-among-next-steps-in-cgvhd-management

Oct 28th, 2021 - As the armamentarium continues expanding for the treatment of patients with chronic graft-vs-host disease (cGVHD), research is ongoing to determine whether earlier integration of novel therapies, such as ruxolitinib (Jakafi), could yield better re...

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Patient Education  9 results see all →