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About 420 results

ALLMedicine™ Erythroleukemia Center

Research & Reviews  164 results

Anti-Cancer Role of Dendrosomal Nano Solanine in Chronic Myelogenous Leukemia Cell Line...
https://doi.org/10.2174/1874467215666220516143155
Current Molecular Pharmacology; Asgaritarghi G, Farsani SSM et. al.

May 18th, 2022 - Background Solanine was primarily known as a toxic compound. Nonetheless, recently the apoptotic role of solanine through suppression of PI3K/AKT/mTOR signaling pathway has been shown against many malignancies except chronic myelogenous leukemia (...

BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors pro...
https://doi.org/10.1182/blood.2021014465
Blood Li B, An W et. al.

Apr 15th, 2022 - Leukemic transformation (LT) of myeloproliferative neoplasm (MPN) has a dismal prognosis and is largely fatal. Mutational inactivation of TP53 is the most common somatic event in LT; however, the mechanisms by which TP53 mutations promote LT remai...

EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity.
https://doi.org/10.1080/09537104.2021.1988548
Platelets Hu L, Zhang W et. al.

Oct 27th, 2021 - Megakaryocytes (MKs) are the unique non-pathological cells that undergo polyploidization in mammals. The polyploid formation is critical for understanding the MK biology, and transcriptional regulation is involved in the differentiation and matura...

Involvement of autophagy in diosgenin‑induced megakaryocyte differentiation in human er...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8436216
Molecular Medicine Reports; Diab D, Pinon A et. al.

Aug 31st, 2021 - Natural agents have been used to restart the process of differentiation that is inhibited during leukemic transformation of hematopoietic stem or progenitor cells. Autophagy is a housekeeping pathway that maintains cell homeostasis against stress ...

BET inhibitors enhance embryonic and fetal globin expression in erythroleukemia cell li...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634195
Haematologica Cao JZ, Bigelow K et. al.

Aug 27th, 2021 - BET inhibitors enhance embryonic and fetal globin expression in erythroleukemia cell lines.|2021|Cao JZ,Bigelow K,Wickrema A,Godley LA,|genetics,drug therapy,genetics,metabolism,

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Clinicaltrials.gov  2 results

Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Ple...
https://clinicaltrials.gov/ct2/show/NCT01143545

Mar 3rd, 2020 - Background: During recent years, the cancer-testis (CT) antigens have emerged as attractive targets for cancer immunotherapy. Whereas lung and esophageal cancers, as well as malignant pleural mesotheliomas express a variety of CT antigens, immune ...

Tumor Cell Vaccine for Patients Undergoing Surgery for Sarcomas, Melanomas, Germ Cell Tumors, or Malignancies That Have Metastasized to the Lungs, Pleura, or Mediastinum
https://clinicaltrials.gov/ct2/show/NCT01313429

Mar 3rd, 2020 - Background: During recent years, the cancer-testis (CT) antigens (CTA) have emerged as attractive targets for cancer immunotherapy. Whereas malignancies of diverse histologies express a variety of CTAs, immune responses to these antigens appear un...

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News  2 results

Understanding the Recent WHO MDS Classification Updates
https://www.onclive.com/view/understanding-the-recent-who-mds-classification-updates

Apr 2nd, 2021 - Transcript:Vinod Pullarkat, MD: Hello, and thank you for joining us today for this OncLive Peer Exchange® on the topic of Myelodysplastic Syndrome: Managing Risk and Complications. Myelodysplastic syndrome is a heterogeneous disease that necessita...

Inhibitor exhibits activity against hematologic malignancies
https://www.mdedge.com/hematology-oncology/article/185742/leukemia-myelodysplasia-transplantation/inhibitor-exhibits
HT Staff

Apr 18th, 2017 - Photo by Rhoda Baer Researchers in the lab A dual kinase inhibitor is active against a range of hematologic malignancies, according to preclinical research. Investigators found that ASN002, a SYK/JAK inhibitor, exhibited “potent” antiproliferative.

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