ALLMedicine™ Megaloblastic Anemia Center

May 16th, 2022 - Practice Essentials The term “pernicious anemia” is an anachronism—it dates from the era when treatment had not yet been discovered, and the disease was fatal—but it remains in use to refer to an autoimmune disorder that affects the gastric mucosa...

May 16th, 2022 - Practice Essentials The term “pernicious anemia” is an anachronism—it dates from the era when treatment had not yet been discovered, and the disease was fatal—but it remains in use to refer to an autoimmune disorder that affects the gastric mucosa...

May 16th, 2022 - Diagnostic Considerations By definition, pernicious anemia refers specifically to vitamin B12 deficiency resulting from a lack of production of intrinsic factor (IF) in the stomach. However, vitamin B12 absorption is a complex process, and other c...

May 14th, 2022 - During its 4th transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters for drug development. Previously highlighted and new transporters were considered based on up...

Apr 30th, 2022 - Transcobalamin deficiency is a rare inborn metabolic disorder, characterized by pancytopenia, megaloblastic anemia, failure to thrive, diarrhea, and psychomotor retardation. We describe a patient who first presented at 3 months of age, with pancyt...

Dec 6th, 2021 - In Ante- and post-natal care, low adherence to recommended health and nutrition strategies during the critical 1,000 day-window of opportunity is multifactorial, but low-quality communication is key limitation. Innovative strategies to improve int...

Mar 9th, 2020 - Oral B12: A Cheap, Effective Choice The Schilling test measures cobalamin absorption by assessing increased urine radioactivity after an oral dose of radioactive cobalamin. It is not readily available in most countries , however, so a measure of s...

Mar 2nd, 2020 - The US Food and Drug Administration (FDA) has approved the first generic version of the antiparasitic drug Daraprim (pyrimethamine) for the treatment of toxoplasmosis when used with a sulfonamide. The generic version of Daraprim tablets is made by...

Sep 9th, 2019 - A 55-year-old woman with type 2 diabetes and recently diagnosed ulcerative colitis is admitted to hospital with confusion and anxiety. She appears pale, and feels feverish. She notes that she is having heart palpitations and is short of breath. Vi...

May 31st, 2015 - In reaction to a paper promoting the common practice of using of nitrous oxide in the operating room, Professor Rolf Rossaint, of the University Hospital Aachen in Germany, and Professor Daniel Sessler, MD, of the Cleveland Clinic, will debate the...

Nov 21st, 2013 - Question Should supplemental folic acid be given with all antiepileptic drugs (AEDs)? Response from Darrell Hulisz, PharmD Associate Professor, Case Western Reserve University School of Medicine; Clinical Specialist in Family Medicine, University ...