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About 1,315 results

ALLMedicine™ Bacterial Sepsis Center

Research & Reviews  639 results

Heparin binding protein in severe COVID-19-A prospective observational cohort study.
https://doi.org/10.1371/journal.pone.0249570
PloS One; Mellhammar L, Thelaus L et. al.

Apr 6th, 2021 - Neutrophil-derived heparin binding protein (HBP; also known as azurocidin or CAP-37) is a key player in bacterial sepsis and a promising biomarker in severe infections. The aims of this study were to assess whether HBP is involved in the pathophys...

Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in p...
https://doi.org/10.1038/s41390-021-01444-3 10.1016/S0378-3782(12)70019-1 10.1016/S0140-6736(17)31002-4 10.1542/peds.2010-3338 10.1371/journal.pone.0159821 10.1093/jpids/piv078 10.1542/peds.2013-2552 10.2119/molmed.2011.00169 10.1371/journal.pone.0233841 10.1007/s00109-016-1466-4 10.2119/molmed.2015.00064 10.1182/blood-2006-02-002477 10.1097/CCM.0b013e3181692c0b 10.1007/s00109-017-1609-2 10.1016/S0169-7439(01)00155-1 10.1021/ac051495j 10.1371/journal.pone.0140993 10.1007/s11306-007-0099-6 10.1016/j.talanta.2013.07.048 10.1371/journal.pone.0160656 10.1006/meth.2001.1262 10.1136/bmj.i1585 10.1002/eji.201242730 10.1371/journal.ppat.1000338 10.1006/smim.1995.0026 10.1074/jbc.M801319200 10.1074/jbc.M513002200 10.1074/jbc.M202009200 10.1016/S0006-291X(03)00468-6 10.1016/j.devcel.2005.11.007 10.1016/j.devcel.2007.11.005 10.1016/j.ccr.2012.03.040 10.1074/jbc.M611269200 10.1038/leu.2011.233 10.1016/S0014-5793(98)01136-3 10.1096/fj.201801478R 10.1016/j.neures.2011.07.1498 10.1016/S1567-5769(02)00019-X 10.1681/ASN.2013091025 10.1007/s00726-010-0601-8 10.1111/j.1399-6576.1996.tb04475.x 10.1097/00005373-199603000-00009
Pediatric Research; Cernada M, Pinilla-González A et. al.

Mar 26th, 2021 - Genome-wide expression profiles have been previously employed as clinical research diagnostic tools for newborn sepsis. We aimed to determine if transcriptomic profiles could discriminate between Gram-positive and Gram-negative bacterial sepsis in...

Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995782
BMC Immunology; AlQranei MS, Senbanjo LT et. al.

Mar 26th, 2021 - Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria's outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation. This s...

Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026643
Journal of Immunology (Baltimore, Md. : 1950); Bolívar BE, Brown-Suedel AN et. al.

Mar 20th, 2021 - Excessive release of heme from RBCs is a key pathophysiological feature of several disease states, including bacterial sepsis, malaria, and sickle cell disease. This hemolysis results in an increased level of free heme that has been implicated in ...

The association of TSH and thyroid hormones with lymphopenia in bacterial sepsis and CO...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989224
The Journal of Clinical Endocrinology and Metabolism; Grondman I, de Nooijer AH et. al.

Mar 13th, 2021 - Lymphopenia is a key feature of immune dysfunction in patients with bacterial sepsis and COVID-19 and associated with poor clinical outcomes, but the cause is largely unknown. Severely ill patients may present with thyroid function abnormalities, ...

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Guidelines  4 results

Management of Neonates Born at ?34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset...
http://pediatrics.aappublications.org/content/142/6/e20182896
Puopolo, Karen M.

Nov 30th, 2018 - Early-onset sepsis (EOS) remains a serious and often fatal illness among infants born preterm, particularly among newborn infants of the lowest gestational age. Currently, most preterm infants with very low birth weight are treated empirically wit.

Beating the Clock to Reduce Sepsis Mortality
https://news.aamc.org/patient-care/article/beating-clock-reduce-sepsis-mortality/
Robin Warshaw

Dec 11th, 2017 - Often overlooked and more difficult to identify than many other life-threatening conditions, sepsis causes one-third to one-half of all deaths in U. S.

Does Early Goal-Directed Therapy Decrease Mortality Compared with Standard Care in Patients ...
http://www.aaem.org/UserFiles/DoesEarlyGoal-DirectedTherapyDecreaseMortalityComparedwithStandardCareinPatientswithSepticShock_.pdf
Robert Sherwin, Michael Winters

Feb 16th, 2016 - Improvements in usual care can largely be attributed to the emphasis that the EGDT study placed on caring for patients with sepsis. Patients in the usual care arms of the ProCESS, ARISE, and ProMISE trials received aggressive intravenous fluids an.

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Clinicaltrials.gov  653 results

Heparin binding protein in severe COVID-19-A prospective observational cohort study.
https://doi.org/10.1371/journal.pone.0249570
PloS One; Mellhammar L, Thelaus L et. al.

Apr 6th, 2021 - Neutrophil-derived heparin binding protein (HBP; also known as azurocidin or CAP-37) is a key player in bacterial sepsis and a promising biomarker in severe infections. The aims of this study were to assess whether HBP is involved in the pathophys...

Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in p...
https://doi.org/10.1038/s41390-021-01444-3 10.1016/S0378-3782(12)70019-1 10.1016/S0140-6736(17)31002-4 10.1542/peds.2010-3338 10.1371/journal.pone.0159821 10.1093/jpids/piv078 10.1542/peds.2013-2552 10.2119/molmed.2011.00169 10.1371/journal.pone.0233841 10.1007/s00109-016-1466-4 10.2119/molmed.2015.00064 10.1182/blood-2006-02-002477 10.1097/CCM.0b013e3181692c0b 10.1007/s00109-017-1609-2 10.1016/S0169-7439(01)00155-1 10.1021/ac051495j 10.1371/journal.pone.0140993 10.1007/s11306-007-0099-6 10.1016/j.talanta.2013.07.048 10.1371/journal.pone.0160656 10.1006/meth.2001.1262 10.1136/bmj.i1585 10.1002/eji.201242730 10.1371/journal.ppat.1000338 10.1006/smim.1995.0026 10.1074/jbc.M801319200 10.1074/jbc.M513002200 10.1074/jbc.M202009200 10.1016/S0006-291X(03)00468-6 10.1016/j.devcel.2005.11.007 10.1016/j.devcel.2007.11.005 10.1016/j.ccr.2012.03.040 10.1074/jbc.M611269200 10.1038/leu.2011.233 10.1016/S0014-5793(98)01136-3 10.1096/fj.201801478R 10.1016/j.neures.2011.07.1498 10.1016/S1567-5769(02)00019-X 10.1681/ASN.2013091025 10.1007/s00726-010-0601-8 10.1111/j.1399-6576.1996.tb04475.x 10.1097/00005373-199603000-00009
Pediatric Research; Cernada M, Pinilla-González A et. al.

Mar 26th, 2021 - Genome-wide expression profiles have been previously employed as clinical research diagnostic tools for newborn sepsis. We aimed to determine if transcriptomic profiles could discriminate between Gram-positive and Gram-negative bacterial sepsis in...

Lipopolysaccharide- TLR-4 Axis regulates Osteoclastogenesis independent of RANKL/RANK s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995782
BMC Immunology; AlQranei MS, Senbanjo LT et. al.

Mar 26th, 2021 - Lipopolysaccharide (LPS) is an endotoxin and a vital component of gram-negative bacteria's outer membrane. During gram-negative bacterial sepsis, LPS regulates osteoclast differentiation and activity, in addition to increasing inflammation. This s...

Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1β Release and Cell Death.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026643
Journal of Immunology (Baltimore, Md. : 1950); Bolívar BE, Brown-Suedel AN et. al.

Mar 20th, 2021 - Excessive release of heme from RBCs is a key pathophysiological feature of several disease states, including bacterial sepsis, malaria, and sickle cell disease. This hemolysis results in an increased level of free heme that has been implicated in ...

The association of TSH and thyroid hormones with lymphopenia in bacterial sepsis and CO...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7989224
The Journal of Clinical Endocrinology and Metabolism; Grondman I, de Nooijer AH et. al.

Mar 13th, 2021 - Lymphopenia is a key feature of immune dysfunction in patients with bacterial sepsis and COVID-19 and associated with poor clinical outcomes, but the cause is largely unknown. Severely ill patients may present with thyroid function abnormalities, ...

see more →

News  19 results

Platelet Contamination Leads to 3 Deaths
https://www.mdedge.com/fedprac/article/171390/mixed-topics/platelet-contamination-leads-3-deaths
Jan Dyer

Aug 15th, 2018 - Platelet-transmitted bacterial infections persist as a cause of transfusion-associated morbidity and mortality, according to researchers writing in Mortality and Morbidity Weekly Report. They describe 2 separate clusters of platelet transfusion-a.

Whole blood PCR improves diagnosis of pediatric bacterial sepsis
https://www.mdedge.com/familymedicine/article/140453/infectious-diseases/whole-blood-pcr-improves-diagnosis-pediatric
Pediatric News; Bruce Jancin

Jun 14th, 2017 - MADRID – Whole blood multiplex polymerase chain reaction (PCR) holds considerable promise as a rapid noninvasive test to improve diagnosis of life-threatening bacterial infections in children with suspected sepsis yet negative blood cultures, Clar.

Low UTI rates after foregoing prophylactic antibiotics for cystoscopy
https://www.mdedge.com/hematology-oncology/article/81272/genitourinary-cancer/low-uti-rates-after-foregoing-prophylactic
Amy Karon

Mar 27th, 2014 - Only 1. 9% of tumor patients who did not have prophylactic antibiotics developed febrile urinary tract infections after flexible cystoscopy, according to research published in the April issue of European Urology.

Assay Could Speed Diagnosis of Bacterial Sepsis
https://www.mdedge.com/authors/jeff-evans?page=28
Jeff Evans

Jan 1st, 2010 - A testing method that uses positive blood cultures and an automated DNA-based polymerase chain reaction and microarray system accurately identified bacteria in sepsis much faster than a standard culture-based process. The test identified bacterial.

FDA Issues Boxed Warning for Efalizumab
https://www.medpagetoday.com/infectiousdisease/publichealth/11358

Oct 16th, 2008 - ROCKVILLE, Md., Oct. 16 -- The FDA today announced that efalizumab (Raptiva) must carry a boxed warning to highlight the risk of life-threatening infections, including progressive multifocal leukoencephalopathy (PML). The warning will also include...

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