About 1,204 results
Sodium–Glucose Cotransporter-2 Inhibitors and the Risk for Severe Urinary Tract Infections: A Population-Based Cohort Study
Annals of Internal Medicine;

Jul 29th, 2019 - Background: Prior studies evaluating risk for severe urinary tract infections (UTIs) with sodium–glucose cotransporter-2 (SGLT-2) inhibitors have reported conflicting findings. Objective: To assess whether patients initiating use of SGLT-2 inhibitors were at increased risk for severe UTI events compared with those initiating use of dipeptidyl peptidase-4 (DPP-4) inhibitors or glucagon-like...

FDA Approves Merck’s RECARBRIO™ (imipenem, cilastatin, and relebactam) For the Treatment of Adults with Complicated Urinary Tract and Complicated Intra-Abdominal Bacterial Infections Where Limited ...

Jul 16th, 2019 - Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved RECARBRIO™ (imipenem, cilastatin, and relebactam) for injection, 1.25 grams, a new combination antibacterial. RECARBRIO is indicated in patients 18 years of age and older who have limited or no alternative treatment options, for the treatment of comp...

Doxycycline: Uses, Side Effects & Dosage Guide - Drugs.com

Jun 30th, 2019 - Doxycycline is an antibiotic used to treat bacterial infections like urinary tract infections, acne and chlamydia. Includes side effects, interactions and indications.

Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline

Apr 30th, 2019 - Over the past few decades, our ability to diagnose, treat, and manage recurrent urinary tract infection (rUTI) long-term has evolved due to additional insights into the pathophysiology of rUTI, a new appreciation for the adverse effects of repetitive antimicrobial therapy (“collateral damage”), rising rates of bacterial antimicrobial resistance, and better reporting of the natural history and c...

Cephalexin Uses, Side Effects & Dosage Guide - Drugs.com

Dec 11th, 2018 - Cephalexin treats infections caused by bacteria, including ear infections, skin infections, and urinary tract infections. Includes cephalexin side effects interactions and indications.

Circumcision Policy Statement

Aug 30th, 2012 - Male circumcision is a common procedure, generally performed during the newborn period in the United States. In 2007, the American Academy of Pediatrics (AAP) formed a multidisciplinary task force of AAP members and other stakeholders to evaluate the recent evidence on male circumcision and update the Academy’s 1999 recommendations in this area. Evaluation of current evidence indicates that the...

Intervention improves antibiotics use in UTIs
Heidi Splete

Mar 3rd, 2020 - A multifaceted intervention significantly changed clinicians’ use of antibiotics to treat urinary tract infections (UTIs) in children, according to data from more than 2,000 cases observed between January 2014 and September 2018. “Changing clinicians’ antibiotic prescribing practices can be challenging; barriers to change include lack of awareness of new evidence, competing clinical demands, an.

Fever, abdominal pain, and adnexal mass
MDedge Family Medicine;

Mar 2nd, 2020 - Our patient underwent diagnostic laparoscopy, hysterectomy, left salpingo-­oophorectomy, and right salpingectomy (with her right ovary left in place due to her perimenopausal status). Intraoperatively, she was found to have cervical stenosis.

Maculopathy Common With Long-Term Pentosan Polysulfate Therapy

Jan 28th, 2020 - NEW YORK (Reuters Health) - Long-term use of pentosan polysulfate sodium, the only oral medicine approved for interstitial cystitis, is associated with development of a unique pigmentary maculopathy, researchers report. "All patients who take Elmiron (pentosan polysulfate) should be seen by a retina specialist," Dr. Robin A. Vora, an ophthalmologist with Kaiser Permanente Northern California (K...

Long-Term Pentosan Polysulfate Sodium Use Tied to Macular Disease

Nov 19th, 2019 - NEW YORK (Reuters Health) - Use of the interstitial cystitis drug pentosan polysulfate sodium (PPS) was associated with a new diagnosis of macular disease at the seven-year follow-up in a large retrospective matched cohort study. "This study adds to a growing body of literature linking PPS exposure with a vision-threatening retinal disorder," Dr. Nieraj Jain of Emory Eye Center in Atlanta told ...

FDA approves cefiderocol for multidrug-resistant, complicated urinary tract infections
Mark S. Lesney

Nov 15th, 2019 - The Food and Drug Administration announced that it has approved cefiderocol (Fetroja), an IV antibacterial drug to treat complicated urinary tract infections (cUTIs), including kidney infections, caused by multidrug-resistant gram-negative microorganisms in patients 18 years of age or older. The safety and effectiveness of cefiderocol was demonstrated in a pivotal study of 448 patients with cUT.

FDA OKs New Antibacterial Cefiderocol (Fetroja) for Complicated UTI

Nov 14th, 2019 - The US Food and Drug Administration (FDA) has approved the antibacterial drug cefiderocol (Fetroja, Shionogi & Co) for complicated urinary tract infections (cUTI), including kidney infections, caused by susceptible Gram-negative microorganisms in patients age 18 years or older with few or no alternative treatment options. Cefiderocol is a cephalosporin antibiotic with a novel mechanism for pene...

