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ALLMedicine™ Leishmaniasis Center

Research & Reviews  9,401 results

Leishmanicidal effect of 1,3,4-thiadiazolium mesoionic salts on Leishmania amazonensis ...
https://doi.org/10.1016/j.parint.2021.102342
Parasitology International; Dos Santos Rosa A, Frauches-Santos C et. al.

Apr 8th, 2021 - Leishmaniasis is a neglected broad clinical spectrum disease caused by protozoa of the genus Leishmania, which affect millions of people annually in the world and the treatment has severe side effects and resistant strains have been reported. Meso...

Monocyte dysregulation: consequences for hepatic infections.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025899
Seminars in Immunopathology; Sellau J, Puengel T et. al.

Apr 8th, 2021 - Liver disorders due to infections are a substantial health concern in underdeveloped and industrialized countries. This includes not only hepatotropic viruses (e.g., hepatitis B, hepatitis C) but also bacterial and parasitic infections such as ame...

Leishmaniasis: where are we and where are we heading?
https://doi.org/10.1007/s00436-021-07139-2 10.1016/j.cimid.2017.02.001 10.1093/jac/49.suppl_1.21 10.4103/0972-9062.249484 10.21767/1791-809X.1000519 10.4269/ajtmh.2005.73.79 10.3201/eid2205.160042 10.1128/CMR.00061-07 10.4269/ajtmh.2005.72.133 10.3390/microorganisms8071069 10.1007/s00508-008-1072-8 10.1056/NEJM199001043220104 10.1086/507708 10.1021/jm900185q 10.1016/S0306-3623(97)00268-1 10.1016/S2214-109X(19)30538-8 10.1016/S0065-308X(06)64001-3 10.1016/j.tmaid.2017.05.013 10.1016/0035-9203(73)90111-9 10.1093/clinids/22.5.878 10.1179/102453311X13025568941844 10.1590/S0102-311X2008001200027 10.1179/136485905X28018 10.1186/s12879-014-0597-x 10.1111/j.1432-1033.1995.tb20583.x 10.1038/s41598-019-56336-8 10.1590/S0074-02762006000100024 10.1016/S0001-706X(00)00179-0 10.1001/archderm.134.2.193 10.1016/S0035-9203(00)90253-0 10.4269/ajtmh.2007.77.95 10.1007/s00436-010-1767-4 10.1371/journal.pntd.0002869 10.1136/bmj.2.2239.1401-a 10.4269/ajtmh.1996.55.125 10.1016/j.actatropica.2017.02.016 10.1111/j.1365-4632.2007.03086.x 10.1128/AAC.00639-13 10.4269/ajtmh.16-0883 10.1006/jmbi.1997.1551 10.1016/j.ijpddr.2012.01.003 10.3390/molecules14072317 10.1016/j.vaccine.2006.03.005 10.1371/journal.pntd.0004138 10.1093/clinids/18.1.83 10.1371/journal.pntd.0008221 10.4049/jimmunol.170.11.5625 10.1016/S0020-7519(03)00142-5 10.1056/NEJM199912093412403 10.1016/j.molbiopara.2008.12.007 10.1016/0166-6851(95)00042-Y 10.1016/0024-3205(96)00341-4 10.1016/S0035-9203(03)90061-7 10.3109/1061186X.2010.492524 10.1186/1471-2334-14-206 10.4269/ajtmh.2007.76.896 10.1016/j.trstmh.2007.10.017 10.1099/jmm.0.076695-0 10.1590/S0074-02762005000800001 10.1128/AAC.42.3.654 10.1080/14756360802208137 10.1136/bmj.1.2213.1252 10.1016/S0166-6851(00)00278-4 10.1590/S0036-46652015000500016 10.1007/BF00931504 10.1006/excr.1997.3500 10.1051/parasite/1998052167 10.1016/j.tmaid.2014.09.007 10.1371/journal.pntd.0007456 10.1093/clind/15.6.924 10.1111/jdv.14506 10.2174/092986707780362862 10.3389/fvets.2019.00168 10.1016/j.actatropica.2004.11.008 10.1086/376510 10.1128/AAC.47.8.2513-2517.2003 10.1128/IAI.73.7.3903-3911.2005 10.1590/S0102-311X2008001200028 10.1186/s13071-016-1551-0 10.3201/eid1307.060773 10.1590/S0074-02761986000300006 10.1016/j.pt.2009.01.003 10.1128/JCM.05966-11 10.1016/S0001-706X(97)00116-2 10.1074/jbc.M308352200 10.1046/j.1198-743x.2001.00262.x 10.1128/IAI.74.1.773-776.2006 10.1016/0035-9203(95)90025-X 10.1179/2047773212Y.0000000054 10.1051/parasite/1990653111 10.1136/bmj.2.2237.1261 10.1371/journal.pone.0018467 10.1039/C5RA02669E 10.4269/ajtmh.2011.11-0021 10.1128/AAC.50.1.73-79.2006 10.4269/ajtmh.2005.72.819 10.1590/S0074-02762007000500001 10.3389/fimmu.2014.00296 10.1093/cid/cir521 10.1086/383321 10.4269/ajtmh.1993.48.666 10.1186/s13071-017-2028-5 10.1093/infdis/172.6.1627 10.1056/NEJMoa066536 10.1080/14787210.2018.1532790 10.1590/S0074-02761995000400020 10.1017/S0031182016001657 10.4049/jimmunol.0803859 10.1017/S0950268806006881 10.1074/jbc.M405635200 10.4269/ajtmh.2012.12-0211 10.1128/AAC.41.4.752 10.1179/000349804X3171 10.1016/S1473-3099(03)00517-6
Parasitology Research; Sasidharan S, Saudagar P

