ALLMedicine™ Sickle Cell Anemia Center

Jun 28th, 2022 - Hemolysis and hemoglobinuria are risk factors for kidney disease and its progression in sickle cell anemia (SCA). Voxelotor is a small molecule allosteric hemoglobin modulator that reduces hemolysis in SCA. We administered GBT1118, an analogue of ...

Jun 28th, 2022 - Sickle cell anemia (SCA) is the leading cause of childhood stroke. We aimed to evaluate whether altered cerebral flow velocities, as measured by transcranial Doppler (TCD), are associated with vaso-occlusive complications in addition to stroke in ...

Jun 27th, 2022 - β-thalassemia is associated with multiple hematological and cerebrovascular symptoms linked to a hypercoagulable state that has not been fully replicated in animal models for the development of stroke treatments. Herein we compared the physiologic...

Jun 24th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Jun 21st, 2022 - Sickle cell anemia is the commonest hemoglobinopathy in pregnant Nigerian women, and cardiac manifestations are a significant feature of the disease especially in pregnancy. Pregnant women with sickle cell anemia are at high risk of morbidity and ...

Jun 19th, 2013 - This aim of this statement is to report an expert consensus on the diagnosis and treatment of cardiac dysfunction in β-thalassemia major (TM). This consensus statement does not cover other hemoglobinopathies, including thalassemia intermedia and s...

Jun 24th, 2022 - Sickle cell anemia is an autosomal recessive disorder and the most common genetic disease affecting African-Americans. Approximately 0.15% of African-Americans are homozygous for sickle cell disease, and 8% have sickle cell trait. Acute pain crisi...

Jun 21st, 2022 - This study is a single center, prospective exploratory pilot study of Sickle Cell Anemia (SCA) participants, age ≥18 years, with SCA. The study will enroll patients with early stages of sickle cell nephropathy (Chronic Kidney Disease (CKD) stage 1...

May 26th, 2022 - Sickle cell anemia is a monogenic disease affecting the beta-chain of hemoglobin. Cognitive impairment is more prevalent in patients with sickle cell disease than in matched unaffected individuals. Validated tests to screen for cognitive impairmen...

May 24th, 2022 - Sickle cell disease (SCD) is characterized by a vasculopathy affecting multiple end organs, with complications including ischemic stroke, pulmonary hypertension, and chronic kidney disease (CKD). Albuminuria, an early measure of glomerular injury ...

May 19th, 2022 - The design of this proposed study is a randomized controlled trial of hospitalized adult general medicine patients with anemia at the University of Chicago (UC). Patients will be randomized to receive transfusion at either a hemoglobin (Hb)<9g/dL ...

May 24th, 2022 - This transcript has been edited for clarity. Peter Higgins, MD, PhD: Hello. I'm Dr Peter Higgins, and welcome to Medscape's InDiscussion series on Crohn's disease. Today we'll be discussing gene therapy trials. Given the recent successes with sick...

Sep 16th, 2021 - Prolonged treatment with hydroxyurea may improve -- and possibly even reverse -- cardiac complications in pediatric patients with sickle cell anemia, a retrospective study found. Those on hydroxyurea for less than 1 year had a significantly greate...

Jul 21st, 2021 - Sickle cell disease (SCD) was associated with a significantly increased risk of COVID-19-related hospitalization and death in adults, U.K. researchers found. Their cohort study showed that having SCD quadrupled a person's risk for COVID-19-related...

Apr 2nd, 2021 - Transfusion is 1 of 2 disease-modifying therapies for adults with sickle cell anemia, the other being hydroxyurea, explains Morey Blinder, MD. There are several indications for transfusion in patients with sickle cell disease, with the best studie...

Dec 9th, 2020 - The cognitive and emotional status of children with sickle cell disease (SCD) appears to have a significant effect on how they cope with pain and use health care resources, investigators have found. Results of a retrospective study of 112 children.