STI update: Testing, treatment, and emerging threats

Nov 1st, 2019 - M GENITALIUM IS EMERGING A member of the Mycoplasmataceae family, M genitalium was originally identified as a pathogen in the early 1980s but has only recently emerged as an important cause of STI. Studies indicate that it is responsible for 10% to 20% of cases of nongonococcal urethritis and 10% to 30% of cases of cervicitis.

GlaxoSmithKline Starts Late-Stage Trials for Experimental Antibiotic

Oct 29th, 2019 - By Reuters Staff (Reuters) - GlaxoSmithKline Plc said on Monday it has begun two late-stage studies testing its experimental antibiotic in patients with uncomplicated urinary tract infections or gonorrhea. The antibiotic, gepotidacin, is the first of a new class of drugs and is expected to treat two common bacterial infections that have been identified as antibiotic-resistant threats by U.S. he...

GlaxoSmithKline starts late-stage trial for experimental antibiotic

Oct 28th, 2019 - FILE PHOTO: The GlaxoSmithKline (GSK) logo is seen on top of GSK Asia House in Singapore, March 21, 2018. REUTERS/Loriene Perera/File Photo (Reuters) - GlaxoSmithKline Plc said on Monday it has begun a late-stage study testing its experimental antibiotic in patients with urinary tract infections and gonorrhoea, a type of sexually transmitted infection. The antibiotic, gepotidacin, is the first ...

More Evidence Links Common Bladder Drug to Retinal Damage

Oct 21st, 2019 - NEW YORK (Reuters Health) - Pentosan polysulfate sodium (PPS), used widely for interstitial cystitis, may lead to retinal damage, according to a new study that adds weight to this previously suggested link. Interstitial cystitis causes chronic bladder and pelvis pain and more than 1 million people in the United States, mostly women, are estimated to suffer from it. PPS is the only drug approved...

FDA Panel Recommends Cefiderocol for Complicated UTI

Oct 16th, 2019 - The US Food and Drug Administration's (FDA's) Antimicrobial Drugs Advisory Committee on Wednesday voted 14–2 to recommend approval of cefiderocol lyophilized powder for intravenous administration for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis caused by gram-negative bacteria in patients with few or no alternative treatment options. "I think the data ...

FDA Panel: Thumbs Up for Cefiderocol in Urinary Tract Infections

Oct 16th, 2019 - SILVER SPRING, Md. -- An FDA advisory panel voted 14-2 to recommend approval for cefiderocol, a novel antibiotic for complicated urinary tract infections (cUTI), including pyelonephritis, in patients with limited or no other treatment options. While members of the FDA's Antimicrobial Drugs Advisory Committee were mostly impressed by the data submitted for the drug, they raised concern about a m...

Cefiderocol for Urinary Infections Set for FDA Advisory Review

Oct 15th, 2019 - Cefiderocol, a new antibiotic, appeared effective and generally safe for treatment of complicated urinary tract infections (cUTI) including pyelonephritis in patients with limited treatment options, FDA staff indicated in briefing documents ahead of an advisory committee meeting scheduled for Wednesday. However, questions remained about its use in critically ill patients with carbapenem-resista...

Delaying revision knee replacement increases the odds of infection
Steve Cimino

Sep 26th, 2019 - According to a study on patients undergoing revision knee replacement, a delay of more than 24 hours between hospital admission and total knee arthroplasty (TKA) for periprosthetic fracture (PPF) led to increased odds of complications such as surgical site and urinary tract infections. gorodenkoff/iStock/Getty Images “Although this association is an important finding, the confounding factors th.

Long-Term Pentosan Polysulfate Sodium Use Associated With Vision-Threatening Maculopathy

Sep 16th, 2019 - NEW YORK (Reuters Health) - Long-term use of the interstitial cystitis drug pentosan polysulfate sodium (PPS) is associated with a vision-threatening pigmentary maculopathy, a case series suggests. "What's concerning is that this drug has been on the U.S. market for over two decades," Dr. Naraj Jain of Emory University School of Medicine in Atlanta told Reuters Health. "There are likely many ot...

Short-term parenteral antibiotics effective for bacteremic UTI in young infants
MDedge Pediatrics; Lucas Franki

Aug 20th, 2019 - Infants with bacteremic urinary tract infections on short-term versus long-term parenteral antibiotics before oral antibiotics had similar outcomes, according to a study. AndyL/iStock/Getty Images Plus While previous studies have shown short-term parenteral antibiotic therapy to be safe and equally effective in uncomplicated urinary tract infections (UTIs), short-term therapy safety in bacterem.

Antibiotics for UTIs: Recipe for Resistance Down the Road?

Aug 13th, 2019 - British patients diagnosed with urinary tract infections (UTIs) rarely had any testing performed before receiving antibiotics, a records analysis indicated. Almost 86% of patients received antibiotics for a UTI on the day they were diagnosed, and 83% of those had no evidence of collecting a urine sample for microbiological testing, reported Mar Pujades-Rodriguez, MD, of the University of Leeds ...

In newborns, concentrated urine helps rule out UTI
M. Alexander Otto

Aug 8th, 2019 - SEATTLE – The more concentrated urine is in newborns, the more you can trust negative nitrite tests to rule out urinary tract infections, according to investigators at the University of Texas Health Science Center, Houston. M.

