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About 638 results

ALLMedicine™ Erythroleukemia Center

Research & Reviews  319 results

Modeling and targeting of erythroleukemia by hematopoietic genome editing.
https://doi.org/10.1182/blood.2020009103
Blood Iacobucci I, Qu C et. al.

Jan 29th, 2021 - Acute erythroid leukemia (AEL) is characterized by distinct morphology, mutational spectrum, a lack of preclinical models and poor prognosis. Here, using multiplexed genome editing of mouse hematopoietic stem and progenitor cells and transplant as...

5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expressi...
https://doi.org/10.1158/1541-7786.MCR-20-0453
Molecular Cancer Research : MCR; Reilly BM, Luger T et. al.

Nov 11th, 2020 - DNA methyltransferase inhibitors (DNMTI) like 5-Azacytidine (5-Aza) are the only disease-modifying drugs approved for the treatment of higher-risk myelodysplastic syndromes (MDS), however less than 50% of patients respond, and there are no predict...

Monoterpenes as therapeutic candidates to induce fetal hemoglobin synthesis and up-regu...
https://doi.org/10.1016/j.ejphar.2020.173700
European Journal of Pharmacology; Iftikhar F, Khan MBN et. al.

Nov 2nd, 2020 - Pharmacologically induced production of fetal hemoglobin (HbF) is a pragmatic therapeutic strategy for the reduction of globin chain imbalance and improving the clinical severities of patients with β-hemoglobinopathies. To identify highly desirabl...

Erythroleukemia: all roads lead to GATA1?
https://doi.org/10.1182/blood.2020006107
Blood Strouboulis J

Aug 7th, 2020 - Erythroleukemia: all roads lead to GATA1?|2020|Strouboulis J,|

Paris Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a...
https://doi.org/10.2174/1871520620666200615134039
Anti-cancer Agents in Medicinal Chemistry; Lin X, Gajendran B et. al.

Jun 14th, 2020 - Leukemia considered a top-listed ailment, according to WHO, which contributes to the death of a major population of the world every year. Paris Saponin VII (PS), a saponin which was isolated from the roots of Trillium kamtschaticum, from our group...

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Clinicaltrials.gov  319 results

Modeling and targeting of erythroleukemia by hematopoietic genome editing.
https://doi.org/10.1182/blood.2020009103
Blood Iacobucci I, Qu C et. al.

Jan 29th, 2021 - Acute erythroid leukemia (AEL) is characterized by distinct morphology, mutational spectrum, a lack of preclinical models and poor prognosis. Here, using multiplexed genome editing of mouse hematopoietic stem and progenitor cells and transplant as...

5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expressi...
https://doi.org/10.1158/1541-7786.MCR-20-0453
Molecular Cancer Research : MCR; Reilly BM, Luger T et. al.

Nov 11th, 2020 - DNA methyltransferase inhibitors (DNMTI) like 5-Azacytidine (5-Aza) are the only disease-modifying drugs approved for the treatment of higher-risk myelodysplastic syndromes (MDS), however less than 50% of patients respond, and there are no predict...

Monoterpenes as therapeutic candidates to induce fetal hemoglobin synthesis and up-regu...
https://doi.org/10.1016/j.ejphar.2020.173700
European Journal of Pharmacology; Iftikhar F, Khan MBN et. al.

Nov 2nd, 2020 - Pharmacologically induced production of fetal hemoglobin (HbF) is a pragmatic therapeutic strategy for the reduction of globin chain imbalance and improving the clinical severities of patients with β-hemoglobinopathies. To identify highly desirabl...

Erythroleukemia: all roads lead to GATA1?
https://doi.org/10.1182/blood.2020006107
Blood Strouboulis J

Aug 7th, 2020 - Erythroleukemia: all roads lead to GATA1?|2020|Strouboulis J,|

Paris Saponin VII Induces Apoptosis and Cell Cycle Arrest in Erythroleukemia Cells by a...
https://doi.org/10.2174/1871520620666200615134039
Anti-cancer Agents in Medicinal Chemistry; Lin X, Gajendran B et. al.

Jun 14th, 2020 - Leukemia considered a top-listed ailment, according to WHO, which contributes to the death of a major population of the world every year. Paris Saponin VII (PS), a saponin which was isolated from the roots of Trillium kamtschaticum, from our group...

see more →