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About 8,455 results

ALLMedicine™ Leishmaniasis Center

Research & Reviews  3,275 results

Molecular identification of two newly identified human pathogens causing leishmaniasis ...
https://doi.org/10.1371/journal.pntd.0009982
PLoS Neglected Tropical Diseases; Jariyapan N, Bates MD et. al.

Dec 1st, 2021 - PCR-based methods to amplify the 3' untranslated region (3'-UTR) of the heat shock protein 70 (type I) gene (HSP70-I) have previously been used for typing of Leishmania but not with Leishmania (Mundinia) martiniquensis and L. (Mundinia) orientalis...

Treatment of Mucosal Bolivian Leishmaniasis
https://clinicaltrials.gov/ct2/show/NCT04799236

Nov 30th, 2021 - The purpose of this protocol is to conduct a randomized comparison of the efficacy and tolerance of miltefosine, LAMB, and pentavalent antimony for the treatment of mucosal leishmaniasis. With such controlled pharmacodynamic data, and additional c...

Association between Hypertriglyceridemia and Disease Severity in Visceral Leishmaniasis.
https://doi.org/10.4269/ajtmh.21-0260
The American Journal of Tropical Medicine and Hygiene; Varela MG, de Oliveira Bezerra M et. al.

Nov 24th, 2021 - Visceral leishmaniasis (VL) is a tropical disease endemic to Brazil. The clinical manifestations of the infection range from asymptomatic to severe. In VL, changes in lipid metabolism, such as hypocholesterolemia and hypertriglyceridemia, occur th...

Increased levels of cortisol are associated with the severity of experimental visceral ...
https://doi.org/10.1371/journal.pntd.0009987
PLoS Neglected Tropical Diseases; Barros-Gonçalves TD, Saavedra AF et. al.

Nov 24th, 2021 - Several infectious diseases are associated with hypothalamic-pituitary-adrenal (HPA) axis disorders by elevating circulating glucocorticoids (GCs), which are known to have an immunosuppressive potential. We conducted this study in golden hamsters,...

Some novel antileishmanial compounds inhibit normal cell cycle progression of Leishmani...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8608343
PloS One; Amlabu WE, Amisigo CM et. al.

Nov 23rd, 2021 - In the midst of numerous setbacks that beclouds the fight against leishmaniasis; a neglected tropical disease, the search for new chemotherapeutics against this disease is of utmost importance. Leishmaniasis is a disease closely associated with po...

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Guidelines  4 results

Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectiou...
https://doi.org/10.1093/cid/ciw742
Clinical Infectious Diseases : an Official Publication Of... Aronson N, Herwaldt BL et. al.

Dec 13th, 2016 - It is important to realize that leishmaniasis guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. The ID...

Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectiou...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239701
The American Journal of Tropical Medicine and Hygiene; Aronson N, Herwaldt BL et. al.

Dec 9th, 2016 - Diagnosis and Treatment of Leishmaniasis: Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH).|2016|Aronson N,Herwaldt BL,Libman M,Pearson R,Lopez-Vele...

Control of visceral leishmaniasis in Brazil: recommendations from Brasileish.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556119
Parasites & Vectors; Ribeiro VM, da Silva SM et. al.

Jan 15th, 2013 - On 26 October 2012, veterinary medicine clinicians and researchers, members of Brasileish - Study Group about Animal Leishmaniasis - met at the Regional Council of Veterinary Medicine of Minas Gerais, in the city Belo Horizonte, in order to discus...

Designing and reporting clinical trials on treatments for cutaneous leishmaniasis.
https://doi.org/10.1086/655134
Clinical Infectious Diseases : an Official Publication Of... González U, Pinart M et. al.

Jul 14th, 2010 - Cutaneous leishmaniasis is considered to be one of the most neglected and serious parasitic infectious skin diseases in many developing countries. We have assessed the design and reporting of randomized, controlled trials evaluating treatments inc...