More Febrile UTIs in Kids Tied to More Renal Scarring

Aug 5th, 2019 - One-quarter of children who had two or more febrile urinary tract infections (UTIs) had renal scarring years later, researchers found, although long-term clinical impacts remain uncertain. A post-hoc analysis of two prospective studies found that 25.7% (95% CI 12.5%-43.3%) of children with two febrile UTIs and 28.6% (95% CI 8.4%-58.1%) of children with three or more had evidence of renal scarri...

SGLT-2 Inhibitors May Not Raise UTI Risk, After All

Jul 30th, 2019 - SGLT-2 inhibitors were not associated with increased risk for severe urinary tract infections (UTI) versus other classes of antidiabetic therapies, according to a population-based cohort study. Compared with patients with type 2 diabetes initiating use of a DPP-4 inhibitor, new initiation of an SGLT-2 inhibitor didn't carry a increased risk for a severe UTI (hazard ratio 0.98, 95% CI 0.68-1.41)...

No increase in UTI risk with SGLT-2 inhibitors
Bianca Nogrady

Jul 29th, 2019 - Sodium-glucose cotransporter 2 inhibitors do not appear to increase the risk of urinary tract infections, compared with other antidiabetic medications, new research has found. In a paper published in Annals of Internal Medicine, researchers reported the outcomes of a population-based, propensity-matched cohort study in which the analyzed data from 235,730 individuals newly prescribed sodium-glu.

'Reassuring': New Type 2 Diabetes Drugs Not Linked to UTIs

Jul 28th, 2019 - Use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors for the treatment of type 2 diabetes does not appear to increase the risk for urinary tract infections (UTIs) compared with two other new classes of type 2 diabetes agents, results from of a large population-based study indicate. While SGLT-2 inhibitors have consistently been shown to increase the risk for genital infections (predominant...

Fast Five Quiz: Urinary Tract Infection

Jul 22nd, 2019 - Urinary tract infection (UTI) is typically defined as significant bacteriuria in the setting of symptoms of cystitis or pyelonephritis. Cystitis (bladder infection) accounts for most cases. UTIs are exceedingly common in women worldwide, accounting for more than 10 million patient visits to physicians per year in the United States alone. The incidence in men approaches that of women only in men...

FDA approves Recarbrio for cUTI, cIAI treatment in adults
Lucas Franki

Jul 17th, 2019 - The Food and Drug Administration has approved Recarbrio for the treatment of complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) in adults. Recarbrio is a three-drug combo injection containing imipenem/cilastatin, an antibiotic previously approved by the FDA, and relebactam, a beta-lactamase inhibitor.

Merck's treatment for urinary, abdominal infections gets FDA approval

Jul 17th, 2019 - (Reuters) - The U.S. Food and Drug Administration has approved Merck & Co Inc’s combination treatment for complicated forms of urinary tract and abdominal infections, the drugmaker said on Wednesday. FILE PHOTO: The Merck logo is seen at a gate to the Merck & Co campus in Linden, New Jersey, U.S., July 12, 2018. REUTERS/Brendan McDermid Recarbrio, approved for patients over 18 years of age, is ...

Urinary Tract Infection in Women Clinical Practice Guidelines (2019)

Jun 2nd, 2019 - Clinical guidelines on urinary tract infection in women were released in May 2019 by the American Urological Association (AUA), Canadian Urological Association (CUA), and the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU).[1] The American Urological Association (AUA) has issued its first guideline for the diagnosis and treatment of uncomplicated recurrent urin...

Dual Antibiotic Zerbaxa Gets FDA Nod for Bacterial Pneumonia

Jun 2nd, 2019 - The US Food and Drug Administration (FDA) has approved a new indication for the antibacterial Zerbaxa (Merck) for the treatment of hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP) in adults 18 years and older. Zerbaxa combines the cephalosporin ceftolozane and the beta-lactamase inhibitor tazobactam, and was initially approved in 2014 for complicat...

AUA Releases First Uncomplicated Recurrent UTI Guideline

May 6th, 2019 - CHICAGO — For the first time, the American Urological Association (AUA) has issued a guideline for the diagnosis and treatment of uncomplicated recurrent urinary tract infections (UTIs), which emphasizes the importance of cultures and antibiotic stewardship. "We really felt as a panel that cultures were quite central to the care, abatement, and treatment of recurrent urinary tract infections," ...

Pelvic Inflammatory Disease Clinical Practice Guidelines (2019)

May 6th, 2019 - Clinical guidelines on pelvic inflammatory disease were released in March 2019 by the Collège National des Gynécologues et Obstétriciens Français (CNGOF) and Société de Pathologie Infectieuse de Langue Française (SPILF).[1,2,3] Diagnosis of Pelvic Inflammatory Disease Positive diagnosis of pelvic inflammatory disease (PID) is based on adnexal pain or tenderness upon cervical motion, reinforced ...

Long-Term Abx May Decrease Risk of Repeat UTI in Kids

May 1st, 2019 - There may be a small benefit of long-term antibiotics in children with urinary tract infections (UTIs), a Cochrane review found. When combining only the studies with concealed treatment allocation, there was a decrease in risk of repeat infection compared with no treatment or placebo (RR 0.68, 95% CI 0.48-0.95), reported Gabrielle Williams, MD, and Jonathan C. Craig, MD, both of the Children's ...

