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About 8,033 results

ALLMedicine™ Vaccinia Center

Research & Reviews  3,967 results

Intranasal boosting with MVA encoding secreted mycobacterial proteins Ag85A and ESAT-6 ...
https://doi.org/10.1016/j.vaccine.2021.01.071
Vaccine Khanna M, Rady H et. al.

Feb 26th, 2021 - Bacille-Calmette-Guerin (BCG) has variable efficacy as an adult tuberculosis (TB) vaccine but can reduce the incidence and severity of TB infection in humans. We have engineered modified vaccinia Ankara (MVA) strain vaccine constructs to express t...

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infec...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859620
Immunity Routhu NK, Cheedarla N et. al.

Feb 25th, 2021 - A combination of vaccination approaches will likely be necessary to fully control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Here, we show that modified vaccinia Ankara (MVA) vectors expressing membrane-anchored pre...

Vaccinia virus-based vector against infectious diseases and tumors.
https://doi.org/10.1080/21645515.2020.1840887
Human Vaccines & Immunotherapeutics; Zhang Z, Dong L et. al.

Feb 19th, 2021 - Vaccinia virus was used to prevent smallpox. After the World Health Organization declared smallpox extinct, vaccinia virus has been explored for the development of vaccines against a variety of infectious diseases. It also finds a new place in onc...

Enhanced antitumor efficacy of a novel oncolytic vaccinia virus encoding a fully monocl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878184
EBioMedicine Zuo S, Wei M et. al.

Feb 13th, 2021 - Oncolytic virotherapy with vaccinia virus (VV) can lead to effective anti-tumor immunity by turning "cold" tumors into "hot" tumors. However, its therapeutic potential is affected by the tumor's local immunosuppressive tumor microenvironment (TME)...

Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883866
Journal for Immunotherapy of Cancer; Hinterberger M, Giessel R et. al.

Feb 13th, 2021 - Background Human cancers are extraordinarily heterogeneous in terms of tumor antigen expression, immune infiltration and composition. A common feature, however, is the host's inability to mount potent immune responses that prevent tumor growth eff...

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Guidelines  2 results

Position on donors and smallpox vaccine: a committee opinion.
https://doi.org/10.1016/j.fertnstert.2012.03.043
Fertility and Sterility;

Apr 27th, 2012 - Although there is presently no definitive evidence linking vaccinia virus transmission through reproductive cells, SART/ASRM accordingly recommends that ART practitioners consider deferring donors who have recently received smallpox vaccine or con...

Society for Assisted Reproductive Technology position statement on donor suitability of...
https://doi.org/10.1016/j.fertnstert.2008.08.052
Fertility and Sterility; ,

Nov 25th, 2008 - Although there is presently no definitive evidence linking vaccinia virus transmission through reproductive cells, SART/ASRM accordingly recommends that ART practitioners consider deferring donors who have recently received smallpox vaccine or con...

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Drugs  4 results see all →

Clinicaltrials.gov  4,011 results

Intranasal boosting with MVA encoding secreted mycobacterial proteins Ag85A and ESAT-6 ...
https://doi.org/10.1016/j.vaccine.2021.01.071
Vaccine Khanna M, Rady H et. al.

Feb 26th, 2021 - Bacille-Calmette-Guerin (BCG) has variable efficacy as an adult tuberculosis (TB) vaccine but can reduce the incidence and severity of TB infection in humans. We have engineered modified vaccinia Ankara (MVA) strain vaccine constructs to express t...

A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infec...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859620
Immunity Routhu NK, Cheedarla N et. al.

Feb 25th, 2021 - A combination of vaccination approaches will likely be necessary to fully control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Here, we show that modified vaccinia Ankara (MVA) vectors expressing membrane-anchored pre...

Vaccinia virus-based vector against infectious diseases and tumors.
https://doi.org/10.1080/21645515.2020.1840887
Human Vaccines & Immunotherapeutics; Zhang Z, Dong L et. al.

Feb 19th, 2021 - Vaccinia virus was used to prevent smallpox. After the World Health Organization declared smallpox extinct, vaccinia virus has been explored for the development of vaccines against a variety of infectious diseases. It also finds a new place in onc...

Enhanced antitumor efficacy of a novel oncolytic vaccinia virus encoding a fully monocl...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878184
EBioMedicine Zuo S, Wei M et. al.

Feb 13th, 2021 - Oncolytic virotherapy with vaccinia virus (VV) can lead to effective anti-tumor immunity by turning "cold" tumors into "hot" tumors. However, its therapeutic potential is affected by the tumor's local immunosuppressive tumor microenvironment (TME)...

Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883866
Journal for Immunotherapy of Cancer; Hinterberger M, Giessel R et. al.

Feb 13th, 2021 - Background Human cancers are extraordinarily heterogeneous in terms of tumor antigen expression, immune infiltration and composition. A common feature, however, is the host's inability to mount potent immune responses that prevent tumor growth eff...

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News  49 results

Two-Vaccine Regimen Yields Best Antibody Response to Ebola
https://www.medscape.com/viewarticle/939303

Oct 18th, 2020 - NEW YORK (Reuters Health) - Sequential administration of two different Ebola vaccines spaced several weeks apart yields the best antibody responses, according to an early trial. Dr. Neil Goldstein of Janssen Infectious Diseases and Vaccines, in Le...

Novel Vaccine May Help Prevent CMV-Related Complications in Transplant Patients
https://www.staging.medscape.com/viewarticle/925036

Feb 10th, 2020 - NEW YORK (Reuters Health) - Patients who underwent an allogeneic hematopoietic stem cell transplant (HCT) experienced fewer cytomegalovirus (CMV)-related complications after Triplex vaccine injections in a phase-2, randomized, placebo-controlled t...

Novel Vaccine May Help Prevent CMV-Related Complications in Transplant Patients
https://www.medscape.com/viewarticle/925036

Feb 10th, 2020 - NEW YORK (Reuters Health) - Patients who underwent an allogeneic hematopoietic stem cell transplant (HCT) experienced fewer cytomegalovirus (CMV)-related complications after Triplex vaccine injections in a phase-2, randomized, placebo-controlled t...

Lab Worker Infected With Smallpox-Related Virus
https://www.medscape.com/viewarticle/920662

Oct 30th, 2019 - A laboratory worker in San Diego, CA, infected herself with a smallpox-related virus after she accidentally pricked her finger during an experiment. The 26-year-old was injecting a mouse with the vaccinia virus (VACV) in 2018 when the needle pierc...

FDA approves first live vaccine for smallpox, monkeypox prevention
https://www.mdedge.com/jcomjournal/article/208800/vaccines/fda-approves-first-live-vaccine-smallpox-monkeypox-prevention?channel=234
Lucas Franki

Sep 25th, 2019 - The Food and Drug Administration has approved Jynneos, a live, nonreplicating vaccine based on the vaccinia virus, for smallpox and monkeypox, becoming the first FDA-approved vaccine for the prevention of monkeypox disease. FDA approval for Jynneo.

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