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About 2,360 results

ALLMedicine™ Sickle Cell Anemia Center

Research & Reviews  791 results

First report of successful treatment for hemoglobin Bristol-Alesha by hemopoietic stem ...
https://doi.org/10.1007/s00277-021-04721-7 10.1016/j.medcli.2018.05.013 10.1007/978-1-4939-7299-9_4 10.1097/01.mph.0000175409.21342.ea 10.1080/03630260701459408 10.1016/j.mcna.2016.09.008 10.1182/blood.V88.1.341.341 10.1101/cshperspect.a011858
Annals of Hematology; Li S, Chen K et. al.

Dec 2nd, 2021 - HBB gene mutations lead to many kinds of diseases, of which, except for the two most common diseases of thalassemia and sickle cell anemia, rare kinds of hemolytic anemia, such as hemoglobin Bristol-Alesha, are rarely reported, no ideal treatment ...

Glucose Metabolism in Sickle Cell Disease
https://clinicaltrials.gov/ct2/show/NCT02922296

Nov 24th, 2021 - Sickle cell disease (SCD) is due to homozygosity for a Glu6Val mutation in HBB (sickle cell anemia; hemoglobin SS) or to compound heterozygous forms like hemoglobin SC disease and hemoglobin S-β thalassemia. Past studies suggested a low prevalence...

A Case of Fat Embolism Syndrome with Cerebral Involvement in Sickle Cell Anemia.
https://doi.org/10.1080/03630269.2021.1990081
Hemoglobin Melvin RG, Liederman Z et. al.

Nov 10th, 2021 - Fat embolism syndrome (FES) is a rare condition that can occur as a complication of sickle cell disease. We describe a case of a patient with sickle cell disease (homozygous Hb S or HBB: c.20A>T) presenting with initial signs and symptoms consiste...

Artifactual hypoglycemia in a patient with sickle cell anemia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8565976
CMAJ : Canadian Medical Association Journal = Journal De ... Wang LR, Morein J et. al.

Nov 3rd, 2021 - Artifactual hypoglycemia in a patient with sickle cell anemia.|2021|Wang LR,Morein J,McCudden C,Sorisky A,|

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Drugs  4 results see all →

Clinicaltrials.gov  55 results

Glucose Metabolism in Sickle Cell Disease
https://clinicaltrials.gov/ct2/show/NCT02922296

Nov 24th, 2021 - Sickle cell disease (SCD) is due to homozygosity for a Glu6Val mutation in HBB (sickle cell anemia; hemoglobin SS) or to compound heterozygous forms like hemoglobin SC disease and hemoglobin S-β thalassemia. Past studies suggested a low prevalence...

A Trial to Assess the Effect of Transfusion Strategies on Fatigability Levels After Hospital Discharge
https://clinicaltrials.gov/ct2/show/NCT04920045

Sep 30th, 2021 - The design of this proposed study is a randomized controlled trial of hospitalized adult general medicine patients with anemia at the University of Chicago (UC). Patients will be randomized to receive transfusion at either a hemoglobin (Hb)<9g/dL ...

Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II )
https://clinicaltrials.gov/ct2/show/NCT04750707

Sep 5th, 2021 - Annually, an estimated 200,000 babies are born with Sickle Cell Anemia (SCA) worldwide. Affected children often suffer repeated acute illnesses and chronic ill health from vascular occlusive phenomenon. In particular, they are at a high risk of st...

Stroke Prevention in Young Adults With Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT04808778

Jul 8th, 2021 - The Investigator's global hypothesis, to be tested eventually in an NIH-funded phase III controlled trial, is that hydroxyurea at a fixed moderate dose of 20 mg/kg is safe and effective for primary and secondary stroke prevention in young adults w...

Improving Scientific Rigor of Renal Clinical Endpoints for Sickle Cell Anemia
https://clinicaltrials.gov/ct2/show/NCT04380610

Apr 12th, 2021 - 200 pediatric and 200 adult SCA participants will undergo mGFR using iohexol at baseline and at one year. On the same day, participants will undergo clinical and laboratory variables important for developing an eGFR equation. From baseline data, t...

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News  88 results

Portico Hits the Market; TAVR Explantation Risks; Beware Unreliable Registries?
https://www.medpagetoday.com/cardiology/prevention/94604

Sep 20th, 2021 - German recipients of the AstraZeneca COVID-19 vaccine showed that severe headache can precede cerebral venous sinus thrombosis by a few days in vaccine-induced immune thrombotic thrombocytopenia (VITT), according to a brief report in the New Engla...

Sickle Cell Disease Tied to COVID-19 Mortality, Hospitalizations
https://www.medpagetoday.com/hematologyoncology/hematology/93683

Jul 21st, 2021 - Sickle cell disease (SCD) was associated with a significantly increased risk of COVID-19-related hospitalization and death in adults, U.K. researchers found. Their cohort study showed that having SCD quadrupled a person's risk for COVID-19-related...

Treating Adult Patients With Sickle Cell Anemia
https://www.onclive.com/view/treating-adult-patients-with-sickle-cell-anemia

Apr 2nd, 2021 - Morey Blinder, MD, professor of medicine at Washington University in St. Louis, is an adult hematologist whose practice is focused on patients with nonmalignant hematologic disorders. A large percentage of these patients have sickle cell anemia an...

Role of Blood Transfusions in Sickle Cell Anemia
https://www.onclive.com/view/role-of-blood-transfusions-in-sickle-cell-anemia

Apr 2nd, 2021 - Transfusions play a large role in the management of sickle cell anemia; however, they are not considered standard of care for the management of anemia alone, states Thomas D. Coates, MD. Although transfusions can reduce pain associated with the an...

Hydroxyurea as an Alternate to Regular Blood Transfusions
https://www.onclive.com/view/hydroxyurea-as-an-alternate-to-regular-blood-transfusions

Apr 2nd, 2021 - Misunderstandings exist with regard to the risk/benefit profile of hydroxyurea, which have led to its underuse, according to Thomas D. Coates, MD. The drug has been shown to reduce the frequency of crisis and the duration of hospitalization by abo...

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Patient Education  6 results see all →