FDA declines to approve Nabriva's antibiotic for urinary tract infections

Apr 30th, 2019 - (Reuters) - The U.S. Food and Drug Administration on Tuesday declined to approve Nabriva Therapeutics Plc’s antibiotic for complicated urinary tract infections (cUTI), even as the nation grapples with the growing problem of antibiotic resistance. The FDA has asked Nabriva to address issues relating to manufacturing deficiencies at one of its contract manufacturers, before the agency can approve...

Pentosan Polysulfate Sodium Treatment Strongly Linked With Maculopathy and Vision Loss

Apr 30th, 2019 - NEW YORK (Reuters Health) - Patients taking pentosan polysulfate sodium (PPS), which has been on the market for many years, appear to be at greater risk for a newly described maculopathy and vision loss, researchers report. "Exposure to PPS, the only FDA-approved oral medication for interstitial cystitis (IC), is strongly linked to a newly described, vision-threatening retinal condition. . . . ...

Antibiotic delay is deadly in elderly patients with UTI

Mar 4th, 2019 - Delaying antibiotics in elderly patients with urinary tract infections is linked to higher sepsis, death rates. A pilot study of smartphone-based visual tests shows promise in multiple sclerosis.

Prompt UTI Antibiotics Cut Mortality, Sepsis Risk in Older Adults

Feb 28th, 2019 - Patients older than 65 years who have urinary tract infections (UTIs) are at increased risk for sepsis and death within 60 days from UTI if not treated with immediate antibiotic therapy. Those older than 85 are at particularly high risk if antibiotics are deferred or are not prescribed, researchers Myriam Gharbi, PharmD, MPH, PhD, and colleagues report in an article published online February 27...

Fluoroquinolone Prescriptions Common at Discharge

Feb 20th, 2019 - Antibiotic stewardship interventions to limit fluoroquinolone prescribing among inpatients do not reduce the prescribing of fluoroquinolones at discharge, according to a "real-world snapshot" of the situation. Overall, one third of patients with pneumonia or urinary tract infections (UTIs) received such prescriptions at discharge. There was no difference in fluoroquinolone prescribing rates bet...

Plazomicin Tx Non-Inferior to Meropenem for Complicated UTI

Feb 20th, 2019 - Intravenous plazomicin was non-inferior to meropenem for the treatment of complicated urinary tract infections (UTIs), including acute pyelonephritis, a randomized trial found. Composite cure was achieved in 88.0% of patients in the plazomicin group compared to 91.4% of those in the meropenem group (difference -3.4, 95% CI -10.0 to 3.1) on day 5, reported Florian M.E. Wagenlehner, MD, of Justus...

Risky Antibiotics Still Widely Prescribed at Hospital Discharge

Feb 13th, 2019 - Hospital-based stewardship programs designed to reduce the rate of Clostridium difficile infections and antibiotic-related adverse events were associated with reduced use of fluoroquinolone antibiotics during hospitalization, but not at hospital discharge, researchers reported. In a study involving 48 Michigan hospitals, including 46 with antibiotic stewardship programs, one in three patients h...

Jury Still Out on Fecal Transplants for Obesity

Feb 5th, 2019 - Could fecal microbiota transplantation (FMT), whereby medical-processed stool material from a healthy donor is introduced into the intestine of a patient with obesity, be one of the answers to tackling this disease? That is the belief of several groups of researchers who are currently studying the potential of this novel approach. Fecal transplants have initially proven successful in tackling l...

FDA permits marketing of first M. genitalium diagnostic test
Lucas Franki

Jan 28th, 2019 - The Food and Drug Administration has permitted marketing of the Aptima Mycoplasma genitalium assay, the first test for the diagnoses of sexually transmitted infections (STIs) caused by the M. genitalium bacterium, the agency reported in a press release.

Five-day fever • elevated creatinine levels • kidney transplant 10 months prior • Dx?
MDedge Family Medicine;

Jan 24th, 2019 - Computed tomography (CT) of the abdomen and pelvis without contrast evaluating for a perinephric or renal abscess was negative. Antibiotic coverage was broadened to meropenem 1 g every 8 hours and vancomycin 1500 mg once, with levels to follow.

FDA Clears First Diagnostic Test for Mycoplasma genitalium

Jan 23rd, 2019 - The US Food and Drug Administration (FDA) has approved the Aptima Mycoplasma genitalium Assay from Hologic Inc, the first and only FDA-approved test to aid in the diagnosis of this sexually transmitted infection. M genitalium is a common cause of nongonococcal urethritis in men and cervicitis and pelvic inflammatory disease in women. These slow-growing bacteria are difficult to detect with trad...

Emphysematous cystitis
Waiel Abusnina, MD, Mena Shehata, MD et. al.

Jan 3rd, 2019 - A 59-year-old woman with a history of chronic kidney disease and atonic bladder was brought to the hospital by emergency medical services. She had fallen in her home 2 days earlier and remained on the floor until neighbors eventually heard her cries and called 911.

Treating Asymptomatic Bacteriuria Before Non-urology Surgery Unlikely to Improve Outcomes

Dec 20th, 2018 - NEW YORK (Reuters Health) - Preoperative screening for and treatment of asymptomatic bacteriuria (ASB) is not associated with a decrease in surgical site or urinary tract infections, researchers say. "This large study demonstrates that routine screening of urine for bacteria prior to major surgical procedures does not help patients who do not have symptoms of a urinary tract infection," said Dr...

