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About 715 results

ALLMedicine™ Picornavirus Center

Research & Reviews  274 results

Structure of Senecavirus A 3C Protease Revealed the Cleavage Pattern of 3C Protease in ...
https://doi.org/10.1128/jvi.00736-22
Journal of Virology; Meng K, Zhang L et. al.

Jun 22nd, 2022 - Senecavirus A (SVA) is an emerging picornavirus infecting porcine of all age groups and causing foot and mouth disease (FMD)-like symptoms. One of its key enzymes is the 3C protease (3Cpro), which is similar to other picornaviruses and essential f...

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replicat...
https://doi.org/10.1371/journal.ppat.1010589
PLoS Pathogens; Ward JC, Lasecka-Dykes L et. al.

Jun 7th, 2022 - Non-coding regions of viral RNA (vRNA) genomes are critically important in the regulation of gene expression. In particular, pseudoknot (PK) structures, which are present in a wide range of RNA molecules, have a variety of roles. The 5' untranslat...

Infectious dose of Senecavirus A in market weight and neonatal pigs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053780
PloS One; Buckley A, Lager K

Apr 30th, 2022 - Foot-and-mouth disease virus (FMDV) is a picornavirus that produces a highly transmissible vesicular disease that can devastate meat and dairy production to such an extent that FMDV-free countries commit significant economic resources to maintain ...

Cell pyroptosis in picornavirus and its potential for treating viral infection.
https://doi.org/10.1002/jmv.27813
Journal of Medical Virology; Wang Z, Yu H et. al.

Apr 28th, 2022 - Cell pyroptosis has received increased attention due to the associations between innate immunity and disease, and it has become a major focal point recently due to in-depth studies of cancer. With increased research on pyroptosis, scientists have ...

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Clinicaltrials.gov  7 results

Study of Gene Modified Immune Cells in Patients With Advanced Melanoma
https://clinicaltrials.gov/ct2/show/NCT00910650

Dec 6th, 2021 - This is a two-stage phase II clinical trial with the combined primary endpoints to determine the safety, feasibility and anti-tumor activity of adoptive transfer of peripheral blood mononuclear cells (PBMC) genetically engineered to express the al...

Effects of Pleconaril Nasal Spray on Common Cold Symptoms and Asthma Exacerbations Following Rhinovirus Exposure (Study P04295)
https://clinicaltrials.gov/ct2/show/NCT00394914

Jul 16th, 2015 - This is a randomized, multi-center, double-blind, placebo-controlled study evaluating the efficacy of pleconaril nasal spray in preventing asthma exacerbation and common cold symptoms in asthmatic participants exposed to picornavirus respiratory i...

A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children
https://clinicaltrials.gov/ct2/show/NCT01734408

Oct 23rd, 2013 - Hand, foot, and mouth disease (HFMD) is a common viral illness in infants and children caused by viruses that belong to the enterovirus genus of the picornavirus family. Although most HFMD cases do not result in serious complications, outbreaks of...

A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants
https://clinicaltrials.gov/ct2/show/NCT01399853

May 31st, 2012 - Hand, foot, and mouth disease (HFMD) is a common viral illness in infants and children caused by viruses that belong to the enterovirus genus of the picornavirus family. Although most HFMD cases do not result in serious complications, outbreaks of...

A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants
https://clinicaltrials.gov/ct2/show/NCT01313715

Jan 2nd, 2012 - Hand, foot, and mouth disease (HFMD) is a common viral illness in infants and children caused by viruses that belong to the enterovirus genus of the picornavirus family. Although most HFMD cases do not result in serious complications, outbreaks of...

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News  5 results

Environmental Factors in Myositis: A Link?
https://www.medpagetoday.com/rheumatology/generalrheumatology/87118

Jun 17th, 2020 - The development of a subtype of inflammatory myopathy characterized by interstitial lung disease and positivity for a specific autoantibody was influenced by seasonality and place of residence, Japanese researchers found. Among patients with polym...

Bacteria and Viruses Cohabitate in Ears of Kids With Otitis Media
https://www.medpagetoday.com/pediatrics/generalpediatrics/4454

Nov 7th, 2006 - Action Points Explain to parents that many cases of otitis media that do not respond to an initial course of antibiotics may be either viral or of mixed bacterial and viral origin, and that these infections may not respond to antibiotics. Explain ...

The Enterovirus D68 Outbreak: A Public Health Concern
https://www.medscape.com/viewarticle/845871_2

Background EV-D68 was first discovered in California in 1962 when it was isolated from samples obtained from children with pneumonia.[1] The higher rate of severe cases in children when compared to adults is likely due to the physiological differe...

Severe Respiratory Illness Associated With Enterovirus D68 -- Missouri and Illinois, 2014
https://www.medscape.com/viewarticle/831563

On August 19, 2014, CDC was notified by Children's Mercy Hospital in Kansas City, Missouri, of an increase (relative to the same period in previous years) in patients examined and hospitalized with severe respiratory illness, including some admitt...

Acute Flaccid Myelitis Associated With Enterovirus D68 in Children, Argentina, 2016
https://www.staging.medscape.com/viewarticle/910197

Abstract and Introduction Abstract After a 2014 outbreak of severe respiratory illness caused by enterovirus D68 in the United States, sporadic cases of acute flaccid myelitis have been reported worldwide. We describe a cluster of acute flaccid my...

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