ALLMedicine™ Vaccinia Center

Aug 5th, 2022 - This is a Phase 1b/2a, open-label, multi-center, dose-escalation and safety/efficacy evaluation trial of Pexa-Vec plus Cemiplimab in patients with metastatic or unresectable renal cell carcinoma (RCC). The trial consists of a dose-escalation stage...

Jul 29th, 2022 - Medication Summary The CDC recommends a smallpox or smallpox/monkeypox vaccination within 2 weeks of exposure, ideally within 4 days, for exposed health care workers and household contacts of confirmed cases. Antiviral agents (ie, tecovirimat, bri...

Jul 27th, 2022 - This is an open-label Phase 4 study designed to collect additional data to assess the safety and efficacy of VIGIV [CNJ-016, Vaccinia Immune Globulin Intravenous (Human), sterile solution] in the first 100 consented patients treated with VIGIV.

Jul 25th, 2022 - Rationale: Tecovirimat (TPOXX) is approved by FDA for treatment of smallpox. However, the therapeutic human dose for treatment of orthopox virus infections or a significant adverse reaction to vaccinia resulting from vaccination, secondary transmi...

Jul 20th, 2022 - Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and at present with no approved or proven antiviral treatment. Imatinib is a tyrosine kinase inhibitor th...

May 7th, 2022 - In 1959, German microbiologist Anton Mayr took a strain of vaccinia, a poxvirus used to inoculate against smallpox, and started to grow it in cells taken from chicken embryos. After several years of transferring the strain to fresh cells every few...

Smallpox/monkeypox vaccine (JYNNEOS™) can help protect against smallpox, monkeypox, and other diseases caused by orthopoxviruses, including vaccinia virus. Smallpox is a very serious disease caused by variola virus. Smallpox was declared eradic...

The monkeypox virus is part of the Orthopoxvirus genus, which also includes variola virus (the cause of smallpox), vaccinia virus, and cowpox virus. Although monkeypox is similar to smallpox, it is much less deadly. Initial symptoms of monkeypox i...

Aug 5th, 2022 - This is a Phase 1b/2a, open-label, multi-center, dose-escalation and safety/efficacy evaluation trial of Pexa-Vec plus Cemiplimab in patients with metastatic or unresectable renal cell carcinoma (RCC). The trial consists of a dose-escalation stage...

Jul 27th, 2022 - This is an open-label Phase 4 study designed to collect additional data to assess the safety and efficacy of VIGIV [CNJ-016, Vaccinia Immune Globulin Intravenous (Human), sterile solution] in the first 100 consented patients treated with VIGIV.

Jul 25th, 2022 - Rationale: Tecovirimat (TPOXX) is approved by FDA for treatment of smallpox. However, the therapeutic human dose for treatment of orthopox virus infections or a significant adverse reaction to vaccinia resulting from vaccination, secondary transmi...

Jul 20th, 2022 - Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and at present with no approved or proven antiviral treatment. Imatinib is a tyrosine kinase inhibitor th...

Jul 18th, 2022 - Olvi-Vec (olvimulogene nanivacirepvec, aka GL-ONC1, laboratory name: GLV-1h68) is an oncolytic vaccinia virus-based immunotherapy. This study is to test the hypothesis that the combination of Olvi-Vec followed by further chemotherapy is particular...

Jul 6th, 2022 - The Centers for Disease Control and Prevention (CDC) and the World Health Organization are investigating an outbreak of monkeypox cases that have occurred around the world in countries that do not have endemic monkeypox virus. 1,2 As of July 5, the.

Jun 29th, 2022 - (Reuters) - The European Union's drug regulator said on Tuesday it has started a review to extend the use of Bavarian Nordic's smallpox vaccine to prevent monkeypox disease as well. The Danish biotech's Imvanex vaccine is approved for smallpox in ...

Jun 8th, 2022 - This transcript has been edited for clarity. Hello. I'm Paul Auwaerter with Medscape Infectious Diseases, speaking from the Johns Hopkins University School of Medicine. Monkeypox joins the legion of occasional emerging infectious diseases that, as...

May 31st, 2022 - (Reuters) - The U.S. Centers for Disease Control and Prevention (CDC) on Friday published recommendations by its group of independent experts on a smallpox vaccine that limit its use to only people who work closely with viruses such as monkeypox. ...

May 24th, 2022 - What is the cause of monkeypox? Monkeypox is a member of the Poxviridae family of viruses called orthopoxvirus and is a double-stranded DNA virus. This subset includes the smallpox (variola), vaccinia, and cowpox viruses. A nice review of monkeypo...