Laparoscope doubles as cystoscope in robotic hysterectomy
M. Alexander Otto

Dec 3rd, 2018 - LAS VEGAS – It’s fine to take a peek inside the bladder with the laparoscope after robotic hysterectomy; there’s no need for a separate cystoscopy setup to check for injuries, according to a review from St. Joseph’s University Medical Center, in Paterson, N.

Health Care–Associated Urinary Tract Infections: Prevention and Management

Nov 1st, 2018 - Growth of S. aureus in the urine should prompt further investigation with blood cultures to explore the possibility of hematogenous dissemination to the urinary tract.

CDC: Healthcare-Associated Infections Down at U.S. Hospitals

Oct 31st, 2018 - Action Points Healthcare-related infections have declined significantly in U.S hospitals in recent years, largely due to reductions in surgical site and urinary tract infections (UTIs). Note that the prevalence of healthcare-related pneumonia and Clostridium difficile (C. difficile) did not decline significantly during the period studied. Healthcare-related infections declined significantly in ...

Healthcare-Associated Infections Down, Survey Finds

Oct 30th, 2018 - Healthcare-associated infections (HAIs) fell by 16% between 2011 and 2015, according to a point-prevalence survey. In 2011, 4% of inpatients in US hospitals developed HAIs compared with 3.2% in 2015. "These results provide evidence of national success in preventing healthcare-associated infections, particularly surgical-site and urinary tract infections," the researchers write. "In contrast, th...

Three-drug combo proves effective against multidrug-resistant UTIs
Infectious Disease Practitioner; Jim Kling

Oct 29th, 2018 - SAN FRANCISCO – A combination of ceftriaxone, a beta-lactamase inhibitor, and disodium ethylenediaminetetraacetic acid (EDTA) is superior to meropenem in the treatment of complicated urinary tract infections caused by extended-spectrum beta-lactamase (ESBL) gram-negative bacteria, according to a new study. Jim Kling/MDedge News Dr.

Investigational Antibiotic Comparable to Current Tx for cUTI

Oct 26th, 2018 - The investigational antibiotic cefiderocol was safe and non-inferior to the current standard-of-care antibiotic for patients with complicated urinary tract infections, a randomized phase II trial found. Of the patients randomized to receive cefiderocol, 73% achieved the primary efficacy endpoint compared with 55% of those in the group receiving imipenem-cilastatin (adjusted treatment difference...

Age, insurance type tied to delay in pediatric febrile UTI treatment
Christopher Palmer

Oct 23rd, 2018 - Both age and type of insurance are significantly associated with greater delays in treatment of febrile urinary tract infections (UTIs), even after adjustment for confounders, according to a report in the Journal of Pediatrics. Zizulhalmi/Thinkstock Stephanie W.

Upping Water Intake Reduces Recurrent UTIs in Women

Oct 5th, 2018 - Action Points Increasing fluid intake by 1.5 L/day of water significantly decreased the number of episodes of recurrent cystitis in women with three or more infections in the previous year, a randomized, open-label study found. Compared with controls who did not increase fluid intake, those who drank 1.5 L/day of water also had fewer antimicrobial regimens and longer time to recurrent urinary t...

Upping Water Intake Reduces Recurrent UTIs in Women

Oct 5th, 2018 - Action Points Increasing fluid intake by 1.5 L/day of water significantly decreased the number of episodes of recurrent cystitis in women with three or more infections in the previous year, a randomized, open-label study found. Compared with controls who did not increase fluid intake, those who drank 1.5 L/day of water also had fewer antimicrobial regimens and longer time to recurrent urinary t...

Drinking More Water Can Curb Recurrent UTIs

Oct 1st, 2018 - (Reuters Health) - A new experiment offers fresh evidence that drinking more water each day can make urinary tract infections (UTIs) less frequent. For a randomized trial, researchers enrolled 140 women with recurrent UTIs who typically drank fewer than 1.5 L of fluid per day. For 12 months, researchers asked half of these women to continue their usual fluid intake and asked the other half to d...

Women who drink more water get fewer UTIs

Oct 1st, 2018 - (Reuters Health) - Women who drink extra water to avoid urinary tract infections (UTIs) may be on to something. A new experiment offers fresh evidence that drinking more water each day can make UTIs less frequent. FILE PHOTO: A woman drinks from a water bottle in Portland, Oregon May 23, 2014. REUTERS/Steve Dipaola/File Photo For the study, researchers focused on 140 women with recurrent UTIs w...

FDA Drug Safety Communication: FDA advises restricting fluoroquinolone antibiotic use for certain uncomplicated infections; warns about disabling side effects that can occur together

[ 05-12-2016 ] The U.S. Food and Drug Administration is advising that the serious side effects associated with fluoroquinolone antibacterial drugs generally outweigh the benefits for patients with acute sinusitis, acute bronchitis, and uncomplicated urinary tract infections who have other treatment options. For patients with these conditions, fluoroquinolones should be reserved for those who do...

New Antibiotics for Europe: CHMP Likes Vabomere, EC Clears Xerava

Sep 20th, 2018 - The European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended approval of the antibiotic Vabomere (Rempex London) to treat various infections in adults. Vabomere combines the carbapenem antibacterial meropenem with vaborbactam, which inhibits certain types of bacterial resistance mechanisms. CHMP recommended Vabomere for treatment of complicated int...

