About 620 results

ALLMedicine™ Poxviruses Center

Research & Reviews  233 results

Evaluation and clinical validation of monkeypox (mpox) virus real-time PCR assays.
Journal of Clinical Virology : the Official Publication O... Mills MG, Juergens KB et. al.

Jan 6th, 2023 - In spring of 2022, an outbreak of monkeypox (mpox) spread worldwide. Here, we describe performance characteristics of monkeypox virus (MPXV)-specific and pan-orthopoxvirus qPCR assays for clinical use. We validated probe-based qPCR assays targetin...

Development of a rapid image-based high-content imaging screening assay to evaluate the...
Antiviral Research; Kota KP, Ziółkowska NE et. al.

Jan 3rd, 2023 - Antibody-based therapy is emerging as a critical therapeutic countermeasure to treat acute viral infections by offering rapid protection against clinical disease. The advancements in structural biology made it feasible to rationalize monoclonal an...

Monkeypox (Mpox) Treatment & Management

Nov 29th, 2022 - Medical Care Also see Guidelines. The disease is usually self-limited; resolution occurs in 2-4 weeks. In the African cases, the mortality rate was 1-10%, and death was related to the patients' health status and other comorbidities. Most patients ...

Monkeypox (Mpox) Medication

Nov 29th, 2022 - Medication Summary The CDC recommends a smallpox or smallpox/monkeypox (mpox) vaccination within 2 weeks of exposure, ideally within 4 days, for exposed health care workers and household contacts of confirmed cases. Antiviral agents (ie, tecovirim...

Role of cytokines in poxvirus host tropism and adaptation.
Current Opinion in Virology; Rahman MM, McFadden G

Nov 26th, 2022 - Poxviruses are a diverse family of double-stranded DNA viruses that cause mild-to-severe disease in selective hosts, including humans. Although most poxviruses are restricted to their hosts, some members can leap host species and cause zoonotic di...

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Clinicaltrials.gov  3 results

Trial of Imatinib for Hospitalized Adults With COVID-19

Jul 20th, 2022 - Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and at present with no approved or proven antiviral treatment. Imatinib is a tyrosine kinase inhibitor th...

Chemotherapy Followed by ESO-1 Lymphocytes and Aldesleukin to Treat Metastatic Cancer

Nov 19th, 2019 - Background: We have constructed a single retroviral vector that contains both alpha and beta chains of a T cell receptor (TCR) that recognizes the NY-ESO-1 (ESO) tumor antigen, which can be used to mediate genetic transfer of this TCR with high ef...

Anti-MART-1 F5 Lymphocytes to Treat High-Risk Melanoma Patients

Oct 28th, 2015 - Background: We have engineered human peripheral blood lymphocytes (PBLs) to express an anti-MART-1 T-cell receptor (TCR) that recognizes an HLA-A*0201 restricted epitope derived from the tumor infiltrating lymphocytes (TIL) clone DMF5. We construc...

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News  12 results

COVID vs Monkeypox: A Tale of Two Pandemics

Aug 10th, 2022 - Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I'm Dr F. Perry Wilson of the Yale School of Medicine. Toward the end of 2019, we all took a crash course in virology and infectious disease epidemiology as we strugg...

Keeping Your Laundry Free From Monkeypox

Aug 8th, 2022 - Is your laundry a way to spread monkeypox? As monkeypox cases rise globally, health officials have warned that the virus mainly spreads through direct skin-to-skin contact with a monkeypox lesion. But according to the CDC, poxviruses like the monk...

Immunotherapy Hits New Peak: ASCO Data Stir Excitement, Investment

Oct 6th, 2021 - Any lingering skepticism about immunotherapy as an anticancer strategy appears to have been banished by research presented at the 2013 American Society of Clinical Oncology (ASCO) Annual Meeting, with fresh data from several key trials translating...

5 Abstracts Offer Snapshot of Immunology Research

Dec 5th, 2020 - The carcinoembryonic antigen (CEA) vaccinia has been researched for more than 20 years. Investigational Glioma Vaccine Results Promising A novel vaccine based on dendritic cells and peptides proved to be safe and capable of delivering an im...

Multidisciplinary Approaches Are Needed in Ovarian Cancer

Dec 5th, 2020 - Nancy E. Davidson, MD Director University of Pittsburgh Cancer Institute, UMPC Cancer Center Pittsburgh, PA While ovarian cancer survival rates have improved slightly since the 1970s, the overall five-year survival for patients diag...

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