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Clinical Practice Guideline: Adult Sinusitis
http://journals.sagepub.com/doi/full/10.1177/0194599815572097
Richard M. Rosenfeld

Mar 31st, 2015 - This update of a 2007 guideline from the American Academy of Otolaryngology—Head and Neck Surgery Foundation provides evidence-based recommendations to manage adult rhinosinusitis, defined as symptomatic inflammation of the paranasal sinuses and nasal cavity. Changes from the prior guideline include a consumer added to the update group, evidence from 42 new systematic reviews, enhanced informat.

Clinical Practice Guideline for the Diagnosis and Management of Acute Bacterial Sinusitis in...
http://pediatrics.aappublications.org/content/132/1/e262
Wald, E.

Jun 30th, 2013 - To update the American Academy of Pediatrics clinical practice guideline regarding the diagnosis and management of acute bacterial sinusitis in children and adolescents.

Medical Therapies for Adult Chronic Sinusitis: A Systematic Review.
https://doi.org/10.1001/jama.2015.7544
JAMA Rudmik L, Soler ZM

Sep 1st, 2015 - Chronic sinusitis is a common inflammatory condition defined by persistent symptomatic inflammation of the sinonasal cavities lasting longer than 3 months. It accounts for 1% to 2% of total physician encounters and is associated with large health care expenditures. Appropriate use of medical therapies for chronic sinusitis is necessary to optimize patient quality of life (QOL) and daily functio...

ADVIL® COLD AND SINUS
https://respiratory.advil.com/advil-cold-and-sinus

Reduce the swelling caused by nasal inflammation to breathe easier with Advil® Cold & Sinus

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusit...
https://doi.org/10.1001/jama.2015.19330
JAMA Bachert C, Mannent L et. al.

Feb 2nd, 2016 - Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases. To assess inhibition of interleukins 4 and 13 with dupilumab in patients with chronic sinusitis and nasal polyposis. A randomized, double-blind, placebo-controlled parallel-group study conducted at 13 sites in the United States and Europe between August 2013 ...

Quality of Life in Patients With Chronic Rhinosinusitis and Sleep Dysfunction Undergoin...
https://doi.org/10.1001/jamaoto.2015.1673
JAMA Otolaryngology-- Head & Neck Surgery; Alt JA, DeConde AS et. al.

Sep 11th, 2015 - Patients with chronic rhinosinusitis (CRS) have reduced sleep quality linked to their overall well-being and disease-specific quality of life (QOL). Other primary sleep disorders also affect QOL. To determine the impact of comorbid obstructive sleep apnea (OSA) on CRS disease-specific QOL and sleep dysfunction in patients with CRS following functional endoscopic sinus surgery. Prospective multi...

Reversal of Smoking Effects on Chronic Rhinosinusitis after Smoking Cessation.
https://doi.org/10.1177/0194599817717960
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Phillips KM, Hoehle L et. al.

Jul 12th, 2017 - Objective To understand whether the impact of smoking on chronic rhinosinusitis (CRS) is reversible after smoking cessation. Study Design Cross-sectional study. Setting Academic tertiary care rhinology clinic. Subjects and Methods A total of 103 former-smoker CRS patients and 103 nonsmoker CRS patients were prospectively recruited. The primary outcome measure was sinonasal symptom severity meas...

CLINICAL PRACTICE. Acute Sinusitis in Adults.
https://doi.org/10.1056/NEJMcp1601749
The New England Journal of Medicine; Rosenfeld RM

Sep 7th, 2016 - CLINICAL PRACTICE. Acute Sinusitis in Adults.|2016|Rosenfeld RM,|therapeutic use,therapeutic use,diagnosis,drug therapy,therapy,therapeutic use,therapeutic use,diagnosis,microbiology,therapy,diagnosis,

Immune deficiency in chronic rhinosinusitis: screening and treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429028
Expert Review of Clinical Immunology; Chiarella SE, Grammer LC

Aug 8th, 2016 - Chronic rhinosinusitis (CRS) is a prevalent disease with a high annual cost of treatment. Immune deficiencies are more common in individuals with CRS and should be especially considered in those patients who are refractory to medical and surgical therapy. Areas covered: We performed a literature search in PubMed of the terms "immunodeficiency" and "sinusitis" or "rhinosinusitis" from 2006 throu...

Burden of illness: A systematic review of depression in chronic rhinosinusitis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4953344
American Journal of Rhinology & Allergy; Schlosser RJ, Gage SE et. al.

Jul 27th, 2016 - Depression has been reported in patients with chronic rhinosinusitis (CRS), but its prevalence varies across studies, and uncertainty remains regarding the association with baseline disease severity and treatment outcomes. To systematically assess the prevalence of depression in CRS and to review its relationship to baseline disease severity and outcomes after treatment. A systematic review of ...

Point-Counterpoint: A Nucleic Acid Amplification Test for Streptococcus pyogenes Should...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035405
Journal of Clinical Microbiology; Pritt BS, Patel R et. al.

Jul 21st, 2016 - Nucleic acid amplification tests (NAATs) have frequently been the standard diagnostic approach when specific infectious agents are sought in a clinic specimen. They can be applied for specific agents such as S. pyogenes, or commercial multiplex NAATs for detection of a variety of pathogens in gastrointestinal, bloodstream, and respiratory infections may be used. NAATs are both rapid and sensiti...

