×
About 1,505 results

ALLMedicine™ Alcoholic Hepatitis Center

Research & Reviews  502 results

Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis.
https://doi.org/10.1038/s41467-021-24843-w 10.1016/S0168-8278(01)00289-6 10.1016/S2468-1253(19)30326-7 10.1016/j.jhep.2018.10.023 10.1038/nbt.1685 10.1016/j.jcmgh.2018.09.005 10.1038/nsmb.2470 10.1038/nrg2957 10.1038/nrm3949 10.1073/pnas.1016071107 10.1038/nrg3682 10.1016/j.molcel.2014.08.024 10.1136/gutjnl-2013-306603 10.1038/nri3399 10.1053/j.gastro.2009.01.056 10.1053/j.gastro.2019.03.013 10.1101/gad.183434.111 10.3390/genes6020299 10.1371/journal.pone.0151063 10.1002/hep.30472 10.1152/ajpgi.00031.2015 10.1046/j.1440-1746.2000.02174.x 10.1016/j.molcel.2019.07.028 10.1038/s41586-019-1373-2 10.1371/journal.pone.0095846 10.1016/j.immuni.2018.09.018 10.1038/s41588-018-0298-2 10.15252/embj.2019103949 10.1080/21541264.2017.1372044 10.1016/j.cell.2013.06.044 10.1016/j.bmcl.2012.02.041 10.1038/nature11247 10.1016/j.cell.2014.11.021 10.1038/nature12644 10.1016/j.cell.2016.09.037 10.1038/cr.2016.1 10.1073/pnas.1424028112 10.1101/gad.1998010 10.1038/s41467-017-02055-5 10.1038/nprot.2013.032 10.1189/jlb.0809532 10.1038/s41598-017-09045-z 10.1002/hep.22847 10.1002/cld.168 10.1136/gutjnl-2011-301146 10.1016/j.immuni.2019.08.017 10.1002/hep.27921 10.1038/nature17040 10.1038/s41586-020-2424-4 10.1038/s41467-018-06318-7 10.1016/j.jcmgh.2020.07.012 10.1038/s41588-019-0494-8 10.1126/science.aao2793 10.1126/science.aal2066 10.1093/annonc/mdx157 10.1128/MCB.01365-08 10.1021/acs.jmedchem.0c00035 10.1016/j.chembiol.2014.05.009 10.1038/onc.2013.179 10.1038/s41598-018-35653-4 10.1016/j.jhep.2018.10.026
Nature Communications; Liu M, Cao S et. al.

Jul 29th, 2021 - Alcoholic hepatitis (AH) is associated with liver neutrophil infiltration through activated cytokine pathways leading to elevated chemokine expression. Super-enhancers are expansive regulatory elements driving augmented gene expression. Here, we e...

Diagnosis and Treatment of Alcohol-Associated Liver Disease: A Review.
https://doi.org/10.1001/jama.2021.7683
JAMA Singal AK, Mathurin P

Jul 14th, 2021 - Alcohol-associated liver disease results in cirrhosis in approximately 10% to 20% of patients. In 2017, more than 2 million people had alcohol-associated cirrhosis in the US. Alcohol-associated liver disease is the primary cause of liver-related m...

Genetic and Environmental Susceptibility to Alcoholic Hepatitis.
https://doi.org/10.1016/j.cld.2021.04.001
Clinics in Liver Disease; Morgan MY, Sharma M et. al.

Jul 8th, 2021 - Constitutional, environmental, and genetic risk factors influence the development of alcohol-related cirrhosis. The amount of alcohol consumed and whether excessive drinking continues after the identification of pre-cirrhotic liver damage are key ...

Assessing the Severity and Prognosis of Alcoholic Hepatitis.
https://doi.org/10.1016/j.cld.2021.03.004
Clinics in Liver Disease; Mitra A, Myers L et. al.

Jul 8th, 2021 - Acute alcoholic hepatitis is a clinical entity with significant consequences. Those with severe disease can have high short-term mortality, and considerations for liver transplant candidacy may be raised. Estimating prognosis and mortality is of t...

Moderate Alcoholic Hepatitis.
https://doi.org/10.1016/j.cld.2021.03.001
Clinics in Liver Disease; Clemente-Sánchez A, Oliveira-Mello A et. al.

Jul 8th, 2021 - The natural history of moderate alcoholic hepatitis (AH) is not well known. It is a frequent disease with a probable underestimated incidence compared with its severe form. Among the different prognostic scores predicting short-term mortality in A...

see more →

Guidelines  3 results

ACG Clinical Guideline: Alcoholic Liver Disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524956
The American Journal of Gastroenterology; Singal AK, Bataller R et. al.

Jan 18th, 2018 - Alcoholic liver disease (ALD) comprises a clinical-histologic spectrum including fatty liver, alcoholic hepatitis (AH), and cirrhosis with its complications. Most patients are diagnosed at advanced stages and data on the prevalence and profile of ...

