ALLMedicine™ Erythromelalgia Center

Mar 21st, 2023 - Diagnostic Considerations The International Association for the Study of Pain (IASP) has developed criteria (also known as the Budapest criteria) for the clinical diagnosis of complex regional pain syndrome and continues to update these criteria. ...

Feb 24th, 2023 - Primary erythromelalgia (PEM) is a rare condition characterized by severe burning pain, erythema, and increased temperature in the extremeties. Mutations in the Nav1.7 sodium channel encoded by the SCN9A are responsible for PEM. The pathophysiolog...

Jan 21st, 2023 - Erythromelalgia is a rare disease characterised by a triad of a clinical syndrome of redness, warmth and painful extremities. We present the case of a male adolescent with no prior medical history who presents to our family medicine clinic with a ...

Dec 6th, 2022 - Erythromelalgia (EM) is a rare disorder characterized by episodic, burning pain associated with erythema and warmth of the extremities. The feet and hands are most commonly affected. The pain can be so severe that patients may engage in behaviors,...

Oct 27th, 2022 - Polycythemia vera (PV) and essential thrombocythemia (ET) are classical Philadelphia-negative myeloproliferative neoplasms (MPN) that are characterized by an excess of cells in the peripheral blood, clonal bone marrow hyperplasia, and extramedulla...

Dec 6th, 2022 - Erythromelalgia (EM) is a rare disorder characterized by episodic, burning pain associated with erythema and warmth of the extremities. The feet and hands are most commonly affected. The pain can be so severe that patients may engage in behaviors,...

Oct 27th, 2022 - Polycythemia vera (PV) and essential thrombocythemia (ET) are classical Philadelphia-negative myeloproliferative neoplasms (MPN) that are characterized by an excess of cells in the peripheral blood, clonal bone marrow hyperplasia, and extramedulla...

Sep 21st, 2022 - Erythromelalgia is a rare disorder characterized by red, warm, and painful extremities, which is often precipitated by warm conditions. The pathophysiology is incompletely understood. The management of pain in erythromelalgia is challenging as no ...

Nov 19th, 2019 - The purpose of this study is to evaluate the efficacy and safety of single doses of PF-05089771 against placebo in treatment of pain in patients with primary, inherited erythromelalgia.

Sep 17th, 2019 - Very little is currently known about the sensory characteristics and central processing of pain in patients with heritable channelopathies. The investigators will carefully study the phenotype of such patients in terms of pain symptomatology, sens...

Jan 10th, 2018 - Indication Lacosamide is a functionalized amino acid with antinociceptive properties in inflammatory and neuropathic pain, and displays a unique mechanism: it enhances slow inactivation of Nav1.3, Nav1.7, and Nav1.8. Rationale A significant body o...

Sep 16th, 2022 - PORTLAND, ORE. – Some pernio-like/chilblains-like lesions on the toes – which became widely known as “COVID toes” – and other acral sites that have occurred during the COVID-19 pandemic are related to COVID-19 infection, while others are not, acco.

Jul 11th, 2022 - Rami Komrokji, MD: We under-recognize the symptom burden in ET [essential thrombocythemia] and PV [polycythemia vera]. How do we assess the quality of life and the impact of symptoms in patients? What are our tools to assess that? Because we pay a...

May 11th, 2022 - Transcript: Pankit Vachhani, MD: Polycythemia vera is diagnosed at a median age of roughly about 60 years. In most patients, it is actually diagnosed in an incidental fashion. Someone goes to their primary care physician or some other physician f...

Apr 14th, 2022 - A punch-biopsy was performed on the left second toe where the erythema was the most intense. It demonstrated classic findings for pernio: superficial and deep perivascular lymphocytic inflammation and papillary dermal edema on the acral surface.

Jan 25th, 2022 - Ruben Mesa, MD: So Stephen, why don’t we start with some of that earlier phase of disease? Why don’t you walk us through ET [essential thrombocythemia]? What are some of the key things we need to be aware of in terms of ET? Stephen Oh, MD, PhD:...