About 1,190 results

ALLMedicine™ African Trypanosomiasis Center

Research & Reviews  463 results

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in d...
PLoS Pathogens; Steketee PC, Dickie EA et. al.

Jul 27th, 2021 - Animal African Trypanosomiasis (AAT) is a debilitating livestock disease prevalent across sub-Saharan Africa, a main cause of which is the protozoan parasite Trypanosoma congolense. In comparison to the well-studied T. brucei, there is a major pau...

Costs and Outcomes of Integrated Human African Trypanosomiasis Surveillance System Usin...
Emerging Infectious Diseases; Snijders R, Fukinsia A et. al.

Jul 22nd, 2021 - We integrated sleeping sickness case detection into the primary healthcare system in 2 health districts in the Democratic Republic of the Congo. We replaced a less field-friendly serologic test with a rapid diagnostic test, which was followed up b...

Correlation of PET/CT and Brain MRI Findings in Human African Trypanosomiasis Encephali...
Clinical Nuclear Medicine; Luna LP, Meleki Z et. al.

Jul 21st, 2021 - A 49-year-old woman from Cameroon presented with history of several months of worsening headache, lethargy, left arm weakness, and generalized lymphadenopathy. Brain MRI demonstrated multifocal signal abnormality and enhancement involving the bila...

Enantiospecific antitrypanosomal in vitro activity of eflornithine.
PLoS Neglected Tropical Diseases; Boberg M, Cal M et. al.

Jul 13th, 2021 - The polyamine synthesis inhibitor eflornithine is a recommended treatment for the neglected tropical disease Gambian human African trypanosomiasis in late stage. This parasitic disease, transmitted by the tsetse fly, is lethal unless treated. Eflo...

Use of vector control to protect people from sleeping sickness in the focus of Bonon (C...
PLoS Neglected Tropical Diseases; Kaba D, Djohan V et. al.

Jun 29th, 2021 - Gambian human African trypanosomiasis (gHAT) is a neglected tropical disease caused by Trypanosoma brucei gambiense transmitted by tsetse flies (Glossina). In Côte d'Ivoire, Bonon is the most important focus of gHAT, with 325 cases diagnosed from ...

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Drugs  1 results see all →

Clinicaltrials.gov  7 results

Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP2 Passive Case Detection

Apr 10th, 2019 - In the last decade, the prevalence of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. At low disease prevalence, integration of case finding into routine activities of peripher...

Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: Early Test-of-cure

Aug 31st, 2018 - In the last decade, the prevalence of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. Development of safe and efficacious drugs for HAT, applicable in an elimination context, i...

Prospective Evaluation of an RDT to Screen for Gambiense HAT and Diagnose P. Falciparum Malaria

Jan 9th, 2018 - A prototype rapid diagnostic test (RDT) to simultaneously screen for gambiense human African trypanosomiasis (HAT) and diagnose P. falciparum malaria (the "HAT/malaria combo") has recently been developed. The performance of this prototype has been...

Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food

Mar 31st, 2017 - Objectives: Primary Objectives: To assess safety and tolerability of two different fexinidazole dosing regimen, for 10 days repeated administration under fed conditions in healthy male sub-Saharan volunteers. Secondary objectives: To validate the ...

Efficacy - Safety of Eflornithine-Nifurtimox Combination Versus Eflornithine to Treat Human African Trypanosomiasis

Sep 29th, 2016 - Melarsoprol is the most commonly used product for the treatment of patients suffering from human African trypanosomiasis (HAT) in the meningoencephalitic (second, late) phase. This treatment is frequently complicated by fatal reactive encephalopat...

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News  5 results

What Neglected Tropical Diseases Teach Us About Stigma
Aileen Y. Chang, MD, Maria T. Ochoa, MD

Oct 3rd, 2019 - Neglected tropical diseases (NTDs) are a group of 20 diseases that typically are chronic and cause long-term disability, which negatively impacts work productivity, child survival, and school performance and attendance with adverse effect on futur.

EMA Panel Backs First Oral-Only Drug for Deadly Sleeping Sickness

Nov 16th, 2018 - The first oral-only treatment for human African trypanosomiasis (HAT), commonly known as sleeping sickness, has received a green light from the Committee for Human Medicinal Products (CHMP) of the European Medicines Agency (EMA). Fexinidazole Wint...

Novel Drug Approvals for 2021

Innovation drives progress. When it comes to innovation in the development of new drugs and therapeutic biological products, FDA’s Center for Drug Evaluation and Research (CDER) supports the pharmaceutical industry at every step of the process. Wi...

Advising Patients on Safe Travel Abroad

May 6th, 2011 - Specific Recommendations Arthropod-Borne Diseases Arthropods are not only a source of nuisance and pain at the site of their bites, but they also may cause more harmful generalized reactions as a result of venom production or allergies to substanc...

New FDA Orphan Drugs: IPI-504, Pafuramidine, Preos

Sep 21st, 2007 - September 21, 2007 — The US Food and Drug Administration (FDA) has granted orphan drug designation for IPI-504 for the treatment of gastrointestinal stromal tumors, pafuramidine for the treatment of African sleeping sickness, and PREOS for the tre...

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