D-Mannose for Urinary Tract Infections

Aug 27th, 2018 - Question Can taking D-mannose supplements treat or prevent urinary tract infections? Response from Philip J. Gregory, PharmD Drug Information Consultant D-mannose, one of the hottest dietary supplements promoted for urinary tract infections (UTIs), is an ingredient in nearly 200 dietary supplement products.[1] While many products contain only D-mannose, several are combined with other ingredien...

Short-course IV antibiotics okay for newborn bacteremic UTI
M. Alexander Otto

Jul 27th, 2018 - ATLANTA – A short course of IV antibiotics – 7 days or less – is fine for most infants with uncomplicated bacteremic urinary tract infections, according to a review of 116 children younger than 60 days. How long to treat bacteremic UTIs in the very young has been debated in pediatrics for a while, with some centers opting for a few days and others for 2 weeks or more.

Multidrug-Resistant Infections: What's on the Horizon?

Jul 17th, 2018 - Ceftazidime-Avibactam Resistance Ceftazidime-avibactam is approved by the US Food and Drug Administration (FDA) for the treatment of complicated intra-abdominal and urinary tract infections, and has activity against carbapenem-resistant Enterobacteriaceae (CRE). Data from the real-world application of this agent, and potential pitfalls, are still emerging. Two recent articles[1,2] illustrate ex...

What's the Verdict for UTIs in Women and Children?

Jul 11th, 2018 - Antibiotic Choice in Urinary Tract Infection Urinary tract infections (UTIs) pose a high burden to the health of women and children, incurring significant challenges in treatment and diagnosis, respectively. Two recent studies[1,2] compared recommended treatments for acute uncomplicated cystitis in women and propose a new diagnostic algorithm to estimate the probability of UTIs in febrile child...

Aquinox to stop development of lead drug; shares plunge

Jun 27th, 2018 - (Reuters) - Aquinox Pharmaceuticals Inc said on Wednesday it planned to stop developing its main drug to treat bladder pain syndrome as it failed to meet the main goal of a late-stage trial, pushing its shares down as much as 85 percent. “We will be undertaking a thorough evaluation of our pipeline and other strategic options available to the company,” Chief Executive Officer David Main said in...

A closer look at the BK polyomavirus
HT Staff

May 28th, 2018 - Photo credit: University of Leeds Structure of the BK polyomavirus A detailed image at near-atomic levels of the BK polyomavirus (BKV), which affects kidney and bone marrow transplant patients, is now available for the first time. This molecular-level structural visualization could allow scientists to study potential targets for antiviral therapies or drugs.

Morning Break: Killer Lettuce; One Thumb Up for Plazomicin; Lifesaving Wearable

May 3rd, 2018 - Note that some links may require subscriptions. One person has died in the E. coli outbreak that has been traced to romaine lettuce grown in Yuma, Ariz. (Los Angeles Times) Plazomicin, a novel IV antibiotic, won an FDA advisory committee's backing for treating complicated urinary tract infections, but the panel thumbed its nose at a proposed indication for bloodstream infections and certain hea...

FDA Panel Recommends Plazomicin for cUTI but Not BSI

May 2nd, 2018 - The US Food and Drug Administration's (FDA's) Antimicrobial Drugs Advisory Committee yesterday recommended plazomicin (Achaogen Inc) for complicated urinary tract infections (cUTIs) but not for bloodstream infections (BSIs) in adults with limited or no treatment options. The panel overwhelmingly recommended (15 "yes" and 1 "no vote") plazomicin for adults with "cUTIs, including pyelonephritis, ...

Little Enthusiasm at FDA for Novel IV Antibiotic

May 1st, 2018 - WASHINGTON -- A novel aminoglycoside antibiotic called plazomicin got a tepid reaction from FDA staff in advance of an advisory committee meeting Wednesday, with a briefing document pointing to safety signals and no clear evidence that the agent is better than existing antibiotics. The agency's Antimicrobial Drugs Advisory Committee will evaluate plazomicin for two indications: Complicated urin...

VIDEO: Meta-analysis: Mortality, safety data may favor SGLT2 inhibitors in T2DM
Clinical Endocrinology News;

Apr 17th, 2018 - Safety outcomes analysis showed that GLP-1 agonists, compared with SGLT2 inhibitors and DPP-4 inhibitors, had a higher risk of adverse events that led patients to withdraw from the study. The DPP-4 inhibitors were associated with increased acute pancreatitis risk, according to the safety analysis.

Evaluation and Management of Female Sexual Dysfunction

Apr 4th, 2018 - Don’t overlook physical therapy Manual therapies, including the transvaginal technique, are used for FSD that results from a variety of causes, including high-tone pelvic floor dysfunction. The transvaginal technique can identify myofascial pain; treatment involves internal release of the PFMs and external trigger-point identification and alleviation.

Prior Chlamydia Infection and Doubled Risk for Ovarian Cancer

Mar 19th, 2018 - In two independent populations, prior infection with Chlamydia appeared to double the risk for ovarian cancer, according to data presented at a presscast in advance of the American Association for Cancer Research (AACR) 2018 Annual Meeting. Presenter Britton Trabert, PhD, Earl Stadtman Investigator in the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, explained t...

