ALLMedicine™ Arenaviruses Center
Research & Reviews 159 results
Journal of Virology; Pyle JD, Whelan SPJ
Aug 26th, 2021 - Arenaviruses initiate infection by delivering a transcriptionally-competent ribonucleoprotein (RNP) complex into the cytosol of host cells. The arenavirus RNP consists of the large (L) RNA-dependent RNA polymerase (RdRP) bound to a nucleoprotein (...
Journal of Medical Virology; Uwishema O, Alshareif BAA et. al.
Jul 22nd, 2021 - Lassa fever, caused by the Lassa virus of the Arenaviruses family, is a re-emerging public health concern that has led to 300,000 infections and 5000 deaths annually in Africa. Highly prevalent in Sierra Leone, Liberia, Guinea, Nigeria, Côte d'lvo...
Antiviral Research; Gowen BB, Naik S et. al.
Jul 2nd, 2021 - Several arenaviruses, including Lassa and Lujo viruses in Africa and five New World arenavirus (NWA) species in the Americas, cause life-threatening viral hemorrhagic fevers. In the absence of licensed antiviral therapies, these viruses pose a sig...
Nature Microbiology; Xu X, Peng R et. al.
Jun 16th, 2021 - Zoonotic arenaviruses can lead to life-threating diseases in humans. These viruses encode a large (L) polymerase that transcribes and replicates the viral genome. At the late stage of replication, the multifunctional Z protein interacts with the L...
PLoS Pathogens; Sarute N, Cheng H et. al.
Jun 8th, 2021 - Signal-regulatory protein alpha (SIRPA) is a well-known inhibitor of phagocytosis when it complexes with CD47 expressed on target cells. Here we show that SIRPA decreased in vitro infection by a number of pathogenic viruses, including New World an...