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About 4,664 results

ALLMedicine™ Sickle Cell Anemia Center

Research & Reviews  2,195 results

Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984885
Mediators of Inflammation; Santiago RP, Carvalho MOS et. al.

Apr 1st, 2021 - Transforming growth factor beta (TGF-β) is a cytokine with important involvement in biological processes related to the pathogenesis of sickle cell disease (SCD), including endothelial and vascular dysfunction, inflammation, and hematopoietic home...

Implementation of near-universal hydroxyurea uptake among children with sickle cell ane...
https://doi.org/10.1002/pbc.29008
Pediatric Blood & Cancer; Karkoska K, Todd K et. al.

Mar 20th, 2021 - Without early initiation of disease-modifying therapy, the acute and chronic complications of sickle cell anemia (SCA) begin early in childhood and progress throughout life. Hydroxyurea is a safe and effective medication that reduces or prevents m...

Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia.
https://doi.org/10.1016/j.ajhg.2021.03.005
American Journal of Human Genetics; Bao X, Zhang X et. al.

Mar 18th, 2021 - The fetal-to-adult hemoglobin switch is regulated in a developmental stage-specific manner and reactivation of fetal hemoglobin (HbF) has therapeutic implications for treatment of β-thalassemia and sickle cell anemia, two major global health probl...

Hydroxyurea Use Associated with Nonverbal and Executive Skills in Sickle Cell Anemia.
https://doi.org/10.1093/jpepsy/jsab015
Journal of Pediatric Psychology; Tarazi RA, Patrick KE et. al.

Mar 11th, 2021 - Hydroxyurea (HU) is used in children with sickle cell disease (SCD) to increase fetal hemoglobin (HF), contributing to a decrease in physical symptoms and potential protection against cerebral microvasculopathy. There has been minimal investigatio...

A pilot study of the effect of rivaroxaban in sickle cell anemia.
https://doi.org/10.1111/trf.16343
Transfusion Ataga KI, Elsherif L et. al.

Mar 4th, 2021 - The contribution of coagulation activation to the pathogenesis of sickle cell disease (SCD) remains incompletely defined. We evaluated the efficacy and safety of rivaroxaban, an oral direct factor Xa inhibitor, in subjects with sickle cell anemia....

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Guidelines  23 results

A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease
http://www.bloodjournal.org/content/early/2019/01/17/blood-2018-08-868893?sso-checked=true
Howard,J,et al

Jan 16th, 2019 - New treatments directly targeting polymerization of sickle hemoglobin (HbS), the proximate event in the pathophysiology of sickle cell disease (SCD), are needed to address the severe morbidity and early mortality associated with the disease. Voxel...

Statement on Opioid Use in Patients with Hematologic Diseases and Disorders
http://www.hematology.org/Advocacy/Statements/8502.aspx
American Society of Hematology

Apr 17th, 2018 - According to the Centers for Disease Control and Prevention, overdoses from prescription opioids in the United States have contributed to the 15-year increase in opioid overdose deaths and nearly half of all opioid overdose deaths involve a prescr.

Pain Management in Vaso-occlusive Sickle Cell Crisis
https://www.emra.org/emresident/article/pain-management-in-vaso-occlusive-sickle-cell-crisis/
Amani Mahdi

Apr 10th, 2017 - To optimize patient care, considerable effort must be directed toward understanding the pathophysiology of SCD, appreciating the severity of each episode, and anticipating the likelihood of VOC recurrence. In addition, the patient's age, comorbidi.

Pediatric Pulmonary Hypertension
http://www.thoracic.org/statements/resources/pldd/pediatric-pulmonary-hypertension.pdf
Steven H. Abman

Mar 14th, 2016 - Pulmonary hypertension is associated with diverse cardiac, pulmonary, and systemic diseases in neonates, infants, and older children and contributes to significant morbidity and mortality. However, current approaches to caring for pediatric patien.

Health Maintenance and Management of Chronic Complications of Sickle Cell Disease: ASH Guide...
http://ashpocketguides.hematology.org/#/app/guides/3/pages/
American Society of Hematology

Oct 31st, 2014 - Guide for Health Maintenance and Management of Chronic Complications of Sickle Cell Disease.

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Drugs  3 results see all →

Clinicaltrials.gov  2,303 results

Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984885
Mediators of Inflammation; Santiago RP, Carvalho MOS et. al.

