ALLMedicine™ Early HIV Infection Center

Dec 1st, 2021 - Initiation of combination antiretroviral therapy (cART) during acute or early HIV-infection (AEHI) limits the size of the viral reservoir and preserves immune function. This renders individuals who started cART during AEHI promising participants i...

Nov 12th, 2021 - In 2019, the US Government announced its goal to end the HIV epidemic within 10 years, mirroring the initiatives set forth by UNAIDS. Public health prevention interventions are a crucial part of this ambitious goal. However, numerous challenges to...

Oct 2nd, 2021 - The inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways. However, a succinct underst...

Sep 7th, 2021 - The lack of acute and early HIV infection (AEHI) diagnosis and care contributes to high HIV incidence in resource-limited settings. We aimed to assess the yield of AEHI, predict and diagnose AEHI, and describe AEHI care outcomes in a public sector...

Sep 2nd, 2021 - Resting CD4+ T cells are primary targets of early HIV infection events in vivo, but do not readily support HIV replication in vitro. This barrier to infection can be overcome by exposing resting CD4+ T cells to endothelial cells (ECs). ECs line bl...

Sep 1st, 2021 - The strategy for Ending the HIV Epidemic (EHE) includes four key strategies that together can end the HIV epidemic in the United States (US): Diagnose, Treat, Prevent, and Respond. Diagnosis is the gateway to all other interventions; it is the cor...

Jun 11th, 2021 - Set-up of a biobank for patients with an estimated date of infection seroconverters: store plasma and cells samples at initial contact and during follow-up for future analysis and analysis in international collaborative cohort seroconverters.

Dec 2nd, 2020 - Specific Aims: Recent studies suggest that very early initiation of ART (prior to seroconversion) does not prevent the establishment of HIV reservoirs, which eventually expand when ART is discontinued (1, 2). Early ART initiation is, however, asso...

Apr 26th, 2019 - This is a prospective, open-label study to describe the effects of early antiretroviral (ART) therapy on 1) viral load, 2) safety and tolerability of Genvoya®, 3) clinical outcomes and secondarily on HIV-specific immune responses. This study is a ...

Apr 5th, 2016 - The trial is a prospective, randomized, double-blinded, placebo-controlled study with follow-up to 5 years. Thirty-two individuals presenting with newly diagnosed acute or early HIV-1 infection as described in the inclusion criteria will be enroll...

Apr 29th, 2015 - Hello. This is Dr Paul Sax from Brigham and Women's Hospital and Harvard Medical School. Today I'd like to discuss the recently updated Department of Health and Human Services (DHHS) HIV treatment guidelines,[1] which were released on April 8. In ...

Jun 21st, 2013 - Action Points New approaches to HIV testing can detect acute infections that would have gone undetected with older methods. Note that new 4th-generation tests detect both immunoglobulin M-class and G-class antibodies as well as the p24 antigen whe...

Nov 11th, 2009 - November 11, 2009 — A review published in the November 1 issue of American Family Physician describes the role of primary care clinicians in the treatment of patients with HIV infection. "Prevention and treatment of...HIV infection have changed co...

Aug 5th, 2008 - Action Points Explain to interested patients that the study suggested lower-than-expected accuracy of the rapid oral HIV test. Inform patients that the rapid test appeared to identify patients at elevated risk for HIV infection. BOSTON, Aug. 5 -- ...

Feb 25th, 2005 - Action Points Advise concerned patients that this is an isolated case and that others like it have not been reported but that this is another reason to practice safe sex. At the same time, remind patients who engage in risky sexual practices to ge...