Apr 7th, 2021 - Leishmaniasis is a zoonotic disease in humans caused by the bite of a parasite-infected sandfly. The disease, widely referred to as "poor man's disease," affects millions of people worldwide. The clinical manifestation of the disease depends upon ...

Safety and efficacy of allylamines in the treatment of cutaneous and mucocutaneous leis...
https://doi.org/10.1371/journal.pone.0249628
PloS One; Bezemer JM, van der Ende J et. al.

Apr 7th, 2021 - Cutaneous and mucocutaneous leishmaniasis affect a million people yearly, leading to skin lesions and potentially disfiguring mucosal disease. Current treatments can have severe side effects. Allylamine drugs, like terbinafine, are safe, including...

Leishmania donovani targets host transcription factor NRF2 to activate anti-oxidant enz...
https://doi.org/10.1128/IAI.00764-20
Infection and Immunity; Saha S, Roy S et. al.

Apr 6th, 2021 - In visceral leishmaniasis, we earlier showed that antioxidant enzyme heme oxygenase-1 (HO-1) is critical for Leishmania survival. HO-1 inhibits host oxidative burst and inflammatory cytokine production leading to parasite persistence. In present s...

see more →

Guidelines  11 results

Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectiou...
https://doi.org/10.1093/cid/ciw742
Clinical Infectious Diseases : an Official Publication Of... Aronson N, Herwaldt BL et. al.

Dec 12th, 2016 - It is important to realize that leishmaniasis guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. The ID...

Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectiou...
https://doi.org/10.1093/cid/ciw670
Clinical Infectious Diseases : an Official Publication Of... Aronson N, Herwaldt BL et. al.

Dec 12th, 2016 - It is important to realize that leishmaniasis guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. The ID...

Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectiou...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239701
The American Journal of Tropical Medicine and Hygiene; Aronson N, Herwaldt BL et. al.

Dec 8th, 2016 - Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).|2016|Aronson N,Herwaldt BL,Libman M,Pearson R,Lopez-Vele...

Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Dis...
https://academic.oup.com/cid/article/63/12/e202/2645609
Naomi Aronson

Dec 6th, 2016 - In these guidelines, we describe our approaches to the diagnosis and management of cases of cutaneous, mucosal, and visceral leishmaniasis, the 3 main clinical syndromes caused by infection with Leishmania parasites. Less common or rare syndromes.

Control of visceral leishmaniasis in Brazil: recommendations from Brasileish.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556119
Parasites & Vectors; Ribeiro VM, da Silva SM et. al.

Jan 14th, 2013 - On 26 October 2012, veterinary medicine clinicians and researchers, members of Brasileish - Study Group about Animal Leishmaniasis - met at the Regional Council of Veterinary Medicine of Minas Gerais, in the city Belo Horizonte, in order to discus...

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Drugs  3 results see all →

Clinicaltrials.gov  9,431 results

Leishmanicidal effect of 1,3,4-thiadiazolium mesoionic salts on Leishmania amazonensis ...
https://doi.org/10.1016/j.parint.2021.102342
Parasitology International; Dos Santos Rosa A, Frauches-Santos C et. al.

Apr 8th, 2021 - Leishmaniasis is a neglected broad clinical spectrum disease caused by protozoa of the genus Leishmania, which affect millions of people annually in the world and the treatment has severe side effects and resistant strains have been reported. Meso...

Monocyte dysregulation: consequences for hepatic infections.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8025899
Seminars in Immunopathology; Sellau J, Puengel T et. al.

Apr 8th, 2021 - Liver disorders due to infections are a substantial health concern in underdeveloped and industrialized countries. This includes not only hepatotropic viruses (e.g., hepatitis B, hepatitis C) but also bacterial and parasitic infections such as ame...

Leishmaniasis: where are we and where are we heading?
https://doi.org/10.1007/s00436-021-07139-2 10.1016/j.cimid.2017.02.001 10.1093/jac/49.suppl_1.21 10.4103/0972-9062.249484 10.21767/1791-809X.1000519 10.4269/ajtmh.2005.73.79 10.3201/eid2205.160042 10.1128/CMR.00061-07 10.4269/ajtmh.2005.72.133 10.3390/microorganisms8071069 10.1007/s00508-008-1072-8 10.1056/NEJM199001043220104 10.1086/507708 10.1021/jm900185q 10.1016/S0306-3623(97)00268-1 10.1016/S2214-109X(19)30538-8 10.1016/S0065-308X(06)64001-3 10.1016/j.tmaid.2017.05.013 10.1016/0035-9203(73)90111-9 10.1093/clinids/22.5.878 10.1179/102453311X13025568941844 10.1590/S0102-311X2008001200027 10.1179/136485905X28018 10.1186/s12879-014-0597-x 10.1111/j.1432-1033.1995.tb20583.x 10.1038/s41598-019-56336-8 10.1590/S0074-02762006000100024 10.1016/S0001-706X(00)00179-0 10.1001/archderm.134.2.193 10.1016/S0035-9203(00)90253-0 10.4269/ajtmh.2007.77.95 10.1007/s00436-010-1767-4 10.1371/journal.pntd.0002869 10.1136/bmj.2.2239.1401-a 10.4269/ajtmh.1996.55.125 10.1016/j.actatropica.2017.02.016 10.1111/j.1365-4632.2007.03086.x 10.1128/AAC.00639-13 10.4269/ajtmh.16-0883 10.1006/jmbi.1997.1551 10.1016/j.ijpddr.2012.01.003 10.3390/molecules14072317 10.1016/j.vaccine.2006.03.005 10.1371/journal.pntd.0004138 10.1093/clinids/18.1.83 10.1371/journal.pntd.0008221 10.4049/jimmunol.170.11.5625 10.1016/S0020-7519(03)00142-5 10.1056/NEJM199912093412403 10.1016/j.molbiopara.2008.12.007 10.1016/0166-6851(95)00042-Y 10.1016/0024-3205(96)00341-4 10.1016/S0035-9203(03)90061-7 10.3109/1061186X.2010.492524 10.1186/1471-2334-14-206 10.4269/ajtmh.2007.76.896 10.1016/j.trstmh.2007.10.017 10.1099/jmm.0.076695-0 10.1590/S0074-02762005000800001 10.1128/AAC.42.3.654 10.1080/14756360802208137 10.1136/bmj.1.2213.1252 10.1016/S0166-6851(00)00278-4 10.1590/S0036-46652015000500016 10.1007/BF00931504 10.1006/excr.1997.3500 10.1051/parasite/1998052167 10.1016/j.tmaid.2014.09.007 10.1371/journal.pntd.0007456 10.1093/clind/15.6.924 10.1111/jdv.14506 10.2174/092986707780362862 10.3389/fvets.2019.00168 10.1016/j.actatropica.2004.11.008 10.1086/376510 10.1128/AAC.47.8.2513-2517.2003 10.1128/IAI.73.7.3903-3911.2005 10.1590/S0102-311X2008001200028 10.1186/s13071-016-1551-0 10.3201/eid1307.060773 10.1590/S0074-02761986000300006 10.1016/j.pt.2009.01.003 10.1128/JCM.05966-11 10.1016/S0001-706X(97)00116-2 10.1074/jbc.M308352200 10.1046/j.1198-743x.2001.00262.x 10.1128/IAI.74.1.773-776.2006 10.1016/0035-9203(95)90025-X 10.1179/2047773212Y.0000000054 10.1051/parasite/1990653111 10.1136/bmj.2.2237.1261 10.1371/journal.pone.0018467 10.1039/C5RA02669E 10.4269/ajtmh.2011.11-0021 10.1128/AAC.50.1.73-79.2006 10.4269/ajtmh.2005.72.819 10.1590/S0074-02762007000500001 10.3389/fimmu.2014.00296 10.1093/cid/cir521 10.1086/383321 10.4269/ajtmh.1993.48.666 10.1186/s13071-017-2028-5 10.1093/infdis/172.6.1627 10.1056/NEJMoa066536 10.1080/14787210.2018.1532790 10.1590/S0074-02761995000400020 10.1017/S0031182016001657 10.4049/jimmunol.0803859 10.1017/S0950268806006881 10.1074/jbc.M405635200 10.4269/ajtmh.2012.12-0211 10.1128/AAC.41.4.752 10.1179/000349804X3171 10.1016/S1473-3099(03)00517-6
Parasitology Research; Sasidharan S, Saudagar P

Apr 7th, 2021 - Leishmaniasis is a zoonotic disease in humans caused by the bite of a parasite-infected sandfly. The disease, widely referred to as "poor man's disease," affects millions of people worldwide. The clinical manifestation of the disease depends upon ...

Safety and efficacy of allylamines in the treatment of cutaneous and mucocutaneous leis...
https://doi.org/10.1371/journal.pone.0249628
PloS One; Bezemer JM, van der Ende J et. al.

Apr 7th, 2021 - Cutaneous and mucocutaneous leishmaniasis affect a million people yearly, leading to skin lesions and potentially disfiguring mucosal disease. Current treatments can have severe side effects. Allylamine drugs, like terbinafine, are safe, including...

Leishmania donovani targets host transcription factor NRF2 to activate anti-oxidant enz...
https://doi.org/10.1128/IAI.00764-20
Infection and Immunity; Saha S, Roy S et. al.

Apr 6th, 2021 - In visceral leishmaniasis, we earlier showed that antioxidant enzyme heme oxygenase-1 (HO-1) is critical for Leishmania survival. HO-1 inhibits host oxidative burst and inflammatory cytokine production leading to parasite persistence. In present s...

see more →

News  47 results

Climate Change: Dermatologists Address Impact on Health, and Mobilize to Increase Awareness
https://www.medscape.com/viewarticle/947786

Mar 18th, 2021 - Climate change will increasingly affect the distribution and frequency of insect-borne diseases, cutaneous leishmaniasis, skin cancer, fungal diseases, and a host of other illnesses that have cutaneous manifestations or involve the skin — and derm...

What’s Eating You? Sand Flies
https://www.mdedge.com/dermatology/article/157830/infectious-diseases/whats-eating-you-sand-flies/page/0/1

Feb 5th, 2018 - Disease Transmission Leishmania refers to a genus of intracellular protozoa found in both the Old World and the New World that causes a variety of clinical syndromes. 5 Approximately 20 Leishmania species are known to cause human disease that inclu.

Cutaneous Leishmaniasis
https://www.mdedge.com/dermatology/article/105196/dermatopathology/cutaneous-leishmaniasis/page/0/1

Dec 15th, 2015 - Lepromatous leprosy presents as a symmetric, widespread eruption of macules, patches, plaques, or papules that are most prominent in acral areas. 4 Perivascular infiltration of lymphocytes and histiocytes is characteristic of lepromatous leprosy.

Cutaneous Leishmaniasis: An Emerging Infectious Disease in Travelers
https://www.mdedge.com/dermatology/article/104658/contact-dermatitis/cutaneous-leishmaniasis-emerging-infectious-disease/page/0/2

Nov 23rd, 2015 - Conclusion Cutaneous leishmaniasis should be included in the differential diagnosis for travelers returning from endemic areas who present with new skin lesions. Since no specific lesion types are pathognomonic for cutaneous leishmaniasis, tissue.

What Is Your Diagnosis? New World Cutaneous Leishmaniasis
https://www.mdedge.com/dermatology/article/98662/wounds/what-your-diagnosis-new-world-cutaneous-leishmaniasis/page/0/1

Apr 10th, 2015 - There currently are no vaccines or drugs available to prevent against leishmaniasis. Preventive measures such as avoiding outdoor activities from dusk to dawn when sandflies are the most active, wearing protective clothing, and applying insect rep.

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Patient Education  1 results see all →