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Drugs  2 results see all →

Clinicaltrials.gov  61 results

Treatment of Mucosal Bolivian Leishmaniasis
https://clinicaltrials.gov/ct2/show/NCT04799236

Nov 30th, 2021 - The purpose of this protocol is to conduct a randomized comparison of the efficacy and tolerance of miltefosine, LAMB, and pentavalent antimony for the treatment of mucosal leishmaniasis. With such controlled pharmacodynamic data, and additional c...

Combination, Miltefosine Monotherapy & Antimonial Therapy for Cutaneous Leishmaniasis in New World
https://clinicaltrials.gov/ct2/show/NCT04515186

Oct 28th, 2021 - This randomized, open label, multi-centre, non-inferiority study aims to compare that the combination of thermotherapy (one application, 50⁰C for 30") and 3 weeks of miltefosine (2.5 mg/kg/day for 21 days orally) (here after referred to as combina...

Cutaneous Leishmaniasis Diagnostic Study
https://clinicaltrials.gov/ct2/show/NCT03837431

Aug 23rd, 2021 - Cutaneous Leishmaniasis is common in Ethiopia and mainly affects the poor living in rural areas. Diagnosis of CL routinely uses invasive skin slits which are examined with microscopy, requiring trained staff and an equipped lab. A new rapid diagno...

Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa
https://clinicaltrials.gov/ct2/show/NCT03129646

Jun 11th, 2021 - The 2 treatment regimens to be tested are: Arm 1: Paromomycin 20 mg/kg/d IM for 14 days combined with oral miltefosine allometric dosing for 14 days Arm 2: Paromomycin 20 mg/kg/d IM for 14 days combined with oral miltefosine allometric dosing for ...

The Association of Miltefosine and Pentoxifylline to Treat Mucosal and Cutaneous Leishmaniasis: A Clinical Trial in Brazil
https://clinicaltrials.gov/ct2/show/NCT02530697

May 6th, 2021 - Mucocutaneous leishmaniasis is endemic in the central region of Brazil and other countries worldwide. The standard treatment with meglumine antimoniate has a high rate of important adverse effects. This interventional study consists in a randomize...

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News  38 results

Miltefosine Granted Orphan Drug Approval for Invasive Candidiasis
https://www.medscape.com/viewarticle/962804

Nov 12th, 2021 - The US Food and Drug Administration (FDA) has granted orphan drug designation approval of miltefosine (Profounda, Inc) for the treatment of invasive candidiasis. This condition includes the potentially life-threatening candidemia, which is among t...

CDC Mandates Measles Quarantine for Afghanistan Evacuees
https://www.medscape.com/viewarticle/959222

Sep 22nd, 2021 - Evacuees of Afghanistan who have arrived in the United States must be vaccinated against measles and undergo quarantine for 21 days, according to a health advisory issued September 20 by the Centers for Disease Control and Prevention (CDC). At the...

A healthy family who had been living in Brazil presented with crusted plaques on their extremities
http://www.mdedge.com/dermatology/article/242971/infectious-diseases/healthy-family-who-had-been-living-brazil-presented
Sabrina Liao, BS, Brooke Resh Sateesh, MD

Jul 15th, 2021 - Trypanosomatidae Leishmaniasis is caused by protozoa of the family Trypanosomatidae, called Leishmania. The vector is a sandfly infected with the protozoa.

Climate Change Could Fuel the Spread of a Flesh-Eating Parasite
https://www.medscape.com/viewarticle/953677

Jun 24th, 2021 - Three years ago, Laura Gaither and her family spent their summer vacation in Panama City Beach, Florida. One afternoon, while rinsing sand off her feet, the 35-year-old Alabama resident felt something biting her legs and noticed tiny black bugs on...

Climate Change: Dermatologists Address Impact on Health, and Mobilize to Increase Awareness
https://www.medscape.com/viewarticle/947786

Mar 19th, 2021 - Climate change will increasingly affect the distribution and frequency of insect-borne diseases, cutaneous leishmaniasis, skin cancer, fungal diseases, and a host of other illnesses that have cutaneous manifestations or involve the skin — and derm...

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Patient Education  2 results see all →