Chronic rhinosinusitis: Epidemiology and burden of disease.
https://doi.org/10.2500/ajra.2016.30.4297
American Journal of Rhinology & Allergy; DeConde AS, Soler ZM

Mar 16th, 2016 - Chronic rhinosinusitis (CRS) is based on sinonasal symptoms coupled with sinonasal tissue inflammation. Establishing the epidemiology and prevalence of CRS, therefore, is challenging given that confirming objective evidence of sinonasal inflammation on a large scale is not feasible. Although the sinonasal symptoms are well documented at the sinonasal level, analysis of emerging data indicates t...

Alteration in Bacterial Culture After Treatment With Topical Mupirocin for Recalcitrant...
https://doi.org/10.1001/jamaoto.2015.3059
JAMA Otolaryngology-- Head & Neck Surgery; Carr TF, Hill JL et. al.

Dec 31st, 2015 - Topical mupirocin therapy is used to treat symptomatic chronic sinusitis (CRS). However, the potential adverse impact of this therapy on the sinus microbiota has not been well quantified. To determine changes in microbiologic culture results before and after topical mupirocin therapy in patients with CRS with medically and surgically refractory disease. We performed a retrospective medical char...

Eosinophilic esophagitis strongly linked to chronic rhinosinusitis.
https://doi.org/10.1002/lary.25798
The Laryngoscope; Padia R, Curtin K et. al.

Nov 26th, 2015 - To determine the relative risk of having eosinophilic esophagitis (EoE) coexist with chronic rhinosinusitis (CRS) in probands and their families using the Utah Population Database (UPDB). This retrospective observational cohort study with population-based matched controls utilized the UPDB, a genealogical database linked to medical records. It was used to identify CRS and EoE patients diagnosed...

Odontogenic and rhinogenic chronic sinusitis: a modern microbiological comparison.
https://doi.org/10.1002/alr.21629
International Forum of Allergy & Rhinology; Saibene AM, Vassena C et. al.

Sep 8th, 2015 - Odontogenic sinusitis and sinonasal complications of dental disease or treatment (SCDDT) play a relevant, often underappreciated role in paranasal sinus infections. Treating SCDDT patients requires tailored medical and surgical approaches in order to achieve acceptable success rates. These approaches differ from common rhinogenic sinusitis treatment protocols mostly because of the different eti...

Immunoglobulin deficiency in patients with chronic rhinosinusitis: Systematic review of...
https://doi.org/10.1016/j.jaci.2015.07.016
The Journal of Allergy and Clinical Immunology; Schwitzguébel AJ, Jandus P et. al.

Sep 3rd, 2015 - Several studies have shown a high prevalence of immunoglobulin deficiencies in patients with chronic rhinosinusitis (CRS). We sought to perform a systematic review and meta-analysis to estimate this prevalence more precisely and to identify patients who need substitution treatment. All case series published after 1990 describing patients with CRS, which was defined as symptomatic rhinosinusitis...

Management of chronic rhinosinusitis with nasal polyps and coexisting asthma: A systema...
https://doi.org/10.2500/ajra.2015.29.4178
American Journal of Rhinology & Allergy; Rix I, Håkansson K et. al.

May 15th, 2015 - Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and asthma are strongly associated, and patients suffering from both diseases are often difficult to treat. However, no guidelines about the management of patients with CRS and coexisting asthma exist. The purpose of this systematic review was to evaluate the management of CRSwNP and coexisting asthma. We systematically searched electronic...

Comparison of Socioeconomic and Demographic Factors in Patients with Chronic Rhinosinus...
https://doi.org/10.1177/0194599815580978
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery; Lu-Myers Y, Deal AM et. al.

Apr 28th, 2015 - The primary objective of this study is to evaluate the differences in socioeconomic, demographic, and disease severity factors between patients with chronic rhinosinusitis (CRS) and those with allergic fungal rhinosinusitis (AFRS). A retrospective cohort analysis was performed. The study was conducted at the hospital of the University of North Carolina at Chapel Hill. A total of 186 patients we...

Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical o...
https://doi.org/10.1016/j.jaci.2015.02.008
The Journal of Allergy and Clinical Immunology; Ramakrishnan VR, Hauser LJ et. al.

Mar 30th, 2015 - Chronic rhinosinusitis (CRS) is a prevalent multifactorial disease process in which bacteria are believed to play a role in the propagation of inflammation. Multiple subtypes of CRS have been described based on clinical and pathologic features, but a detailed examination of the sinus microbiota in patients with CRS and its clinical subtypes has yet to be performed. We sought to examine the resi...

Identification of chronic rhinosinusitis phenotypes using cluster analysis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428937
International Forum of Allergy & Rhinology; Soler ZM, Hyer JM et. al.

Feb 19th, 2015 - Current clinical classifications of chronic rhinosinusitis (CRS) have been largely defined based upon preconceived notions of factors thought to be important, such as polyp or eosinophil status. Unfortunately, these classification systems have little correlation with symptom severity or treatment outcomes. Unsupervised clustering can be used to identify phenotypic subgroups of CRS patients, des...