Chlamydia infections associated with more than a doubling of ovarian cancer risk
Oncology Practice;

Mar 16th, 2018 - “Ovarian cancer is typically diagnosed at a late stage and therefore has a poor prognosis,” said Dr. Mardis of The Nationwide Hospital, Columbus, Ohio.

Which antibiotics should be used with caution in pregnant women with UTI?
Patrick Duff, MD

Feb 28th, 2018 - EXPERT COMMENTARY Lower urinary tract infection (UTI) is one of the most common medical complications of pregnancy. Approximately 5% to 10% of all pregnant women have asymptomatic bacteriuria, which usually antedates the pregnancy and is detected at the time of the first prenatal appointment.

Two-Drug Tx on Par with Standard Care in Complex UTI

Feb 27th, 2018 - Action Points Meropenem-vaborbactam, a combination medication for certain types of drug-resistant infections, was comparable to piperacillin-tazobactam, for treating complicated urinary tract infections (UTI). Note that the portion of patients who experienced adverse events were similar in both groups, and headache was the most common adverse event reported in both groups. Meropenem-vaborbactam...

Tetraphase's antibiotic fails late-stage study, shares plummet

Feb 13th, 2018 - (Reuters) - Tetraphase Pharmaceuticals Inc said on Tuesday its lead experimental antibiotic to treat serious infections did not meet the main goals in a late-stage study, sending its shares plunging more than 60 percent in after-market trading. The antibiotic, eravacycline, was being studied in a pivotal 1,205 patient study for the treatment of complicated urinary tract infections. Tetraphase s...

Avoid These Antibiotics in the First Trimester of Pregnancy

Feb 1st, 2018 - Hello. I'm Dr Arefa Cassoobhoy, a practicing internist, Medscape advisor, and senior medical director for WebMD. Welcome to Morning Report, our 1-minute news story for primary care. We all know to be cautious when prescribing antibiotics to women who are pregnant. A new CDC analysis looked at a commercial insurance database to assess this further. Among almost 35,000 pregnant women treated for ...

Global Problem of Antimicrobial Resistance Intensifies (WHO)

Jan 29th, 2018 - Antibiotic resistance continues to be a global problem, affecting more than 500,000 people with possible bacterial infections across 22 reporting countries, the World Health Organization said. In a statement, the WHO said that among patients who had a bloodstream infection, the portion of patients who also had bacteria resistant to at least one of the most common antibiotics ranged 0% to to 82%...

FDA Drug Safety Communication: FDA revises labels of SGLT2 inhibitors for diabetes to include warnings about too much acid in the blood and serious urinary tract infections

[12-4-2015] A U.S. Food and Drug Administration (FDA) safety review has resulted in adding warnings to the labels of a specific class of type 2 diabetes medicines called sodium-glucose cotransporter-2 (SGLT2) inhibitors about the risks of too much acid in the blood and of serious urinary tract infections.  Both conditions can result in hospitalization. Patients should stop taking their SGLT2 in...

Pregnant Women Often Prescribed Unsafe Antibiotics

Jan 10th, 2018 - Despite recommendations against using sulfonamide antibiotics and nitrofurantoin in early pregnancy, both are commonly prescribed to women with urinary tract infections (UTIs) during their first trimester of pregnancy, a new study shows. In an examination of antibiotic prescriptions filled by pregnant women with urinary tract infections in 2014, researchers from the Centers for Disease Control ...

Key Obstetrics & Gynecology Clinical Practice Guidelines in 2017

Jan 8th, 2018 - In This Issue This issue of Key Obstetrics & Gynecology Clinical Practice Guidelines in 2017 contains 16 sets of Guidelines and Recommendations released during 2017. You can scroll through the guidelines sequentially, from Cystitis/Pyelonephritis/Urosepsis to Vaginal Birth After Cesarean, or you can choose individual guidelines listed alphabetically in the scroll bar. For complete guidelines fr...

Teens with PID underscreened for HIV, syphilis
Pediatric News; Kari Oakes

Jan 5th, 2018 - CHICAGO – Adolescents with pelvic inflammatory disease (PID) were unlikely to be screened for HIV or syphilis, and many didn’t receive an appropriate antibiotic regimen, according to a recent study reported at the annual meeting of the American Academy of Pediatrics. Patients who were sent home rather than admitted were especially likely to miss screening, as were Hispanic patients and those wi.

Skip Antibiotics for Mild Infections (PLoS Biology)

Dec 29th, 2017 - Standard antibiotics should be saved only for serious infections in order to reduce development of resistance, according to researchers at Georgia Institute of Technology in Atlanta. Writing in PLoS Biology, Kristofer Wollein Waldetoft, PhD, and Sam P. Brown, PhD, argued that mild infections might be better treated with other types of drugs now in development, such as antivirulence agents, bact...

Novel Biomarker Helpful in Differential Diagnosis of UTI in Febrile Infants

Nov 16th, 2017 - NEW YORK (Reuters Health) - The novel biomarker urinary neutrophil gelatinase-associated lipocalin (uNGAL) has “substantial accuracy” identifying febrile infants and young children with and without urinary tract infections (UTIs), clinicians from Columbia University in New York City have found. Dr. Tamar Lubell and colleagues did a prospective cross-sectional study of 84 infants younger than 3 ...