Apr 1st, 2021 - Transforming growth factor beta (TGF-β) is a cytokine with important involvement in biological processes related to the pathogenesis of sickle cell disease (SCD), including endothelial and vascular dysfunction, inflammation, and hematopoietic home...

Implementation of near-universal hydroxyurea uptake among children with sickle cell ane...
https://doi.org/10.1002/pbc.29008
Pediatric Blood & Cancer; Karkoska K, Todd K et. al.

Mar 20th, 2021 - Without early initiation of disease-modifying therapy, the acute and chronic complications of sickle cell anemia (SCA) begin early in childhood and progress throughout life. Hydroxyurea is a safe and effective medication that reduces or prevents m...

Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia.
https://doi.org/10.1016/j.ajhg.2021.03.005
American Journal of Human Genetics; Bao X, Zhang X et. al.

Mar 18th, 2021 - The fetal-to-adult hemoglobin switch is regulated in a developmental stage-specific manner and reactivation of fetal hemoglobin (HbF) has therapeutic implications for treatment of β-thalassemia and sickle cell anemia, two major global health probl...

Hydroxyurea Use Associated with Nonverbal and Executive Skills in Sickle Cell Anemia.
https://doi.org/10.1093/jpepsy/jsab015
Journal of Pediatric Psychology; Tarazi RA, Patrick KE et. al.

Mar 11th, 2021 - Hydroxyurea (HU) is used in children with sickle cell disease (SCD) to increase fetal hemoglobin (HF), contributing to a decrease in physical symptoms and potential protection against cerebral microvasculopathy. There has been minimal investigatio...

A pilot study of the effect of rivaroxaban in sickle cell anemia.
https://doi.org/10.1111/trf.16343
Transfusion Ataga KI, Elsherif L et. al.

Mar 4th, 2021 - The contribution of coagulation activation to the pathogenesis of sickle cell disease (SCD) remains incompletely defined. We evaluated the efficacy and safety of rivaroxaban, an oral direct factor Xa inhibitor, in subjects with sickle cell anemia....

see more →

News  125 results

Hydroxyurea Dose Escalation Safe, More Effective Against Childhood Sickle Cell Anemia
https://www.staging.medscape.com/viewarticle/932935

Jun 25th, 2020 - (Reuters Health) - Raising the dose of hydroxyurea by roughly 50% for children with sickle cell anemia dramatically lowers the risk of sickle-cell complications, according to a new study of 187 Ugandan children published in the New England Journal...

Hydroxyurea Dose Escalation Safe, More Effective Against Childhood Sickle Cell Anemia
https://www.medscape.com/viewarticle/932935

Jun 25th, 2020 - (Reuters Health) - Raising the dose of hydroxyurea by roughly 50% for children with sickle cell anemia dramatically lowers the risk of sickle-cell complications, according to a new study of 187 Ugandan children published in the New England Journal...

FDA approves Global Blood Therapeutics sickle cell disease drug
https://www.reuters.com/article/us-global-blood-theraprutics-fda/fda-approves-global-blood-therapeutics-sickle-cell-disease-drug-idUSKBN1XZ2E5

Nov 25th, 2019 - (Reuters) - The U.S. Food and Drug Administration said on Monday it approved a drug from Global Blood Therapeutics Inc to treat sickle cell disease in adults and children 12 years or older. The treatment will be priced at $10,417 per month, or aro...

Suicide trends among youth on Medicaid
https://www.mdedge.com/emergencymedicine/article/193150/suicide-trends-among-youth-medicaid

Jan 24th, 2019 - Younger people who are enrolled in Medicaid who commit suicide are disproportionately female, younger, and more likely to die by hanging. The risk for acute myeloid leukemia and myeloma is higher for breast cancer survivors, matched transplant imp.

Matched transplant improves stroke risk indicator in sickle cell anemia
https://www.mdedge.com/pediatrics/article/193003/anemia/matched-transplant-improves-stroke-risk-indicator-sickle-cell
Andrew D. Bowser

Jan 22nd, 2019 - In children with sickle cell anemia, matched sibling donor transplants improved an indicator of stroke risk in a multicenter French study, suggesting that this intervention may improve outcomes related to cerebral vasculopathy. Matched sibling don.

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Patient Education  15 results see all →