ALLMedicine™ Anaplastic Large Cell Lymphoma Center

Sep 19th, 2021 - The first (2017) and sixth (2021) multistakeholder Paediatric Strategy Forums focused on anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies. ALK is an important oncogene and target in several paediatric tumours (anaplastic larg...

Sep 16th, 2021 - In the 2017 revised World Health Organization classification of tumors of hematopoietic and lymphoid tissues, some mature T-cell lymphomas are reclassified and a few new provisional entities are established based on new data from clinical and labo...

Sep 1st, 2021 - I am one of only a few patients who have undergone reimplantation with breast implants directly after a diagnosis of breast implant associated-anaplastic large cell lymphoma (BIA-ALCL). This decision was a very personal one and many may question w...

Aug 30th, 2021 - Lymphomas associated with breast implants are mostly of the T-cell type. They are predominantly anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK-negative ALCL) characterized by CD30 positivity universally. Whilst the majorit...

Aug 19th, 2021 - ALK-negative anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin T-cell lymphoma. Compared to ALK-positive ALCL, patients with ALK-negative ALCL typically are older, present with nodal disease, and have lower survival rates. We repo...

Nov 23rd, 2020 - Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an uncommon T-cell non-Hodgkin Lymphoma (NHL) associated with breast implants. Raising awareness of the possibility of BIA-ALCL in anyone with breast implants and new breast sy...

Feb 12th, 2020 - To provide guidelines for the accurate pathologic diagnosis of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), the preoperative evaluation of the patient with suspected BIA-ALCL, and the pathologic evaluation of the capsulecto...

Feb 12th, 2017 - Published case series demonstrate a lack of treatment standardization for breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) with a wide variety of therapeutic strategies being employed at all stages of disease. The National Compr...

Apr 13th, 2011 - The peripheral T-cell neoplasms are a biologically and clinically heterogeneous group of rare disorders that result from clonal proliferation of mature post-thymic lymphocytes. Natural killer (NK) cell neoplasms are included in this group. The Wor...

Oct 14th, 2020 - NEW YORK (Reuters Health) - Using textured implants for reconstruction after mastectomy is associated with greater risk of breast cancer recurrence compared to smooth implants, according to new findings in JAMA Surgery. "We initiated this study fo...

Jul 10th, 2020 - The National Institute for Health and Care Excellence (NICE) has published final draft guidance recommending brentuximab vedotin (Adcetris, Takeda) with cyclophosphamide, doxorubicin, and prednisone (CHP) for untreated systemic anaplastic large ce...

Jul 10th, 2020 - The National Institute for Health and Care Excellence (NICE) has published final draft guidance recommending brentuximab vedotin (Adcetris, Takeda) with cyclophosphamide, doxorubicin, and prednisone (CHP) for untreated systemic anaplastic large ce...

Jul 9th, 2020 - As of April 2020, there have been 68 cases of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) reported in the UK. This figure includes cases where the original implantation did not occur in the UK. Based on the number of cases,...

Feb 13th, 2020 - The patient’s biopsy showed sparse and grouped and slightly enlarged atypical stained mononuclear cells in mostly perifollicular areas with focal epidermotropism. CD30 staining was positive.