Medical Management of Severe Alcoholic Hepatitis: Expert Review from the Clinical Practice Updates Committee of the AGA Institute
https://www.cghjournal.org/article/S1542-3565(16)30798-4/fulltext?code=yjcgh-site

Apr 17th, 2017 - The purpose of this clinical practice update is to review diagnostic criteria for severe acute alcoholic hepatitis and to determine the current best practices for this life-threatening condition. The best practices in this review are based on clin...

Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alco...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287362
Gastroenterology Crabb DW, Bataller R et. al.

Feb 28th, 2016 - Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia.|2016|Crabb DW,Bataller R,Chalasani NP,Kamath PS,Lucey M,|classification,standards,...

see more →

Clinicaltrials.gov  30 results

Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial
https://clinicaltrials.gov/ct2/show/NCT02473341

Feb 13th, 2020 - Diagnosis: The diagnosis of Alcoholic hepatitis is made by the following criteria (12) I. Chronic active alcohol abuse - >80 grams in males and > 60 grams in females for > 5 years for developing Alcoholic Cirrhosis (13) Alcohol use will be evaluat...

Pentoxyphilline Versus Fecal Microbiota Therapy in Severe Alcoholic Hepatitis
https://clinicaltrials.gov/ct2/show/NCT02458079

Aug 15th, 2019 - Treatment for severe alcoholic hepatitis patients not eligible for steroid therapy is a dilemma. Pentoxyfilline has been shown to have no improvement in outcomes as per current studies and liver transplantation is with great risk of recidivism in ...

The HepQuant SHUNT Test for Monitoring Liver Disease and Treatment Effects by Measuring Liver Function and Physiology
https://clinicaltrials.gov/ct2/show/NCT03294941

Aug 12th, 2019 - The HepQuant study is to run parallel to the Gilead clinical trials,GS-US-416-2124 trial of Alcoholic Hepatitis, GS-US-384-1943 trial of non-alcoholic steatohepatitis (NASH) fibrosis Stage 3 (STELLAR-3), and, GS-US-384-1944 trial of NASH and compe...

Evaluating Alcohol Use in Alcoholic Liver Disease
https://clinicaltrials.gov/ct2/show/NCT03267069

Mar 13th, 2019 - This is a longitudinal observational study. Subjects with a diagnosis of alcoholic liver disease (acute alcoholic hepatitis or alcoholic cirrhosis) who present to Weill Cornell Medical Center or Columbia University Medical Center New York Presbyte...

Efficacy and Safety of Orally Administered DS102 in Patients With Acute Alcoholic Hepatitis
https://clinicaltrials.gov/ct2/show/NCT03452540

Nov 1st, 2018 - The purpose of this randomised, double-blind, placebo-controlled, phase II study is to assess the efficacy and safety of orally administered DS102 in patients with acute decompensated alcoholic hepatitis

see more →

News  64 results

Rising number of young people dying after heavy drinking
https://www.mdedge.com/internalmedicine/article/218018/addiction-medicine/rising-number-young-people-dying-after-heavy?channel=39313
Marcia Frellick

Feb 27th, 2020 - MAUI, HAWAII – Alcohol use and deaths related to alcohol-use disorders are increasing, and young adults might be the group to watch, said Norah Terrault, MD, MPH, professor at the Keck School of Medicine of USC in Los Angeles. “A lot of young peop.

Rising Number of Young People Dying After Heavy Drinking
https://www.medscape.com/viewarticle/925377

Feb 18th, 2020 - MAUI, Hawaii — Alcohol use and deaths related to alcohol-use disorders are increasing, and young adults might be the group to watch, said Norah Terrault, MD, MPH, professor at the Keck School of Medicine of USC in Los Angeles. "A lot of young peop...

Serum keratin 18 promising as AAH biomarker
https://www.mdedge.com/gihepnews/article/216383/hepatology/serum-keratin-18-promising-aah-biomarker?channel=346
M. Alexander Otto, MDedge News

Jan 29th, 2020 - Serum keratin 18, an epithelial protein released from dying hepatocytes, identifies patients with severe acute alcoholic hepatitis (AAH) at high risk for death, according to an investigation of 173 subjects. Standard biomarker scores – Model for E.

5 Liver-Saving Strategies for the New Year
https://www.medscape.com/viewarticle/922790_2

Dec 23rd, 2019 - 4. Adopt a Mediterranean diet. The Mediterranean diet is rich in plant-based foods, such as whole grains, seeds, nuts, legumes, fruits, and vegetables, and calls for moderate consumption of lean proteins, such as seafood and poultry, and avoidance...

5 Liver-Saving Strategies for the New Year
https://www.staging.medscape.com/viewarticle/922790_2

Dec 23rd, 2019 - 4. Adopt a Mediterranean diet. The Mediterranean diet is rich in plant-based foods, such as whole grains, seeds, nuts, legumes, fruits, and vegetables, and calls for moderate consumption of lean proteins, such as seafood and poultry, and avoidance...

see more →

Patient Education  3 results see all →