About 388 results

ALLMedicine™ Erythroleukemia Center

Research & Reviews  153 results

EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity.
Platelets Hu L, Zhang W et. al.

Oct 27th, 2021 - Megakaryocytes (MKs) are the unique non-pathological cells that undergo polyploidization in mammals. The polyploid formation is critical for understanding the MK biology, and transcriptional regulation is involved in the differentiation and matura...

Involvement of autophagy in diosgenin‑induced megakaryocyte differentiation in human er...
Molecular Medicine Reports; Diab D, Pinon A et. al.

Aug 31st, 2021 - Natural agents have been used to restart the process of differentiation that is inhibited during leukemic transformation of hematopoietic stem or progenitor cells. Autophagy is a housekeeping pathway that maintains cell homeostasis against stress ...

BET inhibitors enhance embryonic and fetal globin expression in erythroleukemia cell li...
Haematologica Cao JZ, Bigelow K et. al.

Aug 27th, 2021 - BET inhibitors enhance embryonic and fetal globin expression in erythroleukemia cell lines.|2021|Cao JZ,Bigelow K,Wickrema A,Godley LA,|

Cabozantinib promotes erythroid differentiation in K562 erythroleukemia cells through g...
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Cancer Gene Therapy; Fu YH, Ou DL et. al.

Jun 13th, 2021 - Cabozantinib is a potent tyrosine kinase inhibitor with multiple targets including MET, VEGFR2, RET, KIT, and FLT3. Cabozantinib is widely used for the treatment of medullary thyroid cancer and renal cell carcinoma. We recently suggested cabozanti...

ERK activation via A1542/3 limonoids attenuates erythroleukemia through transcriptional...
BMC Cancer; Yu F, Gajendran B et. al.

Jun 11th, 2021 - Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or poor prognosis, but the underlying mech...

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Clinicaltrials.gov  1 results

Tumor Cell Vaccine for Patients Undergoing Surgery for Sarcomas, Melanomas, Germ Cell Tumors, or Malignancies That Have Metastasized to the Lungs, Pleura, or Mediastinum

Mar 3rd, 2020 - Background: During recent years, the cancer-testis (CT) antigens (CTA) have emerged as attractive targets for cancer immunotherapy. Whereas malignancies of diverse histologies express a variety of CTAs, immune responses to these antigens appear un...

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News  1 results

Inhibitor exhibits activity against hematologic malignancies
HT Staff

Apr 18th, 2017 - Photo by Rhoda Baer Researchers in the lab A dual kinase inhibitor is active against a range of hematologic malignancies, according to preclinical research. Investigators found that ASN002, a SYK/JAK inhibitor, exhibited “potent” antiproliferative.

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