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About 4,848 results

ALLMedicine™ Vaccinia Center

Research & Reviews  1,638 results

A Study of Recombinant Vaccinia Virus in Combination With Cemiplimab for Renal Cell Carcinoma
https://clinicaltrials.gov/ct2/show/NCT03294083

Aug 5th, 2022 - This is a Phase 1b/2a, open-label, multi-center, dose-escalation and safety/efficacy evaluation trial of Pexa-Vec plus Cemiplimab in patients with metastatic or unresectable renal cell carcinoma (RCC). The trial consists of a dose-escalation stage...

Monkeypox Medication
https://emedicine.medscape.com/article/1134714-medication

Jul 29th, 2022 - Medication Summary The CDC recommends a smallpox or smallpox/monkeypox vaccination within 2 weeks of exposure, ideally within 4 days, for exposed health care workers and household contacts of confirmed cases. Antiviral agents (ie, tecovirimat, bri...

VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia Infection
https://clinicaltrials.gov/ct2/show/NCT01374984

Jul 27th, 2022 - This is an open-label Phase 4 study designed to collect additional data to assess the safety and efficacy of VIGIV [CNJ-016, Vaccinia Immune Globulin Intravenous (Human), sterile solution] in the first 100 consented patients treated with VIGIV.

Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
https://clinicaltrials.gov/ct2/show/NCT02080767

Jul 25th, 2022 - Rationale: Tecovirimat (TPOXX) is approved by FDA for treatment of smallpox. However, the therapeutic human dose for treatment of orthopox virus infections or a significant adverse reaction to vaccinia resulting from vaccination, secondary transmi...

Trial of Imatinib for Hospitalized Adults With COVID-19
https://clinicaltrials.gov/ct2/show/NCT04394416

Jul 20th, 2022 - Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and at present with no approved or proven antiviral treatment. Imatinib is a tyrosine kinase inhibitor th...

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Guidelines  3 results

As monkeypox threat grows, scientists debate best vaccine strategy
https://www.science.org/content/article/monkeypox-threat-grows-scientists-debate-best-vaccine-strategy
Science Kupferschmidt K.

May 7th, 2022 - In 1959, German microbiologist Anton Mayr took a strain of vaccinia, a poxvirus used to inoculate against smallpox, and started to grow it in cells taken from chicken embryos. After several years of transferring the strain to fresh cells every few...

Smallpox/Monkeypox Vaccine Information Statements (VISs)
https://www.cdc.gov/vaccines/hcp/vis/vis-statements/smallpox-monkeypox.html
Centers for Disease Control and Prevention (CDC)

Smallpox/monkeypox vaccine (JYNNEOS™) can help protect against smallpox, monkeypox, and other diseases caused by orthopoxviruses, including vaccinia virus. Smallpox is a very serious disease caused by variola virus. Smallpox was declared eradic...

Monkeypox (NIAID)
https://www.niaid.nih.gov/diseases-conditions/monkeypox
National Institute of Allergy and Infectious Diseases (NIAID)

The monkeypox virus is part of the Orthopoxvirus genus, which also includes variola virus (the cause of smallpox), vaccinia virus, and cowpox virus. Although monkeypox is similar to smallpox, it is much less deadly. Initial symptoms of monkeypox i...

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Drugs  10 results see all →

Clinicaltrials.gov  209 results

A Study of Recombinant Vaccinia Virus in Combination With Cemiplimab for Renal Cell Carcinoma
https://clinicaltrials.gov/ct2/show/NCT03294083

Aug 5th, 2022 - This is a Phase 1b/2a, open-label, multi-center, dose-escalation and safety/efficacy evaluation trial of Pexa-Vec plus Cemiplimab in patients with metastatic or unresectable renal cell carcinoma (RCC). The trial consists of a dose-escalation stage...

VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia Infection
https://clinicaltrials.gov/ct2/show/NCT01374984

Jul 27th, 2022 - This is an open-label Phase 4 study designed to collect additional data to assess the safety and efficacy of VIGIV [CNJ-016, Vaccinia Immune Globulin Intravenous (Human), sterile solution] in the first 100 consented patients treated with VIGIV.

Tecovirimat (ST-246) Treatment for Orthopox Virus Exposure
https://clinicaltrials.gov/ct2/show/NCT02080767

Jul 25th, 2022 - Rationale: Tecovirimat (TPOXX) is approved by FDA for treatment of smallpox. However, the therapeutic human dose for treatment of orthopox virus infections or a significant adverse reaction to vaccinia resulting from vaccination, secondary transmi...

Trial of Imatinib for Hospitalized Adults With COVID-19
https://clinicaltrials.gov/ct2/show/NCT04394416

Jul 20th, 2022 - Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and at present with no approved or proven antiviral treatment. Imatinib is a tyrosine kinase inhibitor th...

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Platinum-doublet + Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer
https://clinicaltrials.gov/ct2/show/NCT05281471

Jul 18th, 2022 - Olvi-Vec (olvimulogene nanivacirepvec, aka GL-ONC1, laboratory name: GLV-1h68) is an oncolytic vaccinia virus-based immunotherapy. This study is to test the hypothesis that the combination of Olvi-Vec followed by further chemotherapy is particular...

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News  76 results

Monkeypox: What FPs need to know, now
https://www.mdedge.com/familymedicine/article/256040/infectious-diseases/monkeypox-what-fps-need-know-now
MDedge Family Medicine; Doug Campos-Outcalt, MD, MPA

Jul 6th, 2022 - The Centers for Disease Control and Prevention (CDC) and the World Health Organization are investigating an outbreak of monkeypox cases that have occurred around the world in countries that do not have endemic monkeypox virus. 1,2 As of July 5, the.

EU Begins Review of Bavarian Nordic's Vaccine for Monkeypox
https://www.medscape.com/viewarticle/976297

Jun 29th, 2022 - (Reuters) - The European Union's drug regulator said on Tuesday it has started a review to extend the use of Bavarian Nordic's smallpox vaccine to prevent monkeypox disease as well. The Danish biotech's Imvanex vaccine is approved for smallpox in ...

Monkeypox Outbreak: Monitoring, Diagnosis, and Treatment
https://www.medscape.com/viewarticle/974968

Jun 8th, 2022 - This transcript has been edited for clarity. Hello. I'm Paul Auwaerter with Medscape Infectious Diseases, speaking from the Johns Hopkins University School of Medicine. Monkeypox joins the legion of occasional emerging infectious diseases that, as...

CDC Publishes Guidelines on Monkeypox Vaccine
https://www.medscape.com/viewarticle/974778

May 31st, 2022 - (Reuters) - The U.S. Centers for Disease Control and Prevention (CDC) on Friday published recommendations by its group of independent experts on a smallpox vaccine that limit its use to only people who work closely with viruses such as monkeypox. ...

Monkeypox: How We Got Here, How Smallpox Vaccines Can Help, and How to Contain It
https://www.medscape.com/viewarticle/974540

May 24th, 2022 - What is the cause of monkeypox? Monkeypox is a member of the Poxviridae family of viruses called orthopoxvirus and is a double-stranded DNA virus. This subset includes the smallpox (variola), vaccinia, and cowpox viruses. A nice review of monkeypo...

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Patient Education  3 results see all →