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Alarming number of heart infections tied to opioid epidemic
https://newsroom.heart.org/news/alarming-number-of-heart-infections-tied-to-opioid-epidemic

Sep 17th, 2019 - An alarming number of people nationwide are developing infections of either the heart’s inner lining or valves, known as infective endocarditis, in large part, due to the current opioid epidemic. This new trend predominantly affects young, white, poor men who also have higher rates of HIV, hepatitis C and alcohol abuse, according to new research published in the Journal of the American Heart As...

National Trends in Hospitalizations for Stroke Associated With Infective Endocarditis and Opioid Use Between 1993 and 2015
https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.118.024436
Omran, S. et. al.

Jan 29th, 2019 - There has been a recent sharp rise in opioid-related deaths in the United States. Intravenous opioid use can lead to infective endocarditis (IE) which can result in stroke. There are scant data on recent trends in this neurological complication of opioid abuse. We hypothesized that increasing opioid abuse has led to a higher incidence of stroke associated with IE and opioid use.

Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Compli...
http://circ.ahajournals.org/content/132/15/1435
Larry M. Baddour

Sep 14th, 2015 - Infective endocarditis is a complex disease, and patients with this disease generally require management by a team of physicians and allied health providers with a variety of areas of expertise. The recommendations provided in this document are intended to assist in the management of this uncommon but potentially deadly infection.

Dental procedures, antibiotic prophylaxis, and endocarditis among people with prostheti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588045
BMJ (Clinical Research Ed.); Tubiana S, Blotière PO et. al.

Sep 8th, 2017 - Objective To assess the relation between invasive dental procedures and infective endocarditis associated with oral streptococci among people with prosthetic heart valves.Design Nationwide population based cohort and a case crossover study.Setting French national health insurance administrative data linked with the national hospital discharge database.Participants All adults aged more than 18 y...

Trends in Infective Endocarditis in California and New York State, 1998-2013.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470417
JAMA Toyoda N, Chikwe J et. al.

Apr 26th, 2017 - Prophylaxis and treatment guidelines for infective endocarditis have changed substantially over the past decade. In the United States, few population-based studies have explored the contemporary epidemiology and outcomes of endocarditis. To quantify trends in the incidence and etiologies of infective endocarditis in the United States. Retrospective population epidemiology study of patients hosp...

Effect of Anakinra on Recurrent Pericarditis Among Patients With Colchicine Resistance ...
https://doi.org/10.1001/jama.2016.15826
JAMA Brucato A, Imazio M et. al.

Nov 8th, 2016 - Anakinra, an interleukin 1β recombinant receptor antagonist, may have potential to treat colchicine-resistant and corticosteroid-dependent recurrent pericarditis. To determine the efficacy of anakinra for colchicine-resistant and corticosteroid-dependent recurrent pericarditis. The Anakinra-Treatment of Recurrent Idiopathic Pericarditis (AIRTRIP) double-blind, placebo-controlled, randomized wit...

Association Between Transcatheter Aortic Valve Replacement and Subsequent Infective End...
https://doi.org/10.1001/jama.2016.12347
JAMA Regueiro A, Linke A et. al.

Sep 13th, 2016 - Limited data exist on clinical characteristics and outcomes of patients who had infective endocarditis after undergoing transcatheter aortic valve replacement (TAVR). To determine the associated factors, clinical characteristics, and outcomes of patients who had infective endocarditis after TAVR. The Infectious Endocarditis after TAVR International Registry included patients with definite infec...

Suboptimal Addiction Interventions for Patients Hospitalized with Injection Drug Use-As...
https://doi.org/10.1016/j.amjmed.2015.09.024
The American Journal of Medicine; Rosenthal ES, Karchmer AW et. al.

Nov 25th, 2015 - Infective endocarditis is a serious infection, often resulting from injection drug use. Inpatient treatment regularly focuses on management of infection without attention to the underlying addiction. We aimed to determine the addiction interventions done in patients hospitalized with injection drug use-associated infective endocarditis. This is a retrospective review of patients hospitalized wi...

Predicting Risk of Endocarditis Using a Clinical Tool (PREDICT): Scoring System to Guid...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542912
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Palraj BR, Baddour LM et. al.

Mar 26th, 2015 - Infective endocarditis (IE) is a serious complication of Staphylococcus aureus bacteremia (SAB). There is limited clinical evidence to guide use of echocardiography in the management of SAB cases. Baseline and 12-week follow-up data of all adults hospitalized at our institution with SAB from 2006 to 2011 were reviewed. Clinical predictors of IE were identified using multivariable logistic regre...

Incidence of infective endocarditis in England, 2000-13: a secular trend, interrupted t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599216
Lancet (London, England); Dayer MJ, Jones S et. al.

Dec 3rd, 2014 - Antibiotic prophylaxis given before invasive dental procedures in patients at risk of developing infective endocarditis has historically been the focus of infective endocarditis prevention. Recent changes in antibiotic prophylaxis guidelines in the USA and Europe have substantially reduced the number of patients for whom antibiotic prophylaxis is recommended. In the UK, guidelines from the Nati...

Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infe...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366581
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Chirouze C, Alla F et. al.

Nov 12th, 2014 - The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. Participants were ...

Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis...
https://doi.org/10.1016/S0140-6736(13)62709-9
Lancet (London, England); Imazio M, Belli R et. al.

Apr 3rd, 2014 - Colchicine is effective for the treatment of acute pericarditis and first recurrences. However, conclusive data are lacking for the efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis. We did this multicentre, double-blind trial at four general hospitals in northern Italy. Adult patients with multiple recurrences of pericarditis (≥two) were randomly assigned ...

Antibiotic Prophylaxis for Preventing Infective Endocarditis Clinical Practice Guideline
https://ebd.ada.org/en/evidence/guidelines/infective-endocarditis

Dec 31st, 2007 - The guidelines update the 1997 recommendations by the American Heart Association for the prevention of infective endocarditis. The committee concluded that infective endocarditis prophylaxis for dental procedures should be recommended only for patients with underlying cardiac conditions associated with the highest risk of adverse outcomes from infective endocarditis.

Long-term outcome of patients with non-operated prosthetic valve infective endocarditis...
https://doi.org/10.1093/cid/ciz1177
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America; Lecomte R, Laine JB et. al.

Dec 8th, 2019 - In non-operated prosthetic valve endocarditis (PVE), long term outcome is largely unknown. We report the follow-up of 129 non-operated patients with PVE alive at discharge. At one year, the mortality rate was 24%, relapses and reinfection were rare (5% each). Enterococcal PVE was associated with a higher risk of relapse.

Long-term Outcomes of Injection Drug-related Infective Endocarditis Among People Who In...
https://doi.org/10.1097/ADM.0000000000000572
Journal of Addiction Medicine; Suzuki J, Johnson JA et. al.

Oct 21st, 2019 - Infective endocarditis (IE) among people who inject drugs is associated with high rates of mortality and repeat episodes of endocarditis. We sought to report on longer-term clinical outcomes of patients with IE who were offered buprenorphine or methadone treatment for opioid use disorder (OUD) at their initial hospital admission. Individuals with OUD hospitalized between 2013 and 2015 with IE w...

Bicarbonate Resensitization of Methicillin-Resistant Staphylococcus aureus to β-Lactam ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591647
Antimicrobial Agents and Chemotherapy; Ersoy SC, Abdelhady W et. al.

Apr 23rd, 2019 - Endovascular infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a major health care concern, especially infective endocarditis (IE). Standard antimicrobial susceptibility testing (AST) defines most MRSA strains as "resistant" to β-lactams, often leading to the use of costly and/or toxic treatment regimens. In this investigation, five prototype MRSA strains, representing...

Clinical Outcomes of Infective Endocarditis in Injection Drug Users.
https://doi.org/10.1016/j.jacc.2018.10.082
Journal of the American College of Cardiology; Rudasill SE, Sanaiha Y et. al.

Feb 8th, 2019 - Rising rates of hospitalization for infective endocarditis (IE) have been increasingly tied to rising injection drug use (IDU) associated with the opioid epidemic. This study analyzed recent trends in IDU-IE hospitalization and characterized outcomes and readmissions for IDU-IE patients. The authors evaluated the National Readmissions Database (NRD) for IE cases between January 2010 and Septemb...

Clinical Characteristics and Factors Associated With Mortality in First-Episode Infecti...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324402
JAMA Network Open; Rodger L, Glockler-Lauf SD et. al.

Jan 15th, 2019 - Persons who inject drugs (PWID) represent a distinct demographic of patients with infective endocarditis. Many centers do not perform valvular surgery on these patients owing to concerns about poor outcomes. Addiction services are underused in hospitals. To compare clinical characteristics in first-episode infective endocarditis in PWID who are surgically vs medically managed and to identify va...

Dysregulated IL-1β-GM-CSF Axis in Acute Rheumatic Fever That Is Limited by Hydroxychlor...
https://doi.org/10.1161/CIRCULATIONAHA.118.033891
Circulation Kim ML, Martin WJ et. al.

Dec 20th, 2018 - Acute rheumatic fever (ARF) and rheumatic heart disease are autoimmune consequences of group A streptococcus infection and remain major causes of cardiovascular morbidity and mortality around the world. Improved treatment has been stymied by gaps in understanding key steps in the immunopathogenesis of ARF and rheumatic heart disease. This study aimed to identify (1) effector T cell cytokine(s) ...

Trends in Drug Use-Associated Infective Endocarditis and Heart Valve Surgery, 2007 to 2...
https://doi.org/10.7326/M18-2124
Annals of Internal Medicine; Schranz AJ, Fleischauer A et. al.

Dec 6th, 2018 - Drug use-associated infective endocarditis (DUA-IE) is increasing as a result of the opioid epidemic. Infective endocarditis may require valve surgery, but surgical treatment of DUA-IE has invoked controversy, and the extent of its use is unknown. To examine hospitalization trends for DUA-IE, the proportion of hospitalizations with surgery, patient characteristics, length of stay, and charges. ...