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About 4,648 results

ALLMedicine™ Aplastic Anemia Center

Research & Reviews  1,367 results

Case Report: A Child With Hemophilia A Serves as Donor for Hematopoietic Stem Cell Tran...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9214756
Pathology Oncology Research : POR; Kertész G, Kállay K et. al.

Jun 28th, 2022 - The first-line treatment of severe aplastic anemia is allogeneic hematopoietic stem cell transplantation with a matched sibling donor. However, co-morbidities of the identical donor can make donation difficult. We present a transplantation where i...

Frequency and utility of bone marrow examination in relapsed/ refractory immune thrombo...
https://doi.org/10.1111/jth.15802
Journal of Thrombosis and Haemostasis : JTH; Taparia K, Wall E et. al.

Jun 26th, 2022 - The diagnosis of immune thrombocytopenia (ITP) is one of exclusion. While guidelines recommend against routine bone marrow examination (BME) at time of ITP diagnosis, the role of BME in relapsed/refractory ITP is unclear. To examine the frequency ...

Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused W...
https://clinicaltrials.gov/ct2/show/NCT01174108

Jun 24th, 2022 - Allogeneic hematopoietic stem cell transplantation (aHSCT) can cure patients with a variety of bone marrow failure syndromes (BMFS) including severe aplastic anemia (SAA), paroxysmal nocturnal hemoglobinuria (PNH) or myelodysplastic syndrome (MDS)...

Retrospective Study of Patients With Severe Aplastic Anemia Who Developed High Risk Clonal Evolution With Chromosome 7 Abnormalities After Immunosuppressive Therapy
https://clinicaltrials.gov/ct2/show/NCT04436367

Jun 24th, 2022 - Severe aplastic anemia (SAA) is a form of bone marrow failure in most cases is the result of a cytotoxic T cell attack on the marrow stem cell. It is effectively treated in most patients with either immunosuppressive treatment (IST) or allogeneic ...

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Guidelines  1 results

Diagnostic criteria to distinguish hypocellular acute myeloid leukemia from hypocellula...
https://doi.org/10.3324/haematol.13755
Haematologica Bennett JM, Orazi A

Jan 16th, 2009 - Members of the French-American-British Cooperative Leukemia Working Group met to review cases of aplastic anemia, hypocellular myelodysplastic syndrome and hypocellular acute myeloid leukemia. Criteria were proposed and modified following three wo...

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Drugs  149 results see all →

Clinicaltrials.gov  222 results

Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite ...
https://clinicaltrials.gov/ct2/show/NCT03173937

Jun 24th, 2022 - Severe aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are life-threatening bone marrow disorders. For SAA patients, long term survival can be achieved with immunosuppressive treatment. However, of those patients treated with immunosuppre...

Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)
https://clinicaltrials.gov/ct2/show/NCT04304820

Jun 24th, 2022 - Severe aplastic anemia (SAA) is a life-threatening bone marrow failure characterized by pancytopenia and a hypocellular marrow. Allogeneic bone marrow transplantation is curative in younger patients, but older age and/or lack of a suitable donor h...

Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers
https://clinicaltrials.gov/ct2/show/NCT00442195

Jun 24th, 2022 - The purpose of this protocol is to collect and analyze blood (ages 8 and older), bone marrow (ages 18 and older), skin tissue samples (ages 18 and older), and/or buccal mucosa samples (ages 8 and older) from healthy volunteers. Samples will be use...

Eltrombopag for People With Fanconi Anemia
https://clinicaltrials.gov/ct2/show/NCT03206086

Jun 24th, 2022 - Fanconi anemia (FA) is a rare genetic disease that often presents as a bone marrow failure (BMF) syndrome but also can affect any other organ. Etiologically, loss of function mutations in more than 21 different gene members of the FA core complex ...

Low-Dose Danazol for the Treatment of Telomere Related Diseases
https://clinicaltrials.gov/ct2/show/NCT03312400

Jun 24th, 2022 - Telomere disease is caused by accelerated telomere attrition and results in multi-organ dysfunction. Telomeres are nucleotide repeats of non-coding DNA at the end of the chromosomes which function as protective caps to prevent erosion of genomic D...

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News  112 results

Topical Ruxolitinib Shown to be Effective and Tolerable in Cutaneous cGVHD
https://www.onclive.com/view/topical-ruxolitinib-shown-to-be-effective-and-tolerable-in-cutaneous-cgvhd

Apr 25th, 2022 - Topical ruxolitinib (Opzelura) has shown improved reduction of body surface area of cutaneous chronic graft-vs-host disease (cGVHD) vs standard moisturizer vehicle cream, according to interim study results from a poster presented at the 2022 Trans...

Complete Response Rate Doubles When Aplastic Anemia Patients Receive Eltrombopag
https://www.medscape.com/viewarticle/966117

Jan 6th, 2022 - (Reuters Health) - Adding the Novartis drug eltrombopag to standard immunosuppressive therapy with horse antithymocyte globulin (ATG) more than doubles the three-month complete response rate for people receiving first-time treatment for severe apl...

Report Says Drugmakers Impose Unjustified US Price Increases; Spending on AbbVie Drug Rises $1.4 Billion
https://www.medscape.com/viewarticle/963028

Nov 17th, 2021 - WASHINGTON (Reuters) - Drugmakers hiked U.S. prices on seven of the 10 costliest prescription drugs in 2020 without justification, increasing drug spending by $1.67 billion, a U.S. group that reviews the value of medicines said on Tuesday. AbbVie ...

Infectious disease pop quiz: Clinical challenges for the ObGyn
https://www.mdedge.com/obgyn/article/248281/mixed-topics/infectious-disease-pop-quiz-clinical-challenges-obgyn
Emily Susan Edwards, MD, MS, Patrick Duff, MD

Nov 4th, 2021 - In this question-and-answer article (the first in a series), our objective is to reinforce for the clinician several practical points of management for common infectious diseases. The principal references for the answers to the questions are 2 tex.

Spreading Newfound Treatment Strategies in Hematologic Malignancies in Seattle
https://www.onclive.com/view/spreading-newfound-treatment-strategies-in-hematologic-malignancies-in-seattle

Oct 6th, 2021 - We recently traveled to Seattle, California for an OncLive® State of the Science Summit™ on Hematologic Malignancies. At the meeting, faculty from Seattle Cancer Care Alliance provided insight on current and evolving standards of care in leukemia,...

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Patient Education  8 results see all →