ALLMedicine™ Avian Influenza Center

Jul 29th, 2021 - Cleavage of the influenza A virus (IAV) hemagglutinin (HA) by host proteases is indispensable for virus replication. Most IAVs possess a monobasic HA cleavage site cleaved by trypsin-like proteases. Previously, the transmembrane protease TMPRSS2 w...

Jul 22nd, 2021 - Two variants of highly pathogenic avian influenza A(H5N8) virus were detected in dead poultry in Western Siberia, Russia, during August and September 2020. One variant was represented by viruses of clade 2.3.4.4b and the other by a novel reassorta...

Jul 16th, 2021 - Cytokines Can Suppress Cardiac Output and Cytokine Storms Inhibit Oxygen Use by Mitochondria and Contribute to the Occurrence of Acute Heart Failure in Patients With Severe Infection Caused by Avian Influenza A (H7N9): We Are Not Sure!|2021|Honore...

Jul 14th, 2021 - Highly pathogenic avian influenza viruses (HPAIVs) pose a significant threat to human health, with high mortality rates and require effective vaccines. We showed that, harnessed with novel RNA-mediated chaperone function, hemagglutinin (HA) of H5N...

Jul 8th, 2021 - In the context of the coronavirus disease 2019 pandemic, we investigated the epidemiological and clinical characteristics of a young patient infected by avian influenza A (H5N6) virus in Anhui Province, East China, and analyzed genomic features of...

May 1st, 2020 - This is a randomized, double-blinded, Phase II study in healthy males and non-pregnant females, 18-64 years of age. This clinical trial is designed to assess the safety, reactogenicity, and immunogenicity of a pre-pandemic 2017 monovalent inactiva...

Sep 26th, 2018 - Following the emergence of avian influenza A/H7N9 influenza virus in humans in China in March 2013, the WHO Essential Regulatory Laboratories prepared candidate vaccine viruses and reagents for further development and several manufacturers have de...

Aug 8th, 2018 - This Phase 3 study evaluates the safety, immunogenicity and lot-to lot consistency of 3 lots of aH5N1c vaccine for pandemic avian influenza, in approximately 2394 healthy adults ≥18 years of age receiving the vaccine and 798 healthy adults receivi...

Jul 31st, 2018 - Avian influenza presents a threat of a future pandemic. Over 200 people have been infected with the influenza A H5N1 virus, and the mortality is near 60 percent. Optimal therapy is not known, and failures of and resistance to currently available a...

Jul 31st, 2018 - A Phase 2, open-label, randomized, parallel group, multi-centered study designed to evaluate the immunogenicity and safety of a 2-dose series of avian influenza vaccine plus AS03 adjuvant according to different regimens, in adults aged 18-64 years...

Apr 9th, 2020 - CHICAGO (Reuters) - The U.S. Department of Agriculture on Thursday confirmed the country’s first case of virulent avian flu in commercial poultry since 2017. The agency found H7N3 avian influenza, a virulent or highly pathogenic strain, in a turke...

Mar 31st, 2020 - I am writing this editorial on a beautiful day in the high desert of the Southwest: a bright blue clear sky such as you see only in the mountain air, a sun warm and comforting, and birds singing as if they had not a care in the world. Spring has c.

Mar 5th, 2020 - HANOI (Reuters) - Vietnam has so far this year culled 137,180 birds to contain the spreading of bird flu outbreaks, the government said on Thursday. The outbreaks, including 38 outbreaks of H5N6 and five outbreaks of H5N1, have been detected in 13...

Dec 11th, 2019 - Twenty-seven thousand chickens are being culled on a farm in Suffolk after avian influenza was confirmed there. A 1km restricted zone has been put in place around the farm. Public Health England (PHE) said in a statement: "Low pathogenic avian inf...

Dec 11th, 2019 - Twenty-seven thousand chickens are being culled on a farm in Suffolk after avian influenza was confirmed there. A 1km restricted zone has been put in place around the farm. Public Health England (PHE) said in a statement: "Low pathogenic avian inf...