Think Beyond the Bladder for Interstitial Cystitis Pain

Oct 30th, 2017 - SAN ANTONIO — When evaluating women with pelvic pain, consider the vestibule, says a urologist and sexual medicine specialist who says clinicians should stop ignoring this underappreciated component of the female anatomy. Many women diagnosed with interstitial cystitis/bladder pain syndrome (IC/BPS) actually have provoked vestibulodynia disorder (PVD), which is not a bladder disorder and which ...

Pelvic Inflammatory Disease: How to Recognize and Treat

Oct 11th, 2017 - TREATMENT According to the CDC’s 2015 treatment guidelines for PID, a negative endocervical exam and negative microbial screening do not rule out an upper reproductive tract infection. Therefore, all sexually active women who present with lower abdominal pain and/or pelvic pain and have evidence of cervical motion, uterine, or adnexal tenderness on bimanual exam should be treated immediately.

Drinking More Water Reduces Repeat Urinary Tract Infections

Oct 8th, 2017 - SAN DIEGO — Premenopausal women prone to urinary tract infections who drink less than 1.5 liters (about 6.25 cups) of water daily can halve the number of repeat infections they experience by increasing their intake of water by approximately 6 cups, a new randomized controlled study suggests. It is likely that the number of infections decreases because frequent flushing means that the bacteria d...

Successful Reduction of Catheter-Associated Urinary Tract Infection Rates in Nursing Homes Through a Multicomponent Prevention Intervention
William W. Hung, MD, MPH

Sep 1st, 2017 - Study Overview Objective. To determine the effect of implementing an intervention to reduce catheter-associated urinary tract infections (CAUTIs) in nursing homes.

FDA OKs Vabomere, New Antibacterial for Complicated UTI

Aug 29th, 2017 - The US Food and Drug Administration (FDA) has approved (Vabomere, Medicines Company) for adults aged 18 years and older with complicated urinary tract infections (cUTIs), including pyelonephritis, caused by designated susceptible Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae species complex). Vabomere combines the carbapenem antibacterial agent meropenem ...

FDA approves Medicines Co's urinary tract infection drug

Aug 29th, 2017 - A view shows the U.S. Food and Drug Administration (FDA) headquarters in Silver Spring, Maryland August 14, 2012. REUTERS/Jason Reed (Reuters) - The U.S. Food and Drug Administration said on Tuesday it has approved Medicines Co’s antibacterial drug for patients with complicated urinary tract infections (cUTI). The drug, Vabomere, was approved to treat adults with cUTI, including pyelonephritis,...

UTI Versus Asymptomatic Bacteriuria in Long-term Care

Aug 20th, 2017 - Urinary Tract Infection Versus Asymptomatic Bacteriuria The Centers for Disease Control and Prevention has named antimicrobial resistance as one of the world's major health threats.[1] Compared with patients living in the community, those living in long-term care (LTC) facilities have a higher incidence of infections with antibiotic-resistant organisms.[2] Urinary tract infections (UTIs) are a ...

Metronidazole clears PID anaerobes with no drop in antibiotic compliance
MDedge ObGyn; M. Alexander Otto

Aug 14th, 2017 - PARK CITY, UTAH – Adding metronidazole to ceftriaxone/doxycycline for acute pelvic inflammatory disease (PID) improved clearance of endometrial anaerobes and reduced the frequency of pelvic tenderness at 30 days, without reducing overall antibiotic compliance, in a randomized, placebo-controlled trial conducted at the University of Pittsburgh. Anaerobic organisms are associated with endometriti.

New Antibiotic for 'Superbug' Gonorrhea

Aug 6th, 2017 - Some types of the sexually transmitted infection known as gonorrhea have become resistant to several antibiotics – but laboratory research on a new drug is showing promise against this 'superbug'. Without treatment, gonorrhea infection can lead to pelvic inflammatory disease and infertility in adults, and vision damage in babies when passed from the mother during childbirth. The organism that c...

Assumptions Blind Practitioners to Human Trafficking

Jun 25th, 2017 - PHILADELPHIA — In young women, a history of abortion, pelvic inflammatory disease, or sexually transmitted infection should trigger suspicions of human trafficking, said an expert here at the American Association of Nurse Practitioners 2017 National Conference. "For somebody you might consider to be promiscuous, you need to consider an alternate paradigm," said Jessica Peck, DNP, associate prof...

FDA: Fluoroquinolone use not linked to retina detachment, aortic problems
Lucas Franki

May 11th, 2017 - The Food and Drug Administration has found no evidence of a link between fluoroquinolone usage and retinal detachment or aortic aneurysm and dissection, according to a new Drug Safety Communication update on potential serious, disabling side effects of oral and injectable fluoroquinolone antibiotics. Fluoroquinolones are used to treat acute bacterial sinusitis, acute bacterial exacerbation of c.

The broad picture of interstitial cystitis
Kenneth M. Peters, MD

May 3rd, 2017 - Interstitial cystitis (IC) is a controversial diagnosis that has become muddied and oversimplified. It was originally described as a distinct ulcer (Hunner’s lesion) seen in the bladder on cystoscopy, the treatment of which often led to symptomatic relief.