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About 1,513 results

ALLMedicine™ African Trypanosomiasis Center

Research & Reviews  573 results

Trypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambie...
https://doi.org/10.1016/j.ebiom.2022.104376
EBioMedicine Ngay Lukusa I, Van Reet N et. al.

Nov 28th, 2022 - Detection of spliced leader (SL)-RNA allows sensitive diagnosis of gambiense human African trypanosomiasis (HAT). We investigated its diagnostic performance for treatment outcome assessment. Blood and cerebrospinal fluid (CSF) from a consecutive s...

Human African trypanosomiasis cases diagnosed in non-endemic countries (2011-2020).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639846
PLoS Neglected Tropical Diseases; Franco JR, Cecchi G et. al.

Nov 8th, 2022 - Sleeping sickness, or human African trypanosomiasis (HAT), is transmitted by tsetse flies in endemic foci in sub-Saharan Africa. Because of international travel and population movements, cases are also occasionally diagnosed in non-endemic countri...

Evaluating and mitigating the potential indirect effect of COVID-19 on control programm...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9579354
The Lancet. Global Health; Borlase A, Le Rutte EA et. al.

Oct 15th, 2022 - In line with movement restrictions and physical distancing essential for the control of the COVID-19 pandemic, WHO recommended postponement of all neglected tropical disease (NTD) control activities that involve community-based surveys, active cas...

Efficacy and Safety of Fexinidazole in Patients With Human African Trypanosomiasis (HAT) Due to Trypanosoma Brucei Rhodesiense
https://clinicaltrials.gov/ct2/show/NCT03974178

Oct 12th, 2022 - Nowadays, the only treatment available for the stage 2 of HAT due to t.b rhodesiense is melarsoprol, a very toxic drug. The primary objective of this trial is to evaluate fexinidazole as an alternative treatment over melarsoprol in patients with s...

Safety and efficacy of oral fexinidazole in children with gambiense human African trypa...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554014
The Lancet. Global Health; Kande Betu Kumesu V, Mutombo Kalonji W et. al.

Oct 1st, 2022 - Fexinidazole has been reported as an effective oral monotherapy against non-severe gambiense human African trypanosomiasis in a recent trial in adults. We aimed to assess the safety and efficacy of fexinidazole in children across all disease stage...

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Drugs  1 results see all →

Clinicaltrials.gov  22 results

Efficacy and Safety of Fexinidazole in Patients With Human African Trypanosomiasis (HAT) Due to Trypanosoma Brucei Rhodesiense
https://clinicaltrials.gov/ct2/show/NCT03974178

Oct 12th, 2022 - Nowadays, the only treatment available for the stage 2 of HAT due to t.b rhodesiense is melarsoprol, a very toxic drug. The primary objective of this trial is to evaluate fexinidazole as an alternative treatment over melarsoprol in patients with s...

Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients
https://clinicaltrials.gov/ct2/show/NCT05433350

Aug 19th, 2022 - Human African trypanosomiasis (HAT), or sleeping sickness, is a life-threatening disease transmitted by tsetse flies and caused by a single-celled extracellular parasite that lives free in the bloodstream and other body fluids, including lymph and...

Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis
https://clinicaltrials.gov/ct2/show/NCT05466630

Jul 20th, 2022 - In the last decade, the prevalence of Trypanosoma brucei gambiense (Tbg) human African trypanosomiasis (HAT) has fallen and HAT has been targeted for transmission interruption by 2030. To achieve this goal, disease surveillance remains essential a...

Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring
https://clinicaltrials.gov/ct2/show/NCT04099628

Apr 15th, 2022 - In the last decade, the prevalence of Trypanosoma brucei gambiense (Tbg) human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. At low disease prevalence, HAT control is increasingly integrated into routine activ...

Prospective Study on Efficacy and Safety of Acoziborole (SCYX-7158) in Patients Infected by Human African Trypanosomiasis Due to T.b. Gambiense
https://clinicaltrials.gov/ct2/show/NCT03087955

Jan 19th, 2022 - The goal of this study is to assess efficacy and safety of Acoziborole (SCYX-7158) given as a single dose oral treatment for adult patients (above or equal 15) in the fasting state with T.b. Gambiense HAT

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News  9 results

One Dose of Acoziborole Led to Cure of 'Sleeping Sickness' Across Disease Stages
https://www.medpagetoday.com/infectiousdisease/generalinfectiousdisease/101970

Nov 29th, 2022 - A single dose of oral acoziborole proved to be efficacious and safe for adults and adolescents with gambiense human African trypanosomiasis (HAT), also known as "sleeping sickness," suggesting its promise in interrupting transmission, a single-arm...

Will a One-Dose Drug Mean the End of Sleeping Sickness?
https://www.medscape.com/viewarticle/984736

Nov 29th, 2022 - A single dose of oral acoziborole resulted in a greater than 95% cure or probable cure rate for human African trypanosomiasis (HAT), also known as sleeping sickness, according to results from a clinical trial testing a one-dose experimental drug. ...

Investigators Hope Glioma Trial of Eflornithine Will Clinch Approval
https://www.onclive.com/view/investigators-hope-glioma-trial-of-eflornithine-will-clinch-approval

Dec 5th, 2020 - Victor A. Levin, MD Eflornithine (α-Difluoromethylornithine) has been investigated for over 30 years as a potential neuro-oncology agent and shown activity against recurrent gliomas, but it has not gained approval as a therapy option for patients...

Novel Combo Explored for Rare Brain Tumor
https://www.onclive.com/view/novel-combo-explored-for-rare-brain-tumor

Dec 5th, 2020 - Victor A. Levin, MD Investigators are seeking to determine whether the combination of eflornithine (alphadifluoromethylornithine) with lomustine can improve survival for patients with recurrent anaplastic astrocytoma (AA). A rare form of brain tu...

What Neglected Tropical Diseases Teach Us About Stigma
https://www.mdedge.com/dermatology/article/209336/infectious-diseases/what-neglected-tropical-diseases-teach-us-about?channel=234
Aileen Y. Chang, MD, Maria T. Ochoa, MD

Oct 3rd, 2019 - Neglected tropical diseases (NTDs) are a group of 20 diseases that typically are chronic and cause long-term disability, which negatively impacts work productivity, child survival, and school performance and attendance with adverse effect on futur.

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