About 773 results

ALLMedicine™ Methemoglobinemia Center

Research & Reviews  224 results

Acquired methemoglobinemia: A systematic review of reported cases.
Transfusion and Apheresis Science : Official Journal of T... Gao H, Basri R et. al.

Nov 7th, 2021 - Acquired methemoglobinemia may cause cyanosis and tissue ischemia unresponsive to oxygen supplementation. We performed a literature search to identify cases of acquired methemoglobinemia published between 1980 and 2020. Clinical, diagnostic, and t...

Methemoglobinemia Workup

Nov 5th, 2021 - Laboratory Studies Investigations to rule out hemolysis (complete blood count [CBC], reticulocyte count, peripheral smear review, lactate dehydrogenase [LDH], bilirubin, haptoglobin and Heinz body preparation) and end-organ dysfunction or failure ...


Nov 5th, 2021 - Practice Essentials Methemoglobinemia occurs when red blood cells (RBCs) contain methemoglobin at levels higher than 1%. Methemoglobin results from the presence of iron in the oxidized ferric form (Fe3+) instead of the usual reduced ferrous form (...


Nov 5th, 2021 - Practice Essentials Methemoglobinemia occurs when red blood cells (RBCs) contain methemoglobin at levels higher than 1%. Methemoglobin results from the presence of iron in the oxidized ferric form (Fe3+) instead of the usual reduced ferrous form (...

Methemoglobinemia Treatment & Management

Nov 5th, 2021 - Approach Considerations Prompt recognition of the condition and initiation of treatment, as indicated (especially in acquired methemoglobinemia), are critical in the management of methemoglobinemia. However, at the same time, it may be imperative ...

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Guidelines  2 results

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase t...
Clinical Pharmacology and Therapeutics; Relling MV, McDonagh EM et. al.

May 3rd, 2014 - Glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with development of acute hemolytic anemia (AHA) induced by a number of drugs. We provide guidance as to which G6PD genotypes are associated with G6PD deficiency in males and female...

ASRA practice advisory on local anesthetic systemic toxicity.
Regional Anesthesia and Pain Medicine; Neal JM, Bernards CM et. al.

Mar 11th, 2010 - The American Society of Regional Anesthesia and Pain Medicine Practice Advisory on Local Anesthetic Systemic Toxicity assimilates and summarizes current knowledge regarding the prevention, diagnosis, and treatment of this potentially fatal complic...

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Drugs  60 results see all →

Clinicaltrials.gov  5 results

MEthylene Blue In Patients With Acquired Methemoglobinemia

Mar 10th, 2021 - This is an open label, uncontrolled, Phase 4 study including 10 patients who present in hospital/urgent care setting with acquired methemoglobinemia. The population may include pediatric and adult patients (males and females of all ages are includ...

Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery

Oct 27th, 2020 - Postoperative neurocognitive impairments often occur in elderly patients undergoing major surgery, including postoperative delirium(POD) characterized by an acute change in cognition with altered consciousness and impaired attention, and postopera...

Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders

Oct 22nd, 2018 - Leg ulcerations have long been identified as a serious and debilitating complication of SCD and even the first SCD patient described in North America in 1910 had leg ulcerations. The prevalence varies, being low before 10 years of age, and in geno...

Pharmacokinetics, Pharmacodynamics, and Impact of Inorganic Nitrate on Exercise in HFpEF

Oct 3rd, 2017 - This study randomized subjects to either placebo (n=3) or KNO3 (n=9) given a sequential dosing regimen: 6 mmol twice daily for 1 week followed by dose escalation to 6 mmol thrice daily for 1 week). Although a primary goal of the study was to asses...

Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics

Apr 25th, 2014 - Methemoglobin is an abnormal hemoglobin that is formed by the oxidation of one or more of the four heme groups of hemoglobin by oxygen and other exogenous oxidizing agents. The injectable local anesthetic prilocaine that is routinely used in the m...

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News  18 results

FDA Drug Safety Communication: FDA recommends not using lidocaine to treat teething pain and requires new Boxed Warning

The U.S. Food and Drug Administration (FDA) warns that prescription oral viscous lidocaine 2 percent solution should not be used to treat infants and children with teething pain.  We are requiring a new Boxed Warning, FDA’s strongest warning, to b...

FDA Warns on OTC Teething Products with Benzocaine

May 23rd, 2018 - WASHINGTON -- Benzocaine-containing products sold over the counter to relieve babies' teething pain are too risky and should no longer be sold, the FDA said Wednesday. The agency "is asking companies to stop selling these products for such use," a...

Stop Using OTC Benzocaine Teething Products, FDA Says

May 23rd, 2018 - The US Food and Drug Administration (FDA) is warning consumers to immediately stop using benzocaine-containing over-the-counter drug products, including those used to treat teething pain, in infants and children under 2 years of age as they can po...

Methemoglobinemia in an HIV patient
Riva Raiker, MD, William C. Lippert, MD, MPH et. al.

Mar 1st, 2018 - A 45-year-old man with known human immunodeficiency virus infection presented with a 5-day history of dyspnea. When his dyspnea had become symptomatic, he had restarted his home dapsone prophylaxis, but his dyspnea had progressively worsened, and.

Recent Controversies in Pediatric Dermatology: The Usage of General Anesthesia in Young Children
Nanette B. Silverberg, MD, Riva R. Ko, MD

Aug 2nd, 2017 - Clinicians who have attempted to perform an in-office procedure on infants or young children will recognize the difficulties that arise from the developmental inability to cooperate with procedures. 1 Potential problems mentioned in the literature.

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