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About 1,348 results

ALLMedicine™ African Trypanosomiasis Center

Research & Reviews  526 results

Hybrid-Compounds Against Trypanosomiases.
https://doi.org/10.2174/1389450123666220509202352
Current Drug Targets; Nunes JA, Ferreira da Silva-Júnior E

May 18th, 2022 - Neglected tropical diseases (NTDs) are a global public health problem that is associated with approximately 20 conditions. Among these, Chagas disease (CD), caused by Trypanosoma cruzi, and human African trypanosomiasis (HAT), caused by T. brucei ...

Unusual neurological presentation of second stage African trypanosomiasis in a young bo...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097424
BMC Pediatrics; Ibrahim EAA, Elmahal MGEM et. al.

May 14th, 2022 - In South Sudan, sleeping sickness is a frequent condition caused by human African trypanosomiasis. There are two stages that are well-known. When the CNS is affected, especially with Trypanosoma gambiense infection, the early hemolymphatic stage a...

Monitoring the elimination of gambiense human African trypanosomiasis in the historical...
https://doi.org/10.1051/parasite/2022024
Parasite (Paris, France); Compaoré CFA, Kaboré J et. al.

May 12th, 2022 - The World Health Organisation has targeted the elimination of human African trypanosomiasis (HAT) as zero transmission by 2030. Continued surveillance needs to be in place for early detection of re-emergent cases. In this context, the performance ...

Transcriptomic profiling of Trypanosoma congolense mouthpart parasites from naturally i...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063227
Parasites & Vectors; Silva Pereira S, Mathenge K et. al.

May 4th, 2022 - Animal African trypanosomiasis, or nagana, is a veterinary disease caused by African trypanosomes transmitted by tsetse flies. In Africa, Trypanosoma congolense is one of the most pathogenic and prevalent causes of nagana in livestock, resulting i...

Etiological spectrum of persistent fever in the tropics and predictors of ubiquitous in...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9059373
BMC Medicine; Bottieau E, Van Duffel L et. al.

May 2nd, 2022 - Persistent fever, defined as fever lasting for 7 days or more at first medical evaluation, has been hardly investigated as a separate clinical entity in the tropics. This study aimed at exploring the frequencies and diagnostic predictors of the ub...

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Drugs  1 results see all →

Clinicaltrials.gov  8 results

Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring
https://clinicaltrials.gov/ct2/show/NCT04099628

Apr 15th, 2022 - In the last decade, the prevalence of Trypanosoma brucei gambiense (Tbg) human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. At low disease prevalence, HAT control is increasingly integrated into routine activ...

Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP2 Passive Case Detection
https://clinicaltrials.gov/ct2/show/NCT03356665

Feb 21st, 2021 - In the last decade, the prevalence of Trypanosoma brucei gambiense human African trypanosomiasis (HAT) has fallen and HAT has been targeted for elimination. At low disease prevalence, integration of case finding into routine activities of peripher...

Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in...
https://clinicaltrials.gov/ct2/show/NCT02169557

Jun 24th, 2020 - Primary Objective -To demonstrate that the success rate of fexinidazole at one year follow-up in stage 1 and early stage 2 patients is greater than 80%. An 80 % success rate is considered as unacceptable. Secondary Objectives To verify whether the...

Prospective Evaluation of an RDT to Screen for Gambiense HAT and Diagnose P. Falciparum Malaria
https://clinicaltrials.gov/ct2/show/NCT03394976

Feb 15th, 2019 - A prototype rapid diagnostic test (RDT) to simultaneously screen for gambiense human African trypanosomiasis (HAT) and diagnose P. falciparum malaria (the "HAT/malaria combo") has recently been developed. The performance of this prototype has been...

Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the Fexinidazole
https://clinicaltrials.gov/ct2/show/NCT00982904

Apr 6th, 2017 - The present study is designed to obtain safety, tolerability and PK data after single and multiple oral administration of increasing doses of fexinidazole in healthy male sub-Saharan African subjects. This study will also assess the relative bioav...

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News  4 results

What Neglected Tropical Diseases Teach Us About Stigma
https://www.mdedge.com/dermatology/article/209336/infectious-diseases/what-neglected-tropical-diseases-teach-us-about?channel=234
Aileen Y. Chang, MD, Maria T. Ochoa, MD

Oct 3rd, 2019 - Neglected tropical diseases (NTDs) are a group of 20 diseases that typically are chronic and cause long-term disability, which negatively impacts work productivity, child survival, and school performance and attendance with adverse effect on futur.

EMA Panel Backs First Oral-Only Drug for Deadly Sleeping Sickness
https://www.medscape.com/viewarticle/905009

Nov 16th, 2018 - The first oral-only treatment for human African trypanosomiasis (HAT), commonly known as sleeping sickness, has received a green light from the Committee for Human Medicinal Products (CHMP) of the European Medicines Agency (EMA). Fexinidazole Wint...

Novel Drug Approvals for 2021
http://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/novel-drug-approvals-2021

Innovation drives progress. When it comes to innovation in the development of new drugs and therapeutic biological products, FDA’s Center for Drug Evaluation and Research (CDER) supports the pharmaceutical industry at every step of the process. Wi...

Advising Patients on Safe Travel Abroad
https://www.medscape.com/viewarticle/741804_3

May 6th, 2011 - Specific Recommendations Arthropod-Borne Diseases Arthropods are not only a source of nuisance and pain at the site of their bites, but they also may cause more harmful generalized reactions as a result of venom production or allergies to substanc...

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