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About 1,438 results

ALLMedicine™ Transfusion Reactions Center

Research & Reviews  386 results

Successful Orthotopic Heart Transplantation in Patient With Anti-U Antibody.
https://doi.org/10.1093/labmed/lmab100
Laboratory Medicine; Hughes C, Sterling B et. al.

Nov 3rd, 2021 - The U (universal) antigen is part of the MNS blood group present at a frequency of nearly 100% in Caucasians and 98% of African Americans. The anti-U antibody is clinically significant and has been reported to cause hemolytic transfusion reactions...

Transfusion Reactions and Adverse Events.
https://doi.org/10.1016/j.cll.2021.07.009
Clinics in Laboratory Medicine; Abdallah R, Rai H et. al.

Oct 26th, 2021 - Blood transfusions are generally safe but can carry considerable risks. This review summarizes the different types of transfusion reactions and ways to diagnose and manage them. Symptoms are often overlapping and nonspecific. When a reaction is su...

Active surveillance of serious adverse events following transfusion of COVID-19 convale...
https://doi.org/10.1111/trf.16711
Transfusion Swenson E, Wong LK et. al.

Oct 23rd, 2021 - The reported incidence of adverse reactions following Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) transfusion has generally been lower than expected based on the incidence of transfusion reactions that have been observed in studi...

A Single-Center Description of Pediatric Transfusion Reactions and Preventable Patient ...
https://doi.org/10.1542/hpeds.2020-005173
Hospital Pediatrics; Johns C, Bakhtary S et. al.

Oct 13th, 2021 - In previous studies, researchers highlight that children have higher rates of transfusion reactions than adults. However, little is known about the pediatric populations that experience reactions, and there are no reports that consider appropriate...

Extended phenotyping does not preclude the occurrence of delayed haemolytic transfusion...
https://doi.org/10.1111/bjh.17875
British Journal of Haematology; Gerritsma J, Bongaerts V et. al.

Oct 12th, 2021 - Delayed haemolytic transfusion reaction (DHTR) is a potentially life-threatening complication of red blood cell (RBC) transfusions in sickle cell disease (SCD) and is classically induced by reactivation of previously formed antibodies. Improved an...

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Guidelines  2 results

American Society of Hematology 2020 guidelines for sickle cell disease: transfusion sup...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988392
Blood Advances; Chou ST, Alsawas M et. al.

Jan 28th, 2020 - Red cell transfusions remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. Guidance for specific indications and administration of transfusion, as well as screening, prevention, and ma...

Red blood cell specifications for patients with hemoglobinopathies: a systematic review...
https://doi.org/10.1111/trf.14611
Transfusion Compernolle V, Chou ST et. al.

Apr 27th, 2018 - Red blood cell (RBC) transfusions remain essential in the treatment of patients with sickle cell disease (SCD) and β-thalassemia. Alloimmunization, a well-documented complication of transfusion, increases the risk of delayed hemolytic transfusion ...

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Drugs  155 results see all →

Clinicaltrials.gov  10 results

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Escalating Multiple Oral Doses of AG-348 in Subjects With Stable Sickle Cell Disease
https://clinicaltrials.gov/ct2/show/NCT04000165

Sep 10th, 2021 - Sickle cell disease (SCD) is a multisystem disorder associated with episodes of acute clinical events and progressive organ damage. Episodic pain, triggered by micro-vasoocclusion induced by sickled red blood cells, is the most common acute compli...

Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions.
https://clinicaltrials.gov/ct2/show/NCT04688736

Dec 30th, 2020 - This is a prospective, randomized, double-blind controlled trial to evaluate the efficacy of placebo versus chlorpheniramine for the prevention of allergic transfusion reactions.

Tranexamic Acid to Reduce Blood Loss in Spine Trauma Surgery
https://clinicaltrials.gov/ct2/show/NCT02314988

Oct 19th, 2020 - Reducing perioperative blood loss is critically important in the treatment of multiply injured combat casualties, and major blood loss during complex spine trauma surgery is a significant concern. Similar to previous studies in dental, cardiac, an...

CONVALESCENT PLASMA FOR ILL PATIENTS BY COVID-19
https://clinicaltrials.gov/ct2/show/NCT04356482

Jun 5th, 2020 - Specific objectives Show the efficacy and safety of fresh plasma in different doses in severe cases and in very severe cases. Assess whether fresh plasma can overcome negative prognostic factors in very severe ill patients with COVID-19 infection....

Effects of Antibodies to White Blood Cells on Platelet Transfusion Patients
https://clinicaltrials.gov/ct2/show/NCT00460122

Dec 12th, 2019 - Leukocyte antibodies can cause febrile transfusion reactions, pulmonary reactions to granulocyte transfusions, and transfusion related acute lung injury (TRALI). Despite the fact that the role of leukocyte antibodies in these reactions was first d...

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News  21 results

Dr. Gerds on Addressing Anemia in Myelofibrosis
https://www.onclive.com/view/dr-gerds-on-addressing-anemia-in-myelofibrosis

Dec 20th, 2020 - Aaron Gerds, MD, assistant professor of medicine in the Hematology and Medical Oncology Department at the Cleveland Clinic Taussig Cancer Institute, discusses the adverse event anemia in patients with myelofibrosis. Anemia is a really big issue i...

Expert Highlights Luspatercept Benefit as Treatment of Anemia in Myelofibrosis
https://www.onclive.com/view/expert-highlights-luspatercept-benefit-as-treatment-of-anemia-in-myelofibrosis

Dec 4th, 2020 - Aaron Gerds, MD Luspatercept has shown efficacy as a treatment of anemia in patients with myelofibrosis (MF), a disease that is associated with high rates of anemia, explained Aaron T. Gerds, MD, MS. While JAK inhibitors including ruxolitinib (Ja...

Most transfusion-dependent MDS patients report positive quality of life
https://www.mdedge.com/fedprac/article/232099/myelodysplastic-syndrome/most-transfusion-dependent-mds-patients-report

Nov 18th, 2020 - Key clinical point : Approximately half of transfusion-dependent MDS patients said they had not discussed ways to reduce the need for transfusions with their doctors and 74% said there were no alternatives to blood transfusions. Major finding : Am.

FDA OKs Emergency Use of Convalescent Plasma for Seriously Ill COVID-19 Patients
https://www.staging.medscape.com/viewarticle/927716

Mar 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's  Coronavirus Resource Center. As the proportion of patients infected with COVID-19 continues to rise in the United States, the Food and Drug Administration is facilitating acc...

FDA OKs Emergency Use of Convalescent Plasma for Seriously Ill COVID-19 Patients
https://www.medscape.com/viewarticle/927716

Mar 28th, 2020 - Editor's note: Find the latest COVID-19 news and guidance in Medscape's  Coronavirus Resource Center. As the proportion of patients infected with COVID-19 continues to rise in the United States, the Food and Drug Administration is facilitating acc...

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Patient Education  1 results see all →