ALLMedicine™ Sickle Cell Anemia Center

Dec 2nd, 2021 - HBB gene mutations lead to many kinds of diseases, of which, except for the two most common diseases of thalassemia and sickle cell anemia, rare kinds of hemolytic anemia, such as hemoglobin Bristol-Alesha, are rarely reported, no ideal treatment ...

Nov 24th, 2021 - Sickle cell disease (SCD) is due to homozygosity for a Glu6Val mutation in HBB (sickle cell anemia; hemoglobin SS) or to compound heterozygous forms like hemoglobin SC disease and hemoglobin S-β thalassemia. Past studies suggested a low prevalence...

Nov 10th, 2021 - Fat embolism syndrome (FES) is a rare condition that can occur as a complication of sickle cell disease. We describe a case of a patient with sickle cell disease (homozygous Hb S or HBB: c.20A>T) presenting with initial signs and symptoms consiste...

Nov 3rd, 2021 - Artifactual hypoglycemia in a patient with sickle cell anemia.|2021|Wang LR,Morein J,McCudden C,Sorisky A,|

Oct 23rd, 2021 - Identification of biomarkers associated with severity in sickle cell anemia is desirable. Circulating serum microRNAs (miRNA) are targets studied as diagnostic or prognostic markers, but few studies have been conducted in sickle cell anemia. The p...

Nov 24th, 2021 - Sickle cell disease (SCD) is due to homozygosity for a Glu6Val mutation in HBB (sickle cell anemia; hemoglobin SS) or to compound heterozygous forms like hemoglobin SC disease and hemoglobin S-β thalassemia. Past studies suggested a low prevalence...

Sep 30th, 2021 - The design of this proposed study is a randomized controlled trial of hospitalized adult general medicine patients with anemia at the University of Chicago (UC). Patients will be randomized to receive transfusion at either a hemoglobin (Hb)<9g/dL ...

Sep 5th, 2021 - Annually, an estimated 200,000 babies are born with Sickle Cell Anemia (SCA) worldwide. Affected children often suffer repeated acute illnesses and chronic ill health from vascular occlusive phenomenon. In particular, they are at a high risk of st...

Jul 8th, 2021 - The Investigator's global hypothesis, to be tested eventually in an NIH-funded phase III controlled trial, is that hydroxyurea at a fixed moderate dose of 20 mg/kg is safe and effective for primary and secondary stroke prevention in young adults w...

Apr 12th, 2021 - 200 pediatric and 200 adult SCA participants will undergo mGFR using iohexol at baseline and at one year. On the same day, participants will undergo clinical and laboratory variables important for developing an eGFR equation. From baseline data, t...

Sep 20th, 2021 - German recipients of the AstraZeneca COVID-19 vaccine showed that severe headache can precede cerebral venous sinus thrombosis by a few days in vaccine-induced immune thrombotic thrombocytopenia (VITT), according to a brief report in the New Engla...

Jul 21st, 2021 - Sickle cell disease (SCD) was associated with a significantly increased risk of COVID-19-related hospitalization and death in adults, U.K. researchers found. Their cohort study showed that having SCD quadrupled a person's risk for COVID-19-related...

Apr 2nd, 2021 - Morey Blinder, MD, professor of medicine at Washington University in St. Louis, is an adult hematologist whose practice is focused on patients with nonmalignant hematologic disorders. A large percentage of these patients have sickle cell anemia an...

Apr 2nd, 2021 - Transfusions play a large role in the management of sickle cell anemia; however, they are not considered standard of care for the management of anemia alone, states Thomas D. Coates, MD. Although transfusions can reduce pain associated with the an...

Apr 2nd, 2021 - Misunderstandings exist with regard to the risk/benefit profile of hydroxyurea, which have led to its underuse, according to Thomas D. Coates, MD. The drug has been shown to reduce the frequency of crisis and the duration